MMPs are regulatory enzymes in pathways of inflammatory disorders, tissue injury, malignancies and remodelling of the lung

European Respiratory Journal

Volumn 38, Issue 1, 2011, Pages 12-14

  Muller Quernheim J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; COLLAGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXYCYCLINE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PENTOXIFYLLINE; TISSUE INHIBITOR OF METALLOPROTEINASE;

ACUTE LUNG INJURY; CANCER GROWTH; DRUG TARGETING; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; LUNG CANCER; METASTASIS POTENTIAL; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUBERCULOSIS;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MATRIX METALLOPROTEINASES;

EID: 79960181855     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00079311     Document Type: Editorial

References (29)

1. Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004; 4: 617-629. (Pubitemid 39025047)
2. Li Q, Park PW, Wilson CL, et al. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 2002; 111: 635-646. (Pubitemid 35441246)
3. Löffek S, Schilling O, Franzke C-W. Biological role of matrix metalloproteinases: a critical balance. Eur Respir J 2011; 38: 191-208.
4. Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3: 207-214.
5. Price NM, Farrar J, Tran TT, et al. Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo. J Immunol 2001; 166: 4223-4230. (Pubitemid 32224957)
6. Elkington PT, Ugarte-Gil CA, Friedland JJ. Matrix metalloproteinases in tuberculosis. Eur Respir J 2011; (in press).
7. Volkman HE, Pozos TC, Zheng J, et al. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science 2010; 327: 466-469.
8. Davey A, McAuley DF, O'Kane CM. Matrix metalloproteinases in acute lung injury: mediators of lung injury and drivers of repair. Eur Respir J 2011; (in press).
9. McKeown S, Richter AG, O'Kane C, et al. MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur Respir J 2009; 33: 77-84.
10. Zuo F, Kaminski N, Eugui E, et al. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 2002; 99: 6292-6297. (Pubitemid 34493305)
11. Huh JW, Kim DS, Oh YM, et al. Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis? Chest 2008; 133: 1101-1106.
12. Dancer RCA, Wood AM, Thickett DR. Metalloproteinases in idiopathic pulmonary fibrosis. Eur Respir J 2011; (In press).
13. Kamio K, Liu XD, Sugiura H, et al. Statins inhibit matrix metalloproteinase release from human lung fibroblasts. Eur Respir J 2010; 35: 637-646.
14. Gaggar A, Hector A, Bratcher PE, et al. The role of matrix metalloproteases in cystic fibrosis lung disease. Eur Respir J 2011; [Epub ahead of print DOI: 10.1183/09031936.00173210].
15. Griese M, Kappler M, Gaggar A, et al. Inhibition of airway proteases in cystic fibrosis lung disease. Eur Respir J 2008; 32: 783-795.
16. Botelho FM, Nikota J, Bauer C, et al. A mouse GM-CSFR antibody attenuates neutrophilia in mice exposed to cigarette smoke. Eur Respir J 2011; [Epub ahead of print DOI: 10.1183/09031936.00076210].
17. Roberts ME, Magowan L, Hall IP, et al. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J 2011; 37: 1482-1493.
18. Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009; 361: 2599-2608.
19. Lee SY, Kim MJ, Kang HG, et al. Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. Respiration 2010; 80: 133-138.
20. Liu D, Nakano J, Ishikawa S, et al. Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer. Lung Cancer 2007; 58: 384-391. (Pubitemid 350051513)
21. Ishikawa S, Takenaka K, Yanagihara K, et al. Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer. Clin Cancer Res 2004; 10: 6579-6585. (Pubitemid 39346554)
22. Qian Q, Wang Q, Zhan P, et al. The role of matrix metalloproteinase 2 on the survival of patients with non-small cell lung cancer: a systematic review with meta-analysis. Cancer Invest 2010; 28: 661-669.
23. Scherf DB, Dally H, Muller P, et al. Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. Eur Respir J 2010; 35: 381-390.
24. Rand L, Green JA, Saraiva L, et al. Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade. J Immunol 2009; 182: 5865-5872.
25. Ren S, Guo LL, Yang J, et al. Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9. Eur J Pharmacol 2011; 650: 418-423.
26. Deree J, Martins J, de Campos T, et al. Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. J Surg Res 2007; 143: 99-108. (Pubitemid 47562450)
27. Yamamoto D, Takai S. Pharmacological implications of MMP-9 inhibition by ACE inhibitors. Curr Med Chem 2009; 16: 1349-1354.
28. Yamamoto D, Takai S, Jin D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol 2007; 43: 670-676. (Pubitemid 350166378)
29. Vandenbroucke RE, Dejonckheere E, Libert C. A therapeutic role for MMP inhibitors in lung diseases? Eur Respir J 2011; (in press).