Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer

Veterinary Immunology and Immunopathology

Volumn 142, Issue 3-4, 2011, Pages 189-200

  Watabe, Ai ^a   Fukumoto, Shinya ^a   Komatsu, Takahiro ^a   Endo, Yoshifumi ^a   Kadosawa, Tsuyoshi ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Aging; Cancer; Canine; Lymphocyte subsets; Tumor stages; Tumor types

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR;

ADENOCARCINOMA; AGING; ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CANCER STAGING; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DECREASED APPETITE; DISEASE ASSOCIATION; DISEASE SEVERITY; DISTANT METASTASIS; DOG DISEASE; FEMALE; FIBROSARCOMA; HEMANGIOPERICYTOMA; IMMUNE DEFICIENCY; IMMUNE STATUS; IMMUNOPHENOTYPING; LEUKOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; MASTOCYTOMA; MELANOMA; NEOPLASM; NONHUMAN; OSTEOSARCOMA; PERIPHERAL LYMPHOCYTE; SQUAMOUS CELL CARCINOMA; TRANSITIONAL CELL CARCINOMA;

AGING; ANIMALS; BLOOD CELL COUNT; CD4-CD8 RATIO; DOGS; FEMALE; FLOW CYTOMETRY; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; MALE; NEOPLASMS; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

CANIS FAMILIARIS;

EID: 79960071133     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.05.008     Document Type: Article

References (39)

