Nano-fibrous tissue engineering scaffolds capable of growth factor delivery

Pharmaceutical Research

Volumn 28, Issue 6, 2011, Pages 1273-1281

  Hu, Jiang ^a   Ma, Peter X ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

drug delivery; growth factor; nano fibrous; polymer scaffold; tissue engineering

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; DOXYCYCLINE; GROWTH FACTOR; MOLECULAR SCAFFOLD; NANOSPHERE; OSTEOGENIC PROTEIN 1; PARATHYROID HORMONE; PLATELET DERIVED GROWTH FACTOR; POLYGLACTIN; POLYMER;

ADSORPTION; BIODEGRADABILITY; CELL DIFFERENTIATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; ELECTROSPINNING; ENCAPSULATION; IMMOBILIZATION; IN VIVO STUDY; NANOFABRICATION; NONHUMAN; OSSIFICATION; PHASE SEPARATION; PRIORITY JOURNAL; REVIEW; THERMAL ANALYSIS; THERMALLY INDUCED PHASE SEPARATION; TISSUE ENGINEERING; TISSUE REGENERATION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NANOFIBERS; POLYMERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 79959912838     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0367-z     Document Type: Review

References (91)

1. R Langer JP Vacanti 1993 Tissue engineering Science 260 920 6 8493529 10.1126/science.8493529 1:CAS:528:DyaK3sXis1Sktrs%3D (Pubitemid 23209960)
2. PX Ma 2008 Biomimetic materials for tissue engineering Adv Drug Deliv Rev 60 184 98 18045729 10.1016/j.addr.2007.08.041 1:CAS:528:DC%2BD2sXhsVelt7vM (Pubitemid 350245692)
3. MP Lutolf JA Hubbell 2005 Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nat Biotechnol 23 47 55 15637621 10.1038/nbt1055 1:CAS:528:DC%2BD2MXhsFGmtg%3D%3D (Pubitemid 41724624)
4. OZ Fisher A Khademhosseini R Langer NA Peppas 2010 Bioinspired materials for controlling stem cell fate Acc Chem Res 43 419 28 20043634 10.1021/ar900226q 1:CAS:528:DC%2BC3cXjtFOq
5. R Peerani PW Zandstra 2010 Enabling stem cell therapies through synthetic stem cell-niche engineering J Clin Invest 120 60 70 20051637 10.1172/JCI41158 1:CAS:528:DC%2BC3cXislWgtQ%3D%3D
6. JP Vacanti MA Morse WM Saltzman AJ Domb A Perez-Atayde R Langer 1988 Selective cell transplantation using bioabsorbable artificial polymers as matrices J Pediatr Surg 23 3 9 2895175 10.1016/S0022-3468(88)80529-3 1:STN:280:DyaL1c7ntF2qtQ%3D%3D (Pubitemid 18061300)
7. R Langer 1990 New methods of drug delivery Science 249 1527 33 2218494 10.1126/science.2218494 1:CAS:528:DyaK3cXmtFOru7w%3D
8. Ma PX. Tissue Engineering. In: Kroschwitz JI, editor. Encyclopedia of polymer science and technology, vol. 12. Hoboken: Wiley; 2005. p. 261-91.
