Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and d-amphetamine models of schizophrenia

Psychopharmacology

Volumn 216, Issue 2, 2011, Pages 235-243

  Profaci, Caterina P ^a   Krolikowski, Kristyn A ^a   Olszewski, Rafal T ^a   Neale, Joseph H ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

d Amphetamine; LY354740; Metabotropic glutamate receptor; N acetylaspartylglutamate; NAAG; PCP; PPI; Schizophrenia

Indexed keywords

2 PMPA; DEXAMPHETAMINE; EGLUMETAD; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; PHENCYCLIDINE; UNCLASSIFIED DRUG; ZJ 43;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DBA 2 MOUSE; DRUG EFFECT; DRUG EFFICACY; MOUSE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; SCHIZOPHRENIA; STARTLE REFLEX;

ANIMALS; BICYCLO COMPOUNDS; DEXTROAMPHETAMINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GLUTAMATE CARBOXYPEPTIDASE II; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; ORGANOPHOSPHORUS COMPOUNDS; PHENCYCLIDINE; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA; SPECIES SPECIFICITY; STARTLE REACTION; UREA;

EID: 79959971545     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2200-0     Document Type: Article

References (64)

1. MO Adedoyin S Vicini JH Neale 2010 Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic placticity/transmission in the amygdala in a mouse model of inflammatory pain Mol Pain 6 60 78 20860833
2. PR Albert L Robillard 2002 G protein specificity: traffic direction required Cell Signal 14 407 418 11882385 10.1016/S0898-6568(01)00259-5 1:CAS:528:DC%2BD38Xhs1ylsrk%3D (Pubitemid 34214845)
3. M Ambrosio A Zürn MJ Lohse 2011 Sensing G protein-coupled receptor activation Neuropharmacology 60 45 51 20727363 10.1016/j.neuropharm.2010.08.006 1:CAS:528:DC%2BC3cXhsVaitLzJ
4. DJ Bacich E Ramadan DS O'Keefe N Bukhari I Wegorzewska O Ojeifo R Olszewski CC Wrenn T Bzdega B Wroblewska WDW Heston JH Neale 2002 Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate J Neurochem 83 20 29 12358725 10.1046/j.1471-4159.2002.01117.x 1:CAS:528:DC%2BD38XnvVGgsL0%3D
5. VP Bakshi NR Swerdlow MA Geyer 1994 Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response J Pharmacol Exp Ther 271 787 794 7965797 1:CAS:528:DyaK2MXisVOqu7o%3D (Pubitemid 24377766)
6. Becker I, Lodder J, Gieselmann V, Eckhardt M (2010) Molecular characterization of N-acetylaspartylglutamate synthetase. The Journal of biological chemistry (e-pub July 2010)
7. DL Braff MA Geyer NR Swerdlow 2001 Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies Psychopharmacology 156 234 258 11549226 10.1007/s002130100810 1:CAS:528:DC%2BD3MXmtlCqtbY%3D (Pubitemid 32705488)
8. T Bzdega T Turi B Wroblewska D She HS Chung H Kim JH Neale 1997 Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library J Neurochem 69 2270 2277 9375657 10.1046/j.1471-4159.1997. 69062270.x 1:CAS:528:DyaK2sXntlKmu7g%3D (Pubitemid 27495411)
9. T Bzdega SL Crowe ER Ramadan KH Sciarretta RT Olszewski OA Ojeifo VA Rafalski B Wroblewska JH Neale 2004 The cloning and characterization of a second brain enzyme with NAAG peptidase activity J Neurochem 89 627 635 15086519 10.1111/j.1471-4159.2004.02361.x 1:CAS:528:DC%2BD2cXjslWqu70%3D (Pubitemid 38534148)
