ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Gαq/11

Pharmacological Research

Volumn 64, Issue 3, 2011, Pages 258-267

  Montmayeur, Jean Pierre ^a,b   Barr, Travis P ^a   Kam, Sarah A ^a   Packer, Samuel J ^a   Strichartz, Gary R ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CNRS   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Calcium; Endothelin 1; ETA receptor; ETB receptor; G q 11; HEK 293T; ND7 104

Indexed keywords

CALCIUM; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; GENE EXPRESSION; KIDNEY CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL LINE; CYTOPLASM; ENDOTHELIN-1; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; KIDNEY; MICE; RATS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SENSORY RECEPTOR CELLS; TYPE C PHOSPHOLIPASES;

EID: 79960018488     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.04.003     Document Type: Article

References (56)

1. M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, and Y. Mitsui A novel potent vasoconstrictor peptide produced by vascular endothelial cells Nature 332 1988 411 415 (Pubitemid 18090241)
2. T.F. Luscher, and M. Barton Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs Circulation 102 2000 2434 2440
3. R.M. Kedzierski, and M. Yanagisawa Endothelin system: the double-edged sword in health and disease Annu Rev Pharmacol Toxicol 41 2001 851 876 (Pubitemid 32385909)
4. M. Barton, and M. Yanagisawa Endothelin: 20 years from discovery to therapy Can J Physiol Pharmacol 86 2008 485 498
5. H. Arai, S. Hori, I. Aramori, H. Ohkubo, and S. Nakanishi Cloning and expression of a cDNA encoding an endothelin receptor Nature 348 1990 730 732 (Pubitemid 120015147)
6. T. Sakurai, M. Yanagisawa, Y. Takuwa, H. Miyazaki, S. Kimura, and K. Goto Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor Nature 348 1990 732 735 (Pubitemid 120015148)
7. T. Sakurai, M. Yanagisawa, and T. Masaki Molecular characterization of endothelin receptors Trends Pharmacol Sci 13 1992 103 108
8. A.P. Davenport International union of pharmacology. XXIX. Update on endothelin receptor nomenclature Pharmacol Rev 54 2002 219 226 (Pubitemid 34575711)
9. A. Khodorova, J.P. Montmayeur, and G. Strichartz Endothelin receptors and pain J Pain 10 2009 4 28
10. F.H. Mujenda, A.M. Duarte, E.K. Reilly, and G.R. Strichartz Cutaneous endothelin-a receptors elevate post-incisional pain Pain 133 2007 161 173 (Pubitemid 350138319)
11. S. Stosser, N. Agarwal, A. Tappe-Theodor, M. Yanagisawa, and R. Kuner Dissecting the functional significance of endothelin a receptors in peripheral nociceptors in vivo via conditional gene deletion Pain 148 2010 206 214
12. A.P. Gokin, M.U. Fareed, H.L. Pan, G. Hans, G.R. Strichartz, and G. Davar Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats J Neurosci 21 2001 5358 5366 (Pubitemid 32622962)
13. J.D. Pomonis, S.D. Rogers, C.M. Peters, J.R. Ghilardi, and P.W. Mantyh Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception J Neurosci 21 2001 999 1006 (Pubitemid 32163140)
14. C.M. Peters, T.H. Lindsay, J.D. Pomonis, N.M. Luger, J.R. Ghilardi, and M.A. Sevcik Endothelin and the tumorigenic component of bone cancer pain Neuroscience 126 2004 1043 1052 (Pubitemid 38780907)
15. L.N. Berti-Mattera, C.E. Gariepy, R.M. Burke, and A.K. Hall Reduced expression of endothelin b receptors and mechanical hyperalgesia in experimental chronic diabetes Exp Neurol 201 2006 399 406 (Pubitemid 44344232)
16. Z. Zhou, G. Davar, and G. Strichartz Endothelin-1 (et-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of et-1 J Neurosci 22 2002 6325 6330 (Pubitemid 35386386)
17. B. Feng, and G. Strichartz Endothelin-1 raises excitability and reduces potassium currents in sensory neurons Brain Res Bull 79 2009 345 350
