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Volumn 30, Issue 26, 2011, Pages 2943-2953

α4 is highly expressed in carcinogen-transformed human cells and primary human cancers

Author keywords

4; cell transformation; human cancers; protein phosphatase 2A

Indexed keywords

MICRORNA; MIR 34B; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN ALPHA4; UNCLASSIFIED DRUG;

EID: 79959829735     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.20     Document Type: Article
Times cited : (40)

References (44)
  • 1
    • 27944448894 scopus 로고    scopus 로고
    • Involvement of PP2A in viral and cellular transformation
    • DOI 10.1038/sj.onc.1209038, PII 1209038
    • Arroyo JD, Hahn WC. (2005). Involvement of PP2A in viral and cellular transformation. Oncogene 24: 7746-7755. (Pubitemid 41670676)
    • (2005) Oncogene , vol.24 , Issue.52 , pp. 7746-7755
    • Arroyo, J.D.1    Hahn, W.C.2
  • 2
    • 34547141377 scopus 로고    scopus 로고
    • Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase
    • DOI 10.1016/j.yexcr.2007.05.008, PII S0014482707002273
    • Bielinski VA, Mumby MC. (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res 313: 3117-3126. (Pubitemid 47125883)
    • (2007) Experimental Cell Research , vol.313 , Issue.14 , pp. 3117-3126
    • Bielinski, V.A.1    Mumby, M.C.2
  • 3
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA, Houghton PJ. (2004). The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348. (Pubitemid 38579480)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.-A.1    Houghton, P.J.2
  • 6
    • 24944485819 scopus 로고    scopus 로고
    • Cancer-associated PP2A Aα subunits induce functional haploinsufficiency and tumorigenicity
    • DOI 10.1158/0008-5472.CAN-05-1103
    • Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC. (2005). Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity. Cancer Res 65: 8183-8192. (Pubitemid 41330582)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8183-8192
    • Chen, W.1    Arroyo, J.D.2    Timmons, J.C.3    Possemato, R.4    Hahn, W.C.5
  • 7
    • 1442310493 scopus 로고    scopus 로고
    • Identification of specific PP2A complexes involved in human cell transformation
    • DOI 10.1016/S1535-6108(04)00026-1, PII S1535610804000261
    • Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC. (2004). Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5: 127-136. (Pubitemid 38283799)
    • (2004) Cancer Cell , vol.5 , Issue.2 , pp. 127-136
    • Chen, W.1    Possemato, R.2    Campbell, K.T.3    Plattner, C.A.4    Pallas, D.C.5    Hahn, W.C.6
  • 8
    • 0035883164 scopus 로고    scopus 로고
    • Reduced expression of the Aα subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aα and Aβ subunit genes
    • DOI 10.1002/ijc.1423
    • Colella S, Ohgaki H, Ruediger R, Yang F, Nakamura M, Fujisawa H et al. (2001). Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes. Int J Cancer 93: 798-804. (Pubitemid 32756748)
    • (2001) International Journal of Cancer , vol.93 , Issue.6 , pp. 798-804
    • Colella, S.1    Ohgaki, H.2    Ruediger, R.3    Yang, F.4    Nakamura, M.5    Fujisawa, H.6    Kleihues, P.7    Walter, G.8
  • 9
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • DOI 10.1158/0008-5472.CAN-07-1585
    • Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. (2007). MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 67: 8433-8438. (Pubitemid 47437414)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Yu.5
  • 10
    • 0035216768 scopus 로고    scopus 로고
    • The protein phosphatase 2A subunit Bγ gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization
    • DOI 10.1097/00008390-200112000-00004
    • Deichmann M, Polychronidis M, Wacker J, Thome M, Naher H. (2001). The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization. Melanoma Res 11: 577-585. (Pubitemid 33152349)
    • (2001) Melanoma Research , vol.11 , Issue.6 , pp. 577-585
    • Deichmann, M.1    Polychronidis, M.2    Wacker, J.3    Thome, M.4    Naher, H.5
  • 11
    • 0029808294 scopus 로고    scopus 로고
    • Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
    • Di Como CJ, Arndt KT. (1996). Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev 10: 1904-1916. (Pubitemid 26281685)
    • (1996) Genes and Development , vol.10 , Issue.15 , pp. 1904-1916
    • Di Como, C.J.1    Arndt, K.T.2
  • 14
    • 72049117072 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth
    • Gibbons JJ, Abraham RT, Yu K. (2009). Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol 36 (Suppl 3): S3-S17.
    • (2009) Semin Oncol , vol.36 , Issue.SUPPL. 3
