메뉴 건너뛰기




Volumn 9, Issue 4, 2011, Pages 521-530

What restricts the clinical use of nicotinic acid?

Author keywords

Adverse events, niacin, nicotinic acid, side effects, toxicity, laropiprant

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ALLOPURINOL; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; BILE ACID SEQUESTRANT; FIBRINOGEN; FLUINDOSTATIN; G PROTEIN RECEPTOR 109A; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDOMETACIN; LAROPIPRANT; MEMBRANE PROTEIN; MEVINOLIN; NAPROXEN; NICOTINIC ACID; ORGANIC ANION TRANSPORTER 10; PHOSPHATE; PHOSPHOPYRUVATE CARBOXYLASE; PRAVASTATIN; PROSTAGLANDIN D2; PROTHROMBIN; PROTON PUMP INHIBITOR; RECEPTOR; SIMVASTATIN; UNCLASSIFIED DRUG; URIC ACID; WARFARIN;

EID: 79960013306     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016111796197215     Document Type: Review
Times cited : (9)

References (124)
  • 1
    • 0000808276 scopus 로고
    • Influence of nicotinic acid on serum cholesterol in man
    • Altschul R, Hoffer A, Stephen JD. Influence of nicotinic acid on serum cholesterol in man. Arch Biochem 1955; 54: 558-9.
    • (1955) Arch Biochem , vol.54 , pp. 558-559
    • Altschul, R.1    Hoffer, A.2    Stephen, J.D.3
  • 2
    • 74049112916 scopus 로고    scopus 로고
    • Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemia
    • Parhofer KG. Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemia. Vasc Health Risk Manag 2009; 5: 901-8.
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 901-908
    • Parhofer, K.G.1
  • 3
    • 0032542302 scopus 로고    scopus 로고
    • Efficacy and safety of an extended-release niacin (Niaspan): A long-term study
    • Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998; 82: 74U-81U.
    • (1998) Am J Cardiol , vol.82
    • Capuzzi, D.M.1    Guyton, J.R.2    Morgan, J.M.3
  • 4
    • 33645743962 scopus 로고    scopus 로고
    • Evaluation of the safety and tolerability of prolonged-release nicotinic acid in a usual care setting: The NAUTILUS study
    • Vogt A, Kassner U, Hostalek U, et al. Evaluation of the safety and tolerability of prolonged-release nicotinic acid in a usual care setting: the NAUTILUS study. Curr Med Res Opin 2006; 22: 417-25.
    • (2006) Curr Med Res Opin , vol.22 , pp. 417-425
    • Vogt, A.1    Kassner, U.2    Hostalek, U.3
  • 5
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999; 341: 410-8.
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 6
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • Miller M, Cannon CP, Murphy SA, et al. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 2008; 51: 724-30.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 724-730
    • Miller, M.1    Cannon, C.P.2    Murphy, S.A.3
  • 7
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and non-vascular mortality
    • Erqou S, Kaptoge S, Perry PL, et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and non-vascular mortality. JAMA 2009; 302: 412-23.
    • (2009) JAMA , vol.302 , pp. 412-423
    • Erqou, S.1    Kaptoge, S.2    Perry, P.L.3
  • 8
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001; 345: 1583-92.
    • (2001) N Engl J Med , vol.345 , pp. 1583-1592
    • Brown, B.G.1    Zhao, X.Q.2    Chait, A.3
  • 9
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986; 8: 1245-55.
    • (1986) J Am Coll Cardiol , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 10
    • 57649219453 scopus 로고    scopus 로고
    • Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
    • Ganji SH, Qin S, Zhang L, et al. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 2009; 202: 68-75.
    • (2009) Atherosclerosis , vol.202 , pp. 68-75
    • Ganji, S.H.1    Qin, S.2    Zhang, L.3
  • 11
    • 33845332071 scopus 로고    scopus 로고
    • Niacin affects cell adhesion molecules and plasminogen activator inhibitor-1 in HepG2 cells
    • Tavintharan S, Sivakumar M, Lim SC, et al. Niacin affects cell adhesion molecules and plasminogen activator inhibitor-1 in HepG2 cells. Clin Chim Acta 2007; 376: 41-4.
    • (2007) Clin Chim Acta , vol.376 , pp. 41-44
    • Tavintharan, S.1    Sivakumar, M.2    Lim, S.C.3
  • 12
    • 0037396765 scopus 로고    scopus 로고
    • Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: A randomized trial
    • Owada A, Suda S, Hata T. Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: a randomized trial. Am J Med 2003; 114: 347-53.
    • (2003) Am J Med , vol.114 , pp. 347-353
    • Owada, A.1    Suda, S.2    Hata, T.3
  • 13
    • 71749115788 scopus 로고    scopus 로고
    • Niacin improves renal lipid metabolism and slows progression in chronic kidney disease
    • Cho KH, Kim HJ, Kamanna VS, et al. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta 2010; 1800: 6-15.
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 6-15
    • Cho, K.H.1    Kim, H.J.2    Kamanna, V.S.3
  • 14
    • 74549172922 scopus 로고    scopus 로고
    • Endothelialvasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy
    • Sorrentino SA, Besler C, Rohrer L, et al. Endothelialvasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy. Circulation 2010; 121: 110-22.
    • (2010) Circulation , vol.121 , pp. 110-122
    • Sorrentino, S.A.1    Besler, C.2    Rohrer, L.3
  • 15
    • 77955846486 scopus 로고    scopus 로고
    • Niaspan treatment induces neuroprotection after stroke
    • [Epub ahead of print]
    • Shehadah A, Chen J, Zacharek A, et al. Niaspan treatment induces neuroprotection after stroke. Neurobiol Dis 2010 [Epub ahead of print].
    • (2010) Neurobiol Dis
    • Shehadah, A.1    Chen, J.2    Zacharek, A.3
  • 16
    • 34047211289 scopus 로고    scopus 로고
    • A novel therapeutic drug (copper nicotinic acid complex) for non-alcoholic fatty liver
    • Salama RH, Nassar AY, Nafady, AA, et al. A novel therapeutic drug (copper nicotinic acid complex) for non-alcoholic fatty liver. Liver Int 2007; 27: 454-64.
    • (2007) Liver Int , vol.27 , pp. 454-464
    • Salama, R.H.1    Nassar, A.Y.2    Nafady, A.A.3
  • 17
    • 73849123857 scopus 로고    scopus 로고
    • What's the deal with niacin development: Is laropiprant add-on therapy a winning strategy to beat a straight flush?
    • Bays HE, Ballantyne C. What's the deal with niacin development: is laropiprant add-on therapy a winning strategy to beat a straight flush? Curr Opin Lipidol 2009; 20: 467-76.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 467-476
    • Bays, H.E.1    Ballantyne, C.2
  • 19
    • 0023803525 scopus 로고
    • Why is flushing limited to a mostly facial cutaneous distribution?
    • Wilkin JK. Why is flushing limited to a mostly facial cutaneous distribution? J Am Acad Dermatol 1988; 19: 309-13.
    • (1988) J Am Acad Dermatol , vol.19 , pp. 309-313
    • Wilkin, J.K.1
  • 21
    • 31044448925 scopus 로고    scopus 로고
    • GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
    • Benyo Z, Gille A, Kero J, et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 2005; 115: 3634-40.
    • (2005) J Clin Invest , vol.115 , pp. 3634-3640
    • Benyo, Z.1    Gille, A.2    Kero, J.3
  • 22
  • 23
    • 0035132681 scopus 로고    scopus 로고
    • Characterization of a G protein-coupled receptor for nicotinic acid
    • Lorenzen A, Stannek C, Lang H, et al. Characterization of a G protein-coupled receptor for nicotinic acid. Mol Pharmacol 2001; 59: 349-57.
    • (2001) Mol Pharmacol , vol.59 , pp. 349-357
    • Lorenzen, A.1    Stannek, C.2    Lang, H.3
  • 24
    • 33751090692 scopus 로고    scopus 로고
    • Langerhans cells release prostaglandin D2 in response to nicotinic acid
    • Maciejewski-Lenoir D, Richman JG, Hakak Y, et al. Langerhans cells release prostaglandin D2 in response to nicotinic acid. J Invest Dermatol 2006; 126: 2637-46.
    • (2006) J Invest Dermatol , vol.126 , pp. 2637-2646
    • McIejewski-Lenoir, D.1    Richman, J.G.2    Hakak, Y.3
  • 25
    • 0000242585 scopus 로고
    • The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis
    • Carlson LA, Oro L. The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis. Acta Med Scand 1962; 172: 641-5.
    • (1962) Acta Med Scand , vol.172 , pp. 641-645
    • Carlson, L.A.1    Oro, L.2
  • 26
    • 68949215867 scopus 로고    scopus 로고
    • The mechanism and mitigation of niacin-induced flushing
    • Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract 2009; 63: 1369-77.
    • (2009) Int J Clin Pract , vol.63 , pp. 1369-1377
    • Kamanna, V.S.1    Ganji, S.H.2    Kashyap, M.L.3
  • 27
    • 33646258753 scopus 로고    scopus 로고
    • Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    • Cheng K, Wu TJ, Wu KK, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci USA 2006; 103: 6682-7.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6682-6687
    • Cheng, K.1    Wu, T.J.2    Wu, K.K.3
  • 28
    • 21644460559 scopus 로고    scopus 로고
    • Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner
    • Ishida H, Masuhiro Y, Fukushima A, et al. Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner. J Biol Chem 2005; 280: 24642-8.
    • (2005) J Biol Chem , vol.280 , pp. 24642-24648
    • Ishida, H.1    Masuhiro, Y.2    Fukushima, A.3
  • 30
    • 43749087586 scopus 로고    scopus 로고
    • Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: Results from a randomised placebo-controlled clinical trial
    • Paolini JF, Mitchel YB, Reyes R, et al. Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: results from a randomised placebo-controlled clinical trial. Int J Clin Pract 2008; 62: 896-904.
    • (2008) Int J Clin Pract , vol.62 , pp. 896-904
    • Paolini, J.F.1    Mitchel, Y.B.2    Reyes, R.3
  • 31
    • 22644437126 scopus 로고    scopus 로고
    • Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review
    • Carlson LA. Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J Intern Med 2005; 258: 94-114.
    • (2005) J Intern Med , vol.258 , pp. 94-114
    • Carlson, L.A.1
  • 32
    • 0014546955 scopus 로고
    • The relationship between the plasma concentration of free nicotinic acid and some of its pharmacologic effects in man
    • Svedmyr N, Harthon L, Lundholm L. The relationship between the plasma concentration of free nicotinic acid and some of its pharmacologic effects in man. Clin Pharmacol Ther 1969; 10: 559-70.
    • (1969) Clin Pharmacol Ther , vol.10 , pp. 559-570
    • Svedmyr, N.1    Harthon, L.2    Lundholm, L.3
  • 33
    • 0036737714 scopus 로고    scopus 로고
    • Understanding niacin formulations
    • Pieper JA. Understanding niacin formulations. Am J Manag Care 2002; 8: S308-14.
