Nationwide sentinel surveillance of bloodstream Candida infections in 40 tertiary care hospitals in Spain

Journal of Clinical Microbiology

Volumn 48, Issue 11, 2010, Pages 4200-4206

  Cisterna, R ^a,a   Ezpeleta, G ^a   Telleria, O ^a   Guinea, J ^b   Regueiro, B ^c,c   Garcia Rodriguez J ^d   Esperalba, J ^e,e   Fernandez B ^f   Velasco, D ^f   Garcia Garrote F ^g   Ordonez P ^h   Iglesias, I ⁱ   Fernandez Natal M I ^j   Garcia M I ^k   Ortiz De Lejarazu, R ^l   Gobernado, C ^l   Blanco, J ^m   Hernandez P ⁿ   Aznar, J ^o   Casal, M ^p   Martin E ^q   Garcia Tapia A M ^r   Fernandez, C ^r   Sampedro, A ^s   Campos, S ^t   Merino, P ^u   Gomila, B ^v   Gobernado, M ^w   Peman J ^w   Camarena, J J ^x   Plazas, J ^y   Royo, G ^z   Blazquez R M ^aa   Yague G ^ab   Iborra, M A ^ab   Palomar, J J ^f   Perez J L ^ac   Garau, M M ^ad   Prats, G ^ae   Rodriguez V ^ae   Jimenez De Anta T ^af   Pitart, C ^af   Ayats, J ^ag   Revillo, M J ^ah   Rezusta, A ^ah   Torroba Alvarez L ^ai   Echeverria M J ^aj   Gozalo, M ^ak   more..

^a HOSPITAL DE BASURTO   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^e HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^f Complexo Hospitalario Xeral Calde ^*  (Spain)

^g HOSPITAL XERAL CALDE   (Spain)

^h Universidad de La Coruña   (Spain)

ⁱ Hospital de Leon ^*  (Spain)

^j HOSPITAL DE LEÓN   (Spain)

^k HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^l HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^m Hospital in Badajoz   (Spain)

ⁿ HOSPITAL SAN PEDRO DE ALCÁNTARA   (Spain)

^o HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^p HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^q HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^r HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^s HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^t HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^u HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^v HOSPITAL GENERAL DE CASTELLÓN   (Spain)

^w HOSPITAL UNIVERSITARIO LA FE   (Spain)

^x HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^y HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^z HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^aa HOSPITAL MORALES MESEGUER   (Spain)

^ab HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^ac HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^ad HOSPITAL SON LLÀTZER   (Spain)

^ae HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^af HOSPITAL CLÍNIC   (Spain)

^ag HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^ah HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^ai Universidad Pública de Navarra   (Spain)

^aj Hospital Donosita   (Spain)

^ak HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANIDULAFUNGIN; ANTIFUNGAL AGENT; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; ITRACONAZOLE; VORICONAZOLE;

ADOLESCENT; ADULT; AGED; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BLOOD CULTURE; BLOODSTREAM INFECTION; BROTH DILUTION; CANDIDA ALBICANS; CANDIDA ENDOCARDITIS; CANDIDA ENDOPHTHALMITIS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CANDIDEMIA; CHILD; CROSS RESISTANCE; DISEASE SURVEILLANCE; FEMALE; FEVER; FUNGUS ISOLATION; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORBIDITY; MORTALITY; NEOPLASM; NEUTROPENIA; NEWBORN; OUTPATIENT; PRIORITY JOURNAL; SPAIN; TERTIARY HEALTH CARE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIFUNGAL AGENTS; CANDIDA; CANDIDIASIS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, FUNGAL; FEMALE; FUNGEMIA; HOSPITALS; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PROSPECTIVE STUDIES; SENTINEL SURVEILLANCE; SPAIN; YOUNG ADULT;

CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS;

EID: 78049500483     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00920-10     Document Type: Article

References (45)

