Mechanistic variations among reverse transcriptases of simian immunodeficiency virus variants isolated from African green monkeys

Biochemistry

Volumn 48, Issue 23, 2009, Pages 5389-5395

  Skasko, Mark ^a,b   Diamond, Tracy L ^a,c   Kim, Baek ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; HIGH FIDELITY; MURINE LEUKEMIA VIRUS; POLYMERASE ACTIVITIES; PRE-STEADY STATE; REVERSE TRANSCRIPTASES; SIMIAN IMMUNODEFICIENCY VIRUS;

BINDING ENERGY;

TANNING;

155 4 REVERSE TRANSCRIPTASE PROTEIN; 9063 2 REVERSE TRANSCRIPTASE PROTEIN; DEOXYRIBONUCLEOTIDE; DEOXYRIBONUCLEOTIDE TRIPHOSPHATE; GRI 1 REVERSE TRANSCRIPTASE PROTEIN; PROTEIN DERIVATIVE; RNA DIRECTED DNA POLYMERASE; SAB 1 REVERSE TRANSCRIPTASE PROTEIN; TAN 1 REVERSE TRANSCRIPTASE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CERCOPITHECIDAE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; KINETICS; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; STEADY STATE; STRAIN DIFFERENCE;

ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; DNA PRIMERS; DNA, VIRAL; KINETICS; RNA-DIRECTED DNA POLYMERASE; SIMIAN IMMUNODEFICIENCY VIRUS;

CERCOPITHECUS AETHIOPS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINE LEUKEMIA VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 67049119432     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900346m     Document Type: Article

References (35)