9. T Elsdale J Bard 1972 Collagen substrata for studies on cell behavior J Cell Biol 54 626 37 4339818 10.1083/jcb.54.3.626 1:CAS:528:DyaE38XkvVClu78%3D
10. JF Cavallaro PD Kemp KH Kraus 1994 Collagen fabrics as biomaterials Biotechnol Bioeng 43 781 91 18615802 10.1002/bit.260430813 1:CAS:528: DyaK2cXit1Kqs7Y%3D (Pubitemid 24127954)
11. A Nathan MA Nugent ER Edelman 1995 Tissue engineered perivascular endothelial cell implants regulate vascular injury Proc Natl Acad Sci USA 92 8130 4 7667257 10.1073/pnas.92.18.8130 1:CAS:528:DyaK2MXnvVymsb8%3D
12. Y Zhang H Ouyang CT Lim S Ramakrishna ZM Huang 2005 Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds J Biomed Mater Res B Appl Biomater 72 156 65 15389493 10.1002/jbm.b.30128 (Pubitemid 40039622)
13. X Liu PX Ma 2009 Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds Biomaterials 30 4094 103 19481080 10.1016/j.biomaterials.2009.04.024 1:CAS:528:DC%2BD1MXotlOktrY%3D
14. JA Matthews GE Wnek DG Simpson GL Bowlin 2002 Electrospinning of collagen nanofibers Biomacromolecules 3 232 8 11888306 10.1021/bm015533u 1:CAS:528:DC%2BD38Xnt1Gksw%3D%3D (Pubitemid 34257140)
15. WJ Li CT Laurencin EJ Caterson RS Tuan FK Ko 2002 Electrospun nanofibrous structure: a novel scaffold for tissue engineering J Biomed Mater Res 60 613 21 11948520 10.1002/jbm.10167 1:CAS:528:DC%2BD38XjsFGksb4%3D (Pubitemid 34492600)
16. H Yoshimoto YM Shin H Terai JP Vacanti 2003 A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering Biomaterials 24 2077 82 12628828 10.1016/S0142-9612(02)00635-X 1:CAS:528:DC%2BD3sXhslGqtLo%3D (Pubitemid 36298779)
17. N Bhattarai D Edmondson O Veiseh FA Matsen M Zhang 2005 Electrospun chitosan-based nanofibers and their cellular compatibility Biomaterials 26 6176 84 15885770 10.1016/j.biomaterials.2005.03.027 1:CAS:528:DC%2BD2MXlt1Wgt7Y%3D (Pubitemid 40826986)
18. HJ Jin SV Fridrikh GC Rutledge DL Kaplan 2002 Electrospinning Bombyx mori silk with poly(ethylene oxide) Biomacromolecules 3 1233 9 12425660 10.1021/bm025581u 1:CAS:528:DC%2BD38XmsVOjurs%3D (Pubitemid 35428773)
19. BM Min G Lee SH Kim YS Nam TS Lee WH Park 2004 Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro Biomaterials 25 1289 97 14643603 10.1016/j.biomaterials.2003.08.045 1:CAS:528:DC%2BD3sXptFGrs7Y%3D (Pubitemid 37476206)
20. WJ Li KG Danielson PG Alexander RS Tuan 2003 Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon- caprolactone) scaffolds J Biomed Mater Res A 67 1105 14 14624495 10.1002/jbm.a.10101 (Pubitemid 37522722)
21. F Yang R Murugan S Wang S Ramakrishna 2005 Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering Biomaterials 26 2603 10 15585263 10.1016/j.biomaterials.2004.06.051 1:CAS:528:DC%2BD2cXhtVChsrzF (Pubitemid 39600712)
22. WJ Li JA Cooper Jr RL Mauck RS Tuan 2006 Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications Acta Biomater 2 377 85 16765878 10.1016/j.actbio.2006. 02.005 (Pubitemid 43840927)
23. XM Mo CY Xu M Kotaki S Ramakrishna 2004 Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation Biomaterials 25 1883 90 14738852 10.1016/j.biomaterials.2003.08. 042 1:CAS:528:DC%2BD2cXktlWlsA%3D%3D (Pubitemid 38102263)
24. KE Park HK Kang SJ Lee BM Min WH Park 2006 Biomimetic nanofibrous scaffolds: preparation and characterization of PGA/chitin blend nanofibers Biomacromolecules 7 635 43 16471941 10.1021/bm0509265 1:CAS:528: DC%2BD28XmsVCjsg%3D%3D
25. M Li MJ Mondrinos X Chen MR Gandhi FK Ko PI Lelkes 2006 Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds J Biomed Mater Res A 79 963 73 16948146 (Pubitemid 44915916)
26. F Chen X Li X Mo C He H Wang Y Ikada 2008 Electrospun chitosan-P(LLA-CL) nanofibers for biomimetic extracellular matrix J Biomater Sci Polym Ed 19 677 91 18419945 10.1163/156856208784089661 1:CAS:528:DC%2BD1cXntFalurw%3D (Pubitemid 351535789)