1. Al-Jasser, A. M., and N. A. Elkhizzi. 2004. Distribution of Candida species among bloodstream isolates. Saudi Med. J. 25:566-569.
2. Almirante, B., D. Rodriguez, B. J. Park, M. Cuenca-Estrella, A. M. Planes, M. Almela, J. Mensa, F. Sanchez, J. Ayats, M. Gimenez, P. Saballs, S. K. Fridkin, J. Morgan, J. L. Rodriguez-Tudela, D. W. Warnock, and A. Pahissa. 2005. Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, Barcelona, Spain, from 2002 to 2003. J. Clin. Microbiol. 43:1829-1835.
3. Alonso-Valle, H., O. Acha, J. D. Garcia-Palomo, C. Farinas-Alvarez, C. Fernandez-Mazarrasa, and M. C. Farinas. 2003. Candidemia in a tertiary care hospital: epidemiology and factors influencing mortality. Eur. J. Clin. Microbiol. Infect. Dis. 22:254-257.
4. Antunes, A. G., A. C. Pasqualotto, M. C. Diaz, P. A. d'Azevedo, and L. C. Severo. 2004. Candidemia in a Brazilian tertiary care hospital: species distribution and antifungal susceptibility patterns. Rev. Inst. Med. Trop. Sao Paulo 46:239-241.
5. Asmundsdottir, L. R., H. Erlendsdottir, and M. Gottfredsson. 2002. Increasing incidence of candidemia: results from a 20-year nationwide study in Iceland. J. Clin. Microbiol. 40:3489-3492.
6. Banerjee, S. N., T. G. Emori, D. H. Culver, R. P. Gaynes, W. R. Jarvis, T. Horan, J. R. Edwards, J. Tolson, T. Henderson, W. J. Martone, et al. 1991. Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989. Am. J. Med. 91:86S-89S.
7. Blumberg, H. M., W. R. Jarvis, J. M. Soucie, J. E. Edwards, J. E. Patterson, M. A. Pfaller, M. S. Rangel-Frausto, M. G. Rinaldi, L. Saiman, R. T. Wiblin, R. P. Wenzel, et al. 2001. Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. Clin. Infect. Dis. 33:177-186.
8. Clark, T. A., S. A. Slavinski, J. Morgan, T. Lott, B. A. Arthington-Skaggs, M. E. Brandt, R. M. Webb, M. Currier, R. H. Flowers, S. K. Fridkin, and R. A. Hajjeh. 2004. Epidemiologic and molecular characterization of an outbreak of Candida parapsilosis bloodstream infections in a community hospital. J. Clin. Microbiol. 42:4468-4472.
9. Colombo, A. L., M. Nucci, R. Salomao, M. L. Branchini, R. Richtmann, A. Derossi, and S. B. Wey. 1999. High rate of non-albicans candidemia in Brazilian tertiary care hospitals. Diagn. Microbiol. Infect. Dis. 34:281-286.
10. Costa, S. F., I. Marinho, E. A. Araujo, A. E. Manrique, E. A. Medeiros, and A. S. Levin. 2000. Nosocomial fungaemia: a 2-year prospective study. J. Hosp. Infect. 45:69-72.
11. Diekema, D. J., S. A. Messer, A. B. Brueggemann, S. L. Coffman, G. V. Doern, L. A. Herwaldt, and M. A. Pfaller. 2002. Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study. J. Clin. Microbiol. 40:1298-1302.
12. Doczi, I., E. Dosa, E. Hajdu, and E. Nagy. 2002. Aetiology and antifungal susceptibility of yeast bloodstream infections in a Hungarian university hospital between 1996 and 2000. J. Med. Microbiol. 51:677-681.
13. Fraser, V. J., M. Jones, J. Dunkel, S. Storfer, G. Medoff, and W. C. Dunagan. 1992. Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. Clin. Infect. Dis. 15:414-421.
14. Garbino, J., L. Kolarova, P. Rohner, D. Lew, P. Pichna, and D. Pittet. 2002. Secular trends of candidemia over 12 years in adult patients at a tertiary care hospital. Medicine (Baltimore) 81:425-433. (Pubitemid 35285962)
15. Girmenia, C., P. Martino, F. De Bernardis, G. Gentile, M. Boccanera, M. Monaco, G. Antonucci, and A. Cassone. 1996. Rising incidence of Candida parapsilosis fungemia in patients with hematologic malignancies: clinical aspects, predisposing factors, and differential pathogenicity of the causative strains. Clin. Infect. Dis. 23:506-514.
16. Gudlaugsson, O., S. Gillespie, K. Lee, B. J. Vande, J. Hu, S. Messer, L. Herwaldt, M. Pfaller, and D. Diekema. 2003. Attributable mortality of nosocomial candidemia, revisited. Clin. Infect. Dis. 37:1172-1177.
17. Imhof, A., S. A. Balajee, D. N. Fredricks, J. A. Englund, and K. A. Marr. 2004. Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole. Clin. Infect. Dis. 39:743-746.
18. Kao, A. S., M. E. Brandt, W. R. Pruitt, L. A. Conn, B. A. Perkins, D. S. Stephens, W. S. Baughman, A. L. Reingold, G. A. Rothrock, M. A. Pfaller, R. W. Pinner, and R. A. Hajjeh. 1999. The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin. Infect. Dis. 29:1164-1170.
19. Komshian, S. V., A. K. Uwaydah, J. D. Sobel, and L. R. Crane. 1989. Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: frequency, characteristics, and evaluation of factors influencing outcome. Rev. Infect. Dis. 11:379-390.
20. Levy, I., L. G. Rubin, S. Vasishtha, V. Tucci, and S. K. Sood. 1998. Emergence of Candida parapsilosis as the predominant species causing candidemia in children. Clin. Infect. Dis. 26:1086-1088.
21. Lin, M. Y., Y. Carmeli, J. Zumsteg, E. L. Flores, J. Tolentino, P. Sreeramoju, and S. G. Weber. 2005. Prior antimicrobial therapy and risk for hospital acquired Candida glabrata and Candida krusei fungemia: a case-case-control study. Antimicrob. Agents Chemother. 49:4555-4560.
22. Luzzati, R., G. Amalfitano, L. Lazzarini, F. Soldani, S. Bellino, M. Solbiati, M. C. Danzi, S. Vento, G. Todeschini, C. Vivenza, and E. Concia. 2000. Nosocomial candidemia in non-neutropenic patients at an Italian tertiary care hospital. Eur. J. Clin. Microbiol. Infect. Dis. 19:602-607.
23. Macphail, G. L., G. D. Taylor, M. Buchanan-Chell, C. Ross, S. Wilson, and A. Kureishi. 2002. Epidemiology, treatment and outcome of candidemia: a five-year review at three Canadian hospitals. Mycoses 45:141-145.
24. Marchetti, O., J. Bille, U. Fluckiger, P. Eggimann, C. Ruef, J. Garbino, T. Calandra, M. P. Glauser, M. G. Tauber, and D. Pittet. 2004. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. Clin. Infect. Dis. 38:311-320.
25. Marr, K. A., K. Seidel, T. C. White, and R. A. Bowden. 2000. Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole. J. Infect. Dis. 181:309-316.
26. Messer, S. A., G. J. Moet, J. T. Kirvy, and R. N. Jones. 2009. Activity of contemporary antifungal agents, including the novel echinocandin anidulafungin, tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: report from the SENTRY antimicrobial surveillance program (2006 to 2007). J. Clin. Microbiol. 47:1942-1946.
27. Morgan, J., M. I. Meltzer, B. D. Plikaytis, A. N. Sofair, S. Huie-White, S. Wilcox, L. H. Harrison, E. C. Seaberg, R. A. Hajjeh, and S. M. Teutsch. 2005. Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance. Infect. Control Hosp. Epidemiol. 26:540-547.
28. National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, 2nd ed. Document M27-A2. National Committee for Clinical Laboratory Standards, Wayne, PA.
29. Nguyen, M. H., C. J. Clancy, V. L. Yu, Y. C. Yu, A. J. Morris, D. R. Snydman, D. A. Sutton, and M. G. Rinaldi. 1998. Do in vitro susceptibility data predict the microbiologic response to amphotericin B? Results of a prospective study of patients with Candida fungemia. J. Infect. Dis. 177:425-430.
30. Nucci, M., A. L. Colombo, F. Silveira, R. Richtmann, R. Salomao, M. L. Branchini, and N. Spector. 1998. Risk factors for death in patients with candidemia. Infect. Control Hosp. Epidemiol. 19:846-850.
