Controlled ovarian hyperstimulation: A review for the non-ART patient

Minerva Ginecologica

Volumn 63, Issue 2, 2011, Pages 119-135

  Willis, M Y ^a   Browne, A S ^a   Session, D R ^a   Spencer, J B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gonadotropins; Infertility; Insemination; Ovulation induction

Indexed keywords

BROMOCRIPTINE; CABERGOLINE; CLOMIFENE; DEXAMETHASONE; DOPAMINE RECEPTOR STIMULATING AGENT; ESTRADIOL; FOLLITROPIN; GLIBENCLAMIDE; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; HUMAN MENOPAUSAL GONADOTROPIN; INHIBIN B; INSULIN; LETROZOLE; LEVOTHYROXINE; LUTEINIZING HORMONE; METFORMIN; MUELLERIAN INHIBITING FACTOR; PLACEBO; PRASTERONE; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE;

AMENORRHEA; AMENORRHEA AND OLIGOMENORRHEA; ANDROGEN THERAPY; ANOVULATION; BASAL BODY TEMPERATURE; BIRTH RATE; BLOATING; CLINICAL PROTOCOL; CONTROLLED OVARY HYPERSTIMULATION; DIARRHEA; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TOLERABILITY; FOLLICULAR PHASE; GASTROINTESTINAL SYMPTOM; HORMONAL REGULATION; HUMAN; HYPERANDROGENISM; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPROLACTINEMIA; HYPOGONADISM; HYPOPHYSIS ADENOMA; HYPOTHYROIDISM; INSULIN RESISTANCE; INTRAUTERINE INSEMINATION; LUTEAL PHASE; MONITORING; MULTIPLE CYCLE TREATMENT; MULTIPLE PREGNANCY; MUSCLE CRAMP; NAUSEA; OBESITY; ORAL CONTRACEPTION; ORTHOSTATIC HYPOTENSION; OVARIAN RESERVE; OVARY CANCER; OVARY HYPERSTIMULATION; OVARY HYPERTROPHY; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY OUTCOME; PREGNANCY RATE; PREMATURE LABOR; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEMEN ANALYSIS; SPONTANEOUS ABORTION; TORSION; TRANSVAGINAL ECHOGRAPHY; TWIN PREGNANCY; ULTRASOUND;

CLINICAL PROTOCOLS; CLOMIPHENE; FEMALE; FERTILITY AGENTS, FEMALE; GONADOTROPINS; HUMANS; INFERTILITY, FEMALE; OVULATION INDUCTION; REPRODUCTIVE TECHNIQUES, ASSISTED;

EID: 79959789202     PISSN: 00264784     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (148)

1. Van Rumste MME, Custers IM, van der Veen F, van Wely M, Evers JLH, Mol BWJ. The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Hum Reprod Update 2008;14:563-70.
2. Rowe PJ, Comhaire FA, Hargreave TJ, Mellows HJ. WHO Manual for the standardized investigation and diagnosis of the infertile couple. Cambridge, UK: Cambridge University Press; 1993.
3. Wathen NC, Perry L, Lilford RJ, Chard T. Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations of analysis of the normal range. Br Med J 1984;288:7.
4. Factor SA. Dopamine agonists. Med Clin North Am 1999;83:415.
5. Bankowski BJ, Zacur HA. Dopamine agonist therapy for hyperprolactinemia. Clin Obstet Gynecolol 2003;46:349.
6. Webster J, Piscitelli G, Polli A, Ferrari CI, Ismail I, Scanlon MF. For the Caberoline Comparative Study Group: a comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. New Engl J Med 1994;331:904.
7. Geva E, Shoham T, Rosler M, Margalioth A, Livine E, Meirow Dror K. Subclinical hypothyroidism in infertile women: The importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test. Gynecol Endocrinology 2007;23:332-7.
8. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2007;92:S1-47.
9. Thonneau P, Marchand S, Tallec A, Ferial ML, Ducot B, Lansac J et al. Incidence and main causes of infertility in a resident population of three French regions (1988-1989). Hum Reprod 1991;6:811-6.
10. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 2006;12:685-718.
