Intensity-modulated radiation therapy in gynecologic malignancies: Current status and future directions

Clinical Advances in Hematology and Oncology

Volumn 4, Issue 5, 2006, Pages 379-386

  Kochanski, Joel D ^a   Mell, Loren K ^a   Roeske, John C ^b   Mundt, Arno J ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gynecologic malignancies; Intensity modulated radiation therapy; Multi leaf collimator

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN;

BONE MARROW SUPPRESSION; BRACHYTHERAPY; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER STAGING; COMPUTER ASSISTED TOMOGRAPHY; DERMATITIS; DOSIMETRY; ENDOMETRIUM CANCER; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GASTROINTESTINAL DISEASE; GYNECOLOGIC CANCER; GYNECOLOGIC SURGERY; HEMATOLOGIC DISEASE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LEUKOPENIA; MEDICAL RESEARCH; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION INJURY; REVIEW; TREATMENT OUTCOME; TREATMENT PLANNING; TUMOR VOLUME; UROGENITAL TRACT DISEASE; UTERINE CERVIX CANCER; VULVA CANCER;

CHEMOTHERAPY, ADJUVANT; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; RADIOTHERAPY, INTENSITY-MODULATED; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 33745764629     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Cleaves M. Radium: With a preliminary note on radium rays in the treatment of cancer. Med Rec. 1903;64:1719-1723.
2. Perez CA, Breaux S, Bedwinek JM, et al. Radiation therapy alone in the treatment of carcinoma of the uterine cervix. II. Analysis of complications. Cancer. 1984;54:235-246.
3. Snijders-Keiholz A, Griffioen G, Davelaar J, et al. Vitamin B12 malabsorption after irradiation for gynaecological tumours. Anticancer Res. 1993;13:1877-1881.
4. Corn BW, Lancaino RM, Greven KM, et al. Impact of improved irradiation technique, age, and lymph node sampling on the severe complication rate of surgically staged endometrial cancer patients: a multivariate analysis. J Clin Oncol. 1994;12:510-515.
5. Stock RG, Chen AS, Flickinger JC, et al. Node-positive cervical cancer: impact of pelvic irradiation and patterns of failure. Int J Radiat Oncol Biol Phys. 1995;31:31-36.
6. Ferreira PR, Braga-Filho A, Barletta A, et al. Radiation therapy alone in stage III-B cancer of the uterine cervix-a 17 year old experience in south Brazil. Int J Radiat Oncol Biol Phys. 1999;45:441-446.
7. Leibel SA, Fuks, Zelefsky MJ, et al. Intensity-modulated radiotherapy. Cancer J. 2002;8:164-175.
8. Nutting C. Intensity-modulated radiotherapy (IMRT): the most important advance in radiotherapy since the linear accelerator? Br J Radiol. 2003;76:673.
9. Mell LK, Mehrotra AK, Mundt AJ. Survey of IMRT use in the United States, 2004. Cancer. 2005;104:1296-1303.
10. Roeske JC, Lujan A, Rotmensch J, et al. Intensity-modulated whole pelvis radiation therapy in patients with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2000;48:1613-1621.
11. Mundt AJ, Roeske JC, Lujan JC. IMRT in gynecologic malignancies. Med Dosim. 2002;27:131-136.
12. Heron DE, Gerszten K, Selvaraj RN, et al. Conventional 3D conformal versus ntensity-modulated radiotherapy for the adjuvant treatment of gynecologic malignancies: a comparative dosimetric study of dose-volume histograms. Gynecol Oncol. 2003;91:39-45.
13. Chen Q, Izadifar N, King S, et al. Comparison of IMRT with 3-D CRT for gynecologic malignancies. Int J Radiat Oncol Biol Phys [abstract]. 2001;51:332.
14. Ahamad A, D'Souza W, Salehpour M, et al. Intensity modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normal-tissue-sparing effect to margin size. Int J Radiat Oncol Biol Phys. 2005;62:1117-1124.
15. Wong E, D'Souza DP, Chen JZ, et al. Intensity-modulated arc therapy for treatment of high-risk endometrial malignancies. Int J Radiat Oncol Biol Phys. 2005;61:830-841.
16. Ellis RE. The distribution of active bone marrow in the adult. Phys Med Biol. 1961;5:255-263.
17. Lujan AE, Mundt AJ, Yamada D, et al. Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. Int J Radiat Oncol Biol Phys. 2003;57:516-521.
18. Portelance L, Chao KS, Grigsby PW, et al.: Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation. Int J Radiat Oncol Biol Phys. 2001;51:261-266.
19. Hong L, Alektiar K, Chui C, et al. IMRT of large fields: whole abdomen irradiation. Int J Radiat Oncol Biol Phys. 2002;54:278-289.
20. Duthoy W, De Gersem W, Vergote K, et al. Whole abdomino-pelvic radiotherapy (WAPRT) using intensity-modulated arc therapy (IMAT): first clinical experience. Int J Radiat Oncol Biol Phys. 2003;57:1019-32.
21. Beriwal S, Heron D, Kim H, et al. Intensity-modulated radiotherapy for the treatment of vulvar carcinoma: a comparative dosimetric study with early clinical outcome. Int J Radiat Oncol Biol Phys. 2005;63:S218 [abstract].
22. Garofalo M, Lujan AE, Roeske JC, et al. Intensity-Modulated Radiation Therapy in the treatment of vulvar carcinoma. Presented at the 88th Annual Meeting of the Radiologic Society of North America (RSNA), Chicago, IL, 2002.
23. Baxter NN, Habermann EB, Tepper JE, et al. Risk of pelvic fractures in older women following pelvic irradiation. JAMA. 2005;294:2597-2593.
24. D'Souza WD, Ahamad AA, Iyer RB, et al. Feasibility of dose escalation using intensity-modulated radiotherapy in post-hysterectomy cervical carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:1062-1070.
