Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical odor intolerance and chemical sensitivity

Archives of Environmental Health

Volumn 51, Issue 1, 1996, Pages 9-21

  Bell, Iris R ^a   Miller, Claudia S ^b   Schwartz, Gary E ^c   Peterson, Julie M ^d   Amend, Diane ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c Departments of Psychiatry Psychology and Neurology   (United Kingdom)

^d Department of Psychiatry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

XENOBIOTIC AGENT;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATOPY; COLLEGE STUDENT; DRUG ABUSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CHEMICAL SENSITIVITY; NEUROPSYCHIATRY; OLFACTORY DISCRIMINATION; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; SELF REPORT;

EID: 0030007979     PISSN: 00039896     EISSN: None     Source Type: Journal    
DOI: 10.1080/00039896.1996.9935987     Document Type: Article

References (114)

1. Emmett EA. Parosmia and hyposmia induced by solvent exposure. Br J Ind Med 1976; 33:196-98.
2. Ryan CM, Morrow LA, Hodgson M. Cacosmia and neuropsychiatrie dysfunction associated with occupational exposure to mixtures of organic solvents. Am J Psychiatry 1988; 145:1442-45.
3. Morrow LA, Kamis H, Hodgson MJ. Psychiatric symptomatology in persons with organic solvent exposure. J Consult Clin Psychol 1993; 61:171-74.
4. Morrow LA, Ryan C, Goldstein G, Hodgson M. A distinct pattern of personality disturbance following exposure to mixtures of organic solvents. J Occup Med 1989; 31:743-46.
5. Morrow LA, Ryan CM, Hodgson MJ, Robin N. Alterations in cognitive and psychological functioning after organic solvent exposure. J Occup Med 1990; 32:444-50.
6. Bowler RM, Mergler D, Rauch SS, Harrison R, Cone J. Affective and personality disturbances among female former microelectronics workers. J Clin Psychol 1991; 47:41-52.
7. Wallace L, Nelson CJ, Kollander M, Leaderer B, Bascom R, Dun- teman G. Indoor air quality and work environment study. Multivariate statistical analysis of health, comfort, and odor perceptions as related to personal and workplace characteristics. US Environmental Protection Agency, vol. 4. EPA Headquarters Buildings. Atmospheric Research and Exposure Assessment Laboratory, June 1991 (21M-3004).
8. Bell IR, Miller CS, Schwartz GE. An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationship to kindling and affective spectrum disorders. Biol Psychiatry 1992; 32:218-42.
9. Bell IR, Schwartz GE, Peterson JM, Amend D. Self-reported illness from chemical odors in young adults without clinical syndromes or occupational exposures. Arch Environ Health 1993; 48:6-13.
10. Bell IR, Schwartz GE, Peterson JM, Amend D. Symptom and personality profiles of young adults from a college student population with self-reported illness from foods and chemicals. J Am Coll Nutr 1993; 12:693-702.
11. Bell IR, Schwartz GE, Peterson JM, Amend D, Stini WA. Possible time-dependent sensitization to xenobiotics: self-reported illness from chemical odors, foods, and opiate drugs in an older adult population. Arch Environ Health 1993; 48:315-27.
12. Bell IR, Schwartz GE, Amend D, Peterson JM, Stini WA. Sensitization to early life stress and responses to chemical odors in older adults. Biol Psychiatry 1994; 35:857-63.
13. Fiedler N, Maccia C, Kipen H. Evaluation of chemically sensitive patients. J Occup Med 1992; 34:529-38.
14. Bell IR, Amend D, Kaszniak AW, Schwartz GE. Memory deficits, sensory impairment, and depression in the elderly. Lancet 1993; 341:62.
15. Ashford NA, Miller CS. Chemical Exposures: Low Levels and High Stakes. NY: Van Nostrand Reinhold, 1991.
16. Black DW, Rathe A, Goldstein RB. Environmental illness. A controlled study of 26 subjects with “20th century disease.” JAMA 1990; 264:3166-70.
17. Simon GE, Katon WJ, Sparks PJ. Allergic to life: psychological factors in environmental illness. Am J Psychiatry 1990; 147: 901-06.
