Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats

Kidney International

Volumn 70, Issue 4, 2006, Pages 641-646

  Kaneshiro, Y ^a   Ichihara, A ^a   Takemitsu, T ^a   Sakoda, M ^a   Suzuki, F ^b   Nakagawa, T ^b   Hayashi, M ^a   Inagami, T ^c  

^a KEIO UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase; Kidney; Microcirculation; Renal circulation; Renin

Indexed keywords

CYCLOOXYGENASE 2; KIDNEY ENZYME; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PRORENIN RECEPTOR; RECEPTOR; RENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; KIDNEY BLOOD FLOW; KIDNEY CIRCULATION; KIDNEY CORTEX; KIDNEY TUBULE CELL; MACULA DENSA; MALE; MICROCIRCULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SODIUM URINE LEVEL; TELEMETRY; TRANSGENIC ANIMAL; WESTERN BLOTTING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYCLOOXYGENASE 2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KIDNEY; KIDNEY CORTEX; MICROCIRCULATION; PHOSPHORYLATION; RATS; RECEPTORS, CELL SURFACE; REGIONAL BLOOD FLOW;

EID: 33747060126     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001627     Document Type: Article

References (18)

1. Kujubu DA, Fletcher BS, Varnum BC et al. TIS10, a phorbol ester tumor promoter-inducible mRNA from swiss3T3 cells, encodes a novel prlstaglandin synthase/cyclooxygenase homologue. J Biol Chem 1991; 266: 12866-12872.
2. Xie W, Chipman JG, Robertson DL et al. Expression of a mitogen-responsive gene encoding prostaglandin systhase is regulated by mRNA splicing. Proc Natl Aca Sci USA 1991; 88: 2692-2696.
3. Ichihara A, Imig JD, Navar LG. Cyclooxygenase-2 modulates afferent arteriolar responses to increases in pressure. Hypertension 1999; 34: 843-847.
4. Ichihara A, Imig JD, Inscho EW, Navar LG. Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS. Am J Physiol 1998; 275: F605-F612.
5. 2 release from macula densa cells. J Clin Invest 2003; 112: 76-82.
6. Khan KNM, Burke A, Stanfield KM et al. Expression of cyclooxygenase-2 in the macula densa of human kidney in hypertension, congestive heart failure, and diabetic nephropathy. Renal Failure 2001; 23: 321-330.
7. Komers R, Lindsly JN, Oyama TT et al. Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. J Clin Invest 2001; 107: 889-898.
8. Nguyen G, Delarue F, Burckle C et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109: 1417-1427.
9. Ichihara A, Hayashi M, Kaneshiro Y et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin. J Clin Invest 2004; 114: 1128-1135.
10. Schefe JH, Kaiser HF, Jost A, Unger T. Signal transduction of the renin/prorenin receptor. J Hypertens 2005; 123: S354-S355.
11. Hernandez J, Astudillo H, Escalante B. Angiotenin II stimulates cyclooxygenase-2 mRNA expression in renal tissue from rats with kidney failure. Am J Physiol 2002; 282: F592-F598.
12. Cheng HF, Wang JL, Zhang MZ et al. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest 1999; 103: 953-961.
13. Cheng HF, Wang JL, Zhang MZ et al. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest 2000; 106: 681-688.
14. 2 release and cyclooxygenase-2 expression in a mouse macula densa cell line. J Biol Chem 2000; 275: 37922-37929.
15. Harding P, Sigmon DH, Alfie ME et al. Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet. Hypertension 1997; 29: 297-302.
16. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-199.
17. Tada Y, Ichihara A, Koura Y et al. Ovariectomy enhances renal cortical expression and function of cyclooxygenase-2. Kidney Int 2004; 66: 1966-1976.
18. Burckle CA, Jan Danser AH, Muller DN et al. Elevated blood pressure and heart rate in human renin receptor Transgenic rats. Hypertension 2006; 47: 1-5.