10. RE Carter AR Feldman JT Coyle 1996 Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase Proc Natl Acad Sci USA 93 749 753 8570628 10.1073/pnas.93.2.749 1:CAS:528:DyaK28XnslOksA%3D%3D (Pubitemid 26041162)
11. J Cartmell DD Schoepp 2000 Regulation of neurotransmitter release by metabotropic glutamate receptors J Neurochem 75 889 907 10936169 10.1046/j.1471-4159.2000.0750889.x 1:CAS:528:DC%2BD3cXmtFykurY%3D (Pubitemid 30660476)
12. J Cartmell JA Monn DD Schoepp 1999 The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats J Pharmacol Exp Ther 291 161 170 10490900 1:CAS:528:DyaK1MXmtlaks7g%3D (Pubitemid 29451586)
13. J Cartmell JA Monn DD Schoepp 2000 The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing Eur J Pharmacol 400 221 224 10988337 10.1016/S0014-2999(00)00423-4 1:CAS:528: DC%2BD3cXkvFSlsrg%3D (Pubitemid 30438730)
14. J Cartmell JA Monn DD Schoepp 2000 Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine Psychopharmacology 148 423 429 10928316 10.1007/s002130050072 1:CAS:528:DC%2BD3cXislSkurs%3D (Pubitemid 30169761)
15. LE Chavez-Noriega H Schaffhauser UC Campbell 2002 Metabotropic glutamate receptors: potential drug targets for the treatment of schizophrenia Curr Drug Targets CNS Neurol Disord 1 261 281 12769619 10.2174/1568007023339337 1:CAS:528:DC%2BD38XjvFKgtrk%3D
16. M Chopra Y Yao TJ Blake DR Hampson EC Johnson 2009 The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor J Pharmacol Exp Ther 330 212 219 19389924 10.1124/jpet.109.152553 1:CAS:528:DC%2BD1MXosFeltbs%3D
17. F Collard V Stroobant P Lamosa CN Kapanda DM Lambert GG Muccioli JH Poupaert F Opperdoes E Van Schaftingen 2010 Molecular identification of N-acetylaspartylglutamate synthase and {beta}-citrylglutamate synthase J Biol Chem 285 29826 29833 20657015 10.1074/jbc.M110.152629 1:CAS:528: DC%2BC3cXhtFKks7fO
18. PJ Conn CW Lindsley CK Jones 2009 Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia Trends Pharmacol Sci 30 25 31 19058862 10.1016/j.tips.2008.10.006 1:CAS:528: DC%2BD1MXktlygsg%3D%3D
19. PA Csomor BK Yee FX Vollenweider J Feldon T Nicolet BB Quednow 2008 On the influence of baseline startle reactivity on the indexation of prepulse inhibition Behav Neurosci 122 885 900 18729642 10.1037/0735-7044.122.4.885
20. D Dietrich T Kral H Clusmann M Friedl J Schramm 2002 Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus Neuropharmacology 42 297 305 11897108 10.1016/S0028-3908(01)00193-9 1:CAS:528:DC%2BD38XhvVCjs70%3D (Pubitemid 34230482)
21. R Farazifard SH Wu 2010 Metabotropic glutamate receptors modulate glutamatergic and GABAergic synaptic transmission in the central nucleus of the inferior colliculus Brain Res 1325 28 40 20153735 10.1016/j.brainres.2010.02.021 1:CAS:528:DC%2BC3cXktlGntrw%3D
22. MJ Fell KA Svensson BG Johnson DD Schoepp 2008 Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R, 4S, 5S, 6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4, 6-dicarboxylic acid (LY404039) J Pharmacol Exp Ther 326 209 217 18424625 10.1124/jpet.108.136861 1:CAS:528:DC%2BD1cXotlyltrw%3D (Pubitemid 351872145)