    • (2002) Am J Manag Care , vol.8 , pp. 308-314
    • Pieper, J.A.1
  • 34
    • 0034700636 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol
    • Piepho RW. The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol. Am J Cardiol 2000; 86: 35L-40L.
    • (2000) Am J Cardiol , vol.86
    • Piepho, R.W.1
  • 35
    • 0038630864 scopus 로고    scopus 로고
    • Niacin for dyslipidemia: Considerations in product selection
    • McKenney J. Niacin for dyslipidemia: considerations in product selection. Am J Health Syst Pharm 2003; 60: 995-1005.
    • (2003) Am J Health Syst Pharm , vol.60 , pp. 995-1005
    • McKenney, J.1
  • 36
    • 0021828236 scopus 로고
    • Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: Clues to mechanism of action of niacin
    • Knopp RH, Ginsberg J, Albers JJ, et al. Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin. Metabolism 1985; 34: 642-50.
    • (1985) Metabolism , vol.34 , pp. 642-650
    • Knopp, R.H.1    Ginsberg, J.2    Albers, J.J.3
  • 37
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol 2007; 99: 22C-31C.
    • (2007) Am J Cardiol , vol.99
    • Guyton, J.R.1    Bays, H.E.2
  • 38
    • 0028057319 scopus 로고
    • A comparison of the efficacy and toxic effects of sustained-vs. immediate-release niacin in hypercholesterolemic patients
    • McKenney JM, Proctor JD, Harris S, et al. A comparison of the efficacy and toxic effects of sustained-vs. immediate-release niacin in hypercholesterolemic patients. JAMA 1994; 271: 672-7.
    • (1994) JAMA , vol.271 , pp. 672-677
    • McKenney, J.M.1    Proctor, J.D.2    Harris, S.3
  • 39
    • 0000253976 scopus 로고
    • Nicotinic acid treatment of hypercholesteremia. Comparison of plain and sustainedaction preparations and report of two cases of jaundice
    • Christensen NA, Achor RW, Berge KG, et al. Nicotinic acid treatment of hypercholesteremia. Comparison of plain and sustainedaction preparations and report of two cases of jaundice. JAMA 1961; 177: 546-50.
    • (1961) JAMA , vol.177 , pp. 546-550
    • Christensen, N.A.1    Achor, R.W.2    Berge, K.G.3
  • 40
    • 53149118986 scopus 로고    scopus 로고
    • Extended-release niacin/ laropiprant: Reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors
    • Paolini JF, Bays HE, Ballantyne CM, et al. Extended-release niacin/ laropiprant: reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors. Cardiol Clin 2008; 26: 547-60.
    • (2008) Cardiol Clin , vol.26 , pp. 547-560
    • Paolini, J.F.1    Bays, H.E.2    Ballantyne, C.M.3
  • 41
    • 50949133756 scopus 로고    scopus 로고
    • Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs. simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)
    • Ballantyne CM, Davidson MH, McKenney J, et al. Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs. simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study). Am J Cardiol 2008; 101: 1428-36.
    • (2008) Am J Cardiol , vol.101 , pp. 1428-1436
    • Ballantyne, C.M.1    Davidson, M.H.2    McKenney, J.3
  • 42
    • 41049092899 scopus 로고    scopus 로고
    • Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: The OCEANS study
    • Karas RH, Kashyap ML, Knopp RH, et al. Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study. Am J Cardiovasc Drugs 2008; 8: 69-81.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 69-81
    • Karas, R.H.1    Kashyap, M.L.2    Knopp, R.H.3
  • 43
    • 33847421500 scopus 로고    scopus 로고
    • Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation
    • Cefali EA, Simmons PD, Stanek EJ, et al. Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation. Int J Clin Pharmacol Ther 2007; 45: 78-88.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 78-88
    • Cefali, E.A.1    Simmons, P.D.2    Stanek, E.J.3
  • 44
    • 0030764837 scopus 로고    scopus 로고
    • Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions
    • Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997; 12: 591-6.
    • (1997) J Gen Intern Med , vol.12 , pp. 591-596
    • Jungnickel, P.W.1    Maloley, P.A.2    vander Tuin, E.L.3
  • 45
    • 33744516859 scopus 로고    scopus 로고
    • Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment
    • Oberwittler H, Baccara-Dinet M. Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment. Int J Clin Pract 2006; 60: 707-15.
    • (2006) Int J Clin Pract , vol.60 , pp. 707-715
    • Oberwittler, H.1    Baccara-Dinet, M.2
  • 46
    • 0026553160 scopus 로고
    • The effect of aspirin on niacin-induced cutaneous reactions
    • Whelan AM, Price SO, Fowler SF, et al. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992; 34: 165-8.
    • (1992) J Fam Pract , vol.34 , pp. 165-168
    • Whelan, A.M.1    Price, S.O.2    Fowler, S.F.3
  • 47
    • 63849130311 scopus 로고    scopus 로고
    • Acetylsalicylic acid reduces niacin extended-release-induced flushing in patients with dyslipidemia
    • Thakkar RB, Kashyap ML, Lewin AJ, et al. Acetylsalicylic acid reduces niacin extended-release-induced flushing in patients with dyslipidemia. Am J Cardiovasc Drugs 2009; 9: 69-79.