18. Simon GE, Daniell W, Stockbridge H, Claypoole K, Rosenstock L. Immunologic, psychological, and neuropsychological factors in multiple chemical sensitivity. A controlled study. Ann Int Med 1993; 19:97-103.
19. Schottenfeld RS, Cullen MR. Occupation-induced posttraumatic stress disorders. Am J Psychiatry 1985; 142:198-202.
20. Bolla-Wilson K, Wilson RJ, Bleecker ML. Conditioning of physical symptoms after neurotoxic exposure. J Occup Med 1988; 30:684-86.
21. Miller CS, Mitzel HC. Chemical sensitivity attributed to pesticide exposure versus remodeling. Arch Environ Health 1995; 50:119-29.
22. Kreiss K. The epidemiology of building-related complaints and illness. Occup Med (State of the Art Reviews) 1989; 4:575-92.
23. Morrow LA. Sick building syndrome and related workplace disorders. Otolaryngol Head Neck Surg 1992; 106:649-54.
24. Kjaergaard S, Molhave L, Pedersen OF. Human reactions to indoor air pollutants: n-decane. Envir Int 1989; 15:473-82.
25. Kjaergaard SK, Molhave L, Pedersen OF. Human reactions to a mixture of indoor air volatile organic compounds. Atmos Environ 1991; 25A:1417-26.
26. Middaugh DA, Pinney SM, Linz DH. Sick building syndrome. Medical evaluation of two work forces. J Occup Med 1992; 34:1197-1203.
27. Otto D, Molhave L, Rose G, Hudnell HK, House D. Neuropsychiatrie and sensory irritant effects of controlled exposure to a complex mixture of volatile organic compounds. Neurotoxicol Teratol 1990; 12:649-52.
28. Callender TJ, Morrow L, Subramanian K, Duhon D, Ristovv M. Three-dimensional brain metabolic imaging in patients with toxic encephalopathy. Environ Res 1993; 60:295-319.
29. Morrow LA, Callender T, Lottenberg S, Buchsbaum M, Hodgson M, Robin N. PET and neuropsychiatrie evidence of tetrabro-moethane encephalopathy. J Neuropsychiatry Clin Neurosci 1990; 2:431-35.
30. Morrow LA, Steinhauer SR, Hodgson MJ. Delay in P300 latency in patients with organic solvent exposure. Arch Neurol 1992; 49:315-20.
31. Arlien-Soborg P, Hansen L, Ladefoged O, Simonsen L. Report on a conference on organic solvents and the nervous system. Neurotoxicol Teratol 1992; 14:81-82.
32. Kilburn KH, Seidman BC, Warshaw R. Neuropsychiatrie and respiratory symptoms of formaldehyde and xylene exposure in histology technicians. Arch Environ Health 1985; 40:229-33.
33. Riihimaki V, Savolainen K. Human exposure to m-xylene. Kinetics and acute effects on the central nervous system. Ann Occup Hyg 1980; 23:411-22.
34. Letz R, Mahoney FC, Hershman DL, Woskie S, Smith TJ. Neuropsychiatrie effects of acute styrene exposure in fiberglass boat- builders. Neurotoxicol Teratol 1990; 12:665-68.
35. Orbaek P, Rosen I, Svensson K. Power spectrum analysis of EEG at diagnosis and follow-up of patients with solvent induced chronic toxic encephalopathy. Br J Ind Med 1988; 45:476-82.
36. Sparks PJ, Daniell W, Black DW, Kipen HM, Altman LC, Simon CE, Terr AI. Multiple chemical sensitivity syndrome: a clinical perspective. I. Case definition, theories of pathogenesis, and research needs. J Occup Med 1994; 36:718-30.
37. Doty RL, Deems DA, Frye RE, Pelberg R, Shapiro A. Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch Otolaryngol Head Neck Surg 1988; 114:1422-127.
38. Buchwald D, Garrity D. Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities. Arch Intern Med 1994; 154:2049-53.
39. Bell IR, Peterson JM, Schwartz GE. Medical histories and psychological profiles of middle-aged women with and without self-reported illness from environmental chemicals. J Clin Psychiatry 1995; 56:151-60.
40. National Research Council. Multiple Chemical Sensitivities. Addendum to Biologic Markers in Immunotoxicology. Washington, DC: National Academy Press, 1992.