    • Gibbons, J.J.1    Abraham, R.T.2    Yu, K.3
  • 15
    • 0032946279 scopus 로고    scopus 로고
    • Protein phosphatase 2A: Who shall regulate the regulator?
    • DOI 10.1016/S0006-2952(98)00245-7, PII S0006295298002457
    • Goldberg Y. (1999). Protein phosphatase 2A: who shall regulate the regulator? Biochem Pharmacol 57: 321-328. (Pubitemid 29065280)
    • (1999) Biochemical Pharmacology , vol.57 , Issue.4 , pp. 321-328
    • Goldberg, Y.1
  • 16
    • 0032528434 scopus 로고    scopus 로고
    • Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
    • Inui S, Sanjo H, Maeda K, Yamamoto H, Miyamoto E, Sakaguchi N. (1998). Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood 92: 539-546.
    • (1998) Blood , vol.92 , pp. 539-546
    • Inui, S.1    Sanjo, H.2    Maeda, K.3    Yamamoto, H.4    Miyamoto, E.5    Sakaguchi, N.6
  • 17
    • 77649220070 scopus 로고    scopus 로고
    • Basic properties and molecular mechanisms of exogenous chemical carcinogens
    • Irigaray P, Belpomme D. (2010). Basic properties and molecular mechanisms of exogenous chemical carcinogens. Carcinogenesis 31: 135-148.
    • (2010) Carcinogenesis , vol.31 , pp. 135-148
    • Irigaray, P.1    Belpomme, D.2
  • 18
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • DOI 10.1042/0264-6021:3530417
    • Janssens V, Goris J. (2001). Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signaling. Biochem J 353: 417-439. (Pubitemid 32158309)
    • (2001) Biochemical Journal , vol.353 , Issue.3 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 21
    • 70349780568 scopus 로고    scopus 로고
    • Alpha4 is an essential regulator of PP2A phosphatase activity
    • Kong M, Ditsworth D, Lindsten T, Thompson CB. (2009). Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell 36: 51-60.
    • (2009) Mol Cell , vol.36 , pp. 51-60
    • Kong, M.1    Ditsworth, D.2    Lindsten, T.3    Thompson, C.B.4
  • 24
    • 79958294934 scopus 로고    scopus 로고
    • Establishment and application of oncogene over expressed human epithelial cell transformation model
    • Ma RL, Pang YQ, Li WX, Xiao YM, Wei Q, Li DC et al. (2008). Establishment and application of oncogene over expressed human epithelial cell transformation model. Zhonghua Yu Fang Yi Xue Za Zhi 42: 395-399.
    • (2008) Zhonghua Yu Fang Yi Xue Za Zhi , vol.42 , pp. 395-399
    • Ma, R.L.1    Pang, Y.Q.2    Li, W.X.3    Xiao, Y.M.4    Wei, Q.5    Li, D.C.6
  • 25
    • 77749298896 scopus 로고    scopus 로고
    • Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination
    • McConnell JL, Watkins GR, Soss SE, Franz HS, McCorvey LR, Spiller BW et al. (2010). Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. Biochemistry 49: 1713-1718.
    • (2010) Biochemistry , vol.49 , pp. 1713-1718
    • McConnell, J.L.1    Watkins, G.R.2    Soss, S.E.3    Franz, H.S.4    McCorvey, L.R.5    Spiller, B.W.6
  • 26
    • 77954931515 scopus 로고    scopus 로고
    • Alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein
    • McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK. (2010). Alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein. J Cell Biochem 110: 1123-1129.
    • (2010) J Cell Biochem , vol.110 , pp. 1123-1129
    • McDonald, W.J.1    Sangster, S.M.2    Moffat, L.D.3    Henderson, M.J.4    Too, C.K.5
  • 27
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam F, Gonzalez-Angulo AM. (2009). Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 27: 2278-2287.
    • (2009) J Clin Oncol , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 28
    • 34447106751 scopus 로고    scopus 로고
    • PP2A: Unveiling a Reluctant Tumor Suppressor
    • DOI 10.1016/j.cell.2007.06.034, PII S0092867407008392
    • Mumby M. (2007). PP2A: unveiling a reluctant tumor suppressor. Cell 130: 21-24. (Pubitemid 47031327)
    • (2007) Cell , vol.130 , Issue.1 , pp. 21-24
    • Mumby, M.1
  • 29
    • 0030984108 scopus 로고    scopus 로고
    • B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
    • DOI 10.1073/pnas.94.20.10624
    • Murata K, Wu J, Brautigan DL. (1997). B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc Natl Acad Sci USA 94: 10624-10629. (Pubitemid 27430784)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.20 , pp. 10624-10629
    • Murata, K.1    Wu, J.2    Brautigan, D.L.3
  • 30
    • 0031573860 scopus 로고    scopus 로고
    • Expression and chromosomal localization of the human α4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway
    • DOI 10.1006/geno.1997.5048
    • Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N. (1997). Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway. Genomics 46: 373-378. (Pubitemid 28063285)
