An anisotropic nanofiber/microsphere composite with controlled release of biomolecules for fibrous tissue engineering

Biomaterials

Volumn 31, Issue 14, 2010, Pages 4113-4120

  Ionescu, Lara C ^a,b   Lee, Gregory C ^a,b   Sennett, Brian J ^a   Burdick, Jason A ^b   Mauck, Robert L ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Drug delivery; Mechanical properties; Microsphere; Nanospun scaffold

Indexed keywords

BURST RELEASE; CONTROLLED RELEASE; DOSE-DEPENDENT MANNER; ELECTROSPUNS; FABRICATION TECHNIQUE; FIBROUS SCAFFOLDS; FIBROUS TISSUE; GROWTH FACTOR DELIVERY; IN-VITRO; MULTI-FACTOR; MULTIPLE MODELS; NANOFIBROUS SCAFFOLDS; NANOSPUN SCAFFOLD; RELEASE PROFILES; STRUCTURAL HIERARCHIES; SUSTAINED RELEASE; TISSUE FORMATION;

BIOMECHANICS; CYTOTOXICITY; DRUG DELIVERY; FIBERS; MECHANICAL PROPERTIES; MICROSPHERES; MUSCULOSKELETAL SYSTEM; STIFFNESS; STRUCTURE (COMPOSITION); TISSUE ENGINEERING;

SCAFFOLDS;

BOVINE SERUM ALBUMIN; CHONDROITIN SULFATE; MICROSPHERE; NANOFIBER; POLYCAPROLACTONE;

ANISOTROPY; ARTICLE; BIODEGRADATION; BIOMECHANICS; COMPOSITE MATERIAL; DENSITY GRADIENT; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG RELEASE; NANOFABRICATION; PRIORITY JOURNAL; TISSUE ENGINEERING;

ANISOTROPY; DRUG DELIVERY SYSTEMS; GLYCOLATES; MECHANICAL PHENOMENA; MICROSPHERES; NANOFIBERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 77649271896     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.098     Document Type: Article

References (54)

