Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress

Microbiology

Volumn 153, Issue 5, 2007, Pages 1372-1381

  Pedreño, Yolanda ^a,b   González Párraga, Pilar ^a   Martínez Esparza, María ^a   Sentandreu, Rafael ^b   Valentín, Eulogio ^b   Argüelles, Juan Carlos ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; FUNGAL PROTEIN; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; PROTEIN ATC1; SUPEROXIDE DISMUTASE; TREHALASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CANDIDA ALBICANS; CARBON SOURCE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FUNGAL GENE; FUNGAL METABOLISM; FUNGAL STRAIN; FUNGAL VIABILITY; FUNGAL VIRULENCE; FUNGUS HYPHAE; FUNGUS IMMUNITY; FUNGUS MUTANT; GENE DISRUPTION; HEAT SHOCK; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CATALASE; DISEASE MODELS, ANIMAL; FEMALE; GENE DELETION; GLUTATHIONE REDUCTASE; HEAT; HYDROGEN PEROXIDE; HYPHAE; MICE; MICROBIAL VIABILITY; MORPHOGENESIS; OSMOTIC PRESSURE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS; TREHALASE; TREHALOSE; VIRULENCE;

CANDIDA ALBICANS;

EID: 34249107665     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2006/003921-0     Document Type: Article

References (41)

1. Akins, R. A. (2005). An update on antifungal targets and mechanisms of resistance in Candida albicans. Med Mycol 43, 285-318.
2. Alvarez-Peral, F. J. & Argüelles, J.-C. (2000). Changes in external trehalase activity during human serum-induced dimorphic transition in Candida albicans. Res Microbiol 151, 837-843.
3. Alvarez-Peral, F. J., Zaragoza, O., Pedreno, Y. & Argüelles, J.-C. (2002). Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans. Microbiology 148, 2599-2606.
4. Argüelles, J. C. (2000). Physiological roles of trehalose in bacteria and yeasts: a comparative analysis. Arch Microbiol 174, 217-224.
5. Argüelles, J. C., Rodriguez, T. & Alvarez-Peral, F. J. (1999). Trehalose hydrolysis is not required for human serum-induced dimorphic transition in Candida albicans: evidence from a tps1/ tps1 mutant deficient in trehalose synthesis. Res Microbiol 150, 521-529.
6. Bates, S., Hughes, H. B., Munro, C. A., Thomas, W. P. H., McCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Brown, A. J. P. & other authors (2006). Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. J Biol Chem 281, 90-98.
7. Berman, J. & Sudbery, P. E. (2002). Candida albicans: a molecular revolution built on lessons from budding yeast. Nat Rev Genet 3, 918-930.
8. Blázquez, M. A., Stucka, R., Feldmann, H. & Gancedo, C. (1994). Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe. J Bacteriol 176, 3895-3902.
9. Calderone, R. A. & Fonzi, W. A. (2001). Virulence factors of Candida albicans. Trends Microbiol 9, 327-335.
10. Cannon, R. D., Timberlake, W. E., Gow, N. A. R., Bailey, D., Brown, A., Gooday, G. W., Hube, B., Monod, M., Nombela, C. & other authors (1994). Molecular biological and biochemical aspects of fungal dimorphism. J Med Vet Mycol 32 (Suppl. 1), 53-64.
11. Chauhan, N., Latge, J. P. & Calderone, R. (2006). Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat Rev Microbiol 4, 435-444.
12. Denning, D. W. (2003). Echinocandin antifungal drugs. Lancet 362, 1142-1151.
13. Eck, R., Bergmann, C., Ziegelbauer, K., Schönfeld, W. & Künkel, K. (1997). A neutral trehalase gene from Candida albicans: molecular cloning, characterization and disruption. Microbiology 143, 3747-3756.
14. Eggimann, P., Garbino, J. & Pittet, D. (2003). Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis 3, 685-702.
15. Elbein, A. D., Pan, Y. T., Pastuszak, I. & Carroll, D. (2003). New insights on trehalose: a multifunctional molecule. Glycobiology 13, 17R-27R.
16. Elorza, M. V., Murgui, A. & Sentandreu, R. (1985). Dimorphism in Candida albicans: contribution of mannoproteins to the architecture of yeast and mycelial cell walls. J Gen Microbiol 131, 2209-2216.
17. Fonzi, W. A. & Irwin, M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
18. Gietz, R. D., Schiestl, R. H., Willems, A. R. & Woods, R. A. (1995). Studies on the transformation of intact yeast cells by the LiAc/ SS-DNA/PEG procedure. Yeast 11, 355-360.
19. 2) and the acquisition of oxidative tolerance in Candida albicans. Yeast 20, 1161-1169.
20. Gow, N. A. R., Brown, A. J. P. & Odds, F. C. (2002). Fungal morphogenesis and host invasion. Curr Opin Microbiol 5, 366-371.
21. Hernández, J. A., Campillo, A., Jiménez, A., Alarcón, J. J. & Sevilla, F. (1999). Response of antioxidant systems and leaf water relations to NaCl stress in pea plants. New Phytol 141, 241-251.
22. Hwang, C.-S., Rhie, G., Oh, J.-H., Huh, W.-K., Yim, H.-S. & Kang, S.-O. (2002). Copper- and zinc-containing superoxide dismutase (Cu/ ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence. Microbiology 148, 3705-3713.
23. Kobayashi, S. D. & Cutler, J. E. (1998). Candida albicans hyphal formation and virulence: is there a clearly defined role? Trends Microbiol 6, 92-94.
24. Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A. & Fink, G. R. (1997). Nonfilamentous C. albicans mutants are avirulent. Cell 90, 939-949.
25. McNeil, M. M., Nash, S. L., Hajjeh, R. A., Phelan, M. A., Conn, L. A., Plikaytis, B. D. & Warnock, D. W. (2001). Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997. Clin Infect Dis 33, 641-647.
26. Mukherjee, P. K., Sheehan, D. J., Hitchcock, C. A. & Ghannoum, M. A. (2005). Combination treatment of invasive fungal infections. Clin Microbiol Rev 18, 163-194.
27. Murad, A. M. A., Lee, P. R., Broadbent, I. D., Barelle, C. J. & Brown, A. J. P. (2000). CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16, 325-327.
28. Odds, F. C. (1994). Candida species and virulence. ASM News 360, 313-318.
29. Patterson, T. F. (2005). Advances and challenges in management of invasive mycoses. Lancet 366, 1013-1025.
30. Pedreño, Y., Maicas, S., Argüelles, J.-C., Sentandreu, R. & Valentin, E. (2004). The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans. J Biol Chem 279, 40852-40860.
31. 2) is independent of neutral trehalase (Ntc1p) activity in Candida albicans. FEMS Yeast Res 6, 57-62.
32. Ram, S. P., Romana, L. K., Shepherd, M. G. & Sullivan, P. A. (1984). Exo-(1→3)-β-glucanase, autolysin and trehalase activities during yeast growth and germ-tube formation in Candida albicans. J Gen Microbiol 130, 1227-1236.
33. Shepherd, M. G. (1985). Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections, Infect Immun 50, 541-544.
34. Singer, M. A. & Lindquist S. (1998). Multiple effects of trehalose on protein folding in vitro and in vivo. Mol Cell 1, 639-648.
35. Sudbery, P., Gow, N. A. R. & Berman, J. (2004). The distinct morphogenic states of Candida albicans. Trends Microbiol 12, 317-324.
36. Thevelein, J. M. (1996). Regulation of trehalose metabolism and its relevance to cell growth and function. In The Mycota, vol. 3, pp. 395-414. Edited by R. Brambl & G. A. Marzluf. Heidelberg, Germany: Springer.
37. Van Dijck, P., De Rop, L., Szlufcik, K., Van Ael, E. & Thevelein, J. M. (2002). Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun 70, 1772-1782.
38. Vázquez-Torres, A. & Balish, E. (1997). Macrophages in resistance to candidiasis. Microbiol Mol Biol Rev 61, 170-192.
39. Verduyn Lunel, F. M., Meis, J. F. & Voss, A. (1999). Nosocomial fungal infections: candidemia. Diagn Microbiol Infect Dis 34, 213-220.
40. Zaragoza, O., Blazquez, M. A. & Gancedo, C. (1998). Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity. J Bacteriol 180, 3809-3815.
41. Zaragoza, O., de Virgilio, C., Ponton, J. & Gancedo, C. (2002). Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity. Microbiology 148, 1281-1290.