27. M Shin H Yoshimoto JP Vacanti 2004 In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold Tissue Eng 10 33 41 15009928 10.1089/107632704322791673 1:CAS:528:DC%2BD2cXhtlSgs7k%3D (Pubitemid 38199358)
28. CY Xu R Inai M Kotaki S Ramakrishna 2004 Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering Biomaterials 25 877 86 14609676 10.1016/S0142-9612(03)00593-3 1:CAS:528:DC%2BD3sXoslOmsr4%3D (Pubitemid 37371995)
29. S Janjanin WJ Li MT Morgan RM Shanti RS Tuan 2008 Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor J Surg Res 149 47 56 18316094 10.1016/j.jss.2007.12.788 1:CAS:528:DC%2BD1cXhtVShsb%2FM
30. A Nieponice L Soletti J Guan Y Hong B Gharaibeh TM Maul, et al. 2010 In vivo assessment of a tissue-engineered vascular graft combining a biodegradable elastomeric scaffold and muscle-derived stem cells in a rat model Tissue Eng A 16 1215 23 10.1089/ten.tea.2009.0427 1:CAS:528:DC%2BC3cXkt1CgsLg%3D
31. CD Pritchard KM Arner RA Neal WL Neeley P Bojo E Bachelder, et al. 2010 The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation Biomaterials 31 2153 62 19962754 10.1016/j.biomaterials.2009.11. 074 1:CAS:528:DC%2BC3cXpsV2hsw%3D%3D
32. TA Telemeco C Ayres GL Bowlin GE Wnek ED Boland N Cohen, et al. 2005 Regulation of cellular infiltration into tissue engineering scaffolds composed of submicron diameter fibrils produced by electrospinning Acta Biomater 1 377 85 16701819 10.1016/j.actbio.2005.04.006 1:STN:280:DC%2BD283ntFelsA%3D%3D (Pubitemid 43348774)
33. A Balguid A Mol MH van Marion RA Bank CV Bouten FP Baaijens 2009 Tailoring fiber diameter in electrospun poly(epsilon-caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering Tissue Eng A 15 437 44 10.1089/ten.tea.2007.0294 1:CAS:528:DC%2BD1MXhs1Cjs7g%3D
34. A Guimaraes A Martins ED Pinho S Faria RL Reis NM Neves 2010 Solving cell infiltration limitations of electrospun nanofiber meshes for tissue engineering applications Nanomedicine (Lond) 5 539 54 10.2217/nnm.10.31 1:CAS:528:DC%2BC3cXntFGjsLY%3D
35. PX Ma R Zhang 1999 Synthetic nano-scale fibrous extracellular matrix J Biomed Mater Res 46 60 72 10357136 10.1002/(SICI)1097-4636(199907)46:1<60:: AID-JBM7>3.0.CO;2-H 1:CAS:528:DyaK1MXjt12iurc%3D (Pubitemid 29233181)
36. VJ Chen PX Ma 2004 Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores Biomaterials 25 2065 73 14741621 10.1016/j.biomaterials.2003.08.058 1:CAS:528:DC%2BD2cXktlajuw%3D%3D (Pubitemid 38102407)
37. G Wei PX Ma 2006 Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres J Biomed Mater Res A 78 306 15 16637043 (Pubitemid 44061068)
38. G Wei PX Ma 2009 Partially nanofibrous architecture of 3D tissue engineering scaffolds Biomaterials 30 6426 34 19699518 10.1016/j.biomaterials. 2009.08.012 1:CAS:528:DC%2BD1MXhtFCktL3I
39. VJ Chen LA Smith PX Ma 2006 Bone regeneration on computer-designed nano-fibrous scaffolds Biomaterials 27 3973 9 16564086 10.1016/j.biomaterials. 2006.02.043 1:CAS:528:DC%2BD28XjslyitL0%3D (Pubitemid 44316598)
40. P Wang J Hu PX Ma 2009 The engineering of patient-specific, anatomically shaped, digits Biomaterials 30 2735 40 19203788 10.1016/j.biomaterials.2009.01. 037 1:CAS:528:DC%2BD1MXjtFamsrs%3D
41. VJ Chen PX Ma 2006 The effect of surface area on the degradation rate of nano-fibrous poly(L-lactic acid) foams Biomaterials 27 3708 15 16519935 10.1016/j.biomaterials.2006.02.020 1:CAS:528:DC%2BD28XjsFeiurw%3D (Pubitemid 43670523)
42. KM Woo VJ Chen PX Ma 2003 Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment J Biomed Mater Res A 67 531 7 14566795 10.1002/jbm.a.10098 (Pubitemid 37522460)
43. KM Woo JH Jun VJ Chen J Seo JH Baek HM Ryoo, et al. 2007 Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization Biomaterials 28 335 43 16854461 10.1016/j.biomaterials.2006.06.013 1:CAS:528:DC%2BD28XhtVOnsb3O (Pubitemid 44537377)