11. Abma JC, Chandra A, Mosher WD, Peterson LS, Piccinino LJ. Fertility, family planning, and women's health: new data from the 1995 National Survey of Family Growth. Vital Health Stat 1997;23:1-114.
12. Sills ES, Alper MM, Walsh AP. Ovarian reserve screening in infertility: practical applications and theoretical directions for research. Eur J Obstet Gynecol Reprod Biol 2009;146:30-6.
13. Buyalos RP, Daneshmand S, Brzechffa PR. Basal estradiol and follicle-stimulating hormone predict fecundity in women of advanced reproductive age undergoing ovulation induction therapy. Fertil Seril 1997;68:272-7. (Pubitemid 27342600)
14. Sowers MR, Eyvazzadeh AD, McConnell D, Yosef M, Jannausch ML, Zhang D et al. Antimullerian hormone and inhibin-B in the definition of ovarian aging and the menopause transition. J Clin Endocrinol Metab 2008;93:3478-83.
15. Seifer DB, Lambert-Messerlian G, Hogan JW, Gardiner AC, Blazar AS, Berk CA. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertil Steril 1997;67:110-4.
16. Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA et al. Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77-83. (Pubitemid 38196508)
17. Domingues T, Rocha A, Serafini P. Tests for ovarian reserve: reliability and utility. Curr Opin Obstet Gynecol 2010;22:271-6.
18. La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology(ART). Human Reprod Update 2009;16:113-30.
19. van Disseldorp J, Faddy MJ, Themmen AP, de Jong FH, Peeters PH, van der Schouw YT, Broekmans FJ. Relationship of serum antimullerian hormone concentration to age at menopause. J Clin Endocrinol Metab 2008;93:2129-34. (Pubitemid 351831526)
20. Gibreel A, Maheshwari A, Bhattacharya S, Johnson NP. Ultrasound tests of ovarian reserve; a systematic review of accuracy in predicting fertility outcomws. Hum Feril (Camb) 2009;12:95-106.
21. Dumesic D, Damario M, Session D, Famuyide A, Lesnick T, Thornhill A, McNeilly A. Ovarian morphology and serum hormone markers as predictors of ovarian follicle recruitment by gonadotropins for in vitro fertilization. J Clin Endorinol Metab 2001;86:2538-43. (Pubitemid 32545704)
22. Muttukrishna S, McGarrigle H, Wakim R. Antral follicle count, antimullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology? BJOG 2005;112:1384-90.
23. Jayaprakasan K, Campbell B, Hopkisson J, Johnson I, Raine-Fenning N. A prospective, comparative analysis of the anti-Mullerian hormone, inhibin-B, and the three-dimentional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation. Fert Steril 2010;93:855-64.
24. Silberstein T, MacLaughlin DT, Shai I, Trimarchi JR, Lambert-Messerlian G, Seifer DB et al. Mullerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology. Hum Reprod 2006;21:159-63.
25. Adahsi EY. Clomiphene citrate: mechanisms and sites of action-a hypothesis revisited. Fertil Steril 1984;42:331-44.
26. Poison DW, Kiddy DS, Mason HD, Franks S. Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and non responders. Fertil Steril 1989;51:30-4. (Pubitemid 19033716)
27. Dickey RP, Taylor SN, Curole DD, Rye PH, Lu PY, Pyrzak R. Relationship of clomiphene dose and patient weight to successful treatment. Hum Reprod 1997;12:449-53. (Pubitemid 27156434)
28. Hammond MG. Monitoring techniques for improved pregnancy rates during clomiphene ovulation induction. Ferti Steril 1984;42:499-508.
29. Dickey RP, Taylor SN, Curole DN, Rye PH, Pyrzak R. Incidence of spontaneous abortion in clomiphene pregnancies. Hum Reprod 1996;11:2623-8. (Pubitemid 27060730)
30. Gysler M, March CM, Mishell DR, Bailey EJ. A decade's experience with an individualized clomiphene treatment regimen including its effects on the post-coital test. Fertil Steril 1982;37:161-7. (Pubitemid 12171166)
31. Neveu N, Granger L, St. Michel P, Lavoie HB. Comparison of clomiphene citrate, metformin, or the combination of both for first line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. Fertil Steril 2007;87:113-20.
