Clinical outcomes of intensity-modulated pelvic radiation therapy for carcinoma of the cervix

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 5, 2011, Pages 1436-1445

  Hasselle, Michael D ^a   Rose, Brent S ^b   Kochanski, Joel D ^a   Nath, Sameer K ^b   Bafana, Rounak ^c   Yashar, Catheryn M ^b   Hasan, Yasmin ^a   Roeske, John C ^d   Mundt, Arno J ^b   Mell, Loren K ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Cervical cancer; Intensity modulated radiation therapy

Indexed keywords

BRACHYTHERAPY; CERVICAL CANCERS; CERVICAL CARCINOMA; CLINICAL OUTCOME; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONVENTIONAL TECHNIQUES; CUMULATIVE INCIDENCE; DISEASE FREE SURVIVAL; FAILURE RATE; INTENSITY MODULATED RADIATION THERAPY; KAPLAN-MEIER METHOD; LOW TOXICITY; OVERALL SURVIVAL; OVERALL SURVIVAL RATES; PELVIC RADIATION; PLANNING TARGET VOLUMES; RADIATION THERAPY ONCOLOGY GROUPS;

DISEASE CONTROL; DISEASES; ONCOLOGY; PATIENT MONITORING; RADIATION; RADIOTHERAPY; TOXICITY;

PHYSICAL THERAPY;

CARBOPLATIN; CISPLATIN; FLUOROURACIL; NAVELBINE; PACLITAXEL;

ADULT; AGED; ARTICLE; BLADDER; BRACHYTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; DISEASE FREE SURVIVAL; DISEASE SEVERITY; FEMALE; FOLLOW UP; GASTROINTESTINAL DISEASE; HUMAN; HYSTERECTOMY; INTENSITY MODULATED RADIATION THERAPY; INTESTINE; INTRACAVITARY BRACHYTHERAPY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT SAFETY; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RECTUM; SURVIVAL RATE; THERAPY EFFECT; TREATMENT FAILURE; TREATMENT PLANNING; UROGENITAL TRACT DISEASE; UTERINE CERVIX CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BRACHYTHERAPY; CARBOPLATIN; CISPLATIN; CONFIDENCE INTERVALS; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; HYSTERECTOMY; MIDDLE AGED; NEOPLASM STAGING; RADIATION DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RECTUM; SURVIVAL RATE; TREATMENT OUTCOME; URINARY BLADDER; UTERINE CERVICAL NEOPLASMS; VINBLASTINE;

EID: 79960091597     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.04.041     Document Type: Article

References (57)