41. Rest KM. Advancing the understanding of multiple chemical sensitivity (MCS): overview and recommendations from an AOEC workshop. Toxicol Ind Health 1992; 8:1-13.
42. Nethercott JR, Davidoff LL, Curbow B, Abbey H. Multiple chemical sensitivities syndrome: toward a working case definition. Arch Environ Health 1993; 48:19-26.
43. Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med (State of the Art Reviews) 1987; 2:655-62.
44. Bell IR, Jasnoski ML, Kagan J, King DS. Is allergic rhinitis more frequent in young adults with extreme shyness? a preliminary survey. Psychosom Med 1990; 52:517-25.
45. Bell IR, Markley EJ, King DS, Asher S, Marby D, Kayne H, Greenwald M, Ogar DA, Margen S. Polysymptomatic syndromes and autonomic reactivity to nonfood stressors in individuals with self-reported adverse food reactions. J Am Coll Nutr 1993; 12:227-38.
46. Charney DS, Neutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 1993; 50:294-305.
47. Levy CJ. Agent Orange exposure and posttraumatic stress disorder. J Nerv Ment Dis 1988; 176:242-245.
48. Derogatis LR. Symptom Checklist-90 (revised). Towson, MD: Clinical Psychometric Research, Inc.
49. Barsky AJ, Goodson JD, Lane RS, Cleary PD. The amplification of somatic symptoms. Psychosom Med 1988; 50:510-19.
50. Pearlin LI, Schooler C. The structure of coping. J Health Soc Behav 1978; 19:2-21.
51. Cheek JM, Buss AH. Shyness and sociability. J Personality Soc Psychol 1981; 41:330-39.
52. Kagan J, Snidman N, Julia-Sellers M, Johnson MO. Temperament and allergic symptoms. Psychosom Med 1991; 53:332-40.
53. Kagan J, Reznick JS, Snidman N. Biological bases of childhood shyness. Science 1988; 240:167-71.
54. Adamec RE. Partial limbic kindling—brain, behavior, and the benzodiazepine receptor. Physiol Behav 1993; 54:531-45.
55. Crowne D, Marlowe D. A new scale of social desirability independent of psychopathology. J Consult Psychol 1960; 24:1397-1403.
56. Lane RD, Merikangas KR, Schwartz GE, Huang SS, Prusoff BA. Inverse relationship between defensiveness and lifetime prevalence of psychiatric disorder. Am J Psychiatry 1990; 147:573-78.
57. Jamner LD, Schwartz GE, Leigh H. The relationship between repressive and defensive coping styles and monocyte, eosinophil, and serum glucose levels: support for the opioid peptide hypothesis of repression. Psychosom Med 1988; 50.567-75.
58. Rothman K. Modern Epidemiology. Boston: Brown, Little, and Co., 1986; pp 147-50.
59. Pennebaker JW. The Psychology of Physical Symptoms. Springer-Verlag, 1982; p 7.
60. Geschwind N, Behan P. Left-handedness: association with immune disease, migraine, and developmental learning disorder. Proc Natl Acad Sci 1982; 79:5097-5100.
61. Weinstein RE, Pieper DR. Altered cerebral dominance in an 20 atopic population. Brain Behav Immun 1988; 2:235-41.
62. Searleman A, Fugali AK. Suspected autoimmune disorders and left-handedness: evidence from individuals with diabetes, Crohn’s disease, and ulcerative colitis. Neuropsychologia 1987; 25:367-74.
63. Salcedo JR, Spiegler BJ, Gibson E, Magilavy DB. The autoimmune disease systemic lupus erythematosus is not associated with left-handedness. Cortex 1985; 21:645-47.
64. Meggs WJ. Neurogenic inflammation and sensitivity to environmental chemicals. Environ Health Perspect 1993; 101:234-38.
65. Bell IR. Neuropsychiatric aspects of sensitivity to low level chemicals: a neural sensitization model. Toxicol Ind Health 1994; 10:277-312.
66. Gilbert ME. Neurotoxicants and limbic kindling. Isaacson RL and Jensen KF, Eds. The Vulnerable Brain and Environmental Risks. Vol. 1. Malnutrition and Hazard Assessment. NY: Plenum Press, 1992; pp 173-92.