    • (1997) Genomics , vol.46 , Issue.3 , pp. 373-378
    • Onda, M.1    Inui, S.2    Maeda, K.3    Suzuki, M.4    Takahashi, E.-I.5    Sakaguchi, N.6
  • 31
    • 53549129484 scopus 로고    scopus 로고
    • Development of human cell models for assessing the carcinogenic potential of chemicals
    • Pang Y, Li W, Ma R, Ji W, Wang Q, Li D et al. (2008). Development of human cell models for assessing the carcinogenic potential of chemicals. Toxicol Appl Pharmacol 232: 478-486.
    • (2008) Toxicol Appl Pharmacol , vol.232 , pp. 478-486
    • Pang, Y.1    Li, W.2    Ma, R.3    Ji, W.4    Wang, Q.5    Li, D.6
  • 32
    • 65549124181 scopus 로고    scopus 로고
    • MiR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia
    • Pigazzi M, Manara E, Baron E, Basso G. (2009). miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res 69: 2471-2478.
    • (2009) Cancer Res , vol.69 , pp. 2471-2478
    • Pigazzi, M.1    Manara, E.2    Baron, E.3    Basso, G.4
  • 33
    • 34250209867 scopus 로고    scopus 로고
    • Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3
    • DOI 10.1128/MCB.00067-07
    • Prickett TD, Brautigan DL. (2007). Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol 27: 4217-4227. (Pubitemid 46906547)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.12 , pp. 4217-4227
    • Prickett, T.D.1    Brautigan, D.L.2
  • 35
    • 77954541457 scopus 로고    scopus 로고
    • A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A
    • Shouse GP, Nobumori Y, Liu X. (2010). A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A. Oncogene 29: 3933-3941.
    • (2010) Oncogene , vol.29 , pp. 3933-3941
    • Shouse, G.P.1    Nobumori, Y.2    Liu, X.3
  • 36
    • 33646488202 scopus 로고    scopus 로고
    • Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42
    • Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M et al. (2006). Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42. Biochim Biophys Acta 1764: 724-734.
    • (2006) Biochim Biophys Acta , vol.1764 , pp. 724-734
    • Smetana, J.H.1    Oliveira, C.L.2    Jablonka, W.3    Aguiar Pertinhez, T.4    Carneiro, F.R.5    Montero-Lomeli, M.6
  • 38
    • 0034009389 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A panoply of enzymes
    • DOI 10.1016/S0955-0674(99)00074-5
    • Virshup DM. (2000). Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol 12: 180-185. (Pubitemid 30142564)
    • (2000) Current Opinion in Cell Biology , vol.12 , Issue.2 , pp. 180-185
    • Virshup, D.M.1
  • 39
    • 51049111624 scopus 로고    scopus 로고
    • Protein phosphatase PP4 is overexpressed in human breast and lung tumors
    • Wang B, Zhao A, Sun L, Zhong X, Zhong J, Wang H et al. (2008). Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res 18: 974-977.
    • (2008) Cell Res , vol.18 , pp. 974-977
    • Wang, B.1    Zhao, A.2    Sun, L.3    Zhong, X.4    Zhong, J.5    Wang, H.6
  • 40
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J, Hahn WC. (2008). Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 14: 152-160.
    • (2008) Trends Mol Med , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 41
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, Hall MN. (2006). TOR signaling in growth and metabolism. Cell 124: 471-484. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 42
    • 34547614282 scopus 로고    scopus 로고
    • The structure of Tap42/α4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation
    • DOI 10.1021/bi7007118
    • Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D. (2007). The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry 46: 8807-8815. (Pubitemid 47204446)
    • (2007) Biochemistry , vol.46 , Issue.30 , pp. 8807-8815
    • Yang, J.1    Roe, S.M.2    Prickett, T.D.3    Brautigan, D.L.4    Barford, D.5
  • 43
    • 67650237693 scopus 로고    scopus 로고
    • Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy
    • Yorimitsu T, He C, Wang K, Klionsky DJ. (2009). Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy 5: 616-624.
    • (2009) Autophagy , vol.5 , pp. 616-624
    • Yorimitsu, T.1    He, C.2    Wang, K.3    Klionsky, D.J.4
  • 44
    • 63449103531 scopus 로고    scopus 로고
    • DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution
    • Zhang Y, Rohde C, Tierling S, Jurkowski TP, Bock C, Santacruz D et al. (2009). DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet 5: e1000438.
    • (2009) PLoS Genet , vol.5
    • Zhang, Y.1    Rohde, C.2    Tierling, S.3    Jurkowski, T.P.4    Bock, C.5    Santacruz, D.6


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