23. A Fricker MHS Mok R de la Flor AJ Shah M Woolley LA Dawson JNC Kew 2009 May-Jun) Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR Neuropharmacology 56 1060 1067 19285517 10.1016/j.neuropharm.2009.03.002 1:CAS:528:DC%2BD1MXls1GkurY%3D
24. R Galici NG Echemendia AL Rodriguez PJ Conn 2005 A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity J Pharmacol Exp Ther 315 1181 1187 16123306 10.1124/jpet.105.091074 1:CAS:528:DC%2BD2MXhtlalurjJ (Pubitemid 41635406)
25. Geyer MA, Dulawa SC (2003) Assessment of murine startle reactivity, prepulse inhibition, and habituation. Current protocols in neuroscience / editorial board, Jacqueline N Crawley [et al ] Chapter 8:Unit 8.17
26. MA Geyer B Ellenbroek 2003 Animal behavior models of the mechanisms underlying antipsychotic atypicality Prog neuro-psychopharmacol biol psychiatry 27 1071 1079 10.1016/j.pnpbp.2003.09.003 1:CAS:528:DC%2BD3sXpt1Sgt7c%3D (Pubitemid 37464953)
27. MA Geyer K Krebs-Thomson DL Braff NR Swerdlow 2001 Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Psychopharmacology 156 117 154 11549216 10.1007/s002130100811 1:CAS:528:DC%2BD3MXmtlCqtLY%3D (Pubitemid 32702206)
28. MA Geyer KL McIlwain R Paylor 2002 Mouse genetic models for prepulse inhibition: an early review Mol Psychiatry 7 1039 1053 12476318 10.1038/sj.mp.4001159 1:CAS:528:DC%2BD38XptlyksLk%3D (Pubitemid 36044262)
29. AL Halberstadt 1995 The phencyclidine-glutamate model of schizophrenia Clin Neuropharmacol 18 237 249 8635182 10.1097/00002826-199506000-00004 1:CAS:528:DyaK28XitVKhsL8%3D
30. W Hasenkamp MP Epstein A Green L Wilcox W Boshoven B Lewison E Duncan 2010 Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families Psychiatry Res 178 236 244 20483176 10.1016/j.psychres.2009.11.012
31. SA Henry V Lehmann-Masten F Gasparini MA Geyer A Markou 2002 The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity Neuropharmacology 43 1199 1209 12527469 10.1016/S0028-3908(02)00332-5 1:CAS:528:DC%2BD3sXislOguw%3D%3D (Pubitemid 36084431)
32. JF Heubach U Ravens AJ Kaumann 2004 Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart Mol Pharmacol 65 1313 1322 15102960 10.1124/mol.65.5.1313 1:CAS:528:DC%2BD2cXjsFKgt7s%3D (Pubitemid 38543502)
33. KE Hutchison R Swift 1999 Effect of d-amphetamine on prepulse inhibition of the startle reflex in humans Psychopharmacology 143 394 400 10367557 10.1007/s002130050964 1:CAS:528:DyaK1MXjs1eks70%3D (Pubitemid 29222485)
34. G Imre A Salomons M Jongsma DS Fokkema JA Den Boer GJ Ter Horst 2006 Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat Pharmacol Biochem Behav 84 392 399 16857251 10.1016/j.pbb.2006.05.021 1:CAS:528:DC%2BD28XptFCiu78%3D (Pubitemid 44292240)
35. KJ Jackson CL Walters MF Miles BR Martin MI Damaj 2009 Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice Neuropharmacology 57 347 355 19619563 10.1016/j.neuropharm.2009.07.020 1:CAS:528:DC%2BD1MXhtVeis73K
36. DC Javitt 2007 Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions Int Rev Neurobiol 78 69 108 17349858 10.1016/S0074-7742(06)78003-5 1:CAS:528: DC%2BD2sXmt1Gmt74%3D
37. DC Javitt SR Zukin 1991 Recent advances in the phencyclidine model of schizophrenia Am J Psychiatry 148 1301 1308 1654746 1:STN:280: DyaK3MznslymsA%3D%3D
