Impact of luteolin on the production of alpha-toxin by Staphylococcus aureus

Letters in Applied Microbiology

Volumn 53, Issue 2, 2011, Pages 238-243

  Qiu, J ^a   Li, H ^a   Meng, H ^a   Hu, C ^a   Li, J ^a   Luo, M ^a   Dong, J ^a   Wang, X ^a   Wang, J ^a   Deng, Y ^a   Deng, X ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Luteolin; Staphylococcus aureus; Subinhibitory concentrations; toxin

Indexed keywords

ANTIMICROBIAL AGENTS; BACTERIA; FLAVONOIDS; MICROWAVE INTEGRATED CIRCUITS; POLYMERASE CHAIN REACTION; TOXIC MATERIALS; TRANSCRIPTION;

AUREUS STRAIN; BROTH MICRODILUTION METHOD; GENE REGULATORS; HAEMOLYSIS; LUTEOLIN; MINIMAL INHIBITORY CONCENTRATION; STAPHYLOCOCCUS AUREUS; SUBINHIBITORY CONCENTRATION; WESTERN BLOTS; Α-TOXIN;

PHYSIOLOGY;

LUTEOLIN; OXACILLIN; STAPHYLOCOCCUS ALPHA TOXIN;

AGAR; ANTIMICROBIAL ACTIVITY; BACTERIUM; GENE EXPRESSION; GENETIC ANALYSIS; INHIBITOR; PIGMENT; POLYMERASE CHAIN REACTION; SECRETION; TOXIN; VIRULENCE;

AGR GENE; ANIMAL CELL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BROTH DILUTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; GENE EXPRESSION; HEMOLYSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; TOXIN SYNTHESIS; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 79960140545     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2011.03098.x     Document Type: Article

References (23)

1. Bernardo, K., Pakulat, N., Fleer, S., Schnaith, A., Utermöhlen, O., Krut, O., Müller, S. and Krönke, M. (2004) Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression. Antimicrob Agents Chemother 48, 546-555.
2. Bramley, A.J., Patel, A.H., O'Reilly, M., Foster, R. and Foster, T.J. (1989) Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun 57, 2489-2494.
3. Bubeck Wardenburg, J., Patel, R.J. and Schneewind, O. (2007) Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun 75, 1040-1044.
4. Callegan, M.C., Engel, L.S., Hill, J.M. and O'Callaghan, R. (1994) Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun 62, 2478-2482.
5. Cegelski, L., Marshall, G.R., Eldridge, G.R. and Hultgren, S.J. (2008) The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6, 17-27.
6. Cheung, A.L. and Zhang, G. (2002) Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family. Front Biosci 7, d1825-d1842.
7. Chowdhury, A.R., Sharma, S., Mandal, S., Goswami, A., Mukhopadhyay, S. and Majumder, H.K. (2002) Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J 366, 653-661.
8. Clinical and Laboratory Standards Institute. (2005) Performance Standards for Antimicrobial Susceptibility Testing; Fifteenth informational supplement. CLSI/NCCLS document M100-S15.Wayne, PA: Clinical and Laboratory Standards Institute (CLSI).
9. Herbert, S., Barry, P. and Novick, R.P. (2001) Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus. Infect Immun 69, 2996-3003.
10. Kim, J.H., Jin, Y.R., Park, B.S., Kim, T.J., Kim, S.Y., Lim, Y., Hong, J.T., Yoo, H.S. et al. (2005) Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF beta-receptor phosphorylation. Biochem Pharmacol 69, 1715-1721.
11. Koszczol, C., Bernardo, K., Krönke, M. and Krut, O. (2006) Subinhibitory quinupristin/dalfopristin attenuates virulence of Staphylococcus aureus. J Antimicrob Chemother 58, 564-574.
12. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
13. Lin, Y., Shi, R., Wang, X. and Shen, H.M. (2008) Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8, 634-646.
14. Llarrull, L.I., Fisher, J.F. and Mobashery, S. (2009) Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrob Agents Chemother 53, 4051-4063.
15. Lv, P.C., Li, H.Q., Xue, J.Y., Shi, L. and Zhu, H.L. (2009) Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. Eur J Med Chem 44, 908-914.
16. Ohlsen, K., Koller, K.-P. and Hacker, J. (1997) Analysis of expression of the alpha-toxin gene (hla) of Staphylococcus aureus by using a chromosomally encoded hla::lacZ gene fusion. Infect Immun 65, 3606-3614.
17. Patel, A.H., Nowlan, P., Weavers, E.D. and Foster, T. (1987) Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement. Infect Immun 55, 3103-3110.
18. Périchon, B. and Courvalin, P. (2009) VanA-type vancomycin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 53, 4580-4587.
19. Qiu, J., Wang, D., Xiang, H., Feng, H., Jiang, Y., Xia, L., Dong, J., Lu, J. et al. (2010a) Subinhibitory concentrations of thymol reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates. PLoS ONE 5, e9736.
20. Qiu, J., Feng, H., Lu, J., Xiang, H., Wang, D., Dong, J., Wang, J., Wang, X. et al. (2010b) Eugenol reduces the expression of virulence-related exoproteins in Staphylococcus aureus. Appl Environ Microbiol 76, 5846-5851.
21. Stevens, D.L., Ma, Y., Salmi, D.B., McIndoo, E., Wallace, R.J. and Bryant, A.E. (2007) Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus. J Infect Dis 195, 202-211.
22. Xiong, Y.Q., Willard, J., Yeaman, M.R., Cheung, A.L. and Bayer, A.S. (2006) Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis. J Infect Dis 194, 1267-1275.
23. Yarwood, J.M., McCormick, J.K. and Schlievert, P.M. (2001) Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus. J Bacteriol 183, 1113-1123.