Doxycycline reduces nitric oxide production in guinea pig inner ears

Auris Nasus Larynx

Volumn 38, Issue 6, 2011, Pages 671-677

  Helling, Kai ^a   Wodarzcyk, Karl ^a   Brieger, Jürgen ^a   Schmidtmann, Irene ^a   Li, Huige ^a   Mann, Wolf J ^a   Heinrich, Ulf Rüdiger ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cytoprotection; Gentamicin; Lateral wall; Organ culture; Organ of Corti; Tetracycline

Indexed keywords

DOXYCYCLINE; DOXYCYCLINHYCLAT; GENTAMICIN; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; BASAL CELL; CHEMOLUMINESCENCE; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; EVOKED BRAIN STEM AUDITORY RESPONSE; EXPERIMENTAL STUDY; HEARING LOSS; IMMUNOHISTOCHEMISTRY; INNER EAR; MALE; NONHUMAN; ORGAN CULTURE; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; SPIRAL LIGAMENT; STRIA VASCULARIS;

ANIMALS; CYTOPROTECTION; DOXYCYCLINE; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GENTAMICINS; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; LUMINESCENCE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OMEGA-N-METHYLARGININE; ORGAN CULTURE TECHNIQUES; ORGAN OF CORTI; PROSPECTIVE STUDIES; UP-REGULATION;

EID: 79959940463     PISSN: 03858146     EISSN: 18791476     Source Type: Journal    
DOI: 10.1016/j.anl.2011.02.013     Document Type: Article

References (35)

