메뉴 건너뛰기




Volumn 366, Issue 1575, 2011, Pages 2230-2237

Transcription factor heterogeneity and epiblast pluripotency

Author keywords

Heterogeneity; Pluripotency; Self renewal; Stem cell; Transcription factor

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4;

EID: 79960058253     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2011.0043     Document Type: Article
Times cited : (27)

References (78)
  • 1
    • 33645113300 scopus 로고    scopus 로고
    • From teratocarcinomas to embryonic stem cells and beyond: A history of embryonic stemcell research
    • doi:10.1038/nrg1827
    • Solter, D. 2006 From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stemcell research. Nat. Rev. Genet. 7, 319-327. (doi:10.1038/nrg1827)
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 319-327
    • Solter, D.1
  • 2
    • 6044269157 scopus 로고    scopus 로고
    • Self-renewal of teratocarcinoma and embryonic stem cells
    • doi:10.1038/sj.onc.1207930
    • Chambers, I. & Smith, A. 2004 Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23, 7150-7160. (doi:10.1038/sj.onc.1207930)
    • (2004) Oncogene , vol.23 , pp. 7150-7160
    • Chambers, I.1    Smith, A.2
  • 3
    • 0000137965 scopus 로고
    • Retention of multiple developmental potentialities by cells of a mouse testicular teratocarcinoma during prolongued culture in vitro and their extinction upon hybridization with cells of permanent lines
    • doi:10.1073/pnas.57.3.615
    • Finch, B. W. & Ephrussi, B. 1967 Retention of multiple developmental potentialities by cells of a mouse testicular teratocarcinoma during prolongued culture in vitro and their extinction upon hybridization with cells of permanent lines. Proc. Natl Acad. Sci. USA 57, 615-621. (doi:10.1073/pnas.57.3.615)
    • (1967) Proc. Natl Acad. Sci. USA , vol.57 , pp. 615-621
    • Finch, B.W.1    Ephrussi, B.2
  • 4
    • 0016489816 scopus 로고
    • Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro
    • doi:10.1073/pnas.72.4.1441
    • Martin, G. R. & Evans, M. J. 1975 Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. Proc. Natl Acad. Sci. USA 72, 1441-1445. (doi:10.1073/pnas.72.4.1441)
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 1441-1445
    • Martin, G.R.1    Evans, M.J.2
  • 5
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • doi:10.1073/pnas.78.12.7634
    • Martin, G. R. 1981 Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl Acad. Sci. USA 78, 7634-7638. (doi:10.1073/pnas.78.12.7634)
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 6
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • doi:10.1038/292154a0
    • Evans, M. J. & Kaufman, M. H. 1981 Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156. (doi:10.1038/292154a0)
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 7
    • 0015732105 scopus 로고
    • Origin of the ectoplacental cone and secondary giant cells in mouse blastocysts reconstituted from isolated trophoblast and inner cell mass
    • Gardner, R. L., Papaioannou, V. E. & Barton, S. C. 1973 Origin of the ectoplacental cone and secondary giant cells in mouse blastocysts reconstituted from isolated trophoblast and inner cell mass. J. Embryol. Exp. Morphol.30, 561-572.
    • (1973) J. Embryol. Exp. Morphol. , vol.30 , pp. 561-572
    • Gardner, R.L.1    Papaioannou, V.E.2    Barton, S.C.3
  • 8
    • 0020004246 scopus 로고
    • Lineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts
    • Papaioannou, V. E. 1982 Lineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts. J. Embryol. Exp. Morphol. 68, 199-209.
    • (1982) J. Embryol. Exp. Morphol. , vol.68 , pp. 199-209
    • Papaioannou, V.E.1
  • 10
    • 0021358883 scopus 로고
    • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
    • doi:10.1038/309255a0
    • Bradley, A., Evans, M., Kaufman, M. H. & Robertson, E. 1984 Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255-256. (doi:10.1038/309255a0)
    • (1984) Nature , vol.309 , pp. 255-256
    • Bradley, A.1    Evans, M.2    Kaufman, M.H.3    Robertson, E.4
  • 11
    • 34447527158 scopus 로고    scopus 로고
    • Derivation of pluripotent epiblast stem cells from mammalian embryos
    • doi:10.1038/nature05950
    • Brons, I. G. et al. 2007 Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448, 191-195. (doi:10.1038/nature05950)
    • (2007) Nature , vol.448 , pp. 191-195
    • Brons, I.G.1
  • 12
    • 34447528757 scopus 로고    scopus 로고
    • New cell lines from mouse epiblast share defining features with human embryonic stem cells
    • doi:10.1038/ nature05972
    • Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J., Evans, E. P., Mack, D. L., Gardner, R. L. & McKay, R. D. G. 2007 New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196-199. (doi:10.1038/ nature05972)
    • (2007) Nature , vol.448 , pp. 196-199
    • Tesar, P.J.1    Chenoweth, J.G.2    Brook, F.A.3    Davies, T.J.4    Evans, E.P.5    Mack, D.L.6    Gardner, R.L.7    McKay, R.D.G.8
  • 13
    • 70350138327 scopus 로고    scopus 로고
    • Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro
    • doi:10.1242/dev.037747
    • Hayashi, K. & Surani, M. A. 2009 Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development 136, 3549-3556. (doi:10.1242/dev.037747)
    • (2009) Development , vol.136 , pp. 3549-3556
    • Hayashi, K.1    Surani, M.A.2
  • 14
    • 69649084228 scopus 로고    scopus 로고
    • The transcriptional foundation of pluripotency
    • doi:10.1242/dev.024398
    • Chambers, I. & Tomlinson, S. R. 2009 The transcriptional foundation of pluripotency. Development 136, 2311-2322. (doi:10.1242/dev.024398)
    • (2009) Development , vol.136 , pp. 2311-2322
    • Chambers, I.1    Tomlinson, S.R.2
  • 15
    • 0346462991 scopus 로고    scopus 로고
    • Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex
    • doi:10.1074/jbc.M309790200
    • Williams Jr, D. C., Cai, M. & Clore, G. M. 2004 Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex. J. Biol. Chem. 279, 1449-1457. (doi:10.1074/jbc.M309790200)
    • (2004) J. Biol. Chem. , vol.279 , pp. 1449-1457
    • Williams, D.C.1    Cai, M.2    Clore, G.M.3
  • 16
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • doi:10.1016/ S0092-8674(00)81769-9
    • Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H. & Smith, A. 1998 Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379-391. (doi:10.1016/ S0092-8674(00)81769-9)
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3    Niwa, H.4    Klewe-Nebenius, D.5    Chambers, I.6    Schöler, H.7    Smith, A.8
  • 17
    • 21744444920 scopus 로고    scopus 로고
    • Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
    • doi:10.1128/MCB.25.14.6031-6046.2005
    • Chew, J. L. et al. 2005 Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25, 6031-6046. (doi:10.1128/MCB.25.14.6031-6046.2005)
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6031-6046
    • Chew, J.L.1
  • 18
    • 0032128171 scopus 로고    scopus 로고
    • New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
    • doi:10.1101/ gad.12.13.2073
    • Botquin, V., Hess, H., Fuhrmann, G., Anastassiadis, C., Gross, M. K., Vriend, G. & Scholer, H. R. 1998 New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12, 2073-2090. (doi:10.1101/ gad.12.13.2073)
    • (1998) Genes Dev , vol.12 , pp. 2073-2090
    • Botquin, V.1    Hess, H.2    Fuhrmann, G.3    Anastassiadis, C.4    Gross, M.K.5    Vriend, G.6    Scholer, H.R.7
  • 19
    • 0028131903 scopus 로고
    • Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer
    • Dailey, L., Yuan, H. & Basilico, C. 1994 Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol. Cell Biol.14, 7758-7769.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 7758-7769
    • Dailey, L.1    Yuan, H.2    Basilico, C.3
  • 20
    • 0032797827 scopus 로고    scopus 로고
    • The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2
    • Nishimoto, M., Fukushima, A., Okuda, A. & Muramatsu, M. 1999 The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol. Cell Biol. 19, 5453-5465.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5453-5465
    • Nishimoto, M.1    Fukushima, A.2    Okuda, A.3    Muramatsu, M.4
  • 21
    • 0037383685 scopus 로고    scopus 로고
    • Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
    • doi:10.1128/ MCB.23.8.2699-2708.2003
    • Tokuzawa, Y., Kaiho, E., Maruyama, M., Takahashi, K., Mitsui, K., Maeda, M., Niwa, H. & Yamanaka, S. 2003 Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell Biol. 23, 2699-2708. (doi:10.1128/ MCB.23.8.2699-2708.2003)
    • (2003) Mol. Cell Biol. , vol.23 , pp. 2699-2708
    • Tokuzawa, Y.1    Kaiho, E.2    Maruyama, M.3    Takahashi, K.4    Mitsui, K.5    Maeda, M.6    Niwa, H.7    Yamanaka, S.8
  • 23
    • 0031949215 scopus 로고    scopus 로고
    • Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site
    • Ben-Shushan, E., Thompson, J. R., Gudas, L. J. & Bergman, Y. 1998 Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol. Cell Biol.18, 1866-1878.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 1866-1878
    • Ben-Shushan, E.1    Thompson, J.R.2    Gudas, L.J.3    Bergman, Y.4
  • 24
    • 58149104232 scopus 로고    scopus 로고
    • Esrrb activates Oct4 transcription and sustains selfrenewal and pluripotency in embryonic stem cells
    • doi:10.1074/jbc. M803481200
    • Zhang, X., Zhang, J., Wang, T., Esteban, M. A. & Pei, D. 2008 Esrrb activates Oct4 transcription and sustains selfrenewal and pluripotency in embryonic stem cells. J. Biol. Chem. 283, 35825-35833. (doi:10.1074/jbc. M803481200)
    • (2008) J. Biol. Chem. , vol.283 , pp. 35825-35833
    • Zhang, X.1    Zhang, J.2    Wang, T.3    Esteban, M.A.4    Pei, D.5
  • 25
    • 33749624178 scopus 로고    scopus 로고
    • Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells
    • doi:10.1128/MCB.00468-06
    • Nakatake, Y. et al. 2006 Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell Biol. 26, 7772-7782. (doi:10.1128/MCB.00468-06)
    • (2006) Mol. Cell Biol. , vol.26 , pp. 7772-7782
    • Nakatake, Y.1
  • 26
    • 28344436489 scopus 로고    scopus 로고
    • Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
    • doi:10.1016/j.cell.2005.08.040
    • Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R. & Rossant, J. 2005 Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123, 917-929. (doi:10.1016/j.cell.2005.08.040)
    • (2005) Cell , vol.123 , pp. 917-929
    • Niwa, H.1    Toyooka, Y.2    Shimosato, D.3    Strumpf, D.4    Takahashi, K.5    Yagi, R.6    Rossant, J.7
  • 27
    • 4744350000 scopus 로고    scopus 로고
    • Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells
    • doi:10.1074/jbc. M405514200
    • Catena, R. et al. 2004 Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. J. Biol. Chem. 279, 41846-41857. (doi:10.1074/jbc. M405514200)
    • (2004) J. Biol. Chem. , vol.279 , pp. 41846-41857
    • Catena, R.1
  • 28
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • doi:10.1016/j.cell.2005.08.020
    • Boyer, L. A. et al. 2005 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956. (doi:10.1016/j.cell.2005.08.020)
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1
  • 29
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • doi:10.1038/ng1760
    • Loh, Y. H. et al. 2006 The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431-440. (doi:10.1038/ng1760)
    • (2006) Nat. Genet. , vol.38 , pp. 431-440
    • Loh, Y.H.1
  • 30
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • doi:10. 1016/j.cell.2008.04.043
