Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors

Cancer Research

Volumn 68, Issue 18, 2008, Pages 7587-7596

  Reamon Buettner, Stella Marie ^a   Borlak, Juergen ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CELL ADHESION MOLECULE; CELL ADHESION MOLECULE 1; MITHRAMYCIN A; MYC PROTEIN; PROTEIN INHIBITOR; RAF PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CADM1 GENE; CANCER CELL; CANCER STEM CELL; CELL ISOLATION; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; EPIGENETICS; GENE; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC REGULATION; LUNG TUMOR; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION; GENE SILENCING; GENES, MYC; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEOPLASTIC STEM CELLS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-RAF; TRANSCRIPTION FACTORS;

EID: 54749154455     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0967     Document Type: Article

References (40)

1. Meuwissen R, Berns A. Mouse models for human lung cancer. Genes Dev 2005;19:643-64.
2. Dutt A, Wong KK. Mouse models of lung cancer. Clin Cancer Res 2006;12:4396-402s.
3. Pfeifer AM, Mark GE III, Malan-Shibley L, Graziano S, Amstad P, Harris CC. Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells. Proc Natl Acad Sci U S A 1989;86:10075-9.
4. Pfeifer AM, Jones RT, Bowden PE, et al. Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: a model for lung carcinogenesis. Cancer Res 1991;51:3793-801.
5. Kerkhoff E, Fedorov LM, Siefken R, Walter AO, Papadopoulos T, Rapp UR. Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ 2000;11:185-90.
6. Ehrhardt A, Bartels T, Geick A, Klocke R, Paul D, Halter R. Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes. Br J Cancer 2001;84:813-8.
7. Ehrhardt A, Bartels T, Klocke R, Paul D, Halter R. Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells. J Cancer Res Clin Oncol 2003;129:71-5.
8. Rutters H, Zurbig P, Halter R, Borlak J. Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice. Proteomics 2006;6:3127-37.
9. Fukami T, Satoh H, Fujita E, et al. Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene. Gene 2002;295:7-12.
10. Kuramochi M, Fukuhara H, Nobukuni T, et al. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 2001;27:427-30.
11. Uchino K, Ito A, Wakayama T, et al. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer 2003;98:1002-7.
12. Ito A, Okada M, Uchino K, et al. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. Lab Invest 2003;83:1175-83.
13. Goto A, Niki T, Chi-Pin L, et al. Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance. Cancer Sci 2005;96:480-6.
14. Mao X, Seidlitz E, Truant R, Hitt M, Ghosh HP. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene 2004;23:5632-42.
15. Masuda M, Yageta M, Fukuhara H, et al. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem 2002;277:31014-9.
16. Mao X, Seidlitz E, Ghosh K, Murakami Y, Ghosh HP. The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res 2003;63:7979-85.
17. Fukami T, Fukuhara H, Kuramochi M, et al. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer 2003;107:53-9.
18. Kikuchi S, Yamada D, Fukami T, et al. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary non small cell lung carcinoma. Cancer 2006;106:1751-8.
19. Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006;7:21-33.
20. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007;128:683-92.
21. Hansen T, Blickwede M, Borlak J. Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies. Toxicol In vitro 2006;20:757-66.
22. Niehof M, Borlak J. RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain. Mol Pharmacol 2005;67:604-11.
23. Fuchs S, Hollins AJ, Laue M, et al. Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C. Cell Tissue Res 2003;311:31-45.
24. Le Calvez F, Mukeria A, Hunt JD, et al. TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers. Cancer Res 2005;65:5076-83.
25. Yageta M, Kuramochi M, Masuda M, et al. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res 2002;62:5129-33.
26. Aslam F, Palumbo L, Augenlicht LH, Velcich A. The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters. Cancer Res 2001;61:570-6.
27. Lin RK, Hsu CH, Wang YC. Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells. Anticancer Drugs 2007;18:1157-64.
28. Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007;8:286-98.
29. Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 2007;447:433-40.
30. Shimizu K, Itsuzaki Y, Onishi M, Fujii H, Honoki K, Tsujiuchi T. Reduced expression of the Tslc1 gene and its aberrant DNA methylation in rat lung tumors. Biochem Biophys Res Commun 2006;347:358-62.
31. Li J, Zhang Z, Bidder M, et al. IGSF4 promoter methylation and expression silencing in human cervical cancer. Gynecol Oncol 2005;96:150-8.
32. Kikuchi S, Yamada D, Fukami T, et al. Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin Cancer Res 2005;11:2954-61.
33. Heller G, Fong KM, Girard L, et al. Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas. Oncogene 2006;25:959-68.
34. Tsujiuchi T, Masaoka T, Sugata E, et al. Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Mol Carcinog 2007;46:819-23.
35. Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL. Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer. Mol Cell Biol 2005;25:10052-9.
36. Zhu WG, Srinivasan K, Dai Z, et al. Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter. Mol Cell Biol 2003;23:4056-65.
37. Michelotti GA, Brinkley DM, Morris DP, Smith MP, Louie RJ, Schwinn DA. Epigenetic regulation of human α1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation. FASEB J 2007;21:1979-93.
38. Douet V, Heller MB, Le Saux O. DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter. Biochem Biophys Res Commun 2007;354:66-71.
39. Kaplan J, Calame K. The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression. Nucleic Acids Res 1997;25:1108-16.
40. Numoto M, Yokoro K, Koshi J. ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association. Biochem Biophys Res Commun 1999;256:573-8.