Sickness response symptoms among healthy volunteers after controlled exposures to diesel exhaust and psychological stress

Environmental Health Perspectives

Volumn 119, Issue 7, 2011, Pages 945-950

  Laumbach, Robert J ^a   Kipen, Howard M ^a   Kelly Mcneil, Kathie ^a   Zhang, Junfeng ^b   Zhang, Lin ^b   Lioy, Paul J ^a   Ohman Strickland, Pamela ^b   Gong, Jing ^b   Kusnecov, Alexander ^c   Fiedler, Nancy ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Diesel exhaust; Gulf war illness; Psychological stress; Sickness response; Symptoms

Indexed keywords

HYDROCORTISONE;

ADULT; AIR; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; END TIDAL CARBON DIOXIDE TENSION; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; MALE; MENTAL STRESS; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; RESPIRATORY TRACT DISEASE; SELF REPORT; SYMPTOM; TASK PERFORMANCE; VOLUNTEER;

ADULT; AIR POLLUTANTS; CARBON MONOXIDE; ENVIRONMENTAL EXPOSURE; FEMALE; HEALTH STATUS; HUMANS; MALE; NEW JERSEY; NITRIC OXIDE; NITROGEN DIOXIDE; ODORS; PARTICULATE MATTER; PSYCHIATRIC STATUS RATING SCALES; QUESTIONNAIRES; STRESS, PSYCHOLOGICAL; VEHICLE EMISSIONS; YOUNG ADULT;

EID: 79960108605     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002631     Document Type: Article

References (41)