44. KM Woo VJ Chen HM Jung TI Kim HI Shin JH Baek, et al. 2009 Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects Tissue Eng A 15 2155 62 10.1089/ten.tea.2008.0433 1:CAS:528:DC%2BD1MXhtVWnurzO
45. J Hu K Feng X Liu PX Ma 2009 Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network Biomaterials 30 5061 7 19564041 10.1016/j. biomaterials.2009.06.013 1:CAS:528:DC%2BD1MXpt1Citr0%3D
46. LA Smith X Liu J Hu P Wang PX Ma 2009 Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers Tissue Eng A 15 1855 64 10.1089/ten.tea.2008.0227 1:CAS:528:DC%2BD1MXos1Sqtb4%3D
47. LA Smith X Liu J Hu PX Ma 2009 The influence of three-dimensional nanofibrous scaffolds on the osteogenic differentiation of embryonic stem cells Biomaterials 30 2516 22 19176243 10.1016/j.biomaterials.2009.01.009 1:CAS:528:DC%2BD1MXisVCmtrs%3D
48. H Sun K Feng J Hu S Soker A Atala PX Ma 2010 Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds Biomaterials 31 1133 9 19857889 10.1016/j.biomaterials.2009.10.030 1:CAS:528:DC%2BD1MXhs1SltL7J
49. K Whang TK Goldstick KE Healy 2000 A biodegradable polymer scaffold for delivery of osteotropic factors Biomaterials 21 2545 51 11071604 10.1016/S0142-9612(00)00122-8 1:CAS:528:DC%2BD3cXmvFyls7Y%3D
50. TP Richardson MC Peters AB Ennett DJ Mooney 2001 Polymeric system for dual growth factor delivery Nat Biotechnol 19 1029 34 11689847 10.1038/nbt1101-1029 1:CAS:528:DC%2BD3MXot1ersL0%3D (Pubitemid 33041886)
51. J Sohier RE Haan K de Groot JM Bezemer 2003 A novel method to obtain protein release from porous polymer scaffolds: emulsion coating J Control Release 87 57 68 12618023 10.1016/S0168-3659(02)00350-4 1:CAS:528: DC%2BD3sXhsFOmu7k%3D (Pubitemid 36258387)
52. G Wei Q Jin WV Giannobile PX Ma 2006 Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB J Control Release 112 103 10 16516328 10.1016/j.jconrel.2006.01.011 1:CAS:528:DC%2BD28XjsFaku7k%3D
53. G Wei Q Jin WV Giannobile PX Ma 2007 The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres Biomaterials 28 2087 96 17239946 10.1016/j.biomaterials.2006.12.028 1:CAS:528:DC%2BD2sXhsFCktb0%3D (Pubitemid 46198923)
54. LC Ionescu GC Lee BJ Sennett JA Burdick RL Mauck 2010 An anisotropic nanofiber/microsphere composite with controlled release of biomolecules for fibrous tissue engineering Biomaterials 31 4113 20 20149432 10.1016/j. biomaterials.2010.01.098 1:CAS:528:DC%2BC3cXjtFKis74%3D
55. K Whang DC Tsai EK Nam M Aitken SM Sprague PK Patel, et al. 1998 Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds J Biomed Mater Res 42 491 9 9827671 10.1002/(SICI)1097-4636(19981215)42: 4<491::AID-JBM3>3.0.CO;2-F 1:CAS:528:DyaK1cXnsVyhsb0%3D (Pubitemid 28503752)
56. CM Valmikinathan S Defroda X Yu 2009 Polycaprolactone and bovine serum albumin based nanofibers for controlled release of nerve growth factor Biomacromolecules 10 1084 9 19323510 10.1021/bm8012499 1:CAS:528: DC%2BD1MXjvVSqtbo%3D
57. S Yan L Xiaoqiang L Shuiping M Xiumei S Ramakrishna 2009 Controlled release of dual drugs from emulsion electrospun nanofibrous mats Colloids Surf B Biointerfaces 73 376 81 19586756 10.1016/j.colsurfb.2009.06.009
58. X Li Y Su S Liu L Tan X Mo S Ramakrishna 2010 Encapsulation of proteins in poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning Colloids Surf B Biointerfaces 75 418 24 19836931 10.1016/j.colsurfb.2009.09.014 1:CAS:528:DC%2BD1MXhsV2ksb7M
59. JT McCann D Li YN Xia 2005 Electrospinning of nanofibers with core-sheath, hollow, or porous structures J Mater Chem 15 735 8 10.1039/b415094e 1:CAS:528:DC%2BD2MXhtVyitLg%3D (Pubitemid 40314789)
60. H Jiang Y Hu Y Li P Zhao K Zhu W Chen 2005 A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents J Control Release 108 237 43 16153737 10.1016/j.jconrel.2005.08.006 1:CAS:528:DC%2BD2MXht1aiu7jP (Pubitemid 41608657)
