In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices

Journal of Biomedical Materials Research

Volumn 61, Issue 2, 2002, Pages 180-187

  Hickey, T ^a   Kreutzer, D ^a   Burgess, D J ^b   Moussy, F ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Dexamethasone; Glu cose sensors; Inflammation; Microspheres; PLGA; Predegrading; Sutures

Indexed keywords

BIOSENSORS; DRUG PRODUCTS; TISSUE;

MICROSPHERES;

BIOMEDICAL ENGINEERING;

CORTICOSTEROID; DEXAMETHASONE; GLUCOSE; MICROSPHERE; POLYGLACTIN; ANTIINFLAMMATORY AGENT; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED DRUG RELEASE; COTTON; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMPLANT; INFLAMMATION; MALE; NONHUMAN; RAT; SENSOR; SUTURE; TISSUE REACTION; WOUND HEALING; ANIMAL; APPARATUS, EQUIPMENT AND SUPPLIES; CHEMISTRY; DELAYED RELEASE FORMULATION; DISEASE MODEL; EVALUATION; GENETIC PROCEDURES; PROSTHESES AND ORTHOSES; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOSENSING TECHNIQUES; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EQUIPMENT AND SUPPLIES; INFLAMMATION; LACTIC ACID; MALE; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036274835     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.10016     Document Type: Article

References (22)

1. Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties
2. Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties
3. Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times
4. Dexamethasone
5. Classical corticosteroids and new lipid peroxidation inhibitors in the therapy of multiple organ failure (MOF)
6. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes
7. Nonsteroidal anti-inflammatory agents: Potential modifiers of periodontal disease progression
8. Microsphere technology and applications
9. Spray-dried albumin microspheres for the intra-articular delivery of dexamethasone
10. Local intraluminal infusion of biodegradable polymeric nanoparticles
11. Prolonged controlled-releasing hormone analogue, from biodegradable polymeric implants: Influence of composition and molecular weight of polymer
12. Prolonged delivery of peptides by microcapsules
13. In vitro and in vivo evaluation of thyrotropin releasing hormone release from co-poly (di-lactic/glycolic acid) microspheres
14. Development of a novel method of microencapsulation for a model protein, β-glucuronidase
15. Stable formulations of recombinant human growth hormone and interferon-γ for microencapsulation in biodegradable microspheres
16. Controlled delivery systems for proteins based on poly(lactic/ glycolic acid) microspheres
17. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders
18. High-performance liquid chromatographic determination of dexamethasone in human plasma
19. Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly (lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly (lactide-co-glycolide) A blocks and hydrophilic poly(ethylene oxide) B block
20. pH and osmotic pressure inside biodegradable microspheres during erosion
21. Inhibition of epidural scar formation after lumbar laminectomy in the rat