1. Li W.J., Mauck R.L., and Tuan R.S. Electrospun nanofibrous scaffolds: production, characterization, and applications for tissue engineering and drug delivery. J Biomed Nanotechnol 1 3 (2005) 259-275
2. Barnes C.P., Sell S.A., Boland E.D., Simpson D.G., and Bowlin G.L. Nanofiber technology: designing the next generation of tissue engineering scaffolds. Adv Drug Deliv Rev 59 14 (2007 Dec 10) 1413-1433
3. Baker B.M., Handorf A.M., Ionescu L.C., Li W.J., and Mauck R.L. New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev Med Devices 6 5 (2009) 515-532
4. Mauck R.L., Baker B.M., Nerurkar N.L., Burdick J.A., Li W.J., Tuan R.S., et al. Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng Part B Rev 15 2 (2009) 171-193
5. Li W.J., Mauck R.L., Cooper J.A., Yuan X., and Tuan R.S. Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 40 8 (2006) 1686-1693
6. Courtney T., Sacks M.S., Stankus J., Guan J., and Wagner W.R. Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy. Biomaterials 27 19 (2006) 3631-3638
7. Ayres C.E., Bowlin G.L., Pizinger R., Taylor L.T., Keen C.A., and Simpson D.G. Incremental changes in anisotropy induce incremental changes in the material properties of electrospun scaffolds. Acta Biomater 3 5 (2007) 651-661
8. Li D., Ouyang G., McCann J.T., and Xia Y. Collecting electrospun nanofibers with patterned electrodes. Nano Lett 5 5 (2005) 913-916
9. Li D., Wang Y., and Xia Y. Electrospinning nanofibers as uniaxially aligned arrays and layer-by-layer stacked films. Adv Mater 16 4 (2004) 361-366
10. Baker B.M., and Mauck R.L. The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials 28 11 (2007 Apr) 1967-1977
11. Nerurkar N.L., Elliott D.M., and Mauck R.L. Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J Orthop Res 25 8 (2007) 1018-1028
12. Nerurkar N.L., Baker B.M., Sen S., Wible E.E., Elliott D.M., and Mauck R.L. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat Mater 8 12 (2009) 986-992
13. Moffat K.L., Wang I.N., Rodeo S.A., and Lu H.H. Orthopedic interface tissue engineering for the biological fixation of soft tissue grafts. Clin Sports Med 28 1 (2009) 157-176
14. Fujimoto K.L., Tobita K., Merryman W.D., Guan J., Momoi N., Stolz D.B., et al. An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction. J Am Coll Cardiol 49 23 (2007) 2292-2300
15. Li W.J., Jiang Y.J., and Tuan R.S. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng 12 7 (2006) 579-587
16. Li W.J., Jiang Y.J., and Tuan R.S. Cell-nanofiber-based cartilage tissue engineering using improved cell seeding, growth factor, and bioreactor technologies. Tissue Eng Part A 14 5 (2008 May) 639-648
17. Baker B.M., Nathan A.S., Huffman G.R., and Mauck R.L. Tissue engineering with meniscus cells derived from surgical debris. Osteoarthr Cartilage 17 3 (2009) 336-345
18. Nerurkar N.L., Mauck R.L., and Elliott D.M. ISSLS prize winner: integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine 33 25 (2008) 2691-2701
19. Richardson T.P., Peters M.C., Ennett A.B., and Mooney D.J. Polymeric system for dual growth factor delivery. Nat Biotechnol 19 11 (2001) 1029-1034
20. Hadjiargyrou M., and Chiu J.B. Enhanced composite electrospun nanofiber scaffolds for use in drug delivery. Expert Opin Drug Deliv 5 10 (2008) 1093-1106
21. He C.L., Huang Z.M., Han X.J., Liu L., Zhang H.S., and Chen L.S. Coaxial electrospun poly(lactic acid) ultrafine fibers for sustained drug delivery. J Macromol Sci Phys 45 (2006) 515-524
22. Katti D.S., Robinson K.W., Ko F.K., and Laurencin C.T. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res B Appl Biomater 70 2 (2004) 286-296
23. Kenawy E.R., Bowlin G.L., Mansfield K., Layman J., Simpson D.G., Sanders E.H., et al. Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 17 81 (2002) 57-64
24. Zong X., Kim K., Fang D., Ran S.H., Hsiao B.S., and Chu B. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer 43 16 (2002) 4403-4412
25. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 98 1 (2004) 47-56
26. Zeng J., Xu X., Chen X., Liang Q., Bian X., Yang L., et al. Biodegradable electrospun fibers for drug delivery. J Control Release 92 3 (2003) 227-231
27. Hong Y., Fujimoto K., Hashizume R., Guan J., Stankus J.J., Tobita K., et al. Generating elastic, biodegradable polyurethane/poly(lactide-co-glycolide) fibrous sheets with controlled antibiotic release via two-stream electrospinning. Biomacromolecules 9 4 (2008) 1200-1207
