Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

Cancer Letters

Volumn 309, Issue 1, 2011, Pages 71-77

  Burmistrova, Olga ^a   Quintana, José ^a   Díaz, Jesús G ^b   Estévez, Francisco ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Apoptosis; Caspases; Flavonoids; Mitogen activated protein kinases; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ASTRAGALIN HEPTAACETATE; CASPASE; CASPASE 3; CASPASE 7; CASPASE 9; CATHEPSIN B; CATHEPSIN L; CYTOCHROME C; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CELL DEATH; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; GLYCOSIDES; HL-60 CELLS; HUMANS; KAEMPFEROLS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLINES;

EID: 79959834011     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.05.018     Document Type: Article

References (20)

1. Li J., Yuan J. Caspases in apoptosis and beyond. Oncogene 2008, 27:6194-6206.
2. Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell. Biol. 2008, 9:47-59.
3. Raman M., Chen W., Cobb M.H. Differential regulation and properties of MAPKs. Oncogene 2007, 26:3100-3112.
4. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol. Therapeut. 2002, 96:67-202.
5. Díaz J.G., Carmona A.J., Perez de Paz P., Herz W. Acylated flavonol glycosides from Delphinium staphisagria. Phytochem. Lett. 2008, 1:125-129.
6. Torres F., Quintana J., Estévez F. 5,7,3′-Trihydroxy-3,4′-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway. Mol. Carcinog. 2010, 49:464-475.
7. Rubio S., Quintana J., López M., Eiroa J.L., Triana J., Estévez F. Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents. Eur. J. Pharmacol. 2006, 548:9-20.
8. Torres F., Quintana J., Díaz J.G., Carmona A.J., Estévez F. Trifolin-acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway. Apoptosis 2008, 13:716-728.
9. Rubio S., Quintana J., Eiroa J.L., Triana J., Estévez F. Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK. Carcinogenesis 2007, 28:2105-2113.
10. Breckenridge D.G., Germain M., Mathai J.P., Nguyen M., Shore G.C. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003, 22:8608-8618.
11. Zhuang S., Demirs J.T., Kochevar I.E. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J. Biol. Chem. 2000, 275:25939-25948.
12. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25years. J. Nat. Prod. 2007, 70:461-477.
13. Margolin N., Raybuck S.A., Wilson K.P., Chen W., Fox T., Gu Y., Livingston D.J. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J. Biol. Chem. 1997, 272:7223-7228.
14. Scoltock A.B., Cidlowski J.A. Activation of intrinsic and extrinsic pathways in apoptotic signaling during UV-C-induced death of Jurkat cells: the role of caspase inhibition. Exp. Cell Res. 2004, 297:212-223.
15. Guicciardi M.E., Leist M., Gores G.J. Lysosomes in cell death. Oncogene 2004, 23:2881-2890.
16. Bellows D.S., Chau B.N., Lee P., Lazebnik Y., Burns W.H., Hardwick J.M. Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. J. Virol. 2000, 74:5024-5031.
17. Owens D.M., Keyse S.M. Differential regulation of MAP kinase signalling by dual-specify protein phosphatases. Oncogene 2007, 26:3203-3213.
18. Tonks N.K. Redox redux: revisiting PTPs and the control of cell signaling. Cell 2005, 121:667-670.
19. Kavanagh T.J., Grossmann A., Jaecks E.P., Jinneman J.C., Eaton D.L., Martin G.M., Rabinovitch P.S. Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content. J. Cell. Physiol. 1990, 145:472-480.
20. Buttke T.M., Sandstrom P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today 1994, 15:7-10.