61. YZ Zhang X Wang Y Feng J Li CT Lim S Ramakrishna 2006 Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release Biomacromolecules 7 1049 57 16602720 10.1021/bm050743i 1:CAS:528:DC%2BD28XitV2qsb8%3D (Pubitemid 43670790)
62. IC Liao SY Chew KW Leong 2006 Aligned core-shell nanofibers delivering bioactive proteins Nanomedicine (Lond). 1 465 71 10.2217/17435889.1.4.465 1:CAS:528:DC%2BD2sXhsV2htbo%3D
63. H Jiang Y Hu P Zhao Y Li K Zhu 2006 Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning J Biomed Mater Res B Appl Biomater 79 50 7 16544305 (Pubitemid 44477473)
64. J Ziegler U Mayr-Wohlfart S Kessler D Breitig KP Gunther 2002 Adsorption and release properties of growth factors from biodegradable implants J Biomed Mater Res 59 422 8 11774299 10.1002/jbm.1258 1:CAS:528:DC%2BD38Xjt1Sktw%3D%3D (Pubitemid 34037485)
65. J Sohier TJ Vlugt N Cabrol C Van Blitterswijk K de Groot JM Bezemer 2006 Dual release of proteins from porous polymeric scaffolds J Control Release 111 95 106 16455149 10.1016/j.jconrel.2005.11.016 1:CAS:528:DC%2BD28XhslKjtLY%3D (Pubitemid 43292485)
66. KA Woodrow Y Cu CJ Booth JK Saucier-Sawyer MJ Wood WM Saltzman 2009 Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA Nat Mater 8 526 33 19404239 10.1038/nmat2444 1:CAS:528:DC%2BD1MXmtFems7Y%3D
67. C Vauthier K Bouchemal 2009 Methods for the preparation and manufacture of polymeric nanoparticles Pharm Res 26 1025 58 19107579 10.1007/s11095-008- 9800-3 1:CAS:528:DC%2BD1cXhsFartLzM
68. VR Sinha A Trehan 2003 Biodegradable microspheres for protein delivery J Control Release 90 261 80 12880694 10.1016/S0168-3659(03)00194-9 1:CAS:528:DC%2BD3sXls1Srt70%3D (Pubitemid 36859959)
69. G Wei GJ Pettway LK McCauley PX Ma 2004 The release profiles and bioactivity of parathyroid hormone from poly(lactic-co-glycolic acid) microspheres Biomaterials 25 345 52 14585722 10.1016/S0142-9612(03)00528-3 1:CAS:528:DC%2BD3sXotlynsb0%3D (Pubitemid 37329723)
70. N Kalaji A Deloge N Sheibat-Othman O Boyron I About H Fessi 2010 Controlled release carriers of growth factors FGF-2 and TGFbeta1: synthesis, characterization and kinetic modelling J Biomed Nanotechnol 6 106 16 20738064 10.1166/jbn.2010.1102 1:CAS:528:DC%2BC3cXpvVOrtLo%3D
71. U Ripamonti B Van Den Heever TK Sampath MM Tucker DC Rueger AH Reddi 1996 Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7) Growth Factors 13 273 89 8919034 10.3109/08977199609003228 1:STN:280:DyaK2s%2FnvV2juw%3D%3D color plates III-VIII,pre bk (Pubitemid 26378946)
72. HD Zegzula DC Buck J Brekke JM Wozney JO Hollinger 1997 Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2) J Bone Joint Surg Am 79 1778 90 9409791 1:STN:280:DyaK1c%2Fnt1Cnuw%3D%3D (Pubitemid 28016582)
73. Wozney JM, Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res. 1998; 26-37. (Pubitemid 28046864)
74. RD Welch AL Jones RW Bucholz CM Reinert JS Tjia WA Pierce, et al. 1998 Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model J Bone Miner Res 13 1483 90 9738522 10.1359/jbmr.1998.13.9.1483 1:CAS:528:DyaK1cXmtVCjsL8%3D (Pubitemid 28418916)
75. SD Cook 1999 Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites Orthopedics 22 669 71 10418861 1:STN:280: DyaK1MzksFajsA%3D%3D (Pubitemid 29343110)
76. MC Robson TA Mustoe TK Hunt 1998 The future of recombinant growth factors in wound healing Am J Surg 176 80S 2 9777977 10.1016/S0002-9610(98)00186-X 1:STN:280:DyaK1cvkvFCjtQ%3D%3D (Pubitemid 28460662)
77. Q Jin G Wei Z Lin JV Sugai SE Lynch PX Ma, et al. 2008 Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo PLoS ONE 3 e1729 18320048 10.1371/journal.pone.0001729 (Pubitemid 351903228)
78. Wei G. Growth factor-delivering nano-fibrous scaffolds for tissue regeneration, PhD Dissertation, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI, 2006.