    • (2009) Am J Cardiovasc Drugs , vol.9 , pp. 69-79
    • Thakkar, R.B.1    Kashyap, M.L.2    Lewin, A.J.3
  • 48
    • 0018728611 scopus 로고
    • Prostaglandins contribute to the vasodilation induced by nicotinic acid
    • Eklund B, Kaijser L, Nowak J, et al. Prostaglandins contribute to the vasodilation induced by nicotinic acid. Prostaglandins 1979; 17: 821-30.
    • (1979) Prostaglandins , vol.17 , pp. 821-830
    • Eklund, B.1    Kaijser, L.2    Nowak, J.3
  • 49
    • 0018747350 scopus 로고
    • Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man
    • Kaijser L, Eklund B, Olsson AG, et al. Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man. Med Biol 1979; 57: 114-7.
    • (1979) Med Biol , vol.57 , pp. 114-117
    • Kaijser, L.1    Eklund, B.2    Olsson, A.G.3
  • 50
    • 1842338863 scopus 로고
    • Low-dose aspirin and ibuprofen reduce the cutaneous reactions following niacin administration
    • Dunn RT, Ford MA, Rindone JP, et al. Low-dose aspirin and ibuprofen reduce the cutaneous reactions following niacin administration. Am J Ther 1995; 2: 478-80.
    • (1995) Am J Ther , vol.2 , pp. 478-480
    • Dunn, R.T.1    Ford, M.A.2    Rindone, J.P.3
  • 51
    • 0034700644 scopus 로고    scopus 로고
    • Evaluating niacin in its various forms
    • Knopp RH. Evaluating niacin in its various forms. Am J Cardiol 2000; 86: 51L-6L.
    • (2000) Am J Cardiol , vol.86
    • Knopp, R.H.1
  • 52
    • 41149170003 scopus 로고    scopus 로고
    • Niacin use and cutaneous flushing: Mechanisms and strategies for prevention
    • Davidson MH. Niacin use and cutaneous flushing: mechanisms and strategies for prevention. Am J Cardiol 2008; 101: 14B-9B.
    • (2008) Am J Cardiol , vol.101
    • Davidson, M.H.1
  • 53
    • 84859526032 scopus 로고    scopus 로고
    • [Online] 2010 Sep 15, [cited 2008]. Available from
    • TREDAPTIVE product overview. [Online] 2010 Sep 15, [cited 2008]. Available from: http://www.ema.europa.eu/humandocs/ Humans/EPAR/tredaptive/tredaptive.htm.
    • TREDAPTIVE product overview
  • 54
    • 33846444938 scopus 로고    scopus 로고
    • The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers
    • Van Hecken A, Depre M, De Lepeleire I, et al. The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. Eur J Clin Pharmacol 2007; 63: 135-41.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 135-141
    • van Hecken, A.1    Depre, M.2    de Lepeleire, I.3
  • 55
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • Maccubbin D, Bays HE, Olsson AG, et al. Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2008; 62: 1959-70.
    • (2008) Int J Clin Pract , vol.62 , pp. 1959-1970
    • McCubbin, D.1    Bays, H.E.2    Olsson, A.G.3
  • 56
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant vs. gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubbin D, Koren MJ, Davidson M, et al. Flushing profile of extended-release niacin/laropiprant vs. gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 2009; 104: 74-81.
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • McCubbin, D.1    Koren, M.J.2    Davidson, M.3
  • 57
    • 63849228890 scopus 로고    scopus 로고
    • Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptoms
    • Dishy V, Liu F, Ebel DL, et al. Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptoms. J Clin Pharmacol 2009; 49: 416-22.
    • (2009) J Clin Pharmacol , vol.49 , pp. 416-422
    • Dishy, V.1    Liu, F.2    Ebel, D.L.3
  • 58
    • 79959986449 scopus 로고    scopus 로고
    • The effect of nicotinic acid administration on lipid profile in patients with mixed dyslipidemia]
    • in press (Abstract in Greek)
    • Kei A, Liberopoulos E, Rizos C, et al. The effect of nicotinic acid administration on lipid profile in patients with mixed dyslipidemia]. Hellenic J Atheroscler 2010; 1 (Suppl 1): in press. (Abstract in Greek)
    • (2010) Hellenic J Atheroscler , vol.1 , Issue.SUPPL 1
    • Kei, A.1    Liberopoulos, E.2    Rizos, C.3
  • 59
    • 84859559385 scopus 로고    scopus 로고
    • [Online] 2010 Sep 15, [cited 2008]. Available from
    • FDA Rejects Merck's Cordaptive. [Online] 2010 Sep 15, [cited 2008]. Available from: http://www.businessweek.com/ bwdaily/dnflash/content/apr2008/db20080429_182260.htm
    • FDA Rejects Merck's Cordaptive
  • 60
    • 43949145969 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist
    • Lai E, Wenning LA, Crumley TM et al. Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist. Clin Pharmacol Ther 2008; 83: 840-7.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 840-847
    • Lai, E.1    Wenning, L.A.2    Crumley, T.M.3
  • 61
    • 0028214401 scopus 로고
    • Acanthosis nigricans caused by nicotinic acid: Case report and review of the literature
    • Stals H, Vercammen C, Peeters C, et al. Acanthosis nigricans caused by nicotinic acid: case report and review of the literature. Dermatology 1994; 189: 203-6.
    • (1994) Dermatology , vol.189 , pp. 203-206
    • Stals, H.1    Vercammen, C.2    Peeters, C.3
  • 62
    • 3042771812 scopus 로고    scopus 로고
    • Extended-release niacin for modifying the lipoprotein profile
    • Guyton JR. Extended-release niacin for modifying the lipoprotein profile. Expert Opin Pharmacother 2004; 5: 1385-98.