1. Al'Absi M, Bongard S, Buchanan T, Pincomb GA, Licinio J, Lovallo WR. 1997. Cardiovascular and neuroendocrine adjustment to public speaking and mental arithmetic stressors. Psychophysiology 34(3):266-275.
2. Baldwin CM, Bell IR, O'Rourke MK, Lebowitz MD. 1997. The association of respiratory problems in a community sample with self-reported chemical intolerance. Eur J Epidemiol 13(5):547-552.
3. Bell IR, Miller CS, Schwartz GE, Peterson JM, Amend D. 1996. Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical odor intolerance and chemical sensitivity. Arch Environ Health 51(1):9-21.
4. Bell IR, Peterson JM, Schwartz GE. 1995. Medical histories and psychological profiles of middle-aged women with and without self-reported illness from environmental chemicals. J Clin Psychiatry 56(4):151-160.
5. Bell IR, Warg-Damiani L, Baldwin CM, Walsh ME, Schwartz GE. 1998. Self-reported chemical sensitivity and wartime chemical exposures in Gulf War veterans with and without decreased global health ratings. Mil Med 163(11):725-732.
6. Chen E, Schreier HMC, Strunk RC, Brauer M. 2008. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect 116:970-975.
7. Clougherty JE, Kubzansky LD. 2009. A framework for examining social stress and susceptibility to air pollution in respiratory health. Environ Health Perspect 117:1351-1358.
8. Clougherty JE, Levy JI, Kubzansky LD, Ryan PB, Suglia SF, Canner MJ, et al. 2007. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environ Health Perspect 115:1140-1146.
9. Crawford JO, Bolas SM. 1996. Sick building syndrome, work factors and occupational stress. Scan J Work Environ Health 22(4):243-250.
10. Dantzer R. 2001. Cytokine-induced sickness behavior: mechanisms and implications. Ann NY Acad Sci 933:222-234.
11. Dantzer R, Bluthe R-M, Kent S, Goodall G. 1993. Behavioral effects of cytokines: an insight into mechanisms of sickness behavior. Methods Neurosci 17:130-150.
12. Ferguson E, Cassaday HJ. 1999. The Gulf War and illness by association. Br J Psychol 90(pt 4):459-475.
13. Ferguson E, Cassaday HJ. 2001. Theoretical accounts of Gulf War syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration. Behav Neurol 13(3-4):133-147.
14. Fiedler N, Giardino N, Natelson B, Ottenweller JE, Weisel C, Lioy P, et al. 2004. Responses to controlled diesel vapor exposure among chemically sensitive Gulf War veterans. Psychosom Med 66(4):588-598.
15. Fiedler N, Kelly-McNeil K, Ohman-Strickland P, Zhang J, Ottenweller J, Kipen HM. 2008. Negative affect and chemical intolerance as risk factors for building-related symptoms: a controlled exposure study. Psychosom Med 70(2):254-262.
16. Fiedler N, Laumbach R, Kelly-McNeil K, Lioy P, Fan Z-H, Zhang J, et al. 2005. Health effects of a mixture of indoor air volatile organics, their ozone oxidation products, and stress. Environ Health Perspect 113:1542-1548.
17. Gamble J, Jones W, Minshall S. 1987. Epidemiological-environmental study of diesel bus garage workers: chronic effects of diesel exhaust on the respiratory system. Environ Res 44(1):6-17.
18. Green BG, Dalton P, Cowart B, Shaffer G, Rankin K, Higgins J. 1996. Evaluating the "Labeled Magnitude Scale" for measuring sensations of taste and smell. Chem Senses 21(3):323-334.
19. Gronseth GS, Gronseth GS. 2005. Gulf War syndrome: a toxic exposure? A systematic review. Neurol Clin 23(2):523-540.
20. Hodgson M. 1995. The sick-building syndrome. Occup Med 10(1):167-175.
21. Kilburn KH. 2000. Effects of diesel exhaust on neurobehavioral and pulmonary functions. Arch Environ Health 55(1):11-17.
22. Kipen HM, Fiedler N. 1999. Invited commentary: sensitivities to chemicals-context and implications [Comment]. Am J Epidemiol 150(1):13-17.
23. Kipen HM, Fiedler N. 2002a. Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge. Environ Health Perspect 110(suppl 4):597-599.
24. Kipen HM, Fiedler N. 2002b. The role of environmental factors in medically unexplained symptoms and related syndromes: conference summary and recommendations. Environ Health Perspect 110(suppl 4):591-595.
25. Kusnecov A, Sved A, Rabin B. 2001. Immunological effects of acute versus chronic stress in animals. In: Psychoneuroendocrinology, Vol 2, Part 3 (Ader R, Cohen N, Felten D, eds). San Diego:Academic Press, 265-278.
26. Laumbach R, Tong J, Zhang L, Ohman-Strickland P, Stern A, Fiedler N, et al. 2009. Quantification of 1-aminopyrene in human urine after a controlled exposure to diesel exhaust. J Environ Monit 11(1):153-159.
27. Maier SF, Watkins LR. 1998. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 105(1):83-107.
28. Mendell MJ. 1993. Non-specific symptoms in office workers: a review and summary of the epidemiologic literature. Indoor Air 3(4):227-236.
29. Miller CS. 1999. Are we on the threshold of a new theory of disease? Toxicant-induced loss of tolerance and its relationship to addiction and abdiction. Toxicol Ind Health 15(3-4):284-294.
30. Otto D, Molhave L, Rose G, Hudnell HK, House D. 1990. Neurobehavioral and sensory irritant effects of controlled exposure to a complex mixture of volatile organic compounds. Neurotoxicol Teratol 12(6):649-652.
31. Peters JL, Kubzansky L, McNeely E, Schwartz J, Spiro A III, Sparrow D, et al. 2007. Stress as a potential modifier of the impact of lead levels on blood pressure: the Normative Aging Study. Environ Health Perspect 115:1154-1159.
32. Prah JD. 1998. 1998 equivalence of sensory responses to single and mixed volatile organic compounds at equimolar concentrations. Environ Health Perspect 106:739-744.
33. Pronk A, Coble J, Stewart PA. 2009. Occupational exposure to diesel engine exhaust: a literature review. J Expo Sci Environ Epidemiol 19(5):443-457.
34. Rudell B, Ledin MC, Hammarstrom U, Stjernberg N, Lundback B, Sandstrom T. 1996. Effects on symptoms and lung function in humans experimentally exposed to diesel exhaust. Occup Environ Med 53(10):658-662.
35. Rudell B, Wass U, Horstedt P, Levin JO, Lindahl R, Rannug U, et al. 1999. Efficiency of automotive cabin air filters to reduce acute health effects of diesel exhaust in human subjects. Occup Environ Med 56(4):222-231.
36. Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, et al. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159(3):702-709.
37. Scheepers PT, Bos RP. 1992. Combustion of diesel fuel from a toxicological perspective. II. Toxicity. Int Arch Occup Environ Health 64(3):163-177.
38. Shusterman D, Matovinovic E, Salmon A, Shusterman D, Matovinovic E, Salmon A. 2006. Does Haber's law apply to human sensory irritation? Inhal Toxicol 18(7):457-471.
39. Szarek MJ, Bell IR, Schwartz GE. 1997. Validation of a brief screening measure of environmental chemical sensitivity: the Chemical Odor Intolerance Index. J Environ Psychol 17(4):345-351.
40. U.S. Environmental Protection Agency. 2002. Health Assessment Document for Diesel Engine Exhaust. Washington, DC:U.S. Environmental Protection Agency.
41. Watkins LR, Maier SF. 1999. Implications of immune-to-brain communication for sickness and pain. Proc Natl Acad Sci USA 96(14):7710-7713.