25. Lujan AE, Mundt AJ, Roeske JC. Sequential versus simultaneous boost in the female pelvis using intensity modulated radiation therapy. Presented at the 43rd Annual Meeting of the American Association of Physicists in Medicine, Salt Lake City, UT, 2001.
26. Mutic S, Malyapa RS, Grigsby PW, et al. PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes: a dose escalation treatment planning study. Int J Radiat Oncol Biol Phys. 2003;55:28-35.
27. Ahmed RS, Kim RY, Duan J et al. IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. Int J Radiat Oncol Biol. 2004;60:505-512.
28. Kavanagh B, Schefter TE, Wu Q, et al. Clinical application of intensity modulated radiotherapy for locally advanced cervical cancer. SeM Radiat Oncol. 2002;12:260-271.
29. Mundt AJ, Roeske JC. Could intensity modulated radiation therapy (IMRT) replace brachytherapy in the treatment of cervical cancer? Brachytherapy J. 2002;1:195-196.
30. Alektiar K. Could intensity modulated radiation therapy (IMRT) replace brachytherapy in the treatment of cervical cancer? Brachytherapy J. 2002;1:194-195.
31. Roeske JC, Mundt, AJ. A feasibility study of IMRT for the treatment of cervical cancer patients unable to receive intracavitary brachytherapy. Med Phys. 2000;27:1382.
32. Low DA, Grigsby PW, Dempsey JF, et al. Applicator-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2002;52:1400-1406.
33. Wahab SH, Malyapa RS, Mutic S, et al. A treatment planning study comparing HDR and AGIMRT for cervical cancer. Med Phys. 2004;31:734-743.
34. Guerrero M, Li XA, Ma L, et al. Simultaneous integrated intensity-modulated radiotherapy boost for locally advanced gynecological cancer: radiobiological and dosimetric considerations. Int J Radiat Oncol Biol Phys. 2005;62:933-939.
35. Schefter TE, Kavanagh BD, Wu Q et al. Technical considerations in the application of intensity-modulated radiotherapy as a concomitant integrated boost for locally advanced cervix cancer. Med Dosim. 2002;27:177-184.
36. Mundt AJ, Roeske JC, Lujan AE, et al. Initial clinical experience with intensity modulated whole-pelvis radiation therapy in women with gynecologic malignancies. Gynecol Oncol. 2001;82:456-463.
37. Mundt AJ, Lujan AE, Rotmensch J, et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2002;52:1330-1337.
38. Roeske JC, Bonta D, Lujan AE, et al. Dose volume histogram analysis of acute gastrointestinal toxicity in gynecologic patients undergoing intensity modulated whole pelvic radiation therapy. Radiother Oncol. 2003;69:201-207.
39. Mundt AJ, Mell LK, Roeske JC. Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy. Int J Radiat Oncol Biol Phys. 2003;56:1354-1360.
40. Brixey CJ, Roeske JC, Lujan AE et a]. Impact of intensity modulated radiation therapy on acute hematologic toxicity in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2002;54:1388-1396:
41. Mell LK, Kochanski JD, Roeske JC et al. Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity modulated pelvic radiation. Int J Radiat Oncol Biol Phys [abstract]. 2005;63(suppl 1):S96-S97.
42. Kochanski JD, Roeske JC, Mell LK, et al. Outcome of cervical cancer patients treated with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys [abstract]. 2005;63(suppl 1):S214.
43. Beriwal S, Jain S, Heron D, et al. Clinical outcomes with adjuvant treatment of endometrial carcinoma using intensity-modulated radiotherapy. Gynecol Oncol. 2006 Apr 27;[Epub ahead of print].
44. Knab B, Mehta N, Roeske JC, et al. Outcome of endometrial cancer patients treated with adjuvant intensity modulated Pelvic Radiation Therapy. Int J Radiat Oncol Biol Phys. [abstract]. 2004;60(suppl 1):S303-S304.
45. Gerszten K, Colonello K, Heron DE et al. Feasibility of concurrent cisplatin and extended field radiation therapy (EFRT) using intensity-modulated radiotherapy (IMRT) for the carcinoma of the cervix. Gynecol Oncol. 2006 Mar 1; [Epub ahead of print].
46. Hall E, Wuu CS. Radiation-induced second cancer: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys. 2003;56:83-88.
47. Taylor A, Rockall AG, Reznek RH, et al. Mapping pelvic lymph nodes: guidelines for delineation in intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2005;63:1604-1612.
48. Roeske JC, Lujan AE, Reba RC, et al. Incorporation of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies. Radiother Oncol. 2005;77:11-17.
49. Maleike D, Unkelbach J, Oelfke U. Simulation and visualization of dose uncertainties due to interfractional organ motion. Phys Med Biol. 2006;51:2237-2252.
50. Oelfke U, Tucking T, Nill S, Seeber A, Hesse B, Huber P, Thilmann C Med Dosim. Linac-integrated kV-cone beam CT: technical features and first applications. Med Dosim. 2006;31:62-70.
51. van de Bunt L, van der Heide UA, Ketelaars M, et al. Conventional, conformal and intensity-modulated radiation therapy treatment planning of external beam radiotherapy for cervical cancer: the impact of tumor regression. Int J Radiat Oncol Biol Phys [abstract]. 2005;63(suppl 1):S343.
52. Mell LK, Fyles AW, Small W, et al. Adjuvant intensity modulated pelvic radiation therapy in gynecologic malignancies: survey of the Gynecologic IMRT Working Group. Int J Radiat Oncol Biol Phys [abstract]. 2004;60(suppl 1):S215-S216.