Impaired Balance of Th17/Treg in Patients with Nasal Polyposis

Scandinavian Journal of Immunology

Volumn 74, Issue 2, 2011, Pages 176-185

  Shen, Y ^a   Tang, X Y ^a   Yang, Y C ^a   Ke, X ^a   Kou, W ^a   Pan, C K ^a   Hong, S L ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; ATOPY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NOSE POLYP; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; AGED; CHRONIC DISEASE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERFERON-GAMMA; INTERLEUKINS; MALE; MIDDLE AGED; NASAL POLYPS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 79960100292     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02546.x     Document Type: Article

References (35)

1. Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004;114:155-212.
2. Wynn R, Har-El G. Recurrence rates after endoscopic sinus surgery for massive sinus polyposis. Laryngoscope 2004;114:811-3.
3. Huang Z, Xie H, Wang R et al. Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opin Ther Targets 2007;11:737-43.
4. Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J Allergy Clin Immunol 2007;120:247-54.
5. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007;8:345-50.
6. Zhao Y, Yang J, Gao YD et al. Th17 immunity in allergic asthma. Int Arch Allergy Immunol 2010;151:297-307.
7. Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133-41.
8. Sakaguchi S, Ono M, Setoguchi R et al. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27.
9. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441:235-8.
10. Zhou L, Lopes JE, Chong MM et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008;453:236-40.
11. Du J, Huang C, Zhou B et al. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol 2008;180:4785-92.
12. Laurence A, Tato CM, Davidson TS et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007;26:371-81.
13. Fokkens W, Lund V, Mullol J, European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 2007;20:1-136.
14. Lund VJ, Holmstrom M, Scadding GK. Functional endoscopic sinus surgery in the management of chronic rhinosinusitis. An objective assessment. J Laryngol Otol 1991;105:832-5.
15. Lund VJ, Kennedy DW. Staging for rhinosinusitis. Otolaryngol Head Neck Surg 1997;117 (Suppl.):S35-40.
16. Lanza DC, Kennedy DW. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg 1997;117 (3 Pt 2):S1-7.
17. Muñoz del Castillo F, Jurado-Ramos A, Fernández-Conde BL et al. Allergenic profile of nasal polyposis. J Investig Allergol Clin Immunol 2009;19:110-6.
18. Palomares O, Yaman G, Azkur AK et al. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010;40:1232-40.
19. Cao PP, Li HB, Wang BF et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 2009;124:478-84, 484.e1-2.
20. Zhang N, Van Zele T, Perez-Novo C et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 2008;122:961-8.
21. Van Bruaene N, Pérez-Novo CA, Basinski TM et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 2008;121:1435-41, 1441.e1-3.
22. Shao XS, Yang XQ, Zhao XD et al. The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome. Pediatr Nephrol 2009;24:1683-90.
23. Eastaff-Leung N, Mabarrack N, Barbour A et al. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol 2010;30:80-9.
24. Nistala K, Moncrieffe H, Newton KR et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 2008;58:875-87.
25. Sakaguchi S. Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-52.
26. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005;6:331-7.
27. Li J, Wang L, Wang S et al. The Treg/Th17 imbalance in patients with idiopathic dilated cardiomyopathy. Scand J Immunol 2010;71:298-303.
28. Wu K, Bi Y, Sun K et al. Suppression of allergic inflammation by allergen-DNA-modified dendritic cells depends on the induction of Foxp3+ Regulatory T cells. Scand J Immunol 2008;67:140-51.
29. Pérez Novo CA, Jedrzejczak-Czechowicz M, Lewandowska-Polak A et al. T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation. Clin Exp Allergy 2010;40:1323-32.
30. Grindebacke H, Wing K, Andersson AC et al. Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004;34:1364-72.
31. Ciprandi G, Fenoglio D, De Amici M et al. Serum IL-17 levels in patients with allergic rhinitis. J Allergy Clin Immunol 2008;122:650-1.
32. Ciprandi G, De Amici M, Murdaca G et al. Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy 2009;64:1375-8.
33. Lin YL, Shieh CC, Wang JY. The functional insufficiency of human CD4+CD25 high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. Allergy 2008;63:67-74.
34. Jäger A, Kuchroo VK. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol 2010;72:173-84.
35. Bachert C, Zhang N, Holtappels G et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol 2010;126:962-8, 968.e1-6.