1. Atzpodien J., Kirchner H. Cancer, cytokines, and cytotoxic cells: interleukin-2 in the immunotherapy of human neoplasms. Klin. Wochenschr. 1990, 68:1-11.
2. Biller B.J., Elmslie R.E., Burnett R.C., Avery A.C., Dow S.W. Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Vet. Immunol. Immunopathol. 2007, 116:69-78.
3. Blount D.G., Pritchard D.I., Heaton P.R. Age-related alterations to immune parameters in Labrador retriever dogs. Vet. Immunol. Immunopathol. 2005, 108:399-407.
4. Bronson R.T. Variation in age at death of dogs of different sexes and breeds. Am. J. Vet. Res. 1982, 43:2057-2059.
5. Burnet F.M. The concept of immunological surveillance. Progress in experimental tumor research. Prog. Exp. Tumor Res. 1970, 13:1-27.
6. Campbell D.J., Rawlings J.M., Koelsch S., Wallace J., Strain J.J., Hannigan B.M. Age-related differences in parameters of feline immune status. Vet. Immunol. Immunopathol. 2004, 100:73-80.
7. Denduluri N., Ershler W.B. Aging biology and cancer. Semin. Oncol. 2004, 31:137-148.
8. Deng Y., Jing Y., Campbell A.E., Gravenstein S. Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J. Immunol. 2004, 172:3437-3446.
9. Dunn G.P., Bruce A.T., Ikeda H., Old L.J., Schreiber R.D. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 2002, 3:991-998.
10. Ershler W.B., Longo D.L. Aging and cancer: issues of basic and clinical science. J. Natl. Cancer Inst. 1997, 89:1489-1497.
11. Faldyna M., Leva L., Knotigova P., Toman M. Lymphocyte subsets in peripheral blood of dogs-a flow cytometric study. Vet. Immunol. Immunopathol. 2001, 82:23-37.
12. Greeley E.H., Ballam J.M., Harrison J.M., Kealy R.D., Lawler D.F., Segre M. The influence of age and gender on the immune system: a longitudinal study in Labrador Retriever dogs. Vet. Immunol. Immunopathol. 2001, 82:57-71.
13. Heaton P.R., Blount D.G., Devlin P., Koelsch S., Mann S.J., Smith B.H., Stevenson J., Harper E.J. Assessing age-related changes in peripheral blood leukocyte phenotypes in Labrador retriever dogs using flow cytometry. J. Nutr. 2002, 132:1655S-1657S.
14. Heaton P.R., Blount D.G., Mann S.J., Devlin P., Koelsch S., Smith B.H., Stevenson J., Harper E.J., Rawlings J.M. Assessing age-related changes in peripheral blood leukocyte phenotypes in domestic shorthaired cats using flow cytometry. J. Nutr. 2002, 132:1607S-1609S.
15. Hirokawa K., Utsuyama M., Ishikawa T., Kikuchi Y., Kitagawa M., Fujii Y., Nariuchi H., Uetake H., Sugihara K. Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells. Mech. Ageing Dev. 2009, 130:86-91.
16. HogenEsch H., Thompson S., Dunham A., Ceddia M., Hayek M. Effect of age on immune parameters and the immune response of dogs to vaccines: a cross-sectional study. Vet. Immunol. Immunopathol. 2004, 97:77-85.
17. Horiuchi Y., Nakajima Y., Nariai Y., Asanuma H., Kuwabara M., Yukawa M. Th1/Th2 balance in canine peripheral blood lymphocytes - a flow cytometric study. Veterinary immunology and immunopathology 2007, 118:179-185.
18. Horiuchi Y., Tominaga M., Ichikawa M., Yamashita M., Jikumaru Y., Nariai Y., Nakajima Y., Kuwabara M., Yukawa M. Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors. Microbiol. Immunol. 2009, 53:468-474.
19. Horohov D.W., Kydd J.H., Hannant D. The effect of aging on T cell responses in the horse. Dev. Comp. Immunol. 2002, 26:121-128.
20. Huppert F.A., Solomou W., O'Connor S., Morgan K., Sussams P., Brayne C. Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals. Exp. Gerontol. 1998, 33:593-600.
21. Ichihara F., Kono K., Takahashi A., Kawaida H., Sugai H., Fujii H. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 2003, 9:4404-4408.
22. Itoh M., Takahashi T., Sakaguchi N., Kuniyasu Y., Shimizu J., Otsuka F., Sakaguchi S. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999, 162:5317-5326.
23. Itoh H., Horiuchi Y., Nagasaki T., Sakonju I., Kakuta T., Fukushima U., Uchide T., Yamashita M., Kuwabara M., Yusa S., Takase K. Evaluation of immunological status in tumor-bearing dogs. Vet. Immunol. Immunopathol. 2009, 132:85-90.
24. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001, 193:1285-1294.
25. Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 2004, 5:133-139.
26. Makinodan T., Kay M.M. Age influence on the immune system. Adv. Immunol. 1980, 29:287-330.
27. Murasko D.M., Goonewardene I.M. T-cell function in aging: mechanisms of decline. Annu. Rev. Gerontol. Geriatr. 1990, 10:71-96.
28. O'Neill K., Guth A., Biller B., Elmslie R., Dow S. Changes in regulatory T cells in dogs with cancer and associations with tumor type. J. Vet. Intern. Med. 2009, 23:875-881.
29. Owen L.M. TNM Classification of Tumors in Domestic Animals 1980, World Health Organization, Geneva.
30. Provinciali M., Moresi R., Donnini A., Lisa R.M. Reference values for CD4+ and CD8+ T lymphocytes with naive or memory phenotype and their association with mortality in the elderly. Gerontology 2009, 55:314-321.
31. Rasku M.A., Clem A.L., Telang S., Taft B., Gettings K., Gragg H., Cramer D., Lear S.C., McMasters K.M., Miller D.M., Chesney J. Transient T cell depletion causes regression of melanoma metastases. J. Transl. Med. 2008, 6:12.
32. Reis A.B., Carneiro C.M., Carvalho M.G., Teixeira-Carvalho A., Giunchetti R.C., Mayrink W., Genaro O., Correa-Oliveira R., Martins-Filho O.A. Establishment of a microplate assay for flow cytometric assessment and it is use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes. Vet. Immunol. Immunopathol. 2005, 103:173-185.
33. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
34. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101:455-458.
35. Shevach E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 2000, 18:423-449.
36. Strasser A., Teltscher A., May B., Sanders C., Niedermuller H. Age-associated changes in the immune system of German shepherd dogs. J. Vet. Med. A: Physiol. Pathol. Clin. Med. 2000, 47:181-192.
37. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998, 188:287-296.
38. Utsuyama M., Kikuchi Y., Kitagawa M., Hirokawa K. Scoring of immunological vigor: trial assessment of immunological status as a whole for elderly people and cancer patients. Immunosenescenes 2007, 15-23. Landes Bioscience, New York. G. Pawelec (Ed.).
39. Zhang L., Dermawan K., Jin M., Liu R., Zheng H., Xu L., Zhang Y., Cai Y., Chu Y., Xiong S. Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy. Clin. Immunol. 2008, 129:219-229.