Trehalose hydrolysis is not required for human serum-induced dimorphic transition in Candida albicans: Evidence from a tps1/tps1 mutant deficient in trehalose synthesis

Research in Microbiology

Volumn 150, Issue 8, 1999, Pages 521-529

  Argüelles, Juan Carlos ^a   Rodriguez, Tomas ^b   Alvarez Peral, Francisco J ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Candida albicans; Dimorphic transition; TPS1; tps1 tps1; Trehalose

Indexed keywords

GALACTOSE; GLUCOSE; GLYCEROL; SYNTHETASE; TREHALASE; TREHALOSE;

ARTICLE; CANDIDA ALBICANS; CARBOHYDRATE METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGUS HYPHAE; FUNGUS MUTANT; HYDROLYSIS; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; SERUM;

CANDIDA ALBICANS;

EID: 0344500851     PISSN: 09232508     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2508(99)00105-9     Document Type: Article

References (45)

1. Ahrens J.C., Daneo-Moore L., Buckley H.R. Differential protein synthesis in Candida albicans during blastospore formation at 24.5 °C and during germ tube formation at 37 °C. J. Gen. Microbiol. 129:1983;1133-1139.
2. Argüelles J.C., Carrillo D., Vicente J., Garcìa-Carmona F., Gacto M. Lack of correlation between trehalase activation and trehalose-6-phosphate synthase deactivation in cAMP-altered mutants of Saccharomyces cerevisiae. Curr. Genet. 23:1993;382-387.
3. Argüelles J.C. Heat-shock response in a yeast tps1 mutant deficient in trehalose synthesis. FEBS Lett. 350:1994;266-270.
4. Argüelles J.C. Thermotolerance and trehalose accumulation induced by heat-shock in yeast cells of Candida albicans. FEMS Microbiol. Lett. 146:1997;65-71.
5. Arnold W.N., McLellan M.N. Trehalose and glycogen levels during the initial stages of growth of Candida albicans. Physiol. Chem. Phys. 7:1975;369-380.
6. Bell W.M., Chaffin W.L. Nutrient-limited yeast growth in Candida albicans: effect on yeast-mycelial transition. Can. J. Microbiol. 26:1980;102-105.
7. Buchan A.R.D., Gow N.A.R. Rates of germ tube formation from growing and non-growing yeast cells of Candida albicans. FEMS Microbiol. Lett. 81:1991;15-18.
8. Blázquez M.A., Lagunas R., Gancedo C., Gancedo J.M. Trehalose-6-phosphate a new regulator of yeast glycolysis. FEBS Lett. 329:1993;51-54.
9. Blázquez M.A., Stucka R., Feldmann H., Gancedo C. Trehalose-6P-synthase is dispensable for growth on glucose but nor for spore germination in Schizosaccharomyces pombe. J. Bacteriol. 176:1994;3895-3902.
10. Braun B.R., Johnson A.D. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science. 277:1997;105-109.
11. Coleman D.C., Bennett D.J., Sullivan P.J., Gallagher M.C., Henman D.B., Shanley D.B., Russell R.J. Oral Candida in HIV infection and AIDS: new perspectives/ new approaches. Crit. Rev. Microbiol. 19:1993;61-82.
12. Cutler J.E. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45:1991;187-218.
13. DeVirgilio C., Bürckert N., Bell W., Jenö P., Boller T., Wiemken A. Disruption of TPS2 the gene encoding the 100 kDa subunit of the trehalose-6-phophate synthase/phosphatase complex in Saccharomyces cerevisiae causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphatase activity. Eur. J. Biochem. 212:1993;315-323.
14. Eck R., Bergmann C., Ziegelbauer K., Schönfeld W., Künkel W. A neutral trehalase gene from Candida albicans: molecular cloning characterization and disruption. Microbiology. 143:1997;4747-4756.
15. Evans E.G., Odds F.C., Richardson M.D., Holl K.T. Optimum conditions for initiation of filamentation in Candida albicans. Can. J. Microbiol. 21:1975;338-342.
16. Fonzi W.A., Irwin M.Y. Isogenic strain construction and gene mapping in Candida albicans. Genetics. 134:1993;717-728.
17. François J., Neves M.J., Hers H.G. The control of trehalose biosynthesis in Saccharomyces cerevisiae: Evidence for catabolite inactivation and repression of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase. Yeast. 7:1991;575-587.
18. González M.I., Stucka R., Blazquez M.A., Gancedo C. Molecular cloning of CIF1 a yeast gene necessary for growth on glucose. Yeast. 8:1992;183-192.
19. Hohmann S., Bell W., Neves M.J., Walcks D., Thevelein J.M. Evidence for trehalose-6-phosphate-dependent and -independent mechanisms in the control of sugar influx into yeast glycolysis. Mol. Microbiol. 20:1996;981-991.
20. Killick K.A. Alteration in trehalase solubility during development in the cellular slime mould Dictyostelium discoideum. J. Gen. Microbiol. 131:1985;273-278.
