Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation

Toxicology and Applied Pharmacology

Volumn 254, Issue 3, 2011, Pages 323-331

  Pan, Xinjuan ^a   Dai, Yujie ^a   Li, Xing ^a   Niu, Nannan ^a   Li, Wenjie ^a   Liu, Fangli ^a   Zhao, Yang ^a   Yu, Zengli ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Chronic arsenic exposure; Grape seed exact; Liver injury; NADPH oxidase; Oxidative stress; TGF Smad signaling

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ANTIOXIDANT; ARSENIC; ASPARTATE AMINOTRANSFERASE; DRINKING WATER; GRAPE SEED EXTRACT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG INHIBITION; IN VITRO STUDY; LIVER INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSACTIVATION;

ANIMALS; ARSENIC; CELLS, CULTURED; DRUG-INDUCED LIVER INJURY; GRAPE SEED EXTRACT; HUMANS; LIVER CIRRHOSIS; MALE; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

RATTUS; VITACEAE;

EID: 79960048471     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.04.022     Document Type: Article

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