The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome

Pediatric Nephrology

Volumn 24, Issue 9, 2009, Pages 1683-1690

  Shao, Xiao Shan ^a   Yang, Xi Qang ^a   Zhao, Xiao Dong ^a   Li, Qiu ^a   Xie, Yuan Yuan ^a   Wang, Xiao Gang ^a   Wang, Mo ^a   Zhang, Wei ^a  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Interleukin 6, 17, 23, 1 ; Primary nephrotic syndrome; Retinoid orphan nuclear receptor; Th17 cells; Treg cells

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23P19; INTERLEUKIN 6; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL INTERACTION; CHILD; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GLOMERULUS; HEMATURIA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE DISORDER; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH17 CELL;

BIOPSY; CELL COUNT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CYTOKINES; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEMATURIA; HUMANS; INTERLEUKIN-17; KIDNEY; LEUKOCYTES, MONONUCLEAR; MALE; NEPHROTIC SYNDROME; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

EID: 68449101715     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1194-x     Document Type: Article

References (26)

1. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT (2005) Interleukin-17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1069-1070
2. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238
3. Dong C (2006) Diversification of T-helper-cell lineages: Finding the family root of IL-17-producing cells. Nat Rev Immunol 6:329-333
4. Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT (2006) Transforming growth factor beta induces development of the T(H) 17 lineage. Nature 441:231-234
5. Ouyang W, Kolls JK, Zheng Y (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28:454-467
6. Dong C (2008) TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat Rev Immunol 8:337-348
7. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR (2006) The orphan nuclear receptor ROR gammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133
8. McGeachy MJ, Cua DJ (2008) Th17 cell differentiation: The long and winding road. Immunity 28:445-453
9. Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA (2008) IL-21 and TGF-β1eta are required for differentiation of human T(H) 17 cells. Nature 454:350-352
10. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupé P, Barillot E, Soumelis V (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9:650-657
11. Manel N, Unutmaz D, Littman DR (2008) The differentiation of human TH-17 cells requires transforming growth factor-b and induction of the nuclear receptor RORct. Nat Immunol 9:641-649
12. Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-476
13. Bettelli E, Oukka M, Kuchroo VK (2007) TH-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8:345-350
14. Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR (2007) Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versushost disease. Blood 110:3804-3813
15. Kiliś-Pstrusińska K, Zwolińska D, Medyńska A, Wawro A, Kordecki H (2006) Interleukin-17 concentration in serum and urine of children with idiopathic nephrotic syndrome. Przegl Lek 63:198-200
16. Matsumoto K, Kanmatsuse K (2002) Increased urinary excretion of interleukin-17 in nephrotic patients. Nephron 91:243-249
17. Rizk MK, El-Nawawy A, Abdel-Kareem E, Amer ES, El-Gezairy D, El-Shafei AZ (2005) Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome. East Mediterr Health J 11:993-1002
18. Qin J, Zhang Z, Liu J, Sun L, Hu L, Cooper ME, Cao Z (2003) Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes. Kidney Int 64:565-571
19. Shalhoub RJ (1974) Pathogenesis of lipoid nephrosis: A disorder of T-cell function. Lancet 2:556-560
20. Afzali B, Lombardi G, Lechler RI, Lord GM (2007) The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 148:32-46
21. Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875-1886
22. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317:256-260
23. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8:950-957
24. Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ (2007) Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 56:2936-2946
25. Alvarez V, Quiroz Y, Nava M, Pons H, Rodríguez-Iturbe B (2002) Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells. Am J Physiol Renal Physiol 283:1132-1141
26. Homey B (2006) After TH1/TH2 now comes Treg/TH17: Significance of T helper cells in immune response organization. Hautarzt 57:730-732