A pharmacokinetic study of diphenhydramine transport across the blood-brain barrier in adult sheep: Potential involvement of a carrier-mediated mechanism

Drug Metabolism and Disposition

Volumn 34, Issue 6, 2006, Pages 955-960

  Au Yeung, Sam C S ^a,c   Rurak, Dan W ^b   Gruber, Nancy ^b   Riggs, K Wayne ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c IQVIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENHYDRAMINE; PROPRANOLOL;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INHIBITION; EXTRACELLULAR FLUID; HEART RATE; IN VIVO STUDY; INFUSION SYSTEM; MICRODIALYSIS; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; SHEEP; STEADY STATE;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; DIPHENHYDRAMINE; EXTRACELLULAR FLUID; FEMALE; HALF-LIFE; HISTAMINE H1 ANTAGONISTS; INFUSIONS, INTRAVENOUS; MICRODIALYSIS; PROPRANOLOL; SHEEP;

ANIMALIA; OVIS; OVIS ARIES;

EID: 33646788040     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.007898     Document Type: Article

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