Amphotericin B induces trehalose synthesis and simultaneously activates an antioxidant enzymatic response in Candida albicans

Biochimica et Biophysica Acta - General Subjects

Volumn 1810, Issue 8, 2011, Pages 777-783

  González Párraga, Pilar ^a   Sánchez Fresneda, Ruth ^a   Zaragoza, Óscar ^b   Argüelles, Juan Carlos ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Amphotericin B; Antioxidant enzymes; Candida albicans; Trehalose

Indexed keywords

AMPHOTERICIN B; CATALASE; GLUTATHIONE REDUCTASE; MESSENGER RNA; NEUTRAL TREHALASE; SYNTHETASE; TREHALASE; TREHALOSE; TREHALOSE SYNTHASE; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA ALBICANS; CARBOHYDRATE SYNTHESIS; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; FUNGAL CELL; FUNGAL GENE; GENE EXPRESSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TPS1 GENE;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; ANTIOXIDANTS; CANDIDA ALBICANS; ENZYME ACTIVATION; OXIDOREDUCTASES; TREHALOSE;

CANDIDA ALBICANS;

EID: 79959885647     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.04.012     Document Type: Article

References (36)

1. N. Chauhan, J.P. Latge, and R. Calderone Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus Nat. Rev. Microbiol. 4 2006 435 444 (Pubitemid 43771863)
2. T.F. Patterson Advances and challenges in management of invasive mycoses Lancet 366 2005 1013 1025 (Pubitemid 41323037)
3. M.A. Pfaller, and D.J. Diekema Epidemiology of invasive candidiasis: a persistent public health problem Clin. Microbiol. Rev. 20 2007 133 163 (Pubitemid 46167771)
4. R.A. Akins An update on antifungal targets and mechanisms of resistance in Candida albicans Med. Mycol. 43 2005 285 318 (Pubitemid 41030457)
5. R. Cisterna, G. Ezpeleta, O. Telleria, J. Guinea, B. Regueiro, J. Rodriguez, and J. Esperalba A nationwide sentinel surveillance of bloodstream Candida spp. Infections study in 40 tertiary-care hospitals in Spain J. Clin. Microbiol. 48 2010 4200 4206
6. P. Eggimann, J. Garbino, and D. Pittet Epidemiology of Candida species infections in critically ill non-immunosuppressed patients Lancet Infect. Dis. 3 2003 685 702 (Pubitemid 37345347)
7. J.C. Argüelles Physiological roles of trehalose in bacteria and yeasts: a comparative analysis Arch. Microbiol. 174 2000 217 224
8. Y. Pedreño, P. Gonzalez-Parraga, M. Martinez-Esparza, R. Sentandreu, E. Valentin, and J.C. Argüelles Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress Microbiology 153 2007 1372 1381
9. Y. Pedreño, S. Maicas, J.C. Argüelles, R. Sentandreu, and E. Valentin The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans J. Biol. Chem. 279 2004 40852 40860 (Pubitemid 39287683)
10. P. Van Dijck, L. De Rop, K. Szlufcik, E. Van Ael, and J.M. Thevelein Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation Infect. Immun. 70 2002 1772 1782 (Pubitemid 34242176)
11. O. Zaragoza, M.A. Blazquez, and C. Gancedo Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity J. Bacteriol. 180 1998 3809 3815 (Pubitemid 28361575)
12. O. Zaragoza, C. de Virgilio, J. Ponton, and C. Gancedo Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity Microbiology 148 2002 1281 1290 (Pubitemid 34567206)
13. F.J. Alvarez-Peral, O. Zaragoza, Y. Pedreño, and J.C. Argüelles Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans Microbiology 148 2002 2599 2606
14. 2 and the acquisition of oxidative tolerance in Candida albicans Yeast 20 2003 1161 1169 (Pubitemid 37369115)
15. M. Oura, T.H. Sternberg, and E.T. Wright A new antifungal antibiotic, amphotericin B Antibiot. Annu. 3 1955 566 573
16. J. Brajtburg, W.G. Powderly, G.S. Kobayashi, and G. Medoff Amphotericin B: current understanding of mechanisms of action Antimicrob. Agents Chemother. 34 1990 183 188 (Pubitemid 20046861)
17. D.P. Kontoyiannis, and R.E. Lewis Antifungal drug resistance of pathogenic fungi Lancet 359 2002 1135 1144 (Pubitemid 34270742)