1. Blakley B.W. Update on intratympanic gentamicin for Ménière's disease. Laryngoscope 2000, 110:236-240.
2. Lange G., Maurer J., Mann W. Long-term results after interval therapy with intratympanic gentamicin for Ménière's disease. Laryngoscope 2004, 114:102-105.
3. Nakashima T., Teranishi M., Hibi T., Kobayashi M., Umemura M. Vestibular and cochlear toxicity of aminoglycosides - a review. Acta Otolaryngol 2000, 120:904-911.
4. Helling K., Schönfeld U., Clarke A.H. Treatment of Ménière's disease by low-dosage intratympanic gentamicin application - effect on otolith function. Laryngoscope 2007, 117:2244-2250.
5. Wanamaker H.H., Gruenwald L., Damm K.J., Ogata Y., Slepecky N. Dose-related vestibular and cochlear effects of transtympanic gentamicin. Am J Otol 1998, 19:170-179.
6. Takumida M., Popa R., Anniko M. Free radicals in the guinea pig inner ear following gentamicin exposure. J Otorhinolaryngol Relat Spec 1999, 61:63-70.
7. Forge A., Schacht J. Aminoglycoside antibiotics. Audiol Neurootol 2000, 5:3-22.
8. Okuda T., Sugahara K., Shimogori H., Yamashita H. Inner ear changes with intracochlear gentamicin administration in guinea pigs. Laryngoscope 2004, 114:694-697.
9. Takumida M., Anniko M. Nitric oxide in guinea pig vestibular sensory cells following gentamicin exposure in vitro. Acta Otolaryngol 2001, 121:346-350.
10. Heinrich U.R., Helling K., Sifferath M., Brieger J., Li H., Schmidtmann I., et al. Gentamicin increases NO production and induces hearing loss in guinea pigs. Laryngoscope 2008, 118:1438-1442.
11. Franz P., Hauser-Kronberger C., Böck P., Quint C., Baumgartner W.D. Localization of nitric oxide synthase I and III in the cochlea. Acta Otolaryngol 1996, 116:726-731.
12. Heinrich U.R., Maurer J., Mann W. Evidence for a possible NOS back-up system in the organ of Corti of the guinea pig. Eur Arch Otorhinolaryngol 2004, 261:121-128.
13. Liu H.Y., Chi F.L., Gao W.Y. Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea. Neuroreport 2008, 19:117-120.
14. Heinrich U.R., Selivanova O., Brieger J., Mann W. Endothelial nitric oxide synthase-upregulation in the cochlea of the guinea pig after intratympanic gentamicin injection. Eur Arch Otorhinolaryngol 2006, 263:62-68.
15. Corbacella E., Lanzoni I., Ding D., Previati M., Salvi R. Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures. Hear Res 2004, 197:11-18.
16. Ryan M.E., Ashley R.A. How do tetracyclines work?. Adv Dent Res 1998, 12:149-151.
17. Yrjänheikki J., Keinänen R., Pellikka M., Hökfelt T., Koistinaho J. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 1998, 95:15769-15774.
18. Yrjänheikki J., Tikka T., Keinänen R., Goldsteins G., Chan P.H., Koistinaho J. A tetracycline derivate, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 1999, 96:13496-13500.
19. Allaerts W., Koopman W.J.H., Verlaan B.P.J., Buzzi M., Steerenberg P.A. Endogenous production of nitric oxide and effects of nitric oxide and superoxide on melanotrope functioning in the pituitary pars intermedia of Xenopus laevis. Nitric Oxide 2000, 4:15-28.
20. Takumida M., Anniko M. Simultaneous detection of both nitric oxide and reactive oxygen species in guinea pig vestibular sensory cells. J Otorhinolaryngol Relat Spec 2002, 64:143-147.
21. Hong S.H., Park S.K., Cho Y.S., Lee H.S., Kim K.R., Kim M.G., et al. Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig. Hear Res 2006, 11:46-53.
22. Wang Y., Hirose K., Liberman M.C. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. JARO 2002, 3:248-268.
23. Helling K., Heinrich U.R., Heusgen L., Brieger J., Schmidtmann I., Li H., et al. Gentamicin alters nitric oxide production in semicircular canals and otolith organs. Laryngoscope 2010, 120:2125-2128.
24. Yamashita D., Jiang H.-Y., Schacht J., Miller J.M. Delayed production of free radicals following noise exposure. Brain Res 2004, 1019:201-209.
25. Heinrich U.R., Fischer I., Brieger J., Rümelin A., Schmidtmann I., Li H., et al. Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear. Laryngoscope 2008, 118:837-842.
26. Amin A.R., Attur M.G., Thakker G.D., Patel P.D., Vyas P.R., Patel R.N., et al. A novel mechanism of action of tetracyclines: effects on nitric oxide synthase. Proc Natl Acad Sci USA 1996, 93:14014-14019.
27. Amin A.R., Patel R.N., Thakker G.D., Lowenstein C.J., Attur M.G., Abramson S.B. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett 1997, 410:259-264.
28. Hoyt J.C., Ballering J., Numanami H., Hayden J.M., Robbins R.A. Doxycycline modulates nitric oxide production in murine lung epithelial cells. J Immunol 2006, 176:567-572.
29. Miyachi Y., Yoshioka A., Imamura S., Niwa Y. Effect of antibiotics on the generation of reactive oxygen species. J Invest Dermatol 1986, 86:449-453.
30. Kraus R.L., Pasieczny R., Lariosa-Willingham K., Turner M.S., Jiang A., Trauger J.W. Antioxidant properties and minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem 2005, 94:819-827.
31. Morimoto N., Shimazawa M., Yamashima T., Nagai H., Hara H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res 2005, 1044:8-15.
32. Whiteman M., Halliwell B. Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics. Free Radic Res 1997, 26:49-56.
33. Meli D.N., Coimbra R.S., Erhart D.G., Loquet G., Bellac C.L., Täuber M.G., et al. Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis. Infect Immun 2006, 74:3890-3896.
34. Nieman G.F., Zerker B.R. A role for the anti-inflammatory properties of tetracyclines in the prevention of acute lung injury. Curr Med Chem 2001, 8:317-325.
35. Krakauer T., Buckley M. Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines. Antimicrob Agents Chemother 2003, 47:3630-3633.