Gadd45α activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo

Cell Death and Disease

Volumn 2, Issue 2, 2011, Pages

  Lembo Fazio, L ^a   Nigro, G ^a,f   Noel G ^a   Rossi, G ^b   Chiara, F ^c   Tsilingiri, K ^d   Rescigno, M ^d   Rasola, A ^c   Bernardini, M L ^a,e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f INSTITUT PASTEUR   (France)

Author keywords

Apoptosis; Gadd45 ; Infection; Mitochondria; Shigella

Indexed keywords

CASPASE 9; DNA; GROWTH ARREST AND AND DNA DAMAGE 45ALPHA; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GADD45A PROTEIN, HUMAN; NUCLEAR PROTEIN;

ARTICLE; CELL ACTIVATION; CELL DEATH; CELL INVASION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; EX VIVO STUDY; GROWTH DISORDER; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; MITOCHONDRION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; SHIGELLA; SHIGELLOSIS; STRESS; APOPTOSIS; COLON; CYTOLOGY; GENETICS; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SHIGELLA FLEXNERI;

EUKARYOTA; SHIGELLA;

APOPTOSIS; CELL CYCLE PROTEINS; CELL DEATH; COLON; DYSENTERY, BACILLARY; EPITHELIAL CELLS; HELA CELLS; HUMANS; MITOCHONDRIA; NUCLEAR PROTEINS; SHIGELLA FLEXNERI;

EID: 79960018823     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.4     Document Type: Article

References (40)

1. Labbe K, Saleh M. Cell death in the host response to infection. Cell Death Differ 2008; 15: 1339-1349.
2. Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009; 5: 527-549.
3. Mathan VI, Mathan MM. Intestinal manifestations of invasive diarrheas and their diagnosis. Rev Infect Dis 1991; 13 (Suppl 4): S311-S313.
4. Sansonetti PJ, Ryter A, Clerc P, Maurelli AT, Mounier J. Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis. Infect Immun 1996; 51: 461-469.
5. Parsot C. Shigella flexneri: genetics of entry and intercellular dissemination in epithelial cells. Curr Top Microbiol Immunol 1994; 192: 217-241. (Pubitemid 24344408)
6. Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003; 300: 1584-1587. (Pubitemid 36682892)
7. Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 2007; 3: e111.
8. Hilbi H, Chen Y, Thirumalai K, Zychlinsky A. The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocytederived macrophages. Infect Immun 1997; 65: 5165-5170. (Pubitemid 27513565)
9. Koterski JF, Nahvi M, Venkatesan MM, Haimovich B. Virulent Shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophages. Infect Immun 2005; 73: 504-513. (Pubitemid 40041145)
10. Nonaka T, Kuwae A, Sasakawa C, Imajoh-Ohmi S. Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937. FEMS Microbiol Lett 1999; 174: 89-95. (Pubitemid 29179437)
11. Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N et al. A novel caspase-1/tolllike receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J Biol Chem 2005; 280: 14042-14050. (Pubitemid 40517305)
12. Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT et al. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 2009; 5: 123-136.
13. Faherty CS, Maurelli AT. Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis. Infect Immun 2009; 77: 5281-5290.
14. Tattoli I, Lembo-Fazio L, Nigro G, Carneiro LA, Ferraro E, Rossi G et al. Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells. Microbes Infect 2008; 10: 1114-1123.
15. Cersini A, Salvia AM, Bernardini ML. Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants. Infect Immun 1998; 66: 549-557. (Pubitemid 28074194)
16. Dupont N, Lacas-Gervais S, Bertout J, Paz I, Freche B, Van Nhieu GT et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 2009; 6: 137-149.
17. Gao M, Guo N, Huang C, Song L. Diverse roles of GADD45alpha in stress signaling. Curr Protein Pept Sci 2009; 10: 388-394.
18. Tong T, Ji J, Jin S, Li X, Fan W, Song Y et al. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol 2005; 25: 4488-4500. (Pubitemid 40705755)
19. Li Y, Qian H, Li X, Wang H, Yu J, Liu Y et al. Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med 2009; 11: 3-13.
20. Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K et al. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci USA 2004; 101: 13618-13623. (Pubitemid 39238452)
21. Martino MC, Rossi G, Martini I, Tattoli I, Chiavolini D, Phalipon A et al. Mucosal lymphoid infiltrate dominates colonic pathological changes in murine experimental shigellosis. J Infect Dis 2005; 192: 136-148. (Pubitemid 40863866)
22. O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC. p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 2003; 278: L552-L559.
23. Rudel T, Kepp O, Kozjak-Pavlovic V. Interactions between bacterial pathogens and mitochondrial cell death pathways. Nat Rev Microbiol 2010; 8: 693-705.
24. Srinivasula SM, Ashwell JD. IAPs: what's in a name? Mol Cell 2008; 30: 123-135. (Pubitemid 351626688)
25. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-182. (Pubitemid 38251646)
26. Pedron T, Thibault C, Sansonetti PJ. The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2. J Biol Chem 2003; 278: 33878-33886. (Pubitemid 38001835)
27. Pendaries C, Tronchere H, Arbibe L, Mounier J, Gozani O, Cantley L et al. PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Embo J 2006; 25: 1024-1034. (Pubitemid 43372116)
28. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol Cell 2010; 37: 299-310.
29. Rasola A, Sciacovelli M, Pantic B, Bernardi P. Signal transduction to the permeability transition pore. FEBS Lett 2010; 584: 1989-1996.
30. Gramaglia D, Gentile A, Battaglia M, Ranzato L, Petronilli V, Fassetta M et al. Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-X(L)- and PKB/AKT-independent fashion. Cell Death Differ 2004; 11: 342-353. (Pubitemid 38313143)
31. Nicotera P, Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 2004; 23: 2757-2765. (Pubitemid 38638839)
32. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003; 4: 552-565. (Pubitemid 36773407)
33. Rasola A, Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis 2007; 12: 815-833. (Pubitemid 46653292)
34. Rosemary Siafakas A, Richardson DR. Growth arrest and DNA damage-45 alpha (GADD45alpha). Int J Biochem Cell Biol 2009; 41: 986-989.
35. Hoffman B, Liebermann DA. Gadd45 modulation of intrinsic and extrinsic stress responses in myeloid cells. J Cell Physiol 2009; 218: 26-31.
36. Hasegawa Y, Mans JJ, Mao S, Lopez MC, Baker HV, Handfield M et al. Gingival epithelial cell transcriptional responses to commensal and opportunistic oral microbial species. Infect Immun 2007; 75: 2540-2547. (Pubitemid 46744346)
37. Martinoli C, Chiavelli A, Rescigno M. Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity 2007; 27: 975-984. (Pubitemid 50013977)
38. Rasola A, Geuna M. A flow cytometry assay simultaneously detects independent apoptotic parameters. Cytometry 2001; 45: 151-157. (Pubitemid 32954245)
39. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods 2001; 25: 402-408. (Pubitemid 34164012)
40. Resendes AR, Majo N, Segales J, Espadamala J, Mateu E, Chianini F et al. Apoptosis in normal lymphoid organs from healthy normal, conventional pigs at different ages detected by TUNEL and cleaved caspase-3 immunohistochemistry in paraffin-embedded tissues. Vet Immunol Immunopathol 2004; 99: 203-213. (Pubitemid 38597006)