    • Chen, X. et al. 2008 Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106-1117. (doi:10. 1016/j.cell.2008.04.043)
    • (2008) Cell , vol.133 , pp. 1106-1117
    • Chen, X.1
  • 31
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • doi:10.1038/74199
    • Niwa, H., Miyazaki, J. & Smith, A. G. 2000 Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372-376. (doi:10.1038/74199)
    • (2000) Nat. Genet. , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 32
    • 0034725588 scopus 로고    scopus 로고
    • Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer
    • doi:10.1074/jbc.M000932200
    • Ambrosetti, D. C., Scholer, H. R., Dailey, L. & Basilico, C. 2000 Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. J. Biol. Chem. 275, 23387-23397. (doi:10.1074/jbc.M000932200)
    • (2000) J. Biol. Chem. , vol.275 , pp. 23387-23397
    • Ambrosetti, D.C.1    Scholer, H.R.2    Dailey, L.3    Basilico, C.4
  • 33
    • 0030820931 scopus 로고    scopus 로고
    • Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites
    • Ambrosetti, D. C., Basilico, C. & Dailey, L. 1997 Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol. Cell. Biol. 17, 6321-6329.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6321-6329
    • Ambrosetti, D.C.1    Basilico, C.2    Dailey, L.3
  • 34
    • 14844359620 scopus 로고    scopus 로고
    • Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression
    • doi:10.1128/MCB.25.6.2475-2485.2005
    • Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S. Y., Suemori, H., Nakatsuji, N. & Tada, T. 2005 Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol. Cell Biol. 25, 2475-2485. (doi:10.1128/MCB.25.6.2475-2485.2005)
    • (2005) Mol. Cell Biol. , vol.25 , pp. 2475-2485
    • Kuroda, T.1    Tada, M.2    Kubota, H.3    Kimura, H.4    Hatano, S.Y.5    Suemori, H.6    Nakatsuji, N.7    Tada, T.8
  • 35
    • 0037227099 scopus 로고    scopus 로고
    • Multipotent cell lineages in early mouse development depend on SOX2 function
    • doi:10.1101/gad. 224503
    • Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N. & Lovell-Badge, R. 2003 Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17, 126-140. (doi:10.1101/gad. 224503)
    • (2003) Genes Dev , vol.17 , pp. 126-140
    • Avilion, A.A.1    Nicolis, S.K.2    Pevny, L.H.3    Perez, L.4    Vivian, N.5    Lovell-Badge, R.6
  • 37
    • 34249876564 scopus 로고    scopus 로고
    • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    • doi:10.1038/ ncb1589
    • Masui, S. et al. 2007 Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat. Cell Biol. 9, 625-635. (doi:10.1038/ ncb1589)
    • (2007) Nat. Cell Biol. , vol.9 , pp. 625-635
    • Masui, S.1
  • 38
    • 38649124339 scopus 로고    scopus 로고
    • Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog
    • doi:10.1016/j.jmb. 2007.11.091
    • Jauch, R., Ng, C. K., Saikatendu, K. S., Stevens, R. C. & Kolatkar, P. R. 2008 Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog. J. Mol. Biol. 376, 758-770. (doi:10.1016/j.jmb. 2007.11.091)
    • (2008) J. Mol. Biol. , vol.376 , pp. 758-770
    • Jauch, R.1    Ng, C.K.2    Saikatendu, K.S.3    Stevens, R.C.4    Kolatkar, P.R.5
  • 39
    • 18844432177 scopus 로고    scopus 로고
    • Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome
    • doi:10.1021/bi0473253
    • Chaney, B. A., Clark-Baldwin, K., Dave, V., Ma, J. & Rance, M. 2005 Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome. Biochemistry 44, 7497-7511. (doi:10.1021/bi0473253)
    • (2005) Biochemistry , vol.44 , pp. 7497-7511
    • Chaney, B.A.1    Clark-Baldwin, K.2    Dave, V.3    Ma, J.4    Rance, M.5
  • 40
    • 79960058807 scopus 로고    scopus 로고
    • The function of nanog in pluripotency
    • (eds J. Ainscough, S. Yamanaka & T. Tada). Totowa, NJ: Humana Press
    • Mullin, N. & Chambers, I. 2011 The function of Nanog in pluripotency. In Nuclear reprogramming and stem cells (eds J. Ainscough, S. Yamanaka & T. Tada). Totowa, NJ: Humana Press.
    • (2011) In Nuclear Reprogramming and Stem Cells
    • Mullin, N.1    Chambers, I.2
  • 41
    • 0037806031 scopus 로고    scopus 로고
    • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    • doi:10.1016/ S0092-8674(03)00393-3
    • Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M. & Yamanaka, S. 2003 The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631-642. (doi:10.1016/ S0092-8674(03)00393-3)
    • (2003) Cell , vol.113 , pp. 631-642
    • Mitsui, K.1    Tokuzawa, Y.2    Itoh, H.3    Segawa, K.4    Murakami, M.5    Takahashi, K.6    Maruyama, M.7    Maeda, M.8    Yamanaka, S.9
  • 42
    • 68749110887 scopus 로고    scopus 로고
    • Nanog is the gateway to the pluripotent ground state
    • doi:10.1016/j.cell. 2009.07.039
    • Silva, J. et al. 2009 Nanog is the gateway to the pluripotent ground state. Cell 138, 722-737. (doi:10.1016/j.cell. 2009.07.039)
    • (2009) Cell , vol.138 , pp. 722-737
    • Silva, J.1
  • 44
    • 77955058345 scopus 로고    scopus 로고
    • Nanog is required for primitive endoderm formation through a noncell autonomous mechanism
    • doi:10.1016/j.ydbio.2010.04.020
    • Messerschmidt, D. M. & Kemler, R. 2010 Nanog is required for primitive endoderm formation through a noncell autonomous mechanism. Dev. Biol. 344, 129-137. (doi:10.1016/j.ydbio.2010.04.020)
    • (2010) Dev. Biol. , vol.344 , pp. 129-137
    • Messerschmidt, D.M.1    Kemler, R.2
  • 45
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • doi:10.1016/S0092-8674(03)00392-1
    • Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S. & Smith, A. 2003 Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655. (doi:10.1016/S0092-8674(03)00392-1)
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 46
    • 2142821474 scopus 로고    scopus 로고
    • Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human
    • doi:10.1002/dvdy.20034
    • Hart, A. H., Hartley, L., Ibrahim, M. & Robb, L. 2004 Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev. Dyn. 230, 187-198. (doi:10.1002/dvdy.20034)
    • (2004) Dev. Dyn. , vol.230 , pp. 187-198
    • Hart, A.H.1    Hartley, L.2    Ibrahim, M.3    Robb, L.4
  • 47
    • 11144309353 scopus 로고
    • Tir na n'Og. The Land of Youth (translation edited from 'Laoi Oisin i dTir na nOg' [The lay of Oisin in the land of youth], M. Comyn, 1750)
    • O'Looney, B. 1859 Tir na n'Og. The Land of Youth (translation edited from 'Laoi Oisin i dTir na nOg' [The lay of Oisin in the land of youth], M. Comyn, 1750). Trans. Ossianic Soc. 4, 227-280.
    • (1859) Trans. Ossianic Soc. , vol.4 , pp. 227-280
    • O'Looney, B.1
  • 48
    • 37549002155 scopus 로고    scopus 로고
    • Nanog safeguards pluripotency and mediates germline development
    • doi:10.1038/nature06403
    • Chambers, I. et al. 2007 Nanog safeguards pluripotency and mediates germline development. Nature 450, 1230-1234. (doi:10.1038/nature06403)
    • (2007) Nature , vol.450 , pp. 1230-1234
    • Chambers, I.1
  • 49
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • doi:10.1016/j.cell.2006.07.024
    • Takahashi, K. & Yamanaka, S. 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. (doi:10.1016/j.cell.2006.07.024)
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 50
    • 70450270857 scopus 로고    scopus 로고
    • Oct4 and LIF/Stat3 additively induce Kruppel factors to sustain embryonic stem cell selfrenewal
    • doi:10.1016/j. stem.2009.11.003
    • Hall, J. et al. 2009 Oct4 and LIF/Stat3 additively induce Kruppel factors to sustain embryonic stem cell selfrenewal. Cell Stem Cell. 5, 597-609. (doi:10.1016/j. stem.2009.11.003)
    • (2009) Cell Stem Cell , vol.5 , pp. 597-609
    • Hall, J.1
  • 51
    • 67650032868 scopus 로고    scopus 로고
    • A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
    • doi:10.1038/nature08113
    • Niwa, H., Ogawa, K., Shimosato, D. & Adachi, K. 2009 A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460, 118-122. (doi:10.1038/nature08113)
    • (2009) Nature , vol.460 , pp. 118-122
    • Niwa, H.1    Ogawa, K.2    Shimosato, D.3    Adachi, K.4
  • 52
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • doi:10.1016/ S0092-8674(03)00847-X
    • Ying, Q. L., Nichols, J., Chambers, I. & Smith, A. 2003 BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292. (doi:10.1016/ S0092-8674(03)00847-X)
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 53
    • 66049136895 scopus 로고    scopus 로고
    • Klf4 reverts developmentally programmed restriction of ground state pluripotency
    • doi:10.1242/dev.030957
    • Guo, G., Yang, J., Nichols, J., Hall, J. S., Eyres, I., Mansfield, W. & Smith, A. 2009 Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 136, 1063-1069. (doi:10.1242/dev.030957)
    • (2009) Development , vol.136 , pp. 1063-1069
    • Guo, G.1    Yang, J.2    Nichols, J.3    Hall, J.S.4    Eyres, I.5    Mansfield, W.6    Smith, A.7
  • 56
    • 1942444447 scopus 로고    scopus 로고
    • Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stagespecific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo
    • doi:10.1095/biolreprod.103.024190
    • Furusawa, T., Ohkoshi, K., Honda, C., Takahashi, S. & Tokunaga, T. 2004 Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stagespecific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo. Biol. Reprod. 70, 1452-1457. (doi:10.1095/biolreprod.103.024190)
    • (2004) Biol. Reprod. , vol.70 , pp. 1452-1457
    • Furusawa, T.1    Ohkoshi, K.2    Honda, C.3    Takahashi, S.4    Tokunaga, T.5
  • 57
    • 33749045459 scopus 로고    scopus 로고
    • Gene expression profiling of mouse embryonic stem cell subpopulations
    • doi:10.1095/biolreprod.105. 049502
    • Furusawa, T., Ikeda, M., Inoue, F., Ohkoshi, K., Hamano, T. & Tokunaga, T. 2006 Gene expression profiling of mouse embryonic stem cell subpopulations. Biol. Reprod. 75, 555-561. (doi:10.1095/biolreprod.105. 049502)
    • (2006) Biol. Reprod. , vol.75 , pp. 555-561
    • Furusawa, T.1    Ikeda, M.2    Inoue, F.3    Ohkoshi, K.4    Hamano, T.5    Tokunaga, T.6
  • 58
    • 33645227503 scopus 로고    scopus 로고
    • Generation of Stella-GFP Transgenic Mice: A Novel Tool to Study Germ Cell Development
    • doi:10.1002/ gene.20187
    • Payer, B., Chuva de Sousa Lopes, S. M., Barton, S. C., Lee, C., Saitou, M. & Surani, M. A. 2006 Generation of stella-GFP transgenic mice: a novel tool to study germ cell development. Genesis 44, 75-83. (doi:10.1002/ gene.20187)
    • (2006) Genesis , vol.44 , pp. 75-83
    • Payer, B.1    de Sousa Lopes, C.2    Barton, S.M.3    Lee, S.C.4    Saitou, C.5    Surani, M.6    Surani, M.A.7
  • 59
    • 53049092465 scopus 로고    scopus 로고
    • Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
    • doi:10.1016/j. stem.2008.07.027
    • Hayashi, K., Lopes, S. M., Tang, F. & Surani, M. A. 2008 Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell 3, 391-401. (doi:10.1016/j. stem.2008.07.027)
    • (2008) Cell Stem Cell , vol.3 , pp. 391-401
    • Hayashi, K.1    Lopes, S.M.2    Tang, F.3    Surani, M.A.4
  • 60
    • 42149192008 scopus 로고    scopus 로고
    • Identification and characterization of subpopulations in undifferentiated ES cell culture
    • doi:10.1242/dev.017400
    • Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K. & Niwa, H. 2008 Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 135, 909-918. (doi:10.1242/dev.017400)
    • (2008) Development , vol.135 , pp. 909-918
    • Toyooka, Y.1    Shimosato, D.2    Murakami, K.3    Takahashi, K.4    Niwa, H.5
  • 61
    • 0030954167 scopus 로고    scopus 로고
    • 1997Multilineage gene expression precedes commitment in the hemopoietic system
    • doi:10.1101/gad.11.6.774
    • Hu, M., Krause, D., Greaves, M., Sharkis, S., Dexter, M, Heyworth, C. & Enver, T. 1997Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11, 774-785.(doi:10.1101/gad.11.6.774)
    • Genes Dev , vol.11 , pp. 774-785
    • Hu, M.1    Krause, D.2    Greaves, M.3    Sharkis, S.4    Dexter, M.5    Heyworth, C.6    Enver, T.7
  • 63
    • 76149087152 scopus 로고    scopus 로고
    • Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
    • doi:10.1101/gad.1833510
    • Niakan, K. K. et al. 2010 Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24, 312-326. (doi:10.1101/gad.1833510)
    • (2010) Genes Dev , vol.24 , pp. 312-326
    • Niakan, K.K.1
  • 64
    • 77952915049 scopus 로고    scopus 로고
    • Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript
    • doi:10.1371/journal.pbio.1000379
    • Canham, M. A., Sharov, A. A., Ko, M. S. & Brickman, J. M. 2010 Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol. 8, e1000379. (doi:10.1371/journal.pbio.1000379)
    • (2010) PLoS Biol , vol.8
    • Canham, M.A.1    Sharov, A.A.2    Ko, M.S.3    Brickman, J.M.4
  • 65
    • 77951912210 scopus 로고    scopus 로고
    • Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst
    • doi:10.1016/j.devcel.2010.02.012
    • Guo, G., Huss, M., Tong, G. Q., Wang, C., Li Sun, L., Clarke, N. D. & Robson, P. 2010 Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev. Cell. 18, 675-685. (doi:10.1016/j.devcel.2010.02.012)
    • (2010) Dev. Cell. , vol.18 , pp. 675-685
    • Guo, G.1    Huss, M.2    Tong, G.Q.3    Wang, C.4    li Sun, L.5    Clarke, N.D.6    Robson, P.7
  • 66
    • 0028808183 scopus 로고
    • Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
    • doi:10.1101/gad.9.21.2635
    • Yuan, H., Corbi, N., Basilico, C. & Dailey, L. 1995 Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9, 2635-2645. (doi:10.1101/gad.9.21.2635)
    • (1995) Genes Dev , vol.9 , pp. 2635-2645
    • Yuan, H.1    Corbi, N.2    Basilico, C.3    Dailey, L.4
  • 67
    • 70349934958 scopus 로고    scopus 로고
    • Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo
    • doi:10.1242/dev.038893
    • Nichols, J., Silva, J., Roode, M. & Smith, A. 2009 Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development 136, 3215-3222. (doi:10.1242/dev.038893)
    • (2009) Development , vol.136 , pp. 3215-3222
    • Nichols, J.1    Silva, J.2    Roode, M.3    Smith, A.4
  • 68
    • 34548587064 scopus 로고    scopus 로고
    • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
    • doi:10.1242/dev.02880
    • Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J., Meloche, S. & Smith, A. 2007 FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134, 2895-2902. (doi:10.1242/dev.02880)
    • (2007) Development , vol.134 , pp. 2895-2902
    • Kunath, T.1    Saba-El-Leil, M.K.2    Almousailleakh, M.3    Wray, J.4    Meloche, S.5    Smith, A.6
  • 69