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 1385-1398
    • Guyton, J.R.1
  • 63
    • 42149136762 scopus 로고    scopus 로고
    • Effects of niacin on glucose control in patients with dyslipidemia
    • Goldberg RB, Jacobson TA. Effects of niacin on glucose control in patients with dyslipidemia. Mayo Clin Proc 2008; 83: 470-8.
    • (2008) Mayo Clin Proc , vol.83 , pp. 470-478
    • Goldberg, R.B.1    Jacobson, T.A.2
  • 64
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999; 48: 1270-4.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 65
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden G, Lebed B, Schatz M, et al. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 2001; 50: 1612-7.
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3
  • 66
    • 0041312408 scopus 로고    scopus 로고
    • Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content
    • Poynten AM, Gan SK, Kriketos AD, et al. Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content. Metabolism 2003; 52 699-704.
    • (2003) Metabolism , vol.52 , pp. 699-704
    • Poynten, A.M.1    Gan, S.K.2    Kriketos, A.D.3
  • 67
    • 19344370665 scopus 로고    scopus 로고
    • Influence of extended-release nicotinic acid on non-esterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia
    • Vega GL, Cater NB, Meguro S, et al. Influence of extended-release nicotinic acid on non-esterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia. Am J Cardiol 2005; 95: 1309-13.
    • (2005) Am J Cardiol , vol.95 , pp. 1309-1313
    • Vega, G.L.1    Cater, N.B.2    Meguro, S.3
  • 68
    • 79959941100 scopus 로고    scopus 로고
    • Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: Implications for unwanted effects of nicotinic acid treatment
    • [Epub ahead of print]
    • Choi S, Yoon H, Oh KS, et al. Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism 2010 [Epub ahead of print].
    • (2010) Metabolism
    • Choi, S.1    Yoon, H.2    Oh, K.S.3
  • 69
    • 77649141899 scopus 로고    scopus 로고
    • The effect of body mass index on fasting blood glucose and development of diabetes mellitus after initiation of extended-release niacin
    • Libby A, Meier J, Lopez J, et al. The effect of body mass index on fasting blood glucose and development of diabetes mellitus after initiation of extended-release niacin. Metab Syndr Relat Disord 2010; 8: 79-84.
    • (2010) Metab Syndr Relat Disord , vol.8 , pp. 79-84
    • Libby, A.1    Meier, J.2    Lopez, J.3
  • 70
    • 64549124829 scopus 로고    scopus 로고
    • Prevalence and control of diabetes and impaired fasting glucose in New York City
    • Thorpe LE, Upadhyay UD, Chamany S, et al. Prevalence and control of diabetes and impaired fasting glucose in New York City. Diabetes Care 2009; 32: 57-62.
    • (2009) Diabetes Care , vol.32 , pp. 57-62
    • Thorpe, L.E.1    Upadhyay, U.D.2    Chamany, S.3
  • 71
    • 0034644442 scopus 로고    scopus 로고
    • Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: The ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial
    • Elam MB, Hunninghake DB, Davis KB, et al. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial. JAMA 2000; 284: 1263-70.
    • (2000) JAMA , vol.284 , pp. 1263-1270
    • Elam, M.B.1    Hunninghake, D.B.2    Davis, K.B.3
  • 72
    • 0037158150 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: Results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial
    • Grundy SM, Vega GL, McGovern ME, et al. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial. Arch Intern Med 2002; 162: 1568-76.
    • (2002) Arch Intern Med , vol.162 , pp. 1568-1576
    • Grundy, S.M.1    Vega, G.L.2    McGovern, M.E.3
  • 73
    • 0017330636 scopus 로고
    • The coronary drug project--findings with regard to estrogen, dextrothyroxine, clofibrate and niacin
    • Stamler J. The coronary drug project--findings with regard to estrogen, dextrothyroxine, clofibrate and niacin. Adv Exp Med Biol 1977; 82: 52-75.
    • (1977) Adv Exp Med Biol , vol.82 , pp. 52-75
    • Stamler, J.1
  • 74
    • 11844304073 scopus 로고    scopus 로고
    • Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project)
    • Canner PL, Furberg CD, Terrin ML, et al. Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project). Am J Cardiol 2005; 95: 254-7.
    • (2005) Am J Cardiol , vol.95 , pp. 254-257
    • Canner, P.L.1    Furberg, C.D.2    Terrin, M.L.3
  • 75
    • 31944438344 scopus 로고    scopus 로고
    • Benefits of niacin in patients with vs. without the metabolic syndrome and healed myocardial infarction (from the Coronary Drug Project)
    • Canner PL, Furberg CD, McGovern ME. Benefits of niacin in patients with vs. without the metabolic syndrome and healed myocardial infarction (from the Coronary Drug Project). Am J Cardiol 2006; 97: 477-9.
    • (2006) Am J Cardiol , vol.97 , pp. 477-479
    • Canner, P.L.1    Furberg, C.D.2    McGovern, M.E.3
  • 76
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials
    • Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010; 375: 735-42.
    • (2010) Lancet , vol.375 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3
  • 78
    • 75149180515 scopus 로고    scopus 로고
    • Standards of medical care in diabetes--2010
    • Association AD. Standards of medical care in diabetes--2010. Diabetes Care 2010; 33 Suppl 1: S11-61.
    • (2010) Diabetes Care , vol.33 , Issue.SUPPL 1 , pp. 11-61
    • Association, A.D.1
  • 79
    • 0032530770 scopus 로고    scopus 로고
    • Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia
    • Guyton JR, Goldberg AC, Kreisberg RA, et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998; 82: 737-43.