38. PM Lea B Wroblewska JM Sarvey JH Neale 2001 beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor J Neurophysiol 85 1097 1106 11247980 1:CAS:528:DC%2BD3MXktVaqtb4%3D (Pubitemid 32209597)
39. A Linden BG Johnson N Trokovic ER Korpi DD Schoepp 2009 Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495 Neuropharmacology 57 172 182 19477188 10.1016/j.neuropharm.2009.05.002 1:CAS:528:DC%2BD1MXos12qsbg%3D
40. G Liu L Robillard B Banihashemi PR Albert 2002 Growth hormone-induced diacylglycerol and ceramide formation via Galpha i3 and Gbeta gamma in GH4 pituitary cells. Potentiation by dopamine-D2 receptor activation J Biol Chem 277 48427 48433 12376552 10.1074/jbc.M202130200 1:CAS:528:DC%2BD38Xptlegtr8%3D (Pubitemid 35470800)
41. R Luthi-Carter UV Berger AK Barczak M Enna JT Coyle 1998 Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II Proc Natl Acad Sci USA 95 3215 3220 9501243 10.1073/pnas.95.6.3215 1:CAS:528: DyaK1cXitV2itLc%3D (Pubitemid 28135882)
42. CD Mills GY Xu DJ McAdoo CE Hulsebosch 2001 Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat J Neurochem 79 835 848 11723176 10.1046/j.1471-4159.2001. 00630.x 1:CAS:528:DC%2BD3MXosl2ksLc%3D (Pubitemid 33086521)
43. Moghaddam B, Adams BW (1998) Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science (New York, N Y ) 281:1349-1352 (Pubitemid 28406826)
44. J Nagel I Belozertseva S Greco V Kashkin A Malyshkin A Jirgensons E Shekunova B Eilbacher A Bespalov W Danysz 2006 Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration Neuropharmacology 51 1163 1171 16926034 10.1016/j.neuropharm.2006.07.018 1:CAS:528:DC%2BD28Xht1ertrbE (Pubitemid 44715967)
45. JH Neale T Bzdega B Wroblewska 2000 N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system J Neurochem 75 443 452 10899918 10.1046/j.1471-4159.2000.0750443.x 1:CAS:528:DC%2BD3cXltFClsbc%3D (Pubitemid 30485424)
46. JH Neale RT Olszewski LM Gehl B Wroblewska T Bzdega 2005 The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia Trends Pharmacol Sci 26 477 484 16055199 1:CAS:528:DC%2BD2MXpslCgsLg%3D (Pubitemid 41207880)
47. RT Olszewski N Bukhari J Zhou AP Kozikowski JT Wroblewski S Shamimi-Noori B Wroblewska T Bzdega S Vicini FB Barton JH Neale 2004 NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR J Neurochem 89 876 885 15140187 10.1111/j.1471-4159.2004.02358.x 1:CAS:528:DC%2BD2cXksVyksLg%3D (Pubitemid 38684735)
48. RT Olszewski MM Wegorzewska AC Monteiro KA Krolikowski J Zhou AP Kozikowski K Long J Mastropaolo SI Deutsch JH Neale 2008 Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors Biol Psychiatry 63 86 91 17597589 10.1016/j.biopsych.2007.04.016 1:CAS:528:DC%2BD2sXhsVCgur3O (Pubitemid 350234887)
49. LS Pilowsky RA Bressan JM Stone K Erlandsson RS Mulligan JH Krystal PJ Ell 2006 First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients Mol Psychiatry 11 118 119 16189506 10.1038/sj.mp.4001751 1:CAS:528:DC%2BD28XnsV2msg%3D%3D (Pubitemid 43164609)
50. NK Popova VS Naumenko MA Tibelkina AV Kulikov 2009 Serotonin Transporter, 5-HT1A receptor and behavior in DBA/2J mice in comparison to four inbred mouse strains J Neurosci Res 87 3649 3657 19533737 10.1002/jnr.22155 1:CAS:528:DC%2BD1MXht1yrsLrP
