Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy

International Journal of Radiation Oncology Biology Physics

Volumn 56, Issue 5, 2003, Pages 1354-1360

  Mundt, Arno J ^a,b   Mell, Loren K ^a   Roeske, John C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cervical cancer; Endometrial cancer; Gastrointestinal toxicity; Intensity modulated radiation therapy

Indexed keywords

COMPUTERIZED TOMOGRAPHY; GASTROENTEROLOGY; GYNECOLOGY; TOXICITY; TUMORS;

CLINICAL TARGET VOLUME (CTV);

RADIOTHERAPY;

ADULT; AGE; AGED; ARTICLE; BRACHYTHERAPY; CANCER CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; MAJOR CLINICAL STUDY; MODULATION; MULTIVARIATE ANALYSIS; PELVIS LYMPH NODE; PRIORITY JOURNAL; RADIOTHERAPY; RECTUM; SMALL INTESTINE; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; TREATMENT PLANNING; UTERINE CERVIX CANCER; UTERUS; VAGINA;

EID: 0037489714     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)00325-0     Document Type: Article

References (34)

1. Grigsby P.W., Perez C.A. Radiotherapy alone for medically inoperable carcinoma of the cervix Stage IA and carcinoma in situ . Int J Radiat Oncol Biol Phys. 21:1991;375-378.
2. Mundt A.J., Waggoner S.E., Rotmensch J., et al. Preoperative intracavitary brachytherapy in early stage cervical carcinoma. Am J Clin Oncol. 22:1999;737-743.
3. Sedlis A., Bundy B.N., Rotman M.Z., et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy A Gynecologic Oncology Group Study . Gynecol Oncol. 73:1999;177-183.
4. Creutzberg C.L., van Putten W.L., Koper P.C., et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma Multicentre randomised trial . PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 355:2000;1404-1411.
5. Keys H.M., Bundy B.N., Stehman F.B., et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med. 340:1999;1154-1161.
6. Rose P.G., Bundy B.N., Watkins E.B., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 340:1999;1144-1153.
7. Corn B.W., Lanciano R.M., Greven K.M., et al. Impact of improved irradiation technique, age, and lymph node sampling on the severe complication rate of surgically staged endometrial cancer patients A multivariate analysis . J Clin Oncol. 12:1994;510-515.
8. Creutzberg C.L., van Putten W.L., Koper P.C., et al. The morbidity of treatment for patients with stage I endometrial cancer Results from a randomized trial . Int J Radiat Oncol Biol Phys. 51:2001;1246-1255.
9. Snijders-Keiholz A., Griffioen G., Davelaar J., et al. Vitamin B12 malabsorption after irradiation for gynaecological tumours. Anticancer Res. 13:1993;1877-1881.
10. Roeske J.C., Lujan A., Rotmensch J., et al. Intensity modulated whole pelvic radiation therapy in patients with gynecological malignancies. Int J Radiat Oncol Biol Phys. 48:2000;1613-1621.
11. Mundt A.J., Roeske J.C., Lujan A.E. Intensity modulated radiation therapy in gynecologic malignancies. Med Dosim. 27:2002;131-136.
12. Chen Q., Izadifar N., King S., et al. Comparison of IMRT with 3-D CRT for gynecologic malignancies (Abstr.). Int J Radiat Oncol Biol Phys. 51:(Suppl. 3):2001;332.
13. Selvaraj R.N., Gerszten K., King G.C., et al. Conventional 3-D versus intensity modulated radiotherapy for the adjuvant treatment of gynecologic malignancies A comparative study of dose-volume histograms and the potential impact on toxicities (Abstr.) . Int J Radiat Oncol Biol Phys. 51:(Suppl. 1):2001;218-219.
14. Kavanagh B.D., Wu Q., Arnfield M., et al. Whole pelvic intensity-modulated radiotherapy (IMRT) for cervix cancer using a "butterfly" isodose plan In vivo dosimetric verification of reduced rectal dose and clinical feasibility evaluation (Abstr.) . Int J Radiat Oncol Biol Phys. 45:1999;412.
15. Kavanagh B.D., Schefter T.E., Wu Q., et al. Clinical application of intensity-modulated radiotherapy for locally advanced cervical cancer. Semin Radiat Oncol. 12:2002;260-271.
