Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling

Osteoarthritis and Cartilage

Volumn 19, Issue 7, 2011, Pages 886-894

  Kudo, S ^a   Mizuta, H ^a   Takagi, K ^a   Hiraki, Y ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Articular cartilage; Chondrogenesis; Osteochondral defects; PTH PTHrP signaling; Tissue repair

Indexed keywords

COLLAGEN TYPE 2; CYCLINE; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; RECOMBINANT PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CARTILAGINOUS TISSUE; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; FULL THICKNESS ARTICULAR CARTILAGE DEFECT; IMMUNOHISTOCHEMISTRY; JOINT CAVITY; MALE; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; TISSUE REPAIR;

ANIMALS; BIOLOGICAL MARKERS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; FEMUR; IMMUNOHISTOCHEMISTRY; MALE; MESODERM; PARATHYROID HORMONE; PROLIFERATING CELL NUCLEAR ANTIGEN; RABBITS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; WOUND HEALING;

EID: 79959991672     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.04.007     Document Type: Article

References (32)

1. Convery F., Akeson W., Koewn G. The repair of osteochondral defects: an experimental study in horses. Clin Orthop 1972, 82:253-262.
2. Shapiro F., Koide S., Glimcher M.J. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am 1993, 75:532-553.
3. Otsuka Y., Mizuta H., Takagi K., Iyama K., Yoshitake Y., Nishikawa K., et al. Requirement of fibroblast growth factor signaling for regeneration of epiphyseal morphology in rabbit full-thickness defects of articular cartilage. Dev Growth Differ 1997, 39:143-156.
4. Mizuta H., Kudo S., Nakamura E., Otsuka Y., Takagi K., Hiraki Y. Active proliferation of mesenchymal cells prior to the chondrogenic repair response in rabbit full-thickness defects of articular cartilage. Osteoarthritis Cartilage 2004, 12:586-596.
5. Hall B.K., Miyake T. All for one and one for all: condensations and the initiation of skeletal development. Bioessays 2000, 22:138-147.
6. Chuma H., Mizuta H., Kudo S., Takagi K., Hiraki Y. One day exposure to FGF-2 was sufficient for the regenerative repair of full-thickness defects of articular cartilage in rabbits. Osteoarthritis Cartilage 2004, 12:834-842.
7. Ishii I., Mizuta H., Sei A., Hirose J., Kudo S., Hiraki Y. Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant. J Bone Joint Surg Br 2007, 89:693-700.
8. Kudo S., Mizuta H., Otsuka Y., Takagi K., Hiraki Y. Inhibition of chondrogenesis by parathyroid hormone in vivo during repair of full-thickness defects of articular cartilage. J Bone Miner Res 2000, 15:253-260.
9. Mizuta H., Kudo S., Nakamura E., Takagi K., Hiraki Y. Expression of the PTH/PTHrP receptor in chondrogenic cells during the repair of full-thickness defects of articular cartilage. Osteoarthritis Cartilage 2006, 14:944-952.
10. Gardella T.J., Rubin D., Abou-Samra A.B., Keutmann H.T., Potts J.T., Kronenberg H.M., et al. Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein. J Biol Chem 1990, 265:15854-15859.
11. Pineda S., Pollack A., Stevenson S., Goldberg V., Caplan A. A semiquantitative scale for histologic grading of articular cartilage repair. Acta Anat (Basel) 1992, 143:335-340.
12. O'Driscoll S.W., Keeley F.W., Salter R.B. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. J Bone Joint Surg Am 1988, 70:595-606.
13. Takeuchi N., Suzuki Y., Sagehashi Y., Yamaguchi T., Itoh H., Iwata H. Histologic examination of meniscal repair in rabbits. Clin Orthop Relat Res 1997, 338:253-261.
14. Iyama K., Ninomiya Y., Olsen B.R., Linsenmayer T.F., Trelstad R.L., Hayashi M. Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification. Anat Rec 1991, 229:462-472.
15. Aizawa T., Kokubun S., Tanaka Y. Apoptosis and proliferation of growth plate chondrocytes in rabbits. J Bone Joint Surg Br 1997, 79:483-486.
16. Amizuka N., Lee H.S., Kwan M.Y., Arazani A., Warshawsky H., Hendy G.N., et al. Cell-specific expression of the parathyroid hormone (PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters. Endocrinology 1997, 138:469-481.
17. Kassem M., Abdallah B.M. Human bone-marrow-derived mesenchymal stem cells: biological characteristics and potential role in therapy of degenerative diseases. Cell Tissue Res 2008, 331:157-163.
18. Oreffo R.O., Cooper C., Mason C., Clements M. Mesenchymal stem cells: lineage, plasticity, and skeletal therapeutic potential. Stem Cell Rev 2005, 1:169-178.
19. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
20. Anraku Y., Mizuta H., Sei A., Kudo S., Nakamura E., Senba K., et al. Analyses of early events during chondrogenic repair in rat full-thickness articular cartilage defects. J Bone Miner Metab 2009, 27:272-286.
21. Anraku Y., Mizuta H., Sei A., Kudo S., Nakamura E., Senba K., et al. The chondrogenic repair response of undifferentiated mesenchymal cells in rat full-thickness articular cartilage defects. Osteoarthritis Cartilage 2008, 16:961-964.
22. Chen X., Macica C.M., Dreyer B.E., Hammond V.E., Hens J.R., Philbrick W.M., et al. Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J Bone Miner Res 2006, 21:113-123.
23. Chen X., Macica C.M., Nasiri A., Broadus A.E. Regulation of articular chondrocyte proliferation and differentiation by Indian hedgehog and parathyroid hormone-related protein in mice. Arthritis Rheum 2008, 58:3788-3797.
24. Kronenberg H.M. PTHrP and skeletal development. Ann N Y Acad Sci 2006, 1068:1-13.
25. Alkhiary Y.M., Gerstenfeld L.C., Krall E., Westmore M., Sato M., Mitlak B.H., et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am 2005, 87:731-741.
26. Andreassen T.T., Willick G.E., Morley P., Whitfield J.F. Treatment with parathyroid hormone hPTH(1-34), hPTH(1-31), and monocyclic hPTH(1-31) enhances fracture strength and callus amount after withdrawal fracture strength and callus mechanical quality continue to increase. Calcif Tissue Int 2004, 74:351-356.
27. Komatsubara S., Mori S., Mashiba T., Nonaka K., Seki A., Akiyama T., et al. Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone 2005, 36:678-687.
28. Nakazawa T., Nakajima A., Shiomi K., Moriya H., Einhorn T.A., Yamazaki M. Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing. Bone 2005, 37:711-719.
29. Shukunami C., Shigeno C., Atsumi T., Ishizeki K., Suzuki F., Hiraki Y. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor. J Cell Biol 1996, 133:457-468.
30. Bodine P.V., Seestaller-Wehr L., Kharode Y.P., Bex F.J., Komm B.S. Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1. J Cell Physiol 2007, 210:352-357.
31. Kakar S., Einhorn T.A., Vora S., Miara L.J., Hon G., Wigner N.A., et al. Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. J Bone Miner Res 2007, 22:1903-1912.
32. Yao W., Cheng Z., Shahnazari M., Dai W., Johnson M.L., Lane N.E. Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects. J Bone Miner Res 2010, 25:190-199.