Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: Evidence that oxygen access is a determinant of secondary reactions with fatty acid hydroperoxides

Journal of Biological Chemistry

Volumn 285, Issue 18, 2010, Pages 13427-13436

  Zheng, Yuxiang ^a   Brash, Alan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANAEROBIC CONDITIONS; ANAEROBIC REACTIONS; ARACHIDONIC ACIDS; CONJUGATED DIENES; CYCLOPROPYL; CYCLOPROPYL RING; DIASTEREOMERS; EPOXIDE INTERMEDIATE; HYDROPEROXIDES; INFLAMMATORY MEDIATORS; INTRAMOLECULAR REACTIONS; LIPOXYGENASES; O INCORPORATION; SECONDARY REACTIONS; SOYBEAN LIPOXYGENASE; SYNTHASES;

ACIDS; BIOCHEMISTRY; ENZYMES; FATTY ACIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; OLEFINS; ORGANIC POLYMERS; OXYGENATION; REACTION INTERMEDIATES; SYNTHESIS (CHEMICAL); THERMOANALYSIS;

MOLECULAR OXYGEN;

14,15 EPOXY [9,12,11 CYCLOPROPYL] EISOSA 5,7,13 TRIENOIC ACID; 15 HYDROPEROXYARACHIDONIC ACID; ALKENE DERIVATIVE; CYCLOPROPYL EPOXIDE; EPOXIDE; FATTY ACID HYDROPEROXIDE; ICOSATRIENOIC ACID; LACTONE; LEUKOTRIENE; LEUKOTRIENE A SYNTHASE; LIPID HYDROPEROXIDE; LIPOXYGENASE; LIPOXYGENASE I; OXYGEN; SYNTHETASE; UNCLASSIFIED DRUG;

ANAEROBIC CAPACITY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIASTEREOISOMER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REACTION ANALYSIS; SIGNAL TRANSDUCTION; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; EPOXY COMPOUNDS; LIPID PEROXIDES; LIPOXYGENASE; MAMMALS; MODELS, CHEMICAL; OXIDATION-REDUCTION; OXYGEN; PLANT PROTEINS; SOYBEANS;

GLYCINE MAX; MAMMALIA;

EID: 77951596474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.084632     Document Type: Article

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