Neurotrophic receptors as potential therapy targets in postnatal development, in adult, and in hearing loss-affected inner ear

Otology and Neurotology

Volumn 32, Issue 5, 2011, Pages 761-773

  Bitsche, Mario ^a   Dudas, Jozsef ^a   Roy, Soumen ^a   Potrusil, Thomas ^a   Schmutzhard, Joachim ^a   Schrott Fischer, Anneliese ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Brain derived neurotrophic factor; Hearing loss; Immunohistochemistry; Inner ear gene delivery; Neurotrophin 3; Trk gene expression

Indexed keywords

NERVE GROWTH FACTOR RECEPTOR;

AGING; ANIMAL; ARTICLE; HEARING; HEARING LOSS; INNER EAR; METABOLISM; MOUSE; NEWBORN; PHYSIOLOGY;

AGING; ANIMALS; ANIMALS, NEWBORN; EAR, INNER; HEARING; HEARING LOSS; MICE; RECEPTORS, NERVE GROWTH FACTOR;

EID: 79959952610     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e31821f7cc1     Document Type: Article

References (31)

1. Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc LondBBiol Sci 2006;361:1545-64. (Pubitemid 44450210)
2. Gestwa G, Wiechers B, Zimmermann U, et al. Differential expression oftrkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function. J Comp Neurol 1999;414: 33-49. (Pubitemid 29477140)
3. Fritzsch B, Barbacid M, Silos-Santiago I. The combined effects of TrkB and TrkC mutations on the innervation of the inner ear. IntJ Dev Neurosci 1998;16:493-505. (Pubitemid 28555717)
4. Fritzsch B, Tessarollo L, Coppola E, Reichardt LF. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Prog Brain Res 2004;146:265-78. (Pubitemid 37541388)
5. Agerman K, Hjerling-Leffler J, Blanchard MP, et al. BDNF gene replacement reveals multiple mechanisms for establishing neuro-trophin specificity during sensory nervous system development. Development 2003;130:1479-91. (Pubitemid 36527510)
6. Farinas I, Jones KR, Tessarollo L, et al. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci 2001;21:6170-80. (Pubitemid 32737749)
7. Schimmang T, Tan J, Muller M, et al. Lack of BDNF and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss. Development 2003;130:4741-50. (Pubitemid 37279425)
8. Vega JA, San J I, Cabo R, Rodriguez S, Represa J. Trks and p75 genes are differentially expressed in the inner ear of human em-bryos. What may Trks and p75 null mutant mice suggest on human development? Neurosci Lett 1999;272:103-6. (Pubitemid 29413211)
9. Glueckert R, Bitsche M, Miller JM, et al. Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor. J Comp Neurol 2008;507:1602-21. (Pubitemid 351428106)
10. Nakagawa T, Ito J. Drug delivery systems for the treatment of sensorineural hearing loss. Acta Otolaryngol Suppl 2007;30-5. (Pubitemid 46440559)
11. Philpott CM, Gane S, McKiernan D. Nanomedicine in otorhino-laryngology: what does the future hold? EurArch Otorhinolaryngol 2011;268:489-96.
12. Saber A, Strand SP, Ulfendahl M. Use of the biodegradable poly-mer chitosan as a vehicle for applying drugs to the inner ear. Eur J Pharm Sci 2010;39:110-5.
13. Roy S, Johnston AH, Newman TA, et al. Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neuro-trophin-derived peptide ligand: potential tool for drug delivery. IntJ Pharm 2010;390:214-24.
14. Coleman B, Rickard NA, de Silva MG, Shepherd RK. A protocol for cryoembedding the adult guinea pig cochlea for fluorescence immunohistology. JNeurosci Methods 2009;176:144-51.
15. Schmutzhard J, Glueckert R, Bitsche M, et al. The cochlea in fe-tuses with neural tube defects. Int J Dev Neurosci 2009;27: 669-76.
16. Schmutzhard J, Glueckert R, Sergi C, Schwentner I, Abraham I, Schrott-Fischer A. Does perinatal asphyxia induce apoptosis in the inner ear? Hear Res 2009;250:1-9.
17. Wiedemann FR, Siemen D, Mawrin C, Horn TF, Dietzmann K. The neurotrophin receptor TrkB is colocalized to mitochondrial mem-branes. Int J Biochem CellBiol 2006;38:610-20. (Pubitemid 43117584)
18. Tadros SF, D'SouzaM, ZhuX, FrisinaRD. Apoptosis-relatedgenes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 2008;13:1303-21.
19. Manji SS, Sorensen BS, Klockars T, Lam T, Hutchison W, Dahl HH. Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner ear. J Neurosci Res 2006;83:181-90. (Pubitemid 43184382)
20. Haller F, Kulle B, Schwager S, et al. Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. AnalBiochem 2004;335: 1-9. (Pubitemid 39446224)
21. Kashiba H, Uchida Y, Senba E. Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats. Brain Res Mol Brain Res 2003;110:52-62. (Pubitemid 36165042)
22. Catania S, Germana A, Cabo R, et al. Neurotrophin and Trk neu-rotrophin receptors in the inner ear of Salmo salar and Salmo trutta. J Anat 2007;210:78-88. (Pubitemid 46040503)
23. Brodeur GM, Minturn JE, Ho R, et al. Trk receptor expression and inhibition inneuroblastomas. Clin CancerRes 2009;15:3244-50.
24. Fritzsch B, Silos-Santiago I, Bianchi LM, Farinas I. The role of neurotrophic factors in regulating the development of inner ear innervation. Trends Neurosci 1997;20:159-64. (Pubitemid 27116287)
25. Fritzsch B, Silos-Santiago I, Bianchi LM, Farinas I. Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation. Semin CellDev Biol 1997;8:277-84. (Pubitemid 127346642)
26. Fritzsch B, Pirvola U, Ylikoski J. Making and breaking the inner-vation of the ear: neurotrophic support during ear development and its clinical implications. Cell Tissue Res 1999;295:369-82. (Pubitemid 29106230)
27. Schimmang T, Alvarez-Bolado G, Minichiello L, et al. Survival of inner ear sensory neurons in trk mutant mice. Mech Dev 1997;64: 77-85. (Pubitemid 27351518)
28. Segal RA. Selectivity in neurotrophin signaling: theme and varia-tions. Annu Rev Neurosci 2003;26:299-330. (Pubitemid 37064936)
29. Narui Y, Minekawa A, Iizuka T, et al. Development of distortion product otoacoustic emissions in C57BL/6J mice. Int J Audiol 2009;48:576-81.
30. Mueller KL, Jacques BE, Kelley MW. Fibroblast growth factor signaling regulates pillar cell development in the organ of Corti. J Neurosci 2002;22:9368-77. (Pubitemid 35356180)
31. Ruttiger L, Panford-Walsh R, Schimmang T, et al. BDNF mRNA expression and protein localization are changed in age-related hearing loss. Neurobiol Aging 2007;28:586-601. (Pubitemid 46282198)