    • (1998) Am J Cardiol , vol.82 , pp. 737-743
    • Guyton, J.R.1    Goldberg, A.C.2    Kreisberg, R.A.3
  • 80
    • 0015188268 scopus 로고
    • Effect of nicotinic acid on gastric secretion of acid in human subjects and in dogs
    • Andersson S, Carlson LA, Oro L, et al. Effect of nicotinic acid on gastric secretion of acid in human subjects and in dogs. Scand J Gastroenterol 1971; 6: 693-8.
    • (1971) Scand J Gastroenterol , vol.6 , pp. 693-698
    • Andersson, S.1    Carlson, L.A.2    Oro, L.3
  • 82
    • 7044253250 scopus 로고    scopus 로고
    • Ocular side effects from herbal medicines and nutritional supplements
    • Fraunfelder FW. Ocular side effects from herbal medicines and nutritional supplements. Am J Ophthalmol 2004; 138: 639-47.
    • (2004) Am J Ophthalmol , vol.138 , pp. 639-647
    • Fraunfelder, F.W.1
  • 83
    • 33646233216 scopus 로고    scopus 로고
    • Optical coherence tomography findings in niacin maculopathy
    • Dajani HM, Lauer AK. Optical coherence tomography findings in niacin maculopathy. Can J Ophthalmol 2006; 41: 197-200.
    • (2006) Can J Ophthalmol , vol.41 , pp. 197-200
    • Dajani, H.M.1    Lauer, A.K.2
  • 84
    • 0038619070 scopus 로고    scopus 로고
    • Optical coherence tomography findings in nicotinic acid maculopathy
    • Spirn MJ, Warren FA, Guyer DR, et al. Optical coherence tomography findings in nicotinic acid maculopathy. Am J Ophthalmol 2003; 135: 913-4.
    • (2003) Am J Ophthalmol , vol.135 , pp. 913-914
    • Spirn, M.J.1    Warren, F.A.2    Guyer, D.R.3
  • 86
    • 0024264055 scopus 로고
    • Niacin maculopathy
    • Jampol LM. Niacin maculopathy. Ophthalmology 1988; 95: 1704-5.
    • (1988) Ophthalmology , vol.95 , pp. 1704-1705
    • Jampol, L.M.1
  • 87
    • 0037230621 scopus 로고    scopus 로고
    • Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects
    • Gadegbeku CA, Dhandayuthapani A, Shrayyef MZ, et al. Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects. Am J Hypertens 2003; 16: 67-71.
    • (2003) Am J Hypertens , vol.16 , pp. 67-71
    • Gadegbeku, C.A.1    Dhandayuthapani, A.2    Shrayyef, M.Z.3
  • 88
    • 0033812857 scopus 로고    scopus 로고
    • Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects
    • Kelly JJ, Lawson JA, Campbell LV, et al. Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects. J Hum Hypertens 2000; 14: 567-72.
    • (2000) J Hum Hypertens , vol.14 , pp. 567-572
    • Kelly, J.J.1    Lawson, J.A.2    Campbell, L.V.3
  • 89
    • 60449103180 scopus 로고    scopus 로고
    • Blood pressurelowering effects of extended-release niacin alone and extendedrelease niacin/laropiprant combination: A post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients
    • Bays HE, Maccubbin D, Meehan AG, et al. Blood pressurelowering effects of extended-release niacin alone and extendedrelease niacin/laropiprant combination: a post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients. Clin Ther 2009; 31: 115-22.
    • (2009) Clin Ther , vol.31 , pp. 115-122
    • Bays, H.E.1    McCubbin, D.2    Meehan, A.G.3
  • 90
    • 57649202648 scopus 로고    scopus 로고
    • Does nicotinic acid (niacin) lower blood pressure?
    • Bays HE, Rader DJ. Does nicotinic acid (niacin) lower blood pressure? Int J Clin Pract 2009; 63: 151-9.
    • (2009) Int J Clin Pract , vol.63 , pp. 151-159
    • Bays, H.E.1    Rader, D.J.2
  • 91
    • 33745369351 scopus 로고    scopus 로고
    • Endothelial and antithrombotic actions of HDL
    • Mineo C, Deguchi H, Griffin JH, et al. Endothelial and antithrombotic actions of HDL. Circ Res 2006; 98: 1352-64.
    • (2006) Circ Res , vol.98 , pp. 1352-1364
    • Mineo, C.1    Deguchi, H.2    Griffin, J.H.3
  • 93
    • 33846090652 scopus 로고    scopus 로고
    • Vasodilation in resistance arteries is related to the apolipoprotein B/A1 ratio in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    • Lind L. Vasodilation in resistance arteries is related to the apolipoprotein B/A1 ratio in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis 2007; 190: 378-84.
    • (2007) Atherosclerosis , vol.190 , pp. 378-384
    • Lind, L.1
  • 94
    • 0026021035 scopus 로고
    • Coronary drug project: Experience with niacin. Coronary Drug Project Research Group
    • Berge KG, Canner PL. Coronary drug project: experience with niacin. Coronary Drug Project Research Group. Eur J Clin Pharmacol 1991; 40(Suppl 1): S49-51.
    • (1991) Eur J Clin Pharmacol , vol.40 , Issue.SUPPL 1 , pp. 49-51
    • Berge, K.G.1    Canner, P.L.2
  • 95
    • 0024605599 scopus 로고
    • Nicotinic acid-associated myopathy: A report of three cases
    • Litin SC, Anderson CF. Nicotinic acid-associated myopathy: a report of three cases. Am J Med 1989; 86: 481-3.