1. L.K. Mell, A.K. Mehrotra, and A.J. Mundt Intensity-modulated radiation therapy use in the U.S., 2004 Cancer 104 2005 1296 1303 (Pubitemid 41278966)
2. J.C. Roeske, A. Lujan, and J. Rotmensch Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies Int J Radiat Oncol Biol Phys 48 2000 1613 1621
3. A.E. Lujan, A.J. Mundt, and S.D. Yamada Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy Int J Radiat Oncol Biol Phys 57 2003 516 521 (Pubitemid 37040950)
4. L.K. Mell, H. Tiryaki, and K.H. Ahn Dosimetric comparison of bone marrow-sparing intensity-modulated radiotherapy versus conventional techniques for treatment of cervical cancer Int J Radiat Oncol Biol Phys 71 2008 1504 1510 (Pubitemid 351978176)
5. A.J. Mundt, A.E. Lujan, and J. Rotmensch Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies Int J Radiat Oncol Biol Phys 52 2002 1330 1337 (Pubitemid 34296492)
6. A.J. Mundt, L.K. Mell, and J.C. Roeske Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy Int J Radiat Oncol Biol Phys 56 2003 1354 1360 (Pubitemid 36842887)
7. C.J. Brixey, J.C. Roeske, and A.E. Lujan Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies Int J Radiat Oncol Biol Phys 54 2002 1388 1396 (Pubitemid 35380039)
8. M.F. Chen, C.J. Tseng, and C.C. Tseng Clinical outcome in posthysterectomy cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy: Comparison with conventional radiotherapy Int J Radiat Oncol Biol Phys 67 2007 1438 1444
9. J.C. Roeske, A.J. Mundt, and H. Halpern Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: A dosimetric analysis Int J Radiat Oncol Biol Phys 37 1997 351 358 (Pubitemid 27138719)
10. J.C. Roeske, D. Bonta, and L.K. Mell A dosimetric analysis of acute gastrointestinal toxicity in women receiving intensity-modulated whole-pelvic radiation therapy Radiother Oncol 69 2003 201 207 (Pubitemid 37485881)
11. L.K. Mell, J.D. Kochanski, and J.C. Roeske Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy Int J Radiat Oncol Biol Phys 66 2006 1356 1365
12. Rose BS, Aydogan B, Liang Y, et al. Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys. In press 2010.
13. M. Guerrero, X.A. Li, L. Ma, J. Linder, C. Deyoung, and B. Erickson Simultaneous integrated intensity-modulated radiotherapy boost for locally advanced gynecological cancer: Radiobiological and dosimetric considerations Int J Radiat Oncol Biol Phys 62 2005 933 939 (Pubitemid 40779789)
14. J. Esthappan, S. Chaudhari, and L. Santanam Prospective clinical trial of positron emission tomography/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes Int J Radiat Oncol Biol Phys 72 2008 1134 1139
15. R.S. Ahmed, R.Y. Kim, and J. Duan IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk Int J Radiat Oncol Biol Phys 60 2004 505 512 (Pubitemid 39233470)
16. C.M. Lee, D.C. Shrieve, and D.K. Gaffney Rapid involution and mobility of carcinoma of the cervix Int J Radiat Oncol Biol Phys 58 2004 625 630 (Pubitemid 38142490)
17. N.A. Mayr, W.T.C. Yuh, and T. Taoka Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response AJR Am J Roentgenol 187 2006 65 72 (Pubitemid 46100147)
18. L. van de Bunt, U.A. van der Heide, and M. Ketelaars Conventional, conformal, and intensity-modulated radiation therapy treatment planning of external beam radiotherapy for cervical cancer: The impact of tumor regression Int J Radiat Oncol Biol Phys 64 2006 189 196 (Pubitemid 41831226)
19. B.M. Beadle, A. Jhingran, and M. Salehpour Cervix regression and motion during the course of external beam chemoradiation for cervical cancer Int J Radiat Oncol Biol Phys 73 2009 235 241
20. P. Chan, R. Dinniwell, and M.A. Haider Inter- and intrafractional tumor and organ movement in patients with cervical cancer undergoing radiotherapy: A cinematic-MRI point-of-interest study Int J Radiat Oncol Biol Phys 70 2008 1507 1515
21. A. Taylor, A.G. Rockall, and R.H. Reznek Mapping pelvic lymph nodes: Guidelines for delineation in intensity-modulated radiotherapy Int J Radiat Oncol Biol Phys 63 2005 1604 1612 (Pubitemid 41628062)
22. W. Small Jr., L.K. Mell, and P. Anderson Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer Int J Radiat Oncol Biol Phys 71 2008 428 434 (Pubitemid 351636192)
23. Lim K, Small W, Portelance L, et al. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the intact cervix. Int J Radiat Oncol Biol Phys. In press 2010.
24. L. van de Bunt, I.M. Jürgenliemk-Schulz, and G.A. de Kort Motion and deformation of the target volumes during IMRT for cervical cancer: What margins do we need? Radiother Oncol 88 2008 233 240
25. A.J. Mundt, J.C. Roeske, and A.E. Lujan Initial clinical experience with intensity-modulated whole-pelvis radiation therapy in women with gynecologic malignancies Gynecol Oncol 82 2001 456 463 (Pubitemid 32826444)
26. J.D. Kochanski, L.K. Mell, and J.C. Roeske Intensity-modulated radiation therapy in gynecologic malignancies: Current status and future directions Clin Adv Hematol Oncol 4 2006 379 386 (Pubitemid 44018499)
27. K. Lim, P. Chan, and R. Dinniwell Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: Radiobiologic modeling and correlation with tumor hypoxia Int J Radiat Oncol Biol Phys 70 2008 126 133 (Pubitemid 350251038)
28. E.L. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