51. ERG Sanabria KM Wozniak BS Slusher A Keller 2004 GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism J Neurophysiol 91 182 193 12917384 10.1152/jn.00465.2003 (Pubitemid 38084363)
52. G Sandner NM Canal 2007 Relationship between PPI and baseline startle response Cogn Neurodyn 1 27 37 19003494 10.1007/s11571-006-9008-3
53. R Schreiber D Lowe A Voerste J De Vry 2000 LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine Eur J Pharmacol 388 R3 R4 10666513 10.1016/S0014-2999(99)00844-4 1:CAS:528:DC%2BD3cXpsVWqsA%3D%3D (Pubitemid 30077509)
54. EB Shubenina VS Kudrin PM Klodt AA Pokrovskǐ TA Gudasheva TA Voronina RU Ostrovskaia 2008 Jul-Aug) [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept] Eksp Klin Farmakol 71 7 10 18819433 1:CAS:528:DC%2BD1cXhtFarsLbI
55. BS Slusher JJ Vornov AG Thomas PD Hurn I Harukuni A Bhardwaj RJ Traystman MB Robinson P Britton XC Lu FC Tortella KM Wozniak M Yudkoff BM Potter PF Jackson 1999 Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury Nat Med 5 1396 1402 10581082 10.1038/70971 1:CAS:528:DyaK1MXnvFGjsLc%3D
56. RE Steinpreis KA Anders EM Branda CK Kruschel 1999 The effects of atypical antipsychotics and phencyclidine (PCP) on rotorod performance Pharmacol Biochem Behav 63 387 394 10418778 10.1016/S0091-3057(99)00010-6 1:CAS:528:DyaK1MXksVWhs7g%3D (Pubitemid 29287154)
57. D Wahlsten A Bachmanov DA Finn JC Crabbe 2006 Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades Proc Natl Acad Sci USA 103 16364 16369 17053075 10.1073/pnas.0605342103 1:CAS:528:DC%2BD28Xht1WmsLvI (Pubitemid 44715202)
58. B Wroblewska IN Wegorzewska T Bzdega RT Olszewski JH Neale 2006 Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes J Neurochem 96 1071 1077 16417588 10.1111/j.1471-4159.2005.03569.x 1:CAS:528:DC%2BD28XivFWjsrk%3D
59. Wroblewska B, Wegorzewska IN, Bzdega T, Neale JH (2010) Metabotropic glutamate receptor (mGluR2) fails to negatively couple to cGMP in stably transfected cells. Neurochemistry International e-pub Dec 14 2010
60. T Yamamoto N Nozaki-Taguchi Y Sakashita 2001 Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat Brain Res 909 138 144 11478930 10.1016/S0006-8993(01)02650-6 1:CAS:528:DC%2BD3MXls1ejsL8%3D (Pubitemid 32710127)
61. T Yamamoto O Saito T Aoe A Bartolozzi J Sarva J Zhou A Kozikowski B Wroblewska T Bzdega JH Neale 2007 Local administration of N- acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats Eur J Neurosci 25 147 158 17241276 10.1111/j.1460-9568.2006.05272.x (Pubitemid 46098894)
62. T Yamamoto A Kozikowski J Zhou JH Neale 2008 Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain Mol Pain 4 31 18673570 10.1186/1744-8069-4-31
63. J Zhao E Ramadan M Cappiello B Wroblewska T Bzdega JH Neale 2001 NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance Eur J Neurosci 13 340 346 11168538 1:STN:280: DC%2BD3M3ktl2nuw%3D%3D (Pubitemid 32142478)
64. C Zhong X Zhao KC Van T Bzdega A Smyth J Zhou AP Kozikowski J Jiang WT O'Connor RF Berman JH Neale BG Lyeth 2006 NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat J Neurochem 97 1015 1025 16606367 10.1111/j.1471-4159.2006.03786.x 1:CAS:528:DC%2BD28XlsVOntrs%3D