1. Coffin, J. M. (1986) Genetic variation in AIDS viruses. Cell 46, 1-4. (Pubitemid 16027821)
2. Coffin, J. M. (1992) Genetic diversity and evolution of retroviruses. Curr. Top. Microbiol. Immunol. 176, 143-164.
3. Coffin, J. M. (1995) HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
4. Goudsmit, J., Back, N. K., and Nara, P. L. (1991) Genomic diversity and antigenic variation of HIV-1: Links between pathogenesis, epidemiology and vaccine development. FASEB J. 5, 2427-2436. (Pubitemid 21905791)
5. Zhang, L., Carruthers, C. D., He, T., Huang, Y., Cao, Y., Wang, G., Hahn, B., and Ho, D. D. (1997) HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism. AIDS Res. Hum. Retroviruses 13, 1357-1366.
6. Kirchhoff, F., Mori, K., and Desrosiers, R. C. (1994) The "V3" domain is a determinant of simian immunodeficiency virus cell tropism. J. Virol. 68, 3682-3692.
7. Shioda, T., Oka, S., Ida, S., Nokihara, K., Toriyoshi, H., Mori, S., Takebe, Y., Kimura, S., Shimada, K., and Nagai, Y.; et al. (1994) A naturally occurring single basic amino acid substitution in the V3 region of the human immunodeficiency virus type 1 env protein alters the cellular host range and antigenic structure of the virus. J. Virol. 68, 7689-7696. (Pubitemid 24362654)
8. Baier, M., Werner, A., Cichutek, K., Garber, C., Muller, C., Kraus, G., Ferdinand, F. J., Hartung, S., Papas, T. S., and Kurth, R. (1989) Molecularly cloned simian immunodeficiency virus SIVagm3 is highly divergent from other SIVagm isolates and is biologically active in vitro and in vivo. J. Virol. 63, 5119-5123. (Pubitemid 19278749)
9. Fomsgaard, A., Hirsch, V. M., Allan, J. S., and Johnson, P. R. (1991) A highly divergent proviral DNA clone of SIV from a distinct species of African green monkey. Virology 182, 397-402.
10. Fukasawa, M., Miura, T., Hasegawa, A., Morikawa, S., Tsujimoto, H., Miki, K., Kitamura, T., and Hayami, M. (1988) Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group. Nature 333, 457-461. (Pubitemid 18130615)
11. Johnson, P. R., Fomsgaard, A., Allan, J., Gravell, M., London, W. T., Olmsted, R. A., and Hirsch, V. M. (1990) Simian immunodeficiency viruses from African green monkeys display unusual genetic diversity. J. Virol. 64, 1086-1092. (Pubitemid 20087745)
12. Li, Y., Naidu, Y. M., Daniel, M. D., and Desrosiers, R. C. (1989) Extensive genetic variability of simian immunodeficiency virus from African green monkeys. J. Virol. 63, 1800-1802. (Pubitemid 19085995)
13. Li, Y., Naidu, Y., Fultz, P., Daniel, M. D., and Desrosiers, R. C. (1989) Genetic diversity of simian immunodeficiency virus. J. Med. Primatol. 18, 261-269.
14. Wertheim, J. O., and Worobey, M. (2007) A challenge to the ancient origin of SIVagm based on African green monkey mitochondrial genomes. PLoS Pathog. 3, e95.
15. Allan, J. S., Short, M., Taylor, M. E., Su, S., Hirsch, V. M., Johnson, P. R., Shaw, G. M., and Hahn, B. H. (1991) Species-specific diversity among simian immunodeficiency viruses from African green monkeys. J. Virol. 65, 2816-2828.
16. Kim, B. (1997) Genetic selection in Escherichia coli for active human immunodeficiency virus reverse transcriptase mutants. Methods 12, 318-324. (Pubitemid 27371256)
17. Kim, B., Hathaway, T. R., and Loeb, L. A. (1996) Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli. J. Biol. Chem. 271, 4872-4878.
18. Diamond, T. L., Kimata, J., and Kim, B. (2001) Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection. J. Biol. Chem. 276, 23624-23631.
19. Skasko, M., Weiss, K. K., Reynolds, H. M., Jamburuthugoda, V., Lee, K., and Kim, B. (2005) Mechanistic differences in RNA dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases. J. Biol. Chem. 280, 12190-12200.
20. Weiss, K. K., Chen, R., Skasko, M., Reynolds, H. M., Lee, K., Bambara, R. A., Mansky, L. M., and Kim, B. (2004) A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis. Biochemistry 43, 4490-4500. (Pubitemid 38500578)
21. Johnson, K. A. (1995) Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates. Methods Enzymol. 249, 38-61.
22. Kati, W. M., Johnson, K. A., Jerva, L. F., and Anderson, K. S. (1992) Mechanism and fidelity of HIV reverse transcriptase. J. Biol. Chem. 267, 25988-25997.
23. Weiss, K. K., Bambara, R. A., and Kim, B. (2002) Mechanistic role of residue Gln151 in error prone DNA synthesis by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Pre-steady state kinetic study of the Q151N HIV-1 RT mutant with increased fidelity. J. Biol. Chem. 277, 22662-22669.
24. Johnson, K. A. (1993) Conformational coupling in DNA polymerase fidelity. Annu. Rev. Biochem. 62, 685-713.
25. Kerr, S. G., and Anderson, K. S. (1997) Pre-steady-state kinetic characterization of wild type and 3′-azido-3′-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: Implication of RNA directed DNA polymerization in the mechanism of AZT resistance. Biochemistry 36, 14064-14070. (Pubitemid 27509841)
26. Feng, J. Y., and Anderson, K. S. (1999) Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase. Biochemistry 38, 9440-9448. (Pubitemid 29347269)
27. Hirsch, V. M., Dapolito, G., Johnson, P. R., Elkins, W. R., London, W. T., Montali, R. J., Goldstein, S., and Brown, C. (1995) Induction of AIDS by simian immunodeficiency virus from an African green monkey: Species-specific variation in pathogenicity correlates with the extent of in vivo replication. J. Virol. 69, 955-967.
28. Jin, M. J., Hui, H., Robertson, D. L., Muller, M. C., Barre-Sinoussi, F., Hirsch, V. M., Allan, J. S., Shaw, G. M., Sharp, P. M., and Hahn, B. H. (1994) Mosaic genome structure of simian immunodeficiency virus from west African green monkeys. EMBO J. 13, 2935-2947. (Pubitemid 24191704)
29. Soares, M. A., Robertson, D. L., Hui, H., Allan, J. S., Shaw, G. M., and Hahn, B. H. (1997) A full-length and replication-competent proviral clone of SIVAGM from tantalus monkeys. Virology 228, 394-399. (Pubitemid 27238808)
30. Diamond, T. L., Souroullas, G., Weiss, K. K., Lee, K. Y., Bambara, R. A., Dewhurst, S., and Kim, B. (2003) Mechanistic Understanding of an Altered Fidelity Simian Immunodeficiency Virus Reverse Transcriptase Mutation, V148I, Identified in a Pig-tailed Macaque. J. Biol. Chem. 278, 29913-29924.
31. Weiss, K. K., Isaacs, S. J., Tran, N. H., Adman, E. T., and Kim, B. (2000) Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: Roles of the β8-RE loop in fidelity, processivity, and substrate interactions. Biochemistry 39, 10684-10694. (Pubitemid 30682777)
32. Operario, D. J., Reynolds, H. M., and Kim, B. (2005) Comparison of DNA polymerase activities between recombinant feline immunodeficiency and leukemia virus reverse transcriptases. Virology 335, 106-121. (Pubitemid 40489056)
33. Kimata, J. T., Kuller, L., Anderson, D. B., Dailey, P., and Overbaugh, J. (1999) Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression. Nat. Med. 5, 535-541.
34. Diamond, T. L., Roshal, M., Jamburuthugoda, V. K., Reynolds, H. M., Merriam, A. R., Lee, K. Y., Balakrishnan, M., Bambara, R. A., Planelles, V., Dewhurst, S., and Kim, B. (2004) Macrophage tropism of HIV-1 depends upon efficient cellular dNTP utilization by reverse transcriptase. J. Biol. Chem. 279, 51545-51553.
35. Jamburuthugoda, V. K., Chugh, P., and Kim, B. (2006) Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations. J. Biol. Chem. 281, 13388-13395.