16. Mundt A.J., Roeske J.C., Lujan A., et al. Initial clinical experience using intensity modulated whole pelvic radiation therapy for gynecologic malignancies. Gynecol Oncol. 82:2001;456-463.
17. Mundt A.J., Lujan A.E., Rotmensch J., et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 52:2002;1330-1337.
18. International Commission on Radiation Units and Measurements (ICRU). Report Number 50. Prescribing, recording and reporting photon beam therapy. Washington, DC: ICRU; 1993.
19. Adli M., Mayr N.A., Kaiser H.S., et al. Does prone positioning reduce bowel dose in pelvic radiation with intensity-modulated radiation therapy (IMRT) for gynecologic cancer? (Abstr.) . Int J Radiat Oncol Biol. 51:(Suppl. 1):2001;334.
20. Portelance L., Chao K.S., Grigsby P.W., et al. Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation. Int J Radiat Oncol Biol Phys. 51:2001;261-266.
21. Hong L., Alektiar K., Chui C., et al. IMRT of large fields Whole-abdomen irradiation . Int J Radiat Oncol Biol Phys. 54:2002;278.
22. Ahamad A., D'Souza W., Salehpour M., et al. Intensity modulated radiation therapy (IMRT) for post-hysterectomy pelvic radiation Selection of patients and planning target volume (PTV) . Int J Radiat Oncol Biol Phys. 54:(Suppl. 1):2002;42.
23. Brixey C., Roeske J.C., Lujan A.E., et al. Impact of intensity modulated whole pelvic radiation therapy on acute hematologic toxicity in patients with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 54:2002;1388-1396.
24. Roeske J.C., Lujan A.E., Rotmensch J., et al. A feasibility study of IMRT for the treatment of cervical cancer patients unable to receive intracavitary brachytherapy (Abstr.). Med Phys. 27:2000;1382.
25. Lujan A.E., Roeske J.C., Mundt A.J. Sequential versus simultaneous integrated boost in the female pelvis using intensity-modulated radiation therapy (Abstr.). Med Phys. 28:2001;1262.
26. Roeske J.C., Lujan A.E., Krishnamachari U., et al. Dose-volume histogram analysis of acute gastrointestinal toxicity for gynecologic patients undergoing intensity modulated whole pelvic radiation therapy (Abstr.). Int J Radiat Oncol Biol Phys. 52:(Suppl. 1):2001;221.
27. Lujan A.E., Roeske J.C., Mundt A.J. Intensity-modulated radiation therapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiation therapy (Abstr.). Int J Radiat Oncol Biol Phys. 51:(Suppl. 3):2001;220.
28. Wang C.J., Leung S.W., Chen H.C., et al. The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma Evidence suggestive of consequential late effect (CQLE) . Int J Radiat Oncol Biol Phys. 40:1998;85-91.
29. Bourne R.G., Kearsley J.H., Grove W.D., et al. The relationship between early and late gastrointestinal complications of radiation therapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 9:1983;1445-1450.
30. Perez C.A., Breaux S., Bedwinek J.M., et al. Radiation therapy alone in the treatment of carcinoma of the uterine cervix II. Analysis of complications . Cancer. 54:1984;235-246.
31. Roeske J.C., Mundt A.J., Halpern H., et al. Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix A dosimetric analysis . Int J Radiat Oncol Biol Phys. 37:1997;351-358.
32. MacLeod C., Fowler A., Duval P., et al. Adjuvant high-dose rate brachytherapy with or without external beam radiotherapy post-hysterectomy for endometrial cancer. Int J Gynecol Cancer. 9:1999;247-255.
33. Jereczek-Fossa B., Jassem J., Nowak R., et al. Late complications after postoperative radiotherapy in endometrial cancer Analysis of 317 consecutive cases with application of linear-quadratic model . Int J Radiat Oncol Biol Phys. 41:1998;329-338.
34. van der Steen-Banasik E., Huls W.J.B.M., Karmer G.W.P.M., et al. Prospective study of late radiotherapeutical complications in patients with gynecological malignancies treated with external beam irradiation (Abstr.). Int J Gynecol Cancer. 9:(Suppl. 1):1999;68.