Negative functional interaction of retinoic acid and TGF-β signaling mediated by TG-interacting factor during chondrogenesis

Cellular Physiology and Biochemistry

Volumn 23, Issue 1-3, 2009, Pages 157-164

  Zhang, Hang ^a   Li, Ning ^a   Tang, Yunan ^a   Wu, Weidong ^a   Zhang, Qi ^a   Yu, Zengli ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

All trans retinoic acid (atRA); Chondrogenesis; Palatal mesenchyme; RAR; TGF ; TGIF

Indexed keywords

BETA ACTIN; HOMEODOMAIN PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR BETA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TG INTERACTING FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHONDROGENESIS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE ACTIVATION; GENE OVEREXPRESSION; GENE REPRESSION; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ATRA;

EID: 60549083689     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000204104     Document Type: Article

References (35)

1. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998;238:265-272.
2. Flanders KC, Kim ES, Roberts AB: Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas. Dev Dyn 2001;220:141-154.
3. Liao X, Lee G., Shimizu H, Collins MD: Comparative molecular pathology of cadmium- and all-trans-retinoic acid-induced postaxial forelimb ectrodactyly. Toxicol Appl Pharmacol 2007;225:47-60.
4. Piek E, Heldin CH, Ten DijkebP: Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 1999;13:2105-2124.
5. Chen Y, Dokmanovic M, Stein WD, Ardecky RJ, Roninson IB: Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Res 2006;66:8749-61.
6. Gillespie RF, Gudas LJ: Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. J Biol Chem 2007;282:33421-34.
7. Uchida H, Kuroki M, Shitama T, Hayashi H, Kuroki M: Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells. Curr Eye Res 2008;33:199-203.
8. Singh B, Murphy RF, Ding XZ, Roginsky AB, Bell RH Jr, Adrian TE: On the role of transforming growth factor-beta in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells. Mol Cancer 2007;6:82-91.
9. Degitz S, Morriss D, Foley G, Francis BM: Role of TGF-b in RA-induced cleft palate in CD-1 mice. Teratology 1998;58:197-204.
10. Gehris AL, Pisano MM, Nugent P, Greene RM: Regulation of TGF1 gene expression in embryonic palatal tissue. In Vitro Dev Biol 1994;30A:671-79.
11. Nunes I, Kojima S, Rifkin DB: Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells. Cancer Res 1996;56:495-99.
12. Borger DR, Mi Y, Geslani G, Zyzak LL, Batova A, Engin TS, Pirisi L, Creek KE; Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta. Virology 2000;270:397-407.
13. Yu Z, Xing Y: All-trans retinoic acid inhibited chondrogenesis of mouse embryonic palate mesenchymal cells by down-regulation of TGF-beta/Smad signaling. Biochem Biophys Res Com 2006;340:929-934.
14. Bertolino E, Reimund B, Wildt-Perinic D, Clerc RG: A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J Biol Chem 1995;270:31178-31188.
15. Ming JE, Muenke M: Holoprosencephaly: from Homer to Hedgehog. Clin Genet 1998;53:155-163.
16. Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massague J, Muenke M, Elledge SJ: Mutations in TGIF cause holoprosencephaly and link NODAL signaling to human neural axis determination. Nat Genet 2000;25:205-208.
17. Wotton. D, Lo RS, Lee S, Massague J: A Smad transcriptional corepressor. Cell 1999;97:29-39.
18. Melhuish TA, Gallo CM, Wotton D: TGIF2 interacts with histone deacetylase 1 and represses transcription. J Biol Chem 2001;276:32109-14.
19. Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massagué J: TGF b signals through a heteromeric protein kinase receptor complex. Cell 1992;71:1003-1014.
20. Lo RS, Wotton D, Massague J: Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001;20:128-136.
21. Wertz K, Seifert N, Hunziker PB, Riss G, Wyss A, Lankin C, Goralczyk R: Betacarotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism. Free Radic Biol Med 2004;37:654-70.
22. Tanaka T, Suh KS, Lo AM, De Luca LM: p21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer. J Biol Chem 2007;282:29987-97.
23. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN: Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-â-induced fibronectin in mesangial cells. Biochem. Biophys. Res Commun 2002;296:1356-1365.
24. Danielpour D: Induction of transforming growth factor-beta autocrine activity by all-trans-retinoic acid and 1 alpha,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells. J Cell Physiol 1996;166:231-239.
25. Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB: Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. Cell Regul 1989;1:87-97.
26. Imai S, Okuno M, Moriwaki H, Muto Y, Murakami K, Shudo K, Suzuki Y, Kojima S: 9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90. FEBS Lett 1997;411:102-106.
27. Kojima S, Rifkin DB: Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells. J Cell Physiol 1993;155:323-332.
28. Frenz DA, Liu W: Treatment with all-trans-retinoic acid decreases levels of endogenous TGF-beta(1) in the mesenchyme of the developing mouse inner ear. Teratology 2000;61:297-304
29. Kubalak SW, Hutson DR, Scott KK, Shannon RA: Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development 2002;129:733-746.
30. Flentke GR, Baker MW, Docterman KE, Power S, Lough J, Smith SM: Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. Dev Dyn 2004;229:886-898.
31. Bohnsack BL, Lai L, Dolle P, Hirschi KK: Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev 2004;18:1345-1358.
32. Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, Wotton D: TGIF inhibits retinoid signaling. Mol Cell Biol 2006;26:990-1001.
33. Melhuish TA, Wotton D: The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J Biol Chem 2000;275:39762-39766.
34. Wotton D, Lo RS, Swaby LA, Massague J: Multiple modes of repression by the Smad transcriptional corepressor TGIF. J Biol Chem 1999;274:37105-37110.
35. Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A: The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J 2004;23:3780-3792.