Substrate specificity and mechanism of the intestinal clonidine uptake by caco-2 cells

Pharmaceutical Research

Volumn 23, Issue 1, 2006, Pages 131-137

  Fischer, Wiebke ^a   Metzner, Linda ^a   Hoffmann, Kathrin ^a   Neubert, Reinhard H H ^a   Brandsch, Matthias ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Caco 2 cells; Clonidine derived drugs; Drug delivery; Membrane transport

Indexed keywords

AMITRIPTYLINE; ANTAZOLINE; CARBAMAZEPINE; CHLORPHENIRAMINE; CIMETIDINE; CLOMIPRAMINE; CLONIDINE; DESIPRAMINE; DIHYDRALAZINE; DIPHENHYDRAMINE; EPHEDRINE; ETILEFRINE; GUANABENZ; GUANFACINE; IMIPRAMINE; METHAMPHETAMINE; MINOXIDIL; MORPHINE; MOXONIDINE; NAPHAZOLINE; NORTRIPTYLINE; PIMOZIDE; PROCAINAMIDE; QUINIDINE; QUININE; RANITIDINE; TOLAZOLINE; UNINDEXED DRUG; XYLAZINE; XYLOMETAZOLINE;

ACTIVE TRANSPORT; ARTICLE; ASSAY; BLOOD BRAIN BARRIER; CELL MEMBRANE POTENTIAL; CELL PH; CELL STRAIN CACO 2; CHOLINE UPTAKE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG SPECIFICITY; ENDOTHELIUM CELL; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HYDROPHILICITY; INTESTINE ABSORPTION; KINETICS; LIPOPHILICITY; PRIORITY JOURNAL;

ADRENERGIC ALPHA-AGONISTS; AMMONIUM CHLORIDE; BLOOD-BRAIN BARRIER; CACO-2 CELLS; CLONIDINE; DRUG INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KINETICS; MEMBRANE POTENTIALS; PHARMACEUTICAL PREPARATIONS; SUBSTRATE SPECIFICITY;

EID: 32244438135     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-8925-x     Document Type: Article

References (27)

1. G. A. Mansoor W. H. Frishman 2002 Comprehensive management of hypertensive emergencies and urgencies Heart Dis. 4 358 371
2. P. M. Sanderson R. Eltringham 1998 The role of clonidine in anaesthesia Hosp. Med. 59 221 223
3. J. N. Cogburn M. G. Donovan C. S. Schasteen 1991 A model of human small intestinal absorptive cells. 1. Transport barrier Pharm. Res. 8 210 216
4. J. Huwyler G. Fricker M. Torok M. Schneider J. Drewe 1997 Transport of clonidine across cultured brain microvessel endothelial cells J. Pharmacol. Exp. Ther. 282 81 85
5. F. Grafe W. Wohlrab R. Neubert M. Brandsch 2004 Carrier-mediated transport of clonidine in human keratinocytes Eur. J. Pharm. Sci. 21 309 312
6. J. Müller R. Neubert M. Brandsch 2004 Transport of clonidine at cultured epithelial cells (JEG-3) of the human placenta Pharm. Res. 21 692 694
7. H. Koepsell H. Endou 2004 The SLC22 drug transporter family Pflugers Arch. 447 666 676
8. H. Koepsell 2004 Polyspecific organic cation transporters: their functions and interactions with drugs Trends Pharmacol. Sci. 25 375 381
9. A. Friedrich R. L. George C. C. Bridges P. D. Prasad V. Ganapathy 2001 Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4) Biochim. Biophys. Acta 1512 299 307
10. K. Hoffmann F. Grafe W. Wohlrab R. H. Neubert M. Brandsch 2002 Functional characterization of a high-affinity choline transport system in human keratinocytes J. Invest. Dermatol. 119 118 121
11. +/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux Pharm. Res. 16 55 61
12. L. Metzner J. Kalbitz M. Brandsch 2004 Intestinal transport of pharmacologically relevant proline derivatives by the human proton-coupled amino acid transporter hPAT1 J. Pharmacol. Exp. Ther. 309 28 35
13. T. N. Faria J. K. Timoszyk T. R. Stouch B. S. Vig C. P. Landowski G. L. Amidon C. D. Weaver D. A. Wall R. L. Smith 2004 A novel high-throughput PepT1 transporter assay differentiates between substrates and antagonists Mol. Pharm. 1 67 76
14. L. Metzner G. Kottra K. Neubert H. Daniel M. Brandsch 2005 l-Tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1 FASEB J. 19 1468 1473
15. +-independent choline transporter in rat astrocytes J. Neurochem. 94 1427 1437
16. D. T. Bravo N. G. Kolmakova S. M. Parsons 2005 Mutational and pH analysis of ionic residues in transmembrane domains of vesicular acetylcholine transporter Biochemistry 44 7955 7966
17. W. M. Barendt S. H. Wright 2002 The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization J. Biol. Chem. 277 22491 22496
18. + exchanger Biochem. Pharmacol. 35 3989 3994
19. G. J. Molderings M. Bruss H. Bonisch M. Gothert 2003 Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines Ann. N. Y. Acad. Sci. 1009 75 81
20. E. Keating C. Lemos R. Monteiro I. Azevedo F. Martel 2004 The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT Life Sci. 76 103 119
21. S. O'Regan E. Traiffort M. Ruat N. Cha D. Compaore F. M. Meunier 2000 An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins Proc. Natl. Acad. Sci. USA. 97 1835 1840
22. H. Mizuuchi T. Katsura H. Saitoh Y. Hashimoto K.-I. Inui 1999 Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system J. Pharmacol. Exp. Ther. 290 388 392
23. H. Mizuuchi T. Katsura K. Ashida Y. Hashimoto K.-I. Inui 2000 Diphenhydramine transport by pH-dependent tertiary amine transport system in Caco-2 cells Am. J. Physiol. Gasterointest. Liver Physiol. 278 G563 G569
24. +/tertiary amine antiport system in rabbit intestinal brush-border membrane Am. J. Physiol.: Gastrointest. Liver Physiol. 279 G799 G805
25. Y. H. Han D. H. Sweet D. N. Hu J. B. Pritchard 2001 Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells J. Pharmacol. Exp. Ther. 296 450 457
26. M. Frisk-Holmberg L. Paalzow P. O. Edlund 1981 Clonidine kinetics in man-evidence for dose dependency and changed pharmacokinetics during chronic therapy Br. J. Clin. Pharmacol. 12 653 658
27. H. Daniel C. Fett A. Kratz 1989 Demonstration and modification of intervillous pH profiles in rat small intestine in vitro Am. J. Physiol. 257 G489 G495