28. Zeng J., Aigner A., Czubayko F., Kissel T., Wendorff H., and Greiner A. Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. Biomacromolecules 6 3 (2005) 1484-1488
29. Zeng J., Yang L., Liang Q., Zhang X., Guan H., Xu X., et al. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Control Release 105 1-2 (2005) 43-51
30. Xie J., and Wang C.H. Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro. Pharm Res 23 8 (2006) 1817-1826
31. Xu X., Yang L., Xu X., Wang X., Chen X., Liang Q., et al. Ultrafine medicated fibers electrospun from W/O emulsions. J Control Release 108 1 (2005) 33-42
32. Jiang H., Hu Y., Li Y., Zhao P., Zhu K., and Chen W. A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. J Control Release 108 2-3 (2005) 237-243
33. Jiang H., Hu Y., Zhao P., Li Y., and Zhu K. Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning. J Biomed Mater Res B Appl Biomater 79B 1 (2006) 50-57
34. Zhang Y.Z., Wang X., Feng Y., Li J., Lim C.T., and Ramakrishna S. Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(e-caprolactone) nanofibers for sustained release. Biomacromolecules 7 4 (2006) 1049-1057
35. Maretschek S., Greiner A., and Kissel T. Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. J Control Release 127 2 (2008) 180-187
36. Yang Y., Li X., Qi M., Zhou S., and Weng J. Release pattern and structural integrity of lysozyme encapsulated in core-sheath structured poly(dl-lactide) ultrafine fibers prepared by emulsion electrospinning. Eur J Pharm Biopharm 69 1 (2008) 106-116
37. Luu Y.K., Kim K., Hsiao B.S., Chu B., and Hadjiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release 89 2 (2003) 341-353
38. Nie H., and Wang C.H. Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. J Control Release 120 1-2 (2007) 111-121
39. Liang D., Luu Y.K., Kim K., Hsiao B.S., Hadjiargyrou M., and Chu B. In vitro non-viral gene delivery with nanofibrous scaffolds. Nucleic Acids Res 33 19 (2005) 170
40. Chew S.Y., Wen J., Yim E.K.F., and Leong K.W. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6 4 (2005) 2017-2024
41. Liao I.C., Chew S.Y., and Leong K.W. Aligned core-shell nanofibers delivering bioactive proteins. Nanomedicine 1 4 (2006) 465-471
42. Li C., Vepari C., Jin H.J., Kim H.J., and Kaplan D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27 16 (2006) 3115-3124
43. Huang Z.M., He C.L., Yang A., Zhang Y., Han X.J., Yin J., et al. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J Biomed Mater Res A 77A 1 (2006) 169-179
44. Cohen S., Yoshioka T., Lucarelli M., Hwang L.H., and Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res 8 6 (1991) 713-720
45. Baker B.M., Gee A.O., Metter R.B., Nathan A.S., Marklein R.A., Burdick J.A., et al. The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials 29 15 (2008) 2348-2358
46. Peltz C.D., Perry S.M., Getz C.L., and Soslowsky L.J. Mechanical properties of the long-head of the biceps tendon are altered in the presence of rotator cuff tears in a rat model. J Orthop Res 27 3 (2009) 416-420
47. Farndale R.W., Buttle D.J., and Barrett A.J. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883 2 (1986) 173-177
48. Lim J.M., Moon J.H., Yi G.R., Heo C.J., and Yang S.M. Fabrication of one-dimensional colloidal assemblies from electrospun nanofibers. Langmuir 22 8 (2006) 3445-3449
49. Dong B., Smith M.E., and Wnek G.E. Encapsulation of multiple biological compounds within a single electrospun fiber. Small 5 13 (2009) 1508-1512
50. Melaiye A., Sun Z., Hindi K., Milsted A., Ely D., Reneker D.H., et al. Silver imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. J Am Chem Soc 127 7 (2005) 2285-2291
51. Qi H., Hu P., Xu J., and Wang A. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules 7 8 (2006) 2327-2330
52. Bursac P., York A., Kuznia P., Brown L.M., and Arnoczky S.P. Influence of donor age on the biomechanical and biochemical properties of human meniscal allografts. Am J Sports Med 37 5 (2009) 884-889
53. Tan A.R., Ifkovits J.L., Baker B.M., Brey D.M., Mauck R.L., and Burdick J.A. Electrospinning of photocrosslinked and degradable fibrous scaffolds. J Biomed Mater Res A 15 87 (2008) 1034-1043
54. Lee W., Wiseman M.E., Cho N.J., Glenn J.S., and Frank C.W. The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. Biomaterials 30 34 (2009) 6648-6654