A novel function of apolipoprotein E: Upregulation of ATP-binding cassette transporter A1 expression

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Zhao, Yanfeng ^a   Chen, Xinping ^b   Yang, Hong ^b   Zhou, Lichun ^b   Okoro, Emmanuel U ^b   Guo, Zhongmao ^b  

^a WUHAN UNIVERSITY   (China)

^b MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; APOLIPOPROTEIN E3; CHOLESTEROL; LIPOPROTEIN; MESSENGER RNA; MITHRAMYCIN; TRANSCRIPTION FACTOR SP1; ABC TRANSPORTER; DRUG DERIVATIVE; MITHRAMYCIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATP BINDING CASSETTE TRANSPORTER A1 GENE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DNA BINDING; GENE; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENETIC ASSOCIATION; MACROPHAGE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

MUS;

ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS E; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CHOLESTEROL; CHROMATIN IMMUNOPRECIPITATION; LIPOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLICAMYCIN; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR;

EID: 79960138449     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021453     Document Type: Article

References (39)

1. Mahley RW, Rall SC Jr, (2000) Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 1: 507-537.
2. Heeren J, Grewal T, Laatsch A, Rottke D, Rinninger F, et al. (2003) Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization. J Biol Chem 278: 14370-14378.
3. Heeren J, Grewal T, Laatsch A, Becker N, Rinninger F, et al. (2004) Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. J Biol Chem 279: 55483-55492.
4. Heeren J, Beisiegel U, Grewal T, (2006) Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 26: 442-448.
5. Zhang WY, Gaynor PM, Kruth HS, (1996) Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J Biol Chem 271: 28641-28646.
6. Dove DE, Linton MF, Fazio S, (2005) ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects. Am J Physiol Cell Physiol 288: C586-C592.
7. Vedhachalam C, Narayanaswami V, Neto N, Forte TM, Phillips MC, et al. (2007) The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry 46: 2583-2593.
8. Huang ZH, Lin CY, Oram JF, Mazzone T, (2001) Sterol efflux mediated by endogenous macrophage ApoE expression is independent of ABCA1. Arterioscler Thromb Vasc Biol 21: 2019-2025.
9. Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, et al. (2005) ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler Thromb Vasc Biol 25: 128-134.
10. Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, et al. (2000) Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A 97: 12097-12102.
11. Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, et al. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 96: 266-271.
12. Geeraert B, De KD, Davey PC, Crombe F, Benhabiles N, et al. (2007) Oxidized low-density lipoprotein-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs. J Thromb Haemost 5: 2529-2536.
13. Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, et al. (2001) A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 7: 161-171.
14. Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, et al. (2005) Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res 68: 425-432.
15. Costet P, Luo Y, Wang N, Tall AR, (2000) Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 275: 28240-28245.
16. Repa JJ, Mangelsdorf DJ, (2002) The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 8: 1243-1248.
17. Thymiakou E, Zannis VI, Kardassis D, (2007) Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry 46: 11473-11483.
18. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N, (1992) Generation of mice carrying a mutatnt apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA 89: 4471-4475.
19. Wu DF, Sharan C, Yang H, Goodwin JS, Zhou L, et al. (2007) Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res 48: 2571-2578.
20. Clavey V, Lestavel-Delattre S, Copin C, Bard JM, Fruchart JC, (1995) Modulation of lipoprotein B binding to the LDL receptor by exogenous lipids and apolipoproteins CI, CII, CIII, and E. Arterioscler Thromb Vasc Biol 15: 963-971.
21. Jong MC, Dahlmans VE, Hofker MH, Havekes LM, (1997) Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner. Biochem J 328 (Pt 3): 745-750.
22. Cohn JS, Tremblay M, Amiot M, Bouthillier D, Roy M, et al. (1996) Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects. Arterioscler Thromb Vasc Biol 16: 149-159.
23. Haddy N, De BD, Chemaly MM, Maurice M, Ehnholm C, et al. (2002) The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe. Eur J Hum Genet 10: 841-850.
24. Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, et al. (2009) Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med 47: 1221-1229.
25. Tang T, Lin X, Yang H, Zhou L, Shan G, et al. (2010) Overexpression of Antioxidant Enzyme Upregulates Aryl Hydrocarbon Receptor Expression via Increasing Sp1 DNA-Binding Activity. Free Radic Biol Med 49: 487-492.
26. Zhao Y, Guo ZM, Lin XH, Zhou L, Okoro EU, et al. (2010) Apolipoprotein E-Deficient Lipoproteins Induce Foam Cell Formation by Activation of PERK-eIF2α Signaling Cascade. J Bioanal Biomed 2: 113-120.
27. Oram JF, Vaughan AM, (2006) ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ Res 99: 1031-1043.
28. Tan NY, Khachigian LM, (2009) Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 29: 2483-2488.
29. Blume SW, Snyder RC, Ray R, Thomas S, Koller CA, et al. (1991) Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest 88: 1613-1621.
30. Reamon-Buettner SM, Borlak J, (2008) Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors. Cancer Res 68: 7587-7596.
31. Wang N, Tall AR, (2003) Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux. Arterioscler Thromb Vasc Biol 23: 1178-1184.
32. Yu JH, Schwartzbauer G, Kazlman A, Menon RK, (1999) Role of the Sp family of transcription factors in the ontogeny of growth hormone receptor gene expression. J Biol Chem 274: 34327-34336.
33. Blacklow SC, (2007) Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Curr Opin Struct Biol 17: 419-426.
34. Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS One 2: e252.
35. van der GP, (2002) Phosphorylation of LRP1: regulation of transport and signal transduction. Trends Cardiovasc Med 12: 160-165.
36. Hakamata H, Sakaguchi H, Zhang C, Sakashita N, Suzuki H, et al. (1998) The very low- and intermediate-density lipoprotein fraction isolated from apolipoprotein E-knockout mice transforms macrophages to foam cells through an apolipoprotein E-independent pathway. Biochemistry 37: 13720-13727.
37. Zhao Z, de Beer MC, Cai L, Asmis R, de Beer FC, et al. (2005) Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner. Arterioscler Thromb Vasc Biol 25: 168-173.
38. Baranova IN, Kurlander R, Bocharov AV, Vishnyakova TG, Chen Z, et al. (2008) Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling. J Immunol 181: 7147-7156.
39. Moore KJ, Freeman MW, (2006) Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol 26: 1702-1711.