18. M.J. Caterina, and D. Julius The vanilloid receptor: a molecular gateway to the pain pathway Annu Rev Neurosci 24 2001 487 517 (Pubitemid 32695237)
19. T. Kawamata, W. Ji, J. Yamamoto, Y. Niiyama, S. Furuse, and K. Omote Involvement of transient receptor potential vanilloid subfamily 1 in endothelin-1-induced pain-like behavior Neuroreport 20 2009 233 237
20. T. Kawamata, W. Ji, J. Yamamoto, Y. Niiyama, S. Furuse, and A. Namiki Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia Neuroscience 154 2008 1067 1076
21. K. Balonov, A. Khodorova, and G.R. Strichartz Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of trpv-1 receptors Exp Biol Med (Maywood) 231 2006 1165 1170 (Pubitemid 43845598)
22. J.M. da Cunha, G.A. Rae, S.H. Ferreira, and Q. Cunha Fde Endothelins induce etb receptor-mediated mechanical hypernociception in rat hindpaw: roles of camp and protein kinase c Eur J Pharmacol 501 2004 87 94 (Pubitemid 39298940)
23. E.M. Motta, J.G. Chichorro, and G.A. Rae Role of et(a) and et(b) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats Neurosci Lett 457 2009 146 150
24. 2+ response via activation of endothelin a receptor in a protein kinase cepsilon-dependent manner in dorsal root ganglion neurons Neuroscience 137 2006 949 960 (Pubitemid 43053957)
25. T.D. Plant, C. Zollner, F. Kepura, S.S. Mousa, J. Eichhorst, and M. Schaefer Endothelin potentiates trpv1 via eta receptor-mediated activation of protein kinase c Mol Pain 3 2007 35
26. Y. Nishizuka Protein kinase c and lipid signaling for sustained cellular responses Faseb J 9 1995 484 496
27. Q.L. Zhou, G. Strichartz, and G. Davar Endothelin-1 activates et(a) receptors to increase intracellular calcium in model sensory neurons Neuroreport 12 2001 3853 3857 (Pubitemid 33105185)
28. N.R. Tykocki, and S.W. Watts The interdependence of endothelin-1 and calcium: a review Clin Sci (Lond) 119 2010 361 372
29. M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative expression software tool (rest) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 30 2002 e36
30. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
31. K. Thakali, J.J. Galligan, G.D. Fink, C.E. Gariepy, and S.W. Watts Pharmacological endothelin receptor interaction does not occur in veins from et(b) receptor deficient rats Vascular Pharmacol 49 2008 6 13
32. N. Harada, A. Himeno, K. Shigematsu, K. Sumikawa, and M. Niwa Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an eta-etb receptor heterodimer Cell Mol Neurobiol 22 2002 207 226
33. B. Gregan, J. Jurgensen, G. Papsdorf, J. Furkert, M. Schaefer, and M. Beyermann Ligand-dependent differences in the internalization of endothelin a and endothelin b receptor heterodimers J Biol Chem 279 2004 27679 27687 (Pubitemid 38812609)
34. 2+ signaling and delayed internalization associated with endothelin receptor heterodimers linked through a pdz finger Can J Physiol Pharmacol 86 2008 526 535
35. N.J. Evans, and J.W. Walker Endothelin receptor dimers evaluated by fret, ligand binding, and calcium mobilization Biophys J 95 2008 483 492
36. B. Gregan, M. Schaefer, W. Rosenthal, and A. Oksche Fluorescence resonance energy transfer analysis reveals the existence of endothelin-a and endothelin-b receptor homodimers J Cardiovasc Pharmacol 44 Suppl. 1 2004 S30 33
37. X. Dai, and J.J. Galligan Differential trafficking and desensitization of human et(a) and et(b) receptors expressed in hek 293 cells Exp Biol Med (Maywood) 231 2006 746 751 (Pubitemid 43845521)
38. J.G. Chichorro, A.R. Zampronio, D.A. Cabrini, C.R. Franco, and G.A. Rae Mechanisms operated by endothelin eta and etb receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats Neuropeptides 43 2009 133 142
39. P. Nambi, M. Pullen, J. Kincaid, P. Nuthulaganti, N. Aiyar, and D.P. Brooks Identification and characterization of a novel endothelin receptor that binds both eta- and etb-selective ligands Mol Pharmacol 52 1997 582 589 (Pubitemid 27443979)