29. J.J. Dignam, and M.N. Kocherginsky Choice and interpretation of statistical tests used when competing risks are present J Clin Oncol 26 2008 4027 4034
30. E.B. Wilson Probable inference, the law of succession, and statistical inference J Am Stat Assoc 22 1927 209 212
31. D.R. Cox Regression models and life-tables (with discussion) J Royal Stat Soc B 34 1972 187 202
32. A. Sedlis, B.N. Bundy, and M.Z. Rotman A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study Gynecol Oncol 73 1999 177 183 (Pubitemid 29215728)
33. W.A. Peters III, P.Y. Liu, and R.J. Barrett II Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix J Clin Oncol 18 2000 1606 1613 (Pubitemid 30220538)
34. C.W. Whitney, W. Sause, and B.N. Bundy Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study J Clin Oncol 17 1999 1339 1348 (Pubitemid 29220838)
35. M. Morris, P.J. Eifel, and J. Lu Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer N Engl J Med 340 1999 1137 1143 (Pubitemid 29177872)
36. P.J. Eifel, K. Winter, and M. Morris Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: An update of radiation therapy oncology group trial (RTOG) 90-01 J Clin Oncol 22 2004 872 880 (Pubitemid 41103599)
37. R. Pearcey, M. Brundage, and P. Drouin Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix J Clin Oncol 20 2002 966 972 (Pubitemid 34141839)
38. P.G. Rose, B.N. Bundy, and E.B. Watkins Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N Engl J Med 340 1999 1144 1153 (Pubitemid 29177873)
39. P.G. Rose, S. Ali, and E. Watkins Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: A Gynecologic Oncology Group Study J Clin Oncol 25 2007 2804 2810 (Pubitemid 47123190)
40. H.M. Keys, B.N. Bundy, and F.B. Stehman Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma N Engl J Med 340 1999 1154 1161 (Pubitemid 29177874)
41. F.B. Stehman, S. Ali, and H.M. Keys Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: Follow-up of a Gynecologic Oncology Group trial Am J Obstet Gynecol 197 2007 503.e1 503.e6
42. M.F. Chen, C.J. Tseng, and C.C. Tseng Adjuvant concurrent chemoradiotherapy with intensity-modulated pelvic radiotherapy after surgery for high-risk, early stage cervical cancer patients Cancer J 14 2008 200 206
43. L. Portelance, K. Winter, and A. Jhingran Post-operative pelvic intensity modulated radiation therapy (IMRT) with chemotherapy for patients with cervical carcinoma/RTOG 0418 phase II study [Abstract] Int J Radiat Oncol Biol Phys 75 2009 S640 S641
44. C.A. Perez, S. Breaux, and J.M. Bedwinek Radiation therapy alone in the treatment of carcinoma of the uterine cervix. II. Analysis of complications Cancer 54 1984 235 246 (Pubitemid 14076604)
45. A. Snijders-Keilholz, G. Griffioen, and J. Davelaar Vitamin B12 malabsorption after irradiation for gynaecological tumours Anticancer Res 13 1993 1877 1881 (Pubitemid 24008121)
46. P. Mauch, L. Constine, and J. Greenberger Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy Int J Radiat Oncol Biol Phys 31 1995 1319 1339
47. J.M. Noh, and S.J. Huh Two cases of post-radiation osteosarcoma of the sacrum after pelvic irradiation for uterine cervical cancer Eur J Gynaecol Oncol 28 2007 497 500
48. N.N. Baxter, E.B. Habermann, J.E. Tepper, S.B. Durham, and B.A. Virnig Risk of pelvic fractures in older women following pelvic irradiation JAMA 294 2005 2587 2593 (Pubitemid 41697248)
49. A.K. Chaturvedi, E.A. Engels, and E.S. Gilbert Second cancers among 104,760 survivors of cervical cancer: Evaluation of long-term risk J Natl Cancer Inst 99 2007 1634 1643
50. A. Dueñas-Gonzalez, L. Cetina-Perez, and C. Lopez-Graniel Pathologic response and toxicity assessment of chemoradiotherapy with cisplatin versus cisplatin plus gemcitabine in cervical cancer: A randomized Phase II study Int J Radiat Oncol Biol Phys 61 2005 817 823 (Pubitemid 40247977)
51. A. Dueñas-González, J.J. Zarba, and J.C. Alcedo A phase III study comparing concurrent gemcitabine (Gem) plus cisplatin (Cis) and radiation followed by adjuvant Gem plus Cis versus concurrent Cis and radiation in patients with stage IIB to IVA carcinoma of the cervix [Abstract] J Clin Oncol 27 2009 18s
52. C.A. Perez, P.W. Grigsby, K.S. Chao, D.G. Mutch, and M.A. Lockett Tumor size, irradiation dose, and long-term outcome of carcinoma of uterine cervix Int J Radiat Oncol Biol Phys 41 1998 307 317 (Pubitemid 28243542)
53. C.A. Perez, P.W. Grigsby, H. Castro-Vita, and M.A. Lockett Carcinoma of the uterine cervix. I. Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy Int J Radiat Oncol Biol Phys 32 1995 1275 1288
54. A. Fyles, T.J. Keane, M. Barton, and J. Simm The effect of treatment duration in the local control of cervix cancer Radiother Oncol 25 1992 273 279 (Pubitemid 23000770)
55. N. Tyagi, C.M. Yashar, and J.H. Lewis Impact of internal organ motion and deformation on target coverage in intact cervical cancer patients undergoing IMRT: A daily cone beam CT study [Abstract] Int J Radiat Oncol Biol Phys 72 2008 S355
56. J.D. Lawson, D.R. Simpson, and B.S. Rose Adaptive radiotherapy in cervical cancer: Dosimetric analysis using daily cone-beam CT [Abstract] Int J Radiat Oncol Biol Phys 75 2009 S85 S86
57. D.R. Zwahlen, J.D. Ruben, and P. Jones Effect of intensity-modulated pelvic radiotherapy on second cancer risk in the postoperative treatment of endometrial and cervical cancer Int J Radiat Oncol Biol Phys 74 2009 539 545