Pharmacokinetic-Pharmacodynamic Modeling of the Inhibitory Effects of Naproxen on the Time-Courses of Inflammatory Pain, Fever, and the Ex Vivo Synthesis of TXB 2 and PGE 2 in Rats

Pharmaceutical Research

Volumn 28, Issue 7, 2011, Pages 1561-1576

  Krekels, Elke H J ^a,b   Angesjö, Marie ^a   Sjögren, Ingemo ^a   Ängeby Möller, Kristina ^a   Berge, Odd Geir ^a   Visser, Sandra A G ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

analgesia; fever; naproxen; pharmacokinetic pharmacodynamic modeling; prostaglandins

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 2; NAPROXEN; PROSTAGLANDIN E2; THROMBOXANE B2;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPYRETIC ACTIVITY; ARTHRITIS; ARTICLE; BEHAVIOR; BODY TEMPERATURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG POTENCY; DRUG SENSITIVITY; EX VIVO STUDY; FEVER; GAIT; IC 50; INFLAMMATION; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; TELEMETRY; YEAST;

ANIMALS; ANTIPYRETICS; ARTHRITIS; DINOPROSTONE; DISEASE MODELS, ANIMAL; FEVER; GENE EXPRESSION REGULATION; INHIBITORY CONCENTRATION 50; MALE; MODELS, CHEMICAL; NAPROXEN; OXYTOCICS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; T-BOX DOMAIN PROTEINS; TIME FACTORS;

EID: 79959914690     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0389-6     Document Type: Article

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