    • (1989) Am J Med , vol.86 , pp. 481-483
    • Litin, S.C.1    Anderson, C.F.2
  • 97
    • 0025678697 scopus 로고
    • Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year followup
    • Cashin-Hemphill L, Mack WJ, Pogoda JM, et al. Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year followup. JAMA 1990; 264: 3013-7.
    • (1990) JAMA , vol.264 , pp. 3013-3017
    • Cashin-Hemphill, L.1    Mack, W.J.2    Pogoda, J.M.3
  • 98
    • 0034191863 scopus 로고    scopus 로고
    • Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia
    • Goldberg A, Alagona P Jr, Capuzzi DM, et al. Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. Am J Cardiol 2000; 85: 1100-5.
    • (2000) Am J Cardiol , vol.85 , pp. 1100-1105
    • Goldberg, A.1    Alagona Jr., P.2    Capuzzi, D.M.3
  • 99
    • 0023697436 scopus 로고
    • Efficacy and long-term adverse effect pattern of lovastatin
    • Tobert JA. Efficacy and long-term adverse effect pattern of lovastatin. Am J Cardiol 1988; 62: 28J-34J.
    • (1988) Am J Cardiol , vol.62
    • Tobert, J.A.1
  • 100
    • 0029166810 scopus 로고
    • Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors
    • Garnett WR. Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm 1995; 52: 1639-45.
    • (1995) Am J Health Syst Pharm , vol.52 , pp. 1639-1645
    • Garnett, W.R.1
  • 101
    • 0037443567 scopus 로고    scopus 로고
    • Comparison of oncedaily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Vs. Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE])
    • Bays HE, Dujovne CA, McGovern ME, et al. Comparison of oncedaily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Vs. Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]). Am J Cardiol 2003; 91: 667-72.
    • (2003) Am J Cardiol , vol.91 , pp. 667-672
    • Bays, H.E.1    Dujovne, C.A.2    McGovern, M.E.3
  • 102
    • 3242717055 scopus 로고    scopus 로고
    • Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) study
    • Rubenfire M. Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) study. Am J Cardiol 2004; 94: 306-11.
    • (2004) Am J Cardiol , vol.94 , pp. 306-311
    • Rubenfire, M.1
  • 103
    • 0029149881 scopus 로고
    • The prevalence of side effects with regular and sustained-release nicotinic acid
    • Gibbons LW, Gonzalez V, Gordon N, et al. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995; 99: 378-85.
    • (1995) Am J Med , vol.99 , pp. 378-385
    • Gibbons, L.W.1    Gonzalez, V.2    Gordon, N.3
  • 104
    • 0022592551 scopus 로고
    • Dose dependence of nicotinic acid-induced hyperbilirubinemia and its dissociation from hemolysis in Gilbert's syndrome
    • Gentile S, Tiribelli C, Persico M, et al. Dose dependence of nicotinic acid-induced hyperbilirubinemia and its dissociation from hemolysis in Gilbert's syndrome. J Lab Clin Med 1986; 107: 166-71.
    • (1986) J Lab Clin Med , vol.107 , pp. 166-171
    • Gentile, S.1    Tiribelli, C.2    Persico, M.3
  • 105
    • 0018662626 scopus 로고
    • Studies on nicotinic acid interaction with bilirubin metabolism
    • Ohkubo H, Musha H, Okuda K. Studies on nicotinic acid interaction with bilirubin metabolism. Dig Dis Sci 1979; 24: 700-4.
    • (1979) Dig Dis Sci , vol.24 , pp. 700-704
    • Ohkubo, H.1    Musha, H.2    Okuda, K.3
  • 106
    • 0015156391 scopus 로고
    • Oral glucose tolerance, plasma insulin, and uric acid excretion in man during chronic administration of nicotinic acid
    • Gaut ZN, Pocelinko R, Solomon HM, et al. Oral glucose tolerance, plasma insulin, and uric acid excretion in man during chronic administration of nicotinic acid. Metabolism 1971; 20: 1031-5.
    • (1971) Metabolism , vol.20 , pp. 1031-1035
    • Gaut, Z.N.1    Pocelinko, R.2    Solomon, H.M.3
  • 107
    • 0016250289 scopus 로고
    • Pharmacologic effects of nicotinic acid on human purine metabolism
    • Gershon SL, Fox IH. Pharmacologic effects of nicotinic acid on human purine metabolism. J Lab Clin Med 1974; 84: 179-86.
    • (1974) J Lab Clin Med , vol.84 , pp. 179-186
    • Gershon, S.L.1    Fox, I.H.2
  • 108
    • 47749112096 scopus 로고    scopus 로고
    • Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
    • Bahn A, Hagos Y, Reuter S, et al. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 2008; 283: 16332-41.
    • (2008) J Biol Chem , vol.283 , pp. 16332-16341
    • Bahn, A.1    Hagos, Y.2    Reuter, S.3
  • 109
    • 3242785541 scopus 로고    scopus 로고
    • Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle aged men: A prospective cohort study
    • Niskanen LK, Laaksonen DE, Nyyssonen K, et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle aged men: a prospective cohort study. Arch Intern Med 2004; 164: 1546-51.
    • (2004) Arch Intern Med , vol.164 , pp. 1546-1551
    • Niskanen, L.K.1    Laaksonen, D.E.2    Nyyssonen, K.3
  • 110
    • 0034630917 scopus 로고    scopus 로고
    • Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey
    • Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000; 283: 2404-10.