40. P. Nambi, N. Elshourbagy, H.L. Wu, M. Pullen, E.H. Ohlstein, and D.P. Brooks Nonpeptide endothelin receptor antagonists. I. Effects on binding and signal transduction on human endothelina and endothelinb receptors J Pharmacol Exp Ther 271 1994 755 761 (Pubitemid 24377761)
41. K. Angelova, A. Ergul, P. Narayan, and D. Puett Endothelin binding to ng108-15 cells: evidence for conventional eta and etb receptor subtypes and super-high affinity binding components Cell Mol Biol (Noisy-le-grand) 42 1996 1243 1257
42. A. Nishimura, M. Okamoto, Y. Sugawara, N. Mizuno, J. Yamauchi, and H. Itoh Ric-8a potentiates gq-mediated signal transduction by acting downstream of g protein-coupled receptor in intact cells Genes Cells 11 2006 487 498
43. I. Vetter, and R.J. Lewis Characterization of endogenous calcium responses in neuronal cell lines Biochem Pharmacol 79 2010 908 920
44. T. Kenakin Differences between natural and recombinant g protein-coupled receptor systems with varying receptor/g protein stoichiometry Trends Pharmacol Sci 18 1997 456 464 (Pubitemid 28051762)
45. D.M. Perez, and S.S. Karnik Multiple signaling states of g-protein-coupled receptors Pharmacol Rev 57 2005 147 161 (Pubitemid 41043881)
46. T. Horinouchi, H. Asano, T. Higa, A. Nishimoto, T. Nishiya, and I. Muramatsu Differential coupling of human endothelin type a receptor to g(q/11) and g(12) proteins: the functional significance of receptor expression level in generating multiple receptor signaling J Pharmacol Sci 111 2009 338 351
47. W. Fischer, K. Wirkner, M. Weber, C. Eberts, L. Koles, and R. Reinhardt Characterization of p2x3, p2y1 and p2y4 receptors in cultured hek293-hp2x3 cells and their inhibition by ethanol and trichloroethanol J Neurochem 85 2003 779 790 (Pubitemid 36531941)
48. T. Tonissoo, R. Meier, K. Talts, M. Plaas, and A. Karis Expression of ric-8 (synembryn) gene in the nervous system of developing and adult mouse Gene Expression Patterns 3 2003 591 594 (Pubitemid 37074911)
49. A. Shankaranarayanan, D.M. Thal, V.M. Tesmer, D.L. Roman, R.R. Neubig, and T. Kozasa Assembly of high order g alpha q-effector complexes with rgs proteins J Biol Chem 283 2008 34923 34934
50. L.M. Luttrell, and R.J. Lefkowitz The role of beta-arrestins in the termination and transduction of g-protein-coupled receptor signals J Cell Sci 115 2002 455 465 (Pubitemid 34182973)
51. G.S. von Banchet, N. Fischer, B. Uhlig, S. Hensellek, A. Eitner, and H.G. Schaible Molecular effects of interleukin-1beta on dorsal root ganglion neurons: prevention of ligand-induced internalization of the bradykinin 2 receptor and downregulation of g protein-coupled receptor kinase 2 Mol Cell Neurosci 46 2011 262 271
52. M. Schmidt, S. Evellin, P.A. Weernink, F. von Dorp, H. Rehmann, and J.W. Lomasney A new phospholipase-c-calcium signalling pathway mediated by cyclic amp and a rap gtpase Nat Cell Biol 3 2001 1020 1024 (Pubitemid 34428748)
53. Y. Takagi, H. Ninomiya, A. Sakamoto, S. Miwa, and T. Masaki Structural basis of g protein specificity of human endothelin receptors. A study with endothelina/b chimeras J Biol Chem 270 1995 10072 10078
54. A. Chahdi, and A. Sorokin The role of beta(1)pix/caveolin-1 interaction in endothelin signaling through galpha subunits Biochem Biophys Res Commun 391 2010 1330 1335
55. H.J. Lee, M. Chun, and K.V. Kandror Tip60 and hdac7 interact with the endothelin receptor a and may be involved in downstream signaling J Biol Chem 276 2001 16597 16600
56. A. Nishimoto, L. Lu, M. Hayashi, T. Nishiya, T. Horinouchi, and S. Miwa Jab1 regulates levels of endothelin type a and b receptors by promoting ubiquitination and degradation Biochem Biophys Res Commun 391 2010 1616 1622