Pentoxifylline Attenuates Lung Injury and Modulates Transcription Factor Activity in Hemorrhagic Shock

Journal of Surgical Research

Volumn 143, Issue 1, 2007, Pages 99-108

  Deree, Jessica ^a   Martins, Joilson ^a   de Campos, Tercio ^a   Putnam, James G ^a   Loomis, William H ^a   Wolf, Paul ^a   Coimbra, Raul ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

acute lung injury; CREB; hemorrhagic shock; ischemia reperfusion; neutrophil; NF B; pentoxifylline; Ringer's lactate

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GELATINASE A; GELATINASE B; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PENTOBARBITAL; PENTOXIFYLLINE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; ENZYME IMMUNOASSAY; GEL MOBILITY SHIFT ASSAY; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; ISCHEMIA; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; HEME OXYGENASE-1; ISOTONIC SOLUTIONS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEUTROPHILS; NF-KAPPA B; PENTOXIFYLLINE; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT; SHOCK, HEMORRHAGIC; TRANSCRIPTION FACTORS;

EID: 35248898854     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.03.083     Document Type: Article

References (57)

1. Zallen G., Moore E.E., Johnson J.L., et al. Posthemorrhagic shock mesenteric lymph primes circulating neutrophils and provokes lung injury. J Surg Res 83 (1999) 83
2. Aldridge A.J. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg 168 (2002) 204
3. Lee W.L., and Downey G.P. Neutrophil activation and acute lung injury. Curr Opin Crit Care 7 (2001) 1
4. Windsor A.C., Mullen P.G., Fowler A.A., et al. Role of the neutrophil in adult respiratory distress syndrome. Br J Surg 80 (1993) 10
5. Bazzoni F., Cassatella M.A., Laudanna C., et al. Phagocytosis of opsonized yeast induces tumor necrosis factor-α mRNA accumulation and protein release by human polymorphonuclear leukocytes. J Leukoc Biol 50 (1991) 223
6. Strieter R.M., Kasahara K., Allen R.M., et al. Cytokine-induced neutrophil-derived interleukin-8. Am J Path 141 (1992) 397
7. Sha W.C. Regulation of immune responses by NF-κB/Rel transcription factors. J Exp Med 187 (1998) 143
8. Alam H.B., Stanton K., Koustova E., et al. Effect of different resuscitation strategies on neutrophil activation in a swine model of hemorrhagic shock. Resuscitation 60 (2004) 91
9. Alam H.B., Sun L., Ruff P., et al. E- and P-selectin expression depends on the resuscitation fluid used in hemorrhaged rats. J Surg Res 94 (2002) 145
10. Savage S.A., Fitzpatrick C.M., Kashyap V., et al. Endothelial dysfunction after lactated Ringer's solution resuscitation for hemorrhagic shock. J Trauma 59 (2005) 284
11. Ayuste E.C., Chen H., Koustova E., et al. Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications in conventional ringer's solution. J Trauma 60 (2006) 52
12. Porter J.M., Cutler B.S., Le B.Y., et al. Pentoxifylline efficacy in the treatment of intermittent claudication: Multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am J Heart 104 (1982) 66
13. Lauterbach R., Pawlik D., Kowalczyk D., et al. Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: A placebo-controlled, double-blind trial. Crit Care Med 27 (1999) 807
14. Akriviadis E., Botla R., Briggs W., et al. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial. Gastroenterology 119 (2000) 1637
15. Coimbra R., Melbostad H., and Hoyt D.B. Effects of phosphodiesterase inhibition on the inflammatory response after shock: Role of pentoxifylline. J Trauma 56 (2004) 442
16. Michetti C., Coimbra R., Hoyt D.B., et al. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res 115 (2003) 92
17. van Leenen D., van der Poll T., Levi M., et al. Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees. J Immunol 151 (1993) 2318
18. Coe D.A., Freischlag J.A., Johnson D., et al. Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. J Surg Res 67 (1997) 21
19. Barroso-Aranda J., and Schmid-Schonbein G.W. Pentoxifylline pretreatment decreases the pool of circulating activated neutrophils, in-vivo adhesion to endothelium, and improves survival from hemorrhagic shock. Biorheology 27 (1990) 401
20. Coimbra R., Melbostad H., Loomis W.H., et al. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: Effects on proinflammatory mediators, metalloproteinases, NF-κB, and ICAM-1 expression. J Trauma 60 (2006) 115
21. Remick D.G. Interleukin-8. Crit Care Med 33 (2005) S466
22. Bauer M., and Bauer I. Heme oxygenase-1: Redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal 4 (2002) 749
23. Ryter S.W., Otterbein L.E., Morse D., et al. Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance. Mol Cell Biochem 249 (2002) 234
24. McDonald P.P., Bald A., and Cassatella M.A. Activation of the NF-κB pathway by inflammatory stimuli in human neutrophils. Blood 89 (1997) 3421
25. Renard P., Percherancier Y., Kroll M., et al. Inducible NF-κB activation is permitted by simultaneous degradation of nuclear IκBα. J Biol Chem 275 (2002) 15193