    • (2000) JAMA , vol.283 , pp. 2404-2410
    • Fang, J.1    Alderman, M.H.2
  • 111
    • 0033529386 scopus 로고    scopus 로고
    • Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study
    • Culleton BF, Larson MG, Kannel WB, et al. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131: 7-13.
    • (1999) Ann Intern Med , vol.131 , pp. 7-13
    • Culleton, B.F.1    Larson, M.G.2    Kannel, W.B.3
  • 112
    • 33846023704 scopus 로고    scopus 로고
    • Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study
    • Athyros VG, Mikhailidis DP, Liberopoulos EN, et al. Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: a subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study. Nephrol Dial Transplant 2007; 22: 118-27.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 118-127
    • Athyros, V.G.1    Mikhailidis, D.P.2    Liberopoulos, E.N.3
  • 113
    • 0347093525 scopus 로고    scopus 로고
    • The effect of short-term treatment with simvastatin on renal function in patients with peripheral arterial disease
    • Youssef F, Gupta P, Seifalian AM, et al. The effect of short-term treatment with simvastatin on renal function in patients with peripheral arterial disease. Angiology 2004; 55: 53-62.
    • (2004) Angiology , vol.55 , pp. 53-62
    • Youssef, F.1    Gupta, P.2    Seifalian, A.M.3
  • 114
    • 0026559912 scopus 로고
    • Niacin-induced clotting factor synthesis deficiency with coagulopathy
    • Dearing BD, Lavie CJ, Lohmann TP, et al. Niacin-induced clotting factor synthesis deficiency with coagulopathy. Arch Intern Med 1992; 152: 861-3.
    • (1992) Arch Intern Med , vol.152 , pp. 861-863
    • Dearing, B.D.1    Lavie, C.J.2    Lohmann, T.P.3
  • 115
    • 0033809508 scopus 로고    scopus 로고
    • Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)
    • Chesney CM, Elam MB, Herd JA, et al. Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT). Am Heart J 2000; 140: 631-6.
    • (2000) Am Heart J , vol.140 , pp. 631-636
    • Chesney, C.M.1    Elam, M.B.2    Herd, J.A.3
  • 116
    • 42949172414 scopus 로고    scopus 로고
    • The role of fibrinogen and fibrinolysis in peripheral arterial disease
    • Paraskevas KI, Baker DM, Vrentzos GE, et al. The role of fibrinogen and fibrinolysis in peripheral arterial disease. Thromb Res 2008; 122: 1-12.
    • (2008) Thromb Res , vol.122 , pp. 1-12
    • Paraskevas, K.I.1    Baker, D.M.2    Vrentzos, G.E.3
  • 118
    • 77950959254 scopus 로고    scopus 로고
    • Hypophosphatemic effect of niacin in patients without renal failure: A randomized trial
    • Maccubbin D, Tipping D, Kuznetsova O, et al. Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial. Clin J Am Soc Nephrol 2010; 5: 582-9.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 582-589
    • McCubbin, D.1    Tipping, D.2    Kuznetsova, O.3
  • 119
    • 26044474486 scopus 로고    scopus 로고
    • Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodiumdependent phosphate transporter in rats with adenine-induced renal failure
    • Eto N, Miyata Y, Ohno H, et al. Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodiumdependent phosphate transporter in rats with adenine-induced renal failure. Nephrol Dial Transplant 2005; 20: 1378-84.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 1378-1384
    • Eto, N.1    Miyata, Y.2    Ohno, H.3
  • 120
    • 77954267949 scopus 로고    scopus 로고
    • Medication-induced hypophosphatemia: A review
    • Liamis G, Milionis HJ, Elisaf M. Medication-induced hypophosphatemia: a review. QJM 2010; 103: 449-59.
    • (2010) QJM , vol.103 , pp. 449-459
    • Liamis, G.1    Milionis, H.J.2    Elisaf, M.3
  • 121
    • 79959922391 scopus 로고    scopus 로고
    • Niacin toxicity resulting from urine drug test evasion scheme
    • [Epub ahead of printing]
    • Daul AM, Beuhler MC. Niacin toxicity resulting from urine drug test evasion scheme. J Emerg Med 2010 [Epub ahead of printing].
    • (2010) J Emerg Med
    • Daul, A.M.1    Beuhler, M.C.2
  • 122
    • 34247555774 scopus 로고    scopus 로고
    • Toxicity from the use of niacin to beat urine drug screening
    • Mittal MK, Florin T, Perrone J, et al. Toxicity from the use of niacin to beat urine drug screening. Ann Emerg Med 2007; 50: 587-90.
    • (2007) Ann Emerg Med , vol.50 , pp. 587-590
    • Mittal, M.K.1    Florin, T.2    Perrone, J.3
  • 123
    • 0026042928 scopus 로고
    • Fulminant hepatic failure following low-dose sustained-release niacin therapy in hospital
    • Fischer DJ, Knight LL, Vestal RE. Fulminant hepatic failure following low-dose sustained-release niacin therapy in hospital. West J Med 1991; 155: 410-2.
    • (1991) West J Med , vol.155 , pp. 410-412
    • Fischer, D.J.1    Knight, L.L.2    Vestal, R.E.3
  • 124
    • 0024403418 scopus 로고
    • Fulminant hepatic failure after ingestion of sustained-release nicotinic acid
    • Mullin GE, Greenson JK, Mitchell MC. Fulminant hepatic failure after ingestion of sustained-release nicotinic acid. Ann Intern Med 1989; 111: 253-5.
    • (1989) Ann Intern Med , vol.111 , pp. 253-255
    • Mullin, G.E.1    Greenson, J.K.2    Mitchell, M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.