79. F Wang Z Li K Tamama CK Sen J Guan 2009 Fabrication and characterization of prosurvival growth factor releasing, anisotropic scaffolds for enhanced mesenchymal stem cell survival/growth and orientation Biomacromolecules 10 2609 18 19689108 10.1021/bm900541u 1:CAS:528:DC%2BD1MXhtVSgtL%2FO
80. KW Chun KC Cho SH Kim JH Jeong TG Park 2004 Controlled release of plasmid DNA from biodegradable scaffolds fabricated using a thermally-induced phase-separation method J Biomater Sci Polym Ed 15 1341 53 15648567 10.1163/1568562042368103 1:CAS:528:DC%2BD2MXhslGhtw%3D%3D (Pubitemid 39654326)
81. JH Jang LD Shea 2003 Controllable delivery of non-viral DNA from porous scaffolds J Control Release 86 157 68 12490381 10.1016/S0168-3659(02)00369-3 1:CAS:528:DC%2BD38XpsFSjsL0%3D (Pubitemid 35469122)
82. YK Luu K Kim BS Hsiao B Chu M Hadjiargyrou 2003 Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers J Control Release 89 341 53 12711456 10.1016/S0168-3659(03) 00097-X 1:CAS:528:DC%2BD3sXjtVegu7w%3D (Pubitemid 36507026)
83. D Liang YK Luu K Kim BS Hsiao M Hadjiargyrou B Chu 2005 In vitro non-viral gene delivery with nanofibrous scaffolds Nucleic Acids Res 33 e170 16269820 10.1093/nar/gni171 (Pubitemid 41748059)
84. A Saraf LS Baggett RM Raphael FK Kasper AG Mikos 2010 Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds J Control Release 143 95 103 20006660 10.1016/j.jconrel.2009.12.009 1:CAS:528:DC%2BC3cXjtFOis78%3D
85. C Kriegel KM Kit DJ McClements J Weiss 2009 Nanofibers as carrier systems for antimicrobial microemulsions. Part I: fabrication and characterization Langmuir 25 1154 61 19105597 10.1021/la803058c 1:CAS:528:DC%2BD1cXhsFejurrP
86. K Feng H Sun MA Bradley EJ Dupler WV Giannobile PX Ma 2010 Novel antibacterial nanofibrous PLLA scaffolds J Control Release 146 363 9 20570700 10.1016/j.jconrel.2010.05.035 1:CAS:528:DC%2BC3cXhtFWgt7vO
87. X Xu L Yang X Wang X Chen Q Liang J Zeng, et al. 2005 Ultrafine medicated fibers electrospun from W/O emulsions J Control Release 108 33 42 16165243 10.1016/j.jconrel.2005.07.021 1:CAS:528:DC%2BD2MXhtFaktrzK (Pubitemid 41476672)
88. JB Wolinsky R Liu J Walpole LR Chirieac YL Colson MW Grinstaff 2010 Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites J Control Release 144 280 7 20184934 10.1016/j.jconrel.2010.02.022 1:CAS:528: DC%2BC3cXms1Cjtrk%3D
89. RL Mandell SS Socransky 1988 Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis J Periodontol 59 373 9 3164779 1:STN:280:DyaL1c3nsVOisw%3D%3D
90. A Heimdahl CE Nord 1988 Antimicrobial agents in the treatment of periodontal diseases: special aspects on tetracycline and doxycycline Scand J Infect Dis Suppl 53 35 45 3047856 1:STN:280:DyaL1czjs1ynsQ%3D%3D
91. JK Tessmar AM Gopferich 2007 Matrices and scaffolds for protein delivery in tissue engineering Adv Drug Deliv Rev 59 274 91 17544542 10.1016/j.addr.2007. 03.020 1:CAS:528:DC%2BD2sXmtlShurs%3D (Pubitemid 46879975)