    • 34548596749 scopus 로고    scopus 로고
    • A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
    • doi:10.1242/dev.02858
    • Stavridis, M. P., Lunn, J. S., Collins, B. J. & Storey, K. G. 2007 A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development 134, 2889-2894. (doi:10.1242/dev.02858)
    • (2007) Development , vol.134 , pp. 2889-2894
    • Stavridis, M.P.1    Lunn, J.S.2    Collins, B.J.3    Storey, K.G.4
  • 70
    • 79960074631 scopus 로고    scopus 로고
    • Systems biology of stem cells: Three useful perspectives to help overcome the paradigm of linear pathways
    • doi:10.1098/rstb.2011.0008
    • Huang, S. 2011 Systems biology of stem cells: three useful perspectives to help overcome the paradigm of linear pathways. Phil. Trans. R. Soc. B 366, 2247-2259. (doi:10.1098/rstb.2011.0008)
    • (2011) Phil. Trans. R. Soc. B , vol.366 , pp. 2247-2259
    • Huang, S.1
  • 71
    • 0032779254 scopus 로고    scopus 로고
    • Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
    • doi:10.1016/S0925-4773(99)00116-1
    • Wood, H. B. & Episkopou, V. 1999 Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech. Dev. 86, 197-201. (doi:10.1016/S0925-4773(99)00116-1)
    • (1999) Mech. Dev. , vol.86 , pp. 197-201
    • Wood, H.B.1    Episkopou, V.2
  • 72
    • 0015027254 scopus 로고
    • Teratomas obtained through extrauterine growth of seven-day mouse embryos
    • Damjanov, I., Solter, D., Belicza, M. & Skreb, N. 1971 Teratomas obtained through extrauterine growth of seven-day mouse embryos. J. Natl Cancer Inst. 46, 471-475.
    • (1971) J. Natl Cancer Inst. , vol.46 , pp. 471-475
    • Damjanov, I.1    Solter, D.2    Belicza, M.3    Skreb, N.4
  • 73
    • 77956566519 scopus 로고    scopus 로고
    • A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency
    • doi:10.1242/dev.052753
    • Guo, G. & Smith, A. 2010 A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development 137, 3185-3192. (doi:10.1242/dev.052753)
    • (2010) Development , vol.137 , pp. 3185-3192
    • Guo, G.1    Smith, A.2
  • 74
    • 77956199358 scopus 로고    scopus 로고
    • Stat3 activation is limiting for reprogramming to ground state pluripotency
    • doi:10.1016/j.stem.2010.06.022
    • Yang, J., van Oosten, A. L., Theunissen, T. W., Guo, G., Silva, J. C. & Smith, A. 2010 Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell 7, 319-328. (doi:10.1016/j.stem.2010.06.022)
    • (2010) Cell Stem Cell , vol.7 , pp. 319-328
    • Yang, J.1    van Oosten, A.L.2    Theunissen, T.W.3    Guo, G.4    Silva, J.C.5    Smith, A.6
  • 75
    • 75349088911 scopus 로고    scopus 로고
    • The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells
    • doi:10.1016/j.stem.2009.12.009
    • Heng, J. C. et al. 2010 The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 6, 167-174. (doi:10.1016/j.stem.2009.12.009)
    • (2010) Cell Stem Cell , vol.6 , pp. 167-174
    • Heng, J.C.1
  • 76
    • 20244381404 scopus 로고    scopus 로고
    • Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development
    • doi:10.1128/MCB.25.9.3492-3505.2005
    • Gu, P. et al. 2005 Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol. Cell Biol. 25, 3492-3505. (doi:10.1128/MCB.25.9.3492-3505.2005)
    • (2005) Mol. Cell Biol. , vol.25 , pp. 3492-3505
    • Gu, P.1
  • 77
    • 78149500053 scopus 로고    scopus 로고
    • Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
    • doi:10.1016/j.cell.2010.10.015
    • Han, D. W. et al. 2010 Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell 143, 617-627. (doi:10.1016/j.cell.2010.10.015)
    • (2010) Cell , vol.143 , pp. 617-627
    • Han, D.W.1
  • 78
    • 67650096520 scopus 로고    scopus 로고
    • Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
    • doi:10.1242/dev.033951
    • Vallier, L. et al. 2009 Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 136, 1339-1349. (doi:10.1242/dev.033951)
    • (2009) Development , vol.136 , pp. 1339-1349
    • Vallier, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.