26. Schmitz M.L., and Baeuerle P.A. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J 10 (1991) 3805
27. Levitt J.E., and Matthay M.A. Treatment of acute lung injury: Historical perspective and potential future therapies. Semin Respir Crit Care Med 27 (2006) 426
28. Corbel M., Biochot E., and Lagente V. Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury. Braz J Med Biol Res 155 (2000) 43
29. Torii K., Iida K., Miyazaki Y., et al. Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 155 (1997) 43
30. Deree J., Lall R., Melbostad H., et al. Neutrophil degranulation and the effects of phosphodiesterase inhibition. J Surg Res 133 (2006) 22
31. Redl H., Gasser H., Schlag, et al. Involvement of oxygen radicals in shock related cell injury. Br Med Bull 49 (1993) 556
32. Abdelrahman M., Mazzon E., Bauer M., et al. Inhibitors of the NADPH oxidase reduce the organ injury in hemorrhagic shock. Shock 23 (2005) 107
33. Krakauer T. Pentoxifylline inhibits ICAM-1 expression and chemokines production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology 46 (2000) 253
34. Yada-Langui M.M., Anjos-Valotta E.A., Sannomiya P., et al. Resuscitation affects microcirculatory polymorphonuclear leukocyte behavior after hemorrhagic shock: Role if hypertonic saline and pentoxifylline. Exp Biol Med 229 (2004) 684
35. Donnelly S.C., Strieter R.M., Kunkel S.L., et al. Interleukin-8 and the development of adult respiratory distress syndrome in at-risk patient groups. Lancet 341 (1993) 643
36. Mukaida N., Matsumoto T., Yokoi K., et al. Inhibition of neutrophil mediated acute inflammatory injury by an antibody against interleukin-8. Inflamm Res 3 (1998) S151
37. Nakamori Y., Koh T., Ogura H., et al. Enhanced expression of intranuclear NF-κB in primed polymorphonuclear leukocytes in systemic inflammatory response syndrome patients. J Trauma 54 (2003) 253
38. Arnalich F., Garcia-Palomero E., Lopez J., et al. Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis. Infect Immun 68 (2000) 1942
39. Mukaida N., Okamoto S., Ishikawa Y., et al. Molecular mechanism of interleukin-8 gene expression. J Leuk Biol 56 (1994) 554
40. Yoshida S., Ono M., Shono T., et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 17 (1997) 4015
41. Shaywitz A.J., and Greenberg M.E. CREB: A stimulus induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68 (1999) 821
42. Ndengele M.M., Muscoli C., Wang Z.Q., et al. Superoxide potentiates NF-κB activation and modulates endotoxin-induced cytokine production in alveolar macrophages. Shock 23 (2005) 186
43. Christman J.W., Lancaster L.H., and Blackwell T.S. Nuclear factor κB: A pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intens Care Med 24 (1998) 1131
44. Coimbra R., Loomis W.H., and Melbostad. LPS-stimulated PMN activation and proinflammatory mediator synthesis is down-regulated by phosphodiesterase inhibition: Role of pentoxifylline. J Trauma 57 (2004) 1157
45. Josaki K., Contrino J., Kristie J., et al. Pentoxifylline-induced modulation of human leukocyte function in vitro. Am J Path 136 (1990) 623
46. Nielson C.P., Crowley J.J., Morgan M.E., et al. Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3′, 5′-adenosine monophosphate. Am J Respir Dis 137 (1988) 25
47. Mayr B., and Montminy M. Transcriptional regulation by the phosphorylation dependent factor CREB. Nat Rev Mol Cell Biol 8 (2001) 599
48. Coimbra R., Melbostad H., Loomis W., et al. Phosphodiesterase inhibition decreases nuclear factor-κB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia. J Trauma 59 (2005) 575
49. Ollivier V., Parry G.C., Cobb R.R., et al. Elevated cyclic AMP inhibits NK-κB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 271 (1996) 20828
50. Takahashi N., Tetsuka T., Uranishi H., et al. Inhibition of the NF-κB transcriptional activity by protein kinase A. Eur J Biochem 269 (2002) 4559
51. Minguet S., Huber M., Rosenkranz L., et al. Adenosine and cAMP are potent inhibitors of the NF-κB pathway downstream on immunoreceptors. Eur J Immunol 35 (2005) 31
52. Perkins N.D., Felzien L.K., Betts J.C., et al. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275 (1997) 523
53. Shenkar R., and Abraham E. Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: Roles of reactive oxygen intermediates, NF-κB, and cyclic AMP response element binding protein. J Immunol 163 (1999) 954
54. Sheppard K.A., Rose D.W., Haque Z.K., et al. Transcriptional activation of NF-κB requires multiple coactivators. Mol Cell Biol 19 (1999) 6367
55. Shaywitz A.J., Dove S.L., Kornhauser J.M., et al. Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB binding protein. Mol Cell Biol 20 (2000) 9409
56. Newell C.L., Deisseroth A.B., and Lopez-Berestein G. Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-α gene. J Leuk Biol 56 (1994) 27
57. Janknecht R. The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol 17 (2002) 657