Electrophysiological identification of mouse islet α-cells: From isolated single α-cells to in situ assessment within pancreas slices

Islets

Volumn 3, Issue 4, 2011, Pages 139-143

  Huang, Ya Chi ^a   Gaisano, Herbert Y ^b   Leung, Yuk Man ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

cell; Diabetes; Glucose homeostasis; Ion channel; Pancreatic slice

Indexed keywords

COMPARATIVE STUDY; DIABETES MELLITUS; ELECTROPHYSIOLOGY; GENETIC MODEL; GLUCOSE HOMEOSTASIS; HUMAN; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; REVIEW; TISSUE SLICE;

ANIMALS; CELL SEPARATION; CELLS, CULTURED; CYTOLOGICAL TECHNIQUES; ELECTROPHYSIOLOGICAL PHENOMENA; GLUCAGON-SECRETING CELLS; INSULIN-SECRETING CELLS; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; PANCREAS; PATCH-CLAMP TECHNIQUES; RECOMBINANT FUSION PROTEINS;

EID: 79960078976     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.3.4.16166     Document Type: Review

References (38)

1. Unger RH. Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 1985; 28:574-8. (Pubitemid 15017391)
2. Williams RH, Ensinck JW. Secretion, fates and actions of insulin and related products. Diabetes 1966; 15:623-54.
3. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L. Endocrine pancreas: three-dimensional reconstruction shows two types of islets of Langerhans. Science 1979; 206:1323-5. (Pubitemid 10170025)
4. Huang YC, Rupnik M, Gaisano HY. Unperturbed islet alpha-cell function examined in mouse pancreas tissue slices. J Physiol 2011; 589:395-408.
5. Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, et al. Transgenic mice with green fluorescent protein-labeled pancreatic beta-cells. Am J Physiol Endocrinol Metab 2003; 284:177-83.
6. Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, et al. Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology 2005; 146:4766-75. (Pubitemid 41446614)
7. Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P. The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Lett 2007; 581:4235-40. (Pubitemid 47301858)
8. 2+] c by different mechanisms in isolated mouse alphacells. Diabetes 2009; 58:412-21.
9. Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007; 28:84-116. (Pubitemid 46220851)
10. Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE. K(ATP)-channels and glucose-regulated glucagon secretion. Trends Endocrinol Metab 2008; 19:277-84.
11. Brolin SE, Agren A. Assay of flavin nucleotides in pancreatic islets by a differential fluorimetric technique. Biochem J 1977; 163:159-62. (Pubitemid 8067071)
12. Van De Winkel M, Pipeleers D. Autofluorescence-activated cell sorting of pancreatic islet cells: purification of insulin-containing B-cells according to glucose-induced changes in cellular redox state. Biochem Biophys Res Commun 1983; 114:835-42. (Pubitemid 13030729)
13. Barg S, Galvanovskis J, Gopel SO, Rorsman P, Eliasson L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 2000; 49:1500-10.
14. Gopel S, Kanno T, Barg S, Galvanovskis J, Rorsman P. Voltage-gated and resting membrane currents recorded from beta-cells in intact mouse pancreatic islets. J Physiol 1999; 521:717-28. (Pubitemid 30042784)
15. Gopel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterization of somatostatin-secreting delta-cells in intact mouse pancreatic islets. J Physiol 2000; 528:497-507.
16. + channels. J Physiol 2000; 528:509-20.
17. Kanno T, Gopel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet. Neurosci Res 2002; 42:79-90. (Pubitemid 34155365)
18. Speier S, Rupnik M. A novel approach to in situ characterization of pancreatic beta-cells. Pflugers Arch 2003; 446:553-8. (Pubitemid 37070211)
19. Meneghel-Rozzo T, Rozzo A, Poppi L, Rupnik M. In vivo and in vitro development of mouse pancreatic beta-cells in organotypic slices. Cell Tissue Res 2004; 316:295-303.
20. 2+-secretion coupling is impaired in diabetic Goto Kakizaki rats. J Gen Physiol 2007; 129:493-508.
21. Rozzo A, Meneghel-Rozzo T, Delakorda SL, Yang SB, Rupnik M. Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas. Ann NY Acad Sci 2009; 1152:53-62.
22. Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M. Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range and affects insulin release kinetics. Diabetes 2007; 56:1078-86. (Pubitemid 46525063)
23. Speier S, Yang SB, Sroka K, Rose T, Rupnik M. KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATP. Mol Cell Endocrinol 2005; 230:51-8. (Pubitemid 40142660)
24. 2+ channel properties. Biochem Biophys Res Commun 2006; 345:340-4.
25. 2+ channel causes a mild phenotype despite an altered glucose induced glucagon response in isolated islets of Langerhans. Euro J Pharmacol 2005; 511:65-72.
26. 2+ channel-dependent exocytosis. Cell Metab 2010; 11:543-53.
27. Hille B. Ion channels of excitable membranes. Sunderland, Mass.: Sinauer 2001.
28. Spigelman AF, Dai X, MacDonald PE. Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans. Diabetologia 2010; 53:1917-26.
29. Wahl-Schott C, Biel M. HCN channels: structure, cellular regulation and physiological function. Cell Mol Life Sci 2009; 66:470-94.
30. Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler MB, et al. Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells. Diabetologia 2008; 51:2290-8.
31. -/- mouse alpha-cells. Diabetes 2004; 53:181-9.
32. Munoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS. Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement. Endocrinology 2005; 146:5514-21. (Pubitemid 41653066)
33. ATP channels. Science New York, NY 1998; 282:1141-4.
34. ATP channels. Science 1998; 282:1138-41.
35. Detimary P, Dejonghe S, Ling Z, Pipeleers D, Schuit F, Henquin JC. The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem 1998; 273:33905-8. (Pubitemid 29008852)
36. Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB. Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 2003; 5:330-5. (Pubitemid 36432297)
37. Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005; 54:1808-15. (Pubitemid 40770771)
38. ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007; 5:143.