32. Schenker JG, Yarkoni S, Granat M, Multiiple pregnancies following induction of ovulation. Fertil Steril 1981;35:105.
33. Correy JF, Marsden DE, Schokman FC. The outcome of pregnancy resulting from clomiphene-induced ovulation. Aus N Z J Obstet Gynaecol 1982;22:18.
34. Carlier P, Choulika S, Efthymiou ML. Clomiphene-exposed pregnancies: analysis of 39 information requests including 25 cases with known outcome. Therapie 1996;51:532.
35. Silva Idos S, Wark PA, McCormack VA, Mayer D, Overton C, Little V et al. Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort. Br J Cancer 2009;100:1824-31.
36. Zreik TG, Mazloom A, Chen Y, Vannucci M, Pinnix CC, Fulton S et al. Fertility drugs and the risk of breast cancer: a meta-analysis and review. Breast Cancer Res Treat 2010;124:13-26.
37. Hughes E, Brown J, Collins JJ, Vanderkerchove P. Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev 2010;20:CD000057.
38. Imani B, Eijkemans MJ, te Veled ER, Habbema JD, Fauser BC. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligomenorrheic infertility. J Clin Endocrinol Metab 1998;83:2361-5.
39. Homburg R, Armar NA, Eshel A, Adams J, Jacobs HS. Influence of serum luteinizing hormone concentrations on ovulation, conception and early pregnancy loss in polycystic ovary syndrome. Br Med J 1988;297:1024-7.
40. Homburg R, Insler V. Ovulation induction in perspective. Hum Reprod 2002;8:449-62.
41. Nestler JE, Jakubowics DJ. Decreases in ovary cytochrome P450c17-alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Eng J Med 1996;335:617-23. (Pubitemid 26277951)
42. Creanga AA, Bradley HM, McCormick C, Takacs Witkop C. Use of metformin in polycystic ovary syndrome A metaanalysis. Obstet Gynecol 2008;111:959-68.
43. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA et al. Clomiphene, metformin or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007;356:551-66.
44. Badawy A, Allam A, Abulatta M. Extending clomiphene treatment in clomiphene-resistant women with PCOS: a randomized controlled trial. Reprod Biomed Online 2008;16:825-9. (Pubitemid 351865345)
45. Daly DC, Walters CA, Soto-Albors CE, Tohan N, Riddick DH. A randomized study of dexamethasone in ovulation induction with clomiphene citrate. Fertil Steril 1984;41:844-8.
46. Trott EW, Plouffe L, Hansen K, Hines R, Brann DW, Mahesh VB. Ovulation induction in clomiphene-resistant anovulatory women with normal dehydroepiandrosterone sulfate levels: beneficial effects of the addition of dexamethasone during the follicular phase. Fertil Steril 1996;66:484-6. (Pubitemid 27009896)
47. Elnashar A, Abdelmageed E, Fayed M, Sharaf M. Clomiphene citrate and dexamethasone in treatment of clomiphene citrate-resistant polycystic ovarian syndrome: a prospective placebo-controlled study. Hum Reprod 2006;21:1805-8. (Pubitemid 44028254)
48. Parsanezhad ME, Alborzi S, Motazedian S, Omrani G. Use of dexamethasone and clomiphene citrate in the treatment of clomiphene citrate-resistant patient with polycystic ovary syndrome and normal dehyroepiandrosterone sulfate levels: a prospective, double-blind, placebo-controlled trial. Fertil Steril 2002;78:101.
49. Branigan E, Estes MA. Treatment of chronic anovulation resistant to clomiphene citrate (CC) by using oral contraceptive ovarian suppression followed by repeat CC treatment. Fertil Steril 1999;71:544-6. (Pubitemid 29094134)
50. Gonen Y, Jacobson W, Casper RF. Gonadotropin suppression with oral contraceptives before in vitro fertilization. Fertil Steril 1990;53:282-7. (Pubitemid 20076357)
51. Nelson LM, Hershalg A, Kurl RS, Hall JL, Stillman RJ. Clomiphene citrate directly impairs endometrial receptivity in mouse. Fertil Steril 1990;53:727-31. (Pubitemid 20143060)
52. Li TC, Warren MA, Murphy C, Sargeant S, Cooke ID. A prospective, randomized, cross-over study comparing the effects of clomiphene citrate and cyclofenU on endometrial morphology in the luteal phase of normal fertile women. Br J Obstet Gynaecol 1992;99:1008-13.
53. Zreik TG, Garcia-Valasco JA, Habboosh MS, Olive DL, Arici A. Prospective randomized, crossover study to evaluate the benefit of human chorionic gonadotropin-timed versus urinay luteinizing hormone-timed intrauterine inseminations in clomiphene citrate-stimulated treatment cycles. Fertil Steril 1999;71:1070.
54. Andersen AG, Als-Nielsen B, Hornnes PJ, Franch Andersen L. Time interval from human chorionic gonadotropin (HCG) injection to follicular rupture. Hum Reprod 1995;10:3202.
55. Agrawal SK, Buyalos RP. Corpus luteum function and pregnancy rates with clomiphene citrate therapy: comparison of human chorionic gonadotropin-induced versus spontaneous ovulation. Hum Reprod 1995;10:328-31.
56. Mitwally MF, Casper RF. Use of aromatase inhibitor for induction of ovulation in patients with inadequate response to clomiphne citrate. Fertil Steril 2001;7:305-9. (Pubitemid 32112106)
57. Holzer H, Casper R, Tulandi T. A new era of ovulation induction. Fertil Steril 2006;85:277-82.
58. Al-Fadhli R, Sylvestre C, Buckett W, Tan SL, Tulandi T. A randomized trial of superovulation with two different doses of letrazole. Fertil Steril 2006;85:161-4. (Pubitemid 43063440)
59. Badawy A, Abdel Aail I, Abulatta M. Clomiphene citrate or letrazole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial. Fertil Steril 2009;92:849-52.
60. Sohrabvand F, Ansari S, Bagheri M, Efficacy of combined metformin-letrazole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum Reprod 2006;21:1432-5. (Pubitemid 44445018)
61. Kamath MS, Aleyamma TK, Chandy A, George K. Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial. Fertil Steril 2010;94:2857-9.
62. Stokman PG, de Leeuw R, van den Wijngaard HA, Kloosterboer HJ, Vemer HM, Sanders A. Human chorionic gonadotropin in commercial human menopausal gonadotropin preparations. Fertil Steril 1993;60:175.
63. Van de Weijer BH, Mulders JW, Bos ES, Verhaert PD, van den Hooven HW. Compositional analysis of a human menopausal gonadotropin preparation extracted from urine (menotropin). Identification of some of its major impurities. Reprod Biomed Online 2003;7:547.
64. Gocial B, Keye WR, Fein SH, Nardi RV. Subcutaneously administered Repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment. Repronex SC, IVF Study Group. Fertil Steril 2000;74:73.
65. Filicori M, Cognigni GE, Pocognoli P, Tabarelli C, Ferlini F, Perri T et al. Comparison of controlled ovarian stimulation with human menopausal gonadotropin or recombinant follicle-stimulating hormone. Fertil Steril 2003;80:390.
66. Shoham Z, Mannaerts B, Insler V, Coelingh-Bennink H. Induction of follicular growth using recombinant human follicle-stimulating hormone in two volunteer women with hypogonadotropic hypogonadism. Fertil Steril 1993;59:738-42. (Pubitemid 23104171)
67. The European Recombinant Human LH Study Group. Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose-finding study. J Clin Endocrinol Metab 1998;83:1507-14.
68. Silverberg KM, Olive DL, Burs WN, Johnson JV, Groff TR, Schenken RS. Follicular size at the time of human chorionic gonadotropin administration predicts ovulation outcome in human menopausal gonadotropin-stimulated cycles. Fertil Steril 1991;56:296.
69. Siristatidis CS, Hamilton MP. What should be the maximum FSH dose in IVF/ICSI in poor responders? J Obstetrics and Gynaecology 2007;27:401-5.
70. Reuter KL, Cohen S. Furey L, Baker S. Sonographic appearance of endometrium and ovaries during cycles stimulated with human menopausal gonadotropin. J Reprod Med 1996;41:509.
71. Diamond MP, Wentz AC. Ovulaton induction with human menopausal gonadotropins. Obstet Gyncol Surv 1986;41:480.
72. Navot D, Margalioth EJ, Laufer N, Brzezinski A, Birkenfeld A, Schenker JG. Periovulatory 17 beta-estadiol patter in conceptional and non-conceptional cycles during menotropin treatment of anovulatory infertility. Fertil Steril 1987;47:234.
73. Dickey RP, Olar TT, Taylor SN, Curole DN, Matulich EM. Relationship of endometrial thickness and pattern to fecundidty in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin. Fertil Steril 1993;59:756.
74. Kalstrom PO, Bergh T, Lundkvist O. A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate. Fertil Steril 1993;59:554-9. (Pubitemid 23086312)
75. Fauser BC, Alper MM, Ledger W, Schoolcraft WB, Zandvliet A, Mannaerts BM; Engage Investigators. Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF. Reprod Biomed Online 2010;21:593-601.
76. Devroey P, Boostanfar R, Koper NP, Mannaerts BM, Ijzerman-Boon PC, Fauser BC; ENGAGE Investigators. A double-blind, non-inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol. Hum Reprod 2009;24:3063-72.
77. Ludwig M, Doody KJ, Doody DM. Use of recombinant human chorionic gonadotropin in ovulation induction. Fertil Steril 2003;79:1051.
78. Butler SA, hCG-mass units, molar conversion, and the standardization of biologic units. Fertil Steril 2003;80:1533.
79. International Recombinant Human Chorionic Gonadotropin Study Group. Induction of ovulation in World Health Organization group II anovulatory women undergoing follicular stimulation with recombinant human follicle-stimulating hormone: a comparison of recombinant human chorionic gonadotropin (rhCG) and urinary hCG. Fertil Steril 2001;75:1111.
80. Hughes EG. The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis. Hum Reprod 1997;12:1865-72. (Pubitemid 27462460)
81. Merviel P, Heraud M, Grenier Nadege, Lourdel E, Sanguinet P, Copin H. Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature. Fertil Steril 2001;93:79-88.
82. Fritz MA, Hess DL, Patton PE. Influence of corpus luteum age on steroidogenic response to exogenous human chorionic gonadotropin in normal cycling women. Am J Obstet Gynecol 1992;167:709.
83. Erdem A, Erdem M, Atmaca S, Guler I. Impact of luteal phase support on pregnancy rates in intrauterine insemination cycles: a prospective randomized study. Fertil Steril 2009;91:2508-13.
84. Kyrou D, Fatemi HM, Tournaye H, Devroey P. Luteal phase support in normo-ovulatory women stimulated with clomiphene citrate for intrauterine insemination: need or habit? Hum Reprod 2010;25:2501-6.
85. Costello MF, Emerson S, Lukic J, Sjoblom P, Garrett D, Hughes G et al. Predictive value of mid luteal progesterone concentration before luteal support in controlled ovarian hyperstimulation with intrauterine insemination. Aust N Z J Obstet Gynaecol 2004;44:51-6. (Pubitemid 38239699)
86. Daya S, Gunby J. Luteal phase support in assisted reproduction cycles. Cochrane Database Syst Rev 2004; CD004830.
87. FIVNAT [1995 FIVNAT evaluation]. Contracept Feril Sex 1996;24:694.
88. Martin JA, MacDorman MF, Mathews TJ. Triplet births: trends and outcomes. Natl Vital Stat Rep 1999;47:1-16.
89. American College of Obstetricians and Gynecologists. Special problems of multiple gestations. Washington, DC: Educational Bulletin; 2009.
90. Bryan E. The impact of multiple preterm births on the family. Br J Obstet Gynaecol 2003;110:24.
91. ESHRE Capri Workshop Group. Multiple gestation pregnancy. Hum Reprod 2000;15:1856.
92. Dickey RP, Taylor SN, Lu PY, Sartor BM, Rye PH, Pyrzak R. Relationship of follicle numbers and estadiol levels to multiple implantation in 3608 intrauterine insemination cycles. Fertil Steril 2001;75.69.
93. Dickey RP, Pyrzak, R. Prevention of high order multiple pregnancy. Hum Reprod 2002;17:1411.
94. De Geyter C, De Geyter M, Nieschlag E. Low multiple pregnancy rates and reduced frequency of cancellation after ovulation induction with gonadotropins, if eventual supernumerary follicles are aspiration to prevent polyovulation. J Assist Reprod Genet 1998;15:111.
95. Albano C, Platteau P, Nogueira D, Corvrindt R, Smitz J, Devroey P. Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction. Feril Steril 2001;76:820.
96. Landy HJ, Keith LG. The vanishing twin: a review. Hum Reprod Update 1998;4:177.
97. Lipitz S, Shulman A, Achiron R, Zalel Y, Seidman DS. A comparative study of multifetal pregnancy reduction from triplets to twins in the first versus early second trimester after detailed fetal screening. Ultrasound Obstet Gnecol 2001;18:35.
98. Enskog A, Henriksson M, Unander M, Nilsson L, Brannstrom M. Prospective study of the clinical and laboratory parameters of patients in whom ovarian hyperstimulation syndrome developed during controlled ovarian hyperstimulation for in vitro fertilization. Feril Steril 1999;71:808.
99. Delvigne A, Demoulin A, Smitz J, Donnez J, Koninckx P, Dhont M et al. The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicentric study of clinical and biologic features. Hum Reprod 1993;8:1353-60.
100. Ulug U, Bahceci M, Erden HF, Shalev E, Ben-Shlomo I. The significance of coasting duration during ovarian stimulation for conception in assisted fertilization cycles. Hum Reprod 2002;17:310.
101. Al-Shawaf T, Zosmer A, Hussain S, Tozer A, Panay N, Wilson C et al. Prevention of severe ovarian hyperstimulation syndrome in IVF with or without ICSI and embryo transfer: a modified "coasting" strategy based on ultrasound for identification of high-risk patients. Hum Reprod 2001;16:24.
102. Grochowski D, Wolczynski S, Kuczynski W, Domitrz J, Szamatowicz J, Szamatowicz M. Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program. Gynecol Endocrinol 2001;15:234.
103. Lu PY, Chen AL, Atkinson EJ, Lee SH, Erickson LD, Ory SJ. Minimal stimulation achieves pregnancy rates comparable to human menopausal gonadotropins in the treatment of infertility. Fertil Steril 1996;65:583-7. (Pubitemid 26069117)
104. Dhaliwal LK, Sialy RK, Gopalan S, Majumdar S. Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility. J Obstet Gynaecol Res 2002;28:295-9. (Pubitemid 36096878)
105. Houmard BS, Juang MP, Soules MR, Fujimoto VY. Factors influencing pregnancy rates with a combined clomiphene citrate/gonadotropin protocol for non-assisted reproductive technology fertility treatment. Fertil Steril 2002;77:384-6. (Pubitemid 34086915)
106. Park JK, Clark R, Session DR. Follicular recruitment is reduced in minimal stimulation for controlled ovarian hyperstimulation using purified human menopausal gonadotropin compared with follicle-stimulating hormone. Fertil Steril 2009;91(4 Suppl):1434-6.
107. Ryan GL, Moss V, Davis WA, Sparks AE, Dokras A, Van Voorhis BJ. Oral ovulation induction agents combined with low-dose gonadotropin injections and intrauterine insemination: cost- and clinical effectiveness. J Reprod Med 2005;50:943-50. (Pubitemid 43031257)
108. Jee BC, Ku SY, Suh CS, Kim KC, Lee WD, Kim SH. Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. Fertil Steril 2006;85:1774-7. (Pubitemid 43816436)
109. Badawy A, Elnashar A, Totongy M. Clomiphene citrate or aromatase inhibitors combined with gonadotropins for superovulation in women undergoing intrauterine insemination: a prospective randomised trial. J Obstet Gynaecol 2010;30:617-21
110. Dodson WC, Walmer DK, Hughes CL Jr, Yancy SE, Haney AF. Adjunctive leuprolide therapy does not improve cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination of subfertile women. Obstet Gynecol 1991;78:187-90.
111. Sengoku K, Tamate K, Takaoka Y, Morishita N, Ishikawa M. A randomized prospective study of gonadotropin with or without gonadotrophin-releasing hormone agonist for treatment of unexplained infertility. Hum Reprod 1994;9:1043-7. (Pubitemid 24203891)
112. Lambalk CB, Leader A, Olivennes F, Fluker MR, Andersen AN, Ingerslev J et al. Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial. Hum Reprod 2006;21:632-9. (Pubitemid 43372966)
113. Kopp-Woodroffe SA, Manore MM, Dueck CA, Skinner JS, Matt KS. Energy and nutrient status of amenorrheic athletes participating in a diet and exercise training intervention program. Int J Sport Nutr 1999;9:70-88. (Pubitemid 29122763)
114. Berga SL, Marcus MD, Loucks TL, Hlastala S, Ringham R, Krohn MA. Recovery of ovarian activity in women with functional hypothalamic amenorrhea who were treated with cognitive behavior therapy. Fertil Steril 2003;80:976-81.
115. Santoro N, Wierman ME, Filicori M, Waldstreicher J, Crowley WF Jr. Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage. J Clin Endocrinol Metab 1986;62:109-16. (Pubitemid 16186851)
116. Miller DS, Reid RR, Cetel NS, Rebar RW, Yen SS. Pulsatile administration of low-dose gonadotropin-releasing hormone. Ovulation and pregnancy in women with hypothalamic amenorrhea. JAMA 1983;250:2937-41.
117. Martin KA, Hall JE, Adams JM, Crowley WF Jr. Comparison of exogenous gonadotropins and pulsatile gonadotropin-releasing hormone for induction of ovulation in hypogonadotropic amenorrhea. J Clin Endocrinol Metab 1993;77:125-9. (Pubitemid 23206789)
118. Borges LE, Morgante G, Musacchio MC, Petraglia F, De Leo V New protocol of clomiphene citrate treatment in women with hypothalamic amenorrhea. Gynecol Endocrinol 2007;23:343-6. (Pubitemid 47038255)
119. Shoham Z, Balen A, Patel A, Jacobs HS. Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients. Fertil Steril 1991;56:1048.
120. Christin-Maitre S, Hugues JN; Recombinant FSH Study Group. A comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndrome. Hum Reprod 2003;18:1626-31.
121. Orvieto R, Homburg R. Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy. Fertil Steril 2009;91:1533-5.
122. Pandian Z, McTavish AR, Aucott L, Hamilton MP, Bhattacharya S. Interventions for 'poor responders' to controlled ovarian hyper stimulation (COH) in invitro fertilization (IVF). Cochrane Database Syst Rev 2010;(1):CD004379.
123. Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Repro Update 2003;9:61-76. (Pubitemid 36305584)
124. Mais V, Cetel NS, Muse KN, Quigley ME, Reid RL, Yen SS. Hormonal dynamics during luteal-follicular transition. J Clin Endocrinol Metab 1987;64:1109-14.
125. Roseff SJ, Bangah ML, Kettel LM, Vale W, Rivier J, Burger HG et al. Dynamic changes in circulating inhibin levels during the luteal0follicular transition of the human menstrual cycle. J Clin Endocrin Metab 1989;69:1033-9. (Pubitemid 19261835)
126. Chun SY, Eisenhauer KM, Minami S, Billig H, Perlas E, Hsueh AJ. Hormonal regulation of apoptosis in early antral follicles:follicle stimulating hormone as a major survival factor. Endocrinology 1996;137:1447-56.
127. Fanchin R, Cunha-Filho JS, Schonauer L, Kadoch IJ, Cohen-Bacri P, Frydman R. Coordination of early antral follicles by luteal estradiol administration provides a basis for alternative controlled ovarian hyperstimmulation regimens. Fertil Steril 2003a;79:316-21.
128. Fanchin R, Salomon L, Castelo-Branco A, Olivennes F, Frydman N, Frydman R. Luteal estradiol pre-treatment coordinates follicular growth during controlled ovarian hyperstimulation with GnRH antagonists. Hum Reprod 2003b;18:2698-703. (Pubitemid 37536643)
129. Fanchin R, Branco AC, Kadoch IJ, Hosny G, Bagirova M, Frydman R. Premenstrual administration of gonadotropin-releasing hormone antagonist coordinates early antral follicle sizes and sets up the basis for an innovative concept of controlled ovarian hyperstimulation. Fertil Steril 2004;81:1554-59.
130. Dragisic KC, Davis OK, Fasouliotis SJ, Rosenwaks Z. Use of luteal estradiol patch and a gonadotropinreleasing hormone antagonist suppression protocol before gonadotropin stimulation for in vitro fertilization in poor responders. Fertil Steril 2005;84:1023-6. (Pubitemid 41414601)
131. Hill M, McWilliams G, Miller K, Scott R, Frattarelli J. A luteal estradiol protocol for anticipated poor-responder patients may improve delivery rates. Fertil Steril 2009;91:739-43.
132. Gonen Y, Casper RF. Sonographic determination of an adverse effect of clomiphene citrate on endometrial growth. Hum Reprod 1990;5:670-4. (Pubitemid 20308440)
133. Biljan M, Mahutte N, Dean N, Hemmings R, Bissonnette F, Tan S. Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent pregnancy rates. Fertil Steril 1998;70:1063-9.
134. Lindheim SR, Barad DH, Witt B, Ditkoff E, Sauer MW. Short-term gonadotropins suppression with oral contraceptives benefits poor responders prior to controlled ovarian hyperstimulation. J Assist Reprod Genet 1996;13:745-7. (Pubitemid 26405919)
135. Burger H. Androgen production in women. Fertil Steril 2002;77:S3-S5. (Pubitemid 34465837)
136. Haning RV, Hackett RJ, Flood CA, Loughlin JS, Zhao QY, Longcope C. Plasma Dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins. J Clin Endocrinol Metab 1993;76:1301-7.
137. Morales AJ, Nolan JJ, Nelson JC, Yen SS. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360-7. (Pubitemid 24181005)
138. Casson PR, Santoro N, Elkind-Hirsch K, Carson S, Hornsby P, Abraham G et al. Postmenopausal dehydroepiandrosterone administration increased free insulin-like growth facor-1 and decreased high-denisity lipoprotein:a six month trial. Fert Ster Vol 1998;70:107-10.
139. Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 2006;21:2845-9.
140. Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007;24:629-34.
141. Keay S. Poor ovarian response to gonadotropin stimulation-the role of adjuvant treatments. Human Fertility. 2002;S46-S52.
142. Mitwally MF, Casper R. Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertil Steril 2002;776-80. (Pubitemid 34275361)
143. Rebar RW. Premature ovarian failure. Obstet Gynec 2009;113:1355-63.
144. Van Kasteren YM, Schoemaker J. Premature ovarian failure: a systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. Hum Reprod Update 1999;5:483-92. (Pubitemid 29512134)
145. Check JH, Nowroozi K, Chase JS, Nazari A, Shapse D, Vaze M. Ovulation induction and pregnancies in 100 consecutive women with hypergonadotropic amenorrhea. Fertil Steril 1990;53:811-6. (Pubitemid 20180468)
146. Tartagani M, Cicinelli E, De Pergola G, De Salvia MA, Lavopa C, Loverro G. Effects of pretreatment with estrogens on ovarian stimulation with gonadotropins in women with premature ovarian failure: a randomized, placebo-controlled trial. Fertil Steril 2007;87:858-61. (Pubitemid 46566354)
147. Badawy A, Goda H, Ragab A. Induction of ovulation in indiopathic premature ovarian failure: a randomized double-blind trial. Reprod Biomed Online 2007;15:215-9. (Pubitemid 47263331)
148. Mamas L, Mamas E. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Curr Opinion Obstet Gynecol 2009;21:306-8.