31. Ostrosky-Zeichner, L., J. H. Rex, P. G. Pappas, R. J. Hamill, R. A. Larsen, H. W. Horowitz, W. G. Powderly, N. Hyslop, C. A. Kauffman, J. Cleary, J. E. Mangino, and J. Lee. 2003. Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States. Antimicrob. Agents Chemother. 47:3149-3154.
32. Pappas, P. G., J. H. Rex, J. Lee, R. J. Hamill, R. A. Larsen, W. Powderly, C. A. Kauffman, N. Hyslop, J. E. Mangino, S. Chapman, H. W. Horowitz, J. E. Edwards, and W. E. Dismukes. 2003. A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin. Infect. Dis. 37:634-643.
33. Pasqualotto, A. C., T. C. Sukiennik, L. C. Severo, C. S. de Amorim, and A. L. Colombo. 2005. An outbreak of Pichia anomala fungemia in a Brazilian pediatric intensive care unit. Infect. Control Hosp. Epidemiol. 26:553-558.
34. Pfaller, M. A., R. N. Jones, G. V. Doern, H. S. Sader, R. J. Hollis, and S. A. Messer for the SENTRY Participant Group. 1998. International surveillance of bloodstream infections due to Candida species: frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY program. J. Clin. Microbiol. 36:1886-1889.
35. Pfaller, M. A., S. A. Messer, L. Boyken, S. Tendolkar, R. J. Hollis, and D. J. Diekema. 2004. Geographic variation in the susceptibilities of invasive isolates of Candida glabrata to seven systemically active antifungal agents: a global assessment from the ARTEMIS Antifungal Surveillance Program conducted in 2001 and 2002. J. Clin. Microbiol. 42:3142-3146.
36. Pittet, D., and R. P. Wenzel. 1995. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch. Intern. Med. 155:1177-1184.
37. Richet, H., P. Roux, C. C. Des, Y. Esnault, and A. Andremont. 2002. Candidemia in French hospitals: incidence rates and characteristics. Clin. Microbiol. Infect. 8:405-412.
38. Sandven, P., L. Bevanger, A. Digranes, P. Gaustad, H. H. Haukland, and M. Steinbakk. 1998. Constant low rate of fungemia in Norway, 1991 to 1996. The Norwegian Yeast Study Group. J. Clin. Microbiol. 36:3455-3459.
39. San Miguel, L. G., J. Cobo, E. Otheo, A. Sanchez-Sousa, V. Abraira, and S. Moreno. 2005. Secular trends of candidemia in a large tertiary-care hospital from 1988 to 2000: emergence of Candida parapsilosis. Infect. Control Hosp. Epidemiol. 26:548-552.
40. Silva, V., M. C. Diaz, and N. Febre. 2004. Invasive fungal infections in Chile: a multicenter study of fungal prevalence and susceptibility during a 1-year period. Med. Mycol. 42:333-339.
41. Tortorano, A. M., E. Biraghi, A. Astolfi, C. Ossi, M. Tejada, C. Farina, S. Perin, C. Bonaccorso, C. Cavanna, A. Raballo, and A. Grossi. 2002. European Confederation of Medical Mycology (ECMM) prospective survey of candidaemia: report from one Italian region. J. Hosp. Infect. 51:297-304.
42. Tortorano, A. M., J. Peman, H. Bernhardt, L. Klingspor, C. C. Kibbler, O. Faure, E. Biraghi, E. Canton, K. Zimmermann, S. Seaton, and R. Grillot. 2004. Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur. J. Clin. Microbiol. Infect. Dis. 23:317-322.
43. Trick, W. E., S. K. Fridkin, J. R. Edwards, R. A. Hajjeh, and R. P. Gaynes. 2002. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999. Clin. Infect. Dis. 35:627-630.
44. Viudes, A., J. Peman, E. Canton, P. Ubeda, J. L. Lopez-Ribot, and M. Gobernado. 2002. Candidemia at a tertiary-care hospital: epidemiology, treatment, clinical outcome and risk factors for death. Eur. J. Clin. Microbiol. Infect. Dis. 21:767-774.
45. Weems, J. J., Jr. 1992. Candida parapsilosis: epidemiology, pathogenicity, clinical manifestations, and antimicrobial susceptibility. Clin. Infect. Dis. 14:756-766.