67. Lorig TS, Herman KB, Schwartz GE, Cain WS. EEG activity during administration of low-concentration odors. Bull Psychonom Sci 1990; 28:405-08.
68. Lorig TS, Huffman E, DeMartino A, DeMarco J. The effects of low concentration odors on EEG activity and behavior. J Psychophysiol 1991; 5:67-77.
69. Schwartz GE, Bell IR, Dikman ZV, Kline JP, Peterson JM, Polak EH, Wright KP. EEG responses to low level chemicals in normals and cacosmics. Toxicol Ind Health 1994; 10:633-43.
70. Morrow LA, Robin N, Hodgson MJ, Kamis H. Assessment of attention and memory efficiency in persons with solvent neurotoxicity. Neuropsychologia 1992; 30:911-22.
71. Watson D, Pennebaker JW. Health complaints, stress, and distress: exploring the central role of negative affectivity. Psychol Rev 1989; 96:234-54.
72. Meggs WJ, Cleveland CH. Rhinolaryngoscopic examination of patients with the multiple chemical sensitivity syndrome. Arch Environ Health 1993; 48:14-18.
73. Staudenmayer H, Seiner JC. Neuropsychophysiology during relaxation in generalized, universal “allergic” reactivity to the environment: a comparison study. J Psychosom Res 1990; 34: 259-70.
74. Alexopoulos GS, Meyers BS, Young RC, Mattis S, Kakuma T. The course of geriatric depression with “reversible dementia”: a controlled study. Am J Psychiatry 1993; 150:1693-99.
75. Antelman SM, Kocan D, Knopf S, Edwards DJ, Caggiula AR. One brief exposure to a psychological stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol. Life Sci 1992; 51:261-66.
76. Antelman SM, Caggiula AR, Knopf S, Kocan DJ, Edwards DJ. Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs. Psychopharmacology 1992; 107:331-36.
77. Kalivas PW, Richardson-Carlson R, Van Orden G. Cross-sensitization between foot shock stress and enkephalin-induced motor activity. Biol Psychiatry 1986; 21:939-50.
78. Robinson TE, Becker JB, Presty SK. Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: sex differences. Brain Res 1982; 253:231-41.
79. Peris J, Decambre N, Coleman-Hardee ML, Simpkins JW. Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release. Brain Res 1991; 566:255-64.
80. Haney M, Castanon N, Cador M, Le Moal M, Mormede P. Cocaine sensitivity in Roman high and low avoidance rats is modulated by sex and gonadal hormone status. Brain Res 1994; 645:179-85.
81. Kalivas PW, Sorg BA, Hooks MS. The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol 1993; 4:315-34.
82. Antelman SM. Time-dependent sensitization as the cornerstone for a new approach to pharmacotherapy: drugs as foreign/stressful stimuli. Drug Devel Res 1988; 14:1-30.
83. Kalivas PW, Stewart J. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 1991; 16:223-44.
84. Snyder-Keller AM. Striatal c-fos induction by drugs and stress in neonatally dopamine-depleted rats given nigral transplants: importance of NMDA activation and relevance to sensitization phenomena. Exp Neurol 1991; 113:155-65.
85. Hooks MS, Jones GH, Neuill DB, Justice JB. Individual differences in amphetamine sensitization: dose-dependent effects. Pharmacol Biochem Behav 1992; 41:203-210.
86. Burchfiel JL, Duffy FJ, Sim VM. Persistent effects of sarin and dieldrin upon the primate electroencephalogram. Toxicol Appl Pharmacol 1976; 35:365-79.
87. Antelman SM, Caggiula AR, Kocan D, Knopf S, Meyer D, Edwards DJ, Barry H. One experience with “lower” or “higher” intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Res 1991; 566:276-283.
88. Newlin DB, Thomson JB. Chronic tolerance and sensitization to alcohol in sons of alcoholics. Alcohol Clin Exp Res 1991; 15: 399-405.
89. Kalivas PW, Alesdatter JE. Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine. J Pharmacol Exp Ther 1993; 267:486-95.
90. Post RM. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am J Psychiatry 1992; 149:999-1010.
91. Vezina P, Stewart J. Amphetamine administered to the ventral segmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Res 1990; 516:99-106.
