Small leucine-rich proteoglycans in the aging skeleton

Journal of Musculoskeletal Neuronal Interactions

Volumn 6, Issue 4, 2006, Pages 364-365

  Young, Marian F ^a   Bi, Y ^a   Ameye, L ^a   Xu, T ^a   Wadhwa, S ^a   Heegaard, A ^a   Kilts, T ^a   Chen, X D ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Biglycan; Bone; Osteoblasts; Small Leucine Rich Proteoglycans (SLRPs)

Indexed keywords

FIBROMODULIN; PROTEOGLYCAN; SMALL LEUCINE RICH PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE AGE; CELL FATE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; OSSIFICATION; OSTEOARTHRITIS; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; RESEARCH; REVIEW; STEM CELL; TENDON LESION;

AGING; AMINO ACID MOTIFS; ANIMALS; BONE AND BONES; COCULTURE TECHNIQUES; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; PHYSICAL CONDITIONING, ANIMAL; PROTEOGLYCANS;

EID: 33846259672     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (7)

1. Xu T, Bianco P, Fisher LW, Longenecker G, Smith E, Goldstein S, Bonadio J, Boskey A, Heegaard AM, Sommer B, Satomura K, Dominguez P, Zhao C, Kulkarni AB, Robey PG, Young MF. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet 1998; 20:78-82.
2. Chen XD, Fisher LW, Robey PG, Young MF. The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation. FASEB J 2004; 18:948-958.
3. Chen XD, Bian X, Teslovich TM, Stephan DA, Young MF. Dissection of the sets of genes that control the behavior of biglycan-deficient pre-osteoblasts using oligonucleotide microarrays. Bone 2005; 37:192-203.
4. Bi Y, Nielsen KL, Kilts TM, Yoon A, A Karsdal M, Wimer HF, Greenfield EM, Heegaard AM, Young ME Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts. Bone 2006; 38:778-786.
5. Corsi A, Xu T, Chen XD, Boyde A, Liang J, Mankani M, Sommer B, Iozzo RV, Eichstetter I, Robey PG, Bianco P, Young ME Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res 2002; 17:1180-1189.
6. Bi Y, Stuelten CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG, Chen XD, Young ME Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem 2005; 280:30481-30489.
7. Ameye L, Aria D, Jepsen K, Oldberg A, Xu T, Young MF. Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J 2002; 16:673-680.