18. D.S. Palacios, T.M. Anderson, and M.D. Burker A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for the channel formation is not required for potent antifungal activity J. Am. Chem. Soc. 129 2007 13804 13805 (Pubitemid 350106059)
19. M. An, H. Shen, Y. Cao, J. Zhang, Y. Cai, R. Wang, and Y. Jiang Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans Int. J. Antimicrob. Agents 33 2009 258 263
20. Y. Okamoto, S. Aoki, and I. Mataga Enhancement of amphotericin B activity against Candida albicans by superoxide radical Mycopathologia 158 2004 9 15 (Pubitemid 39187846)
21. M. Sokol-Anderson, J.E. Sligh Jr., S. Elberg, J. Brajtburg, G.S. Kobayashi, and G. Medoff Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B Antimicrob. Agents Chemother. 32 1988 702 705
22. M.L. Sokol-Anderson, J. Brajtburg, and G. Medoff Amphotericin B-induced oxidative damage and killing of Candida albicans J. Infect. Dis. 154 1986 76 83 (Pubitemid 16088305)
23. Y. Wang, and A. Casadevall Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B Antimicrob. Agents Chemother. 38 1994 2648 2650 (Pubitemid 24332601)
24. W.A. Fonzi, and M.Y. Irwin Isogenic strain construction and gene mapping in Candida albicans Genetics 134 1993 717 728 (Pubitemid 23193572)
25. M.B. Kurtz, M.W. Cortelyou, and D.R. Kirsch Integrative transformation of Candida albicans, using a cloned Candida ADE2 gene Mol. Cell. Biol. 6 1986 142 149 (Pubitemid 16182093)
26. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor N.Y.
27. P. Gonzalez-Parraga, R. Alonso-Monge, J. Pla, and J.C. Argüelles Adaptive tolerance to oxidative stress and the induction of antioxidant enzymatic activities in Candida albicans are independent of the Hog1 and Cap1-mediated pathways FEMS Yeast Res. 10 2010 747 756
28. J.C. Argüelles, T. Rodriguez, and F.J. Alvarez-Peral Trehalose hydrolysis is not required for human serum-induced dimorphic transition in Candida albicans: evidence from a tps1/tps1 mutant deficient in trehalose synthesis Res. Microbiol. 150 1999 521 529 (Pubitemid 29510636)
29. R. Eck, C. Bergmann, K. Ziegelbauer, W. Schonfeld, and W. Kunkel A neutral trehalase gene from Candida albicans: molecular cloning, characterization and disruption Microbiology 143 Pt 12 1997 3747 3756 (Pubitemid 28004607)
30. A.J. Phillips, I. Sudbery, and M. Ramsdale Apoptosis induced by environmental stresses and amphotericin B in Candida albicans Proc. Natl. Acad. Sci. U. S. A. 100 2003 14327 14332 (Pubitemid 37499236)
31. M. Martinez-Esparza, E. Martinez-Vicente, P. Gonzalez-Parraga, J.M. Ros, P. Garcia-Penarrubia, and J.C. Argüelles Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans Int. J. Med. Microbiol. 299 2009 453 464
32. A. Fekete, T. Emri, A. Gyetvai, Z. Gazdag, M. Pesti, Z. Varga, J. Balla, C. Cserhati, L. Emody, L. Gergely, and I. Pocsi Development of oxidative stress tolerance resulted in reduced ability to undergo morphologic transitions and decreased pathogenicity in a t-butylhydroperoxide-tolerant mutant of Candida albicans FEMS Yeast Res. 7 2007 834 847 (Pubitemid 47256358)
33. C.S. Hwang, G.E. Rhie, J.H. Oh, W.K. Huh, H.S. Yim, and S.O. Kang Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence Microbiology 148 2002 3705 3713
34. H.J. Jung, W.S. Sung, S.H. Yeo, H.S. Kim, I.S. Lee, E.R. Woo, and D.G. Lee Antifungal effect of amentoflavone derived from Selaginella tamariscina Arch. Pharm. Res. 29 2006 746 751
35. D.G. Lee, H.J. Jung, and E.R. Woo Antimicrobial property of (+)-lyoniresinol-3alpha-O-beta-D-glucopyranoside isolated from the root bark of Lycium chinense Miller against human pathogenic microorganisms Arch. Pharm. Res. 28 2005 1031 1036
36. B. Enjalbert, D.A. Smith, M.J. Cornell, I. Alam, S. Nicholls, A.J. Brown, and J. Quinn Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans Mol. Biol. Cell 17 2006 1018 1032 (Pubitemid 43191132)