92. Jackson HC, Nutt DJ. A single preexposure produces sensitization to the locomotor effects of cocaine in mice. Pharmacol Biochem Behav 1993; 45:733-35.
93. Yehuda R, Antelman SM. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiatry 1993; 33:479-86.
94. Dager SR, Holland JP, Cowley DS, Dunner DL. Panic disorder precipitated by exposure to organic solvents in the work place. Am J Psychiatry 1987; 144:1056-58.
95. Bell IR. Somatization disorder: health care costs in the decade of the brain. Biol Psychiatry 1994; 35:81-83.
96. Cervero F, Janig W. Visceral nociceptors: a new world order? Trends in Neuroscience 1992; 15:374-78.
97. California Medical Association Scientific Board Task Force on Clinical Ecology. Clinical ecology—a critical appraisal. West J Med 1986; 144:239-15.
98. Locatelli M, Bellodi L, Perna G, Scarone S. EEC power modifications in panic disorder during a temporolimbic activation task: relationships with temporal lobe clinical symptomatology. J Neuropsychiatry Clin Neurosci 1993; 5:409-14.
99. Rosenthal NE, Cameron CL. Exaggerated sensitivity to an organophosphate pesticide. Am J Psychiatry 1991; 148:270.
100. Bell IR, Amend D, Kaszniak AW, Schwartz GE, Peterson JM, Stini WA, Miller J, Selhub J. Trait shyness in the elderly: evidence for an association with Parkinson’s disease in family members and biochemical correlates. J Geriatr Psychiatry Neurol 1995;8:16-22.
101. Bell IR, Schwartz GE, Amend D, Peterson JM, Kaszniak AW, Miller CS. Psychological characteristics and subjective intolerance for xenobiotic agents of normal young adults with trait shyness and defensiveness: a Parkinsonian-like personality type? J Nerv Mental Dis 1994; 182:367-74.
102. Rajput AH, Offord KP, Beard M, Kurland LT. A case-control study of smoking habits, dementia, and other illnesses in idiopathic Parkinson’s disease. Neurology 1987; 37:226-32.
103. Littorin ME, Fehling C, Attewell RG, Skerfving S. Focal epilepsy and exposure to organic solvents: a case-referent study. J Occup Med 1988; 30:805-08.
104. Lindelof B, Almkvist O, Gothe CJ. Sleep disturbances and exposure to organic solvents. Arch Environ Health 1992; 47:104-06.
105. Morrow LA, Ryan CM, Hodgson MJ, Robin N. Risk factors associated with persistence of neuropsychological deficits in persons with organic solvent exposure. J Nerv Mental Dis 1991; 179:540-45.
106. Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypoole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991; 338:223-27.
107. Teicher MH, Glod CA, Surrey J, Swett C. Early childhood abuse and limbic system ratings in adult psychiatric outpatients. J Neuropsychiatry Clin Neurosci 1993; 5:301-06.
108. Ito Y, Teicher MH, Glod CA, Harper D, Magnus E, Gelbard HA. Increased prevalence of electrophysiological abnormalities in children with psychological, physical, and sexual abuse. J Neuropsychiatry Clin Neurosci 1993; 5:401-08.
109. Bell IR, Hardin E, Baldwin CM, Schwartz GE. Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ Res (in press).
110. Bell IR, Bootzin RR, Ritenbaugh C, Wyatt JK, DeGiovanni G, Kulinovich T, Anthony J, Kuo TF, Rider SP, Peterson JM, Schwartz GE, Johnson KA. A polysomnographic study of sleep disturbance in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry (in press).
111. Bell IR, Bootzin RR, Davis T, Hau V, Ritenbaugh C, Johnson KA, Schwartz GE. The Time-dependent sensitization of plasma beta-endorphins in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry (in press).
112. Bell IR, Schwartz GE, Peterson JM, Kline JP. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerances. (In preparation.)
113. Bell IR, Wyatt JK, Bootzin RR, Schwartz GE. Slowed reaction time performance on a divided attention task in elderly with environmental chemical odor intolerance. Int J Neurosci (in press).
114. Bell IR, Schwartz GE, Bootzin RR, Wyatt JK. Time-dependent sensitization of heart rate and blood pressure over multiple laboratory sessions in elderly individuals with and without chemical odor intolerance (under review).