21. Köhler J.R., Fink G.R. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signalling components have defects in hyphal development. Proc. Natl. Acad. Sci. 93:1996;13223-13228.
22. Kopp M., Müller H., Holzer H. Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae. J. Biol. Chem. 268:1993;4744-4766.
23. Lo H.J., Köhler J.R., Didomenico B., Loebenberg D., Cacciapuoti A., Fink G.R. Nonfilamentous Candida albicans mutants are avirulent. Cell. 90:1997;939-949.
24. Londesborough J., Varimo K. Characterization of two trehalases in baker's yeastn. Biochem. J. 219:1984;511-518.
25. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Proetin measurement with the Folin phenol reagentn. J. Biol. Chem. 193:1951;265-275.
26. Luyten K., DeKoning W., Tesseur Y., Ruiz M.C., Ramos J., Cobbaert P., Thevelein J.M., Hohmann S. Disruption of the Kluyveromyces GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptaken. Eur. J. Biochem. 217:1993;701-713.
27. Odds F.C. Candida and Candidiosis A review and bibliography. 1988;Bailliere, Tindall, London.
28. Operti M.S., Oliveira D.E., Freitas-Valle A.B., Oestreicher E.G., Mattoon J.R., Panek A.D. Relationships between trehalose metabolism and maltose utilization in Saccharomyces cerevisiae. Curr. Genet. 5:1982;69-76.
29. Panneman H., Ruijter G.J., Van Den Broeck H.C., Visser J. Cloning and biochemical characterisation of Aspergillus niger hexokinase. The enzyme is strongly inhibited by physiological concentrations of trehalose-6-phosphate. Eur. J. Biochem. 258:1998;223-232.
30. Pollack J.H., Hashimoto T. The role of glucose in the pH regulation of germ-tube formation in Candida albicans. J. Gen. Microbiol. 133:1987;415-424.
31. Ram S.P., Romana L., Shepherd M.G., Sullivan P.A. Exo-(13) - glucanase autolysin and trehalase activities during yeast growth and germ-tube formation in Candida albicans. J. Gen. Microbiol. 130:1984;1227-1236.
32. San Miguel P., Fargüelles J.C. Differential changes in the activity of cytosolic and vacuolar trehalases along the growth cycle of Saccharomyces cerevisiae. Biochim. Biophys. Acta. 1200:1994;155-160.
33. Shepherd M.G., Yin C.Y., Ram S.P., Sullivan P.A. Germ tube induction in Candida albicans. Can. J. Microbiol. 26:1980;21-26.
34. Shepherd M.G., Poulter R.M., Sullivan P.A. Candida albicans: Biology genetics and pathogenicity. Ann. Rev. Microbiol. 39:1985;579-614.
35. Soll D.R., Bedell G. Bud formation and the inducibility of pseudomycelium outgrowth during release from stationary phase in Candida albicans. J. Gen. Microbiol. 108:1978;173-180.
36. Soll D.R., Herman M.A. Growth and the inducibility of mycelium formation in Candida albicans: a single-cell analysis using a perfusion chamber. J. Gen. Microbiol. 129:1983;2809-2824.
37. Sullivan P.A., Yin C.Y., Molloy C., Templeton M.D. An analysis of the metabolism and cell wall composition of Candida albicans during germ-tube formation. Can. J. Microbiol. 29:1983;1514-1525.
38. Thevelein J.M. Regulation of trehalose mobilization in fungi. Microbiol. Rev. 48:1984;42-59.
39. Thevelein J.M. Regulation of trehalose metabolism and its relevance to cell growth and function. Brambl R, Marzluf G.A. The Mycota. 1996;395-414 Springer Verlag Heidelberg. 3.
40. Van Aelst L., Hohmann S., Bulaya B., De Koning W., Sierkstra L., Neves M.J., Luyten K., Alijo R., Ramos J., Cocceti P., Martegani E., Magalhaes-Rocha M., Lopes-Brandao R., VanDijck P., Vanhalewyn M., Durnez P., Jans A., Thevelein J.M. Molecular cloning of a gene involved in glucose sensing. Mol. Microbiol. 8:1993;927-943.
41. Vandercammen A., François J., Hers H.G. Characterization of trehalose-6-phosphate synthase and trehalose-6-phosphatase of Saccharomyces cerevisiae, Eur. J. Biochem. 182:1989;613-620.
42. VanLaere A. Trehalose reserve and/or stress metabolite. FEMS Microbiol. Lett. 63:1989;201-210.
43. Wiemken A. Trehalose in yeast stress protectant rather than reserve carboydrate. Antonie Leeuwenhoek. 59:1990;209-217.
44. Wolschek M.F., Kubicek C.P. The filamentous fungi Aspergillus niger contains two 'differently regulated' trehalose-6-phosphate synthase encoding genes tpsA and tpsB. J. Biol. Chem. 272:1997;2729-2735.
45. Zaragoza O., Blázquez M.A., Gancedo C. Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity. J. Bacteriol. 180:1998;3809-3815.