Ovulation-stimulation drugs and cancer risks: A long-term follow-up of a British cohort

British Journal of Cancer

Volumn 100, Issue 11, 2009, Pages 1824-1831

  Dos Santos Silva, I ^a   Wark, P A ^a,d   McCormack, V A ^a,e   Mayer, D ^a   Overton, C ^b,f   Little, V ^b   Nieto, J ^c,g   Hardiman, P ^c   Davies, M ^b   MacLean, A B ^c  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^f ST MICHAEL'S HOSPITAL   (United Kingdom)

^g NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Clomiphene; Gonadotrophins; Infertility; Mortality; Ovarian stimulation

Indexed keywords

CLOMIFENE CITRATE; GONADOTROPIN;

ADULT; ARTICLE; BREAST CANCER; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CAUSE OF DEATH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OVARY CANCER; OVARY INSUFFICIENCY; OVULATION INDUCTION; PRIORITY JOURNAL; UNITED KINGDOM; UTERINE CERVIX CANCER; UTERUS CANCER;

ADULT; ENGLAND; FEMALE; FERTILITY AGENTS, FEMALE; FOLLOW-UP STUDIES; HUMANS; NEOPLASMS; OVULATION; RISK FACTORS; TIME FACTORS;

EID: 67349117664     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605086     Document Type: Article

References (40)

1. Althuis MD, Moghissi KS, Westhoff CL, Scoccia B, Lamb EJ, Lubin JH, Brinton LA (2005) Uterine cancer after use of clomiphene citrate to induce ovulation. Am JEpidemiol 161: 607-615
2. Breslow NE, Day NE (1987) Statistical Methods in Cancer Research. Volume II- The Design and Analysis of Cohort Studies. IARC: Lyon
3. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, Westhoff CL (2004) Ovarian cancer risk after the use of ovulation-stimulating drugs. Obstet Gynecol 103: 1194-1203
4. Burkman RT, Tang MT, Malone KE, Marchbanks PA, McDonald JA, Folger SG, Norman SA, Strom BL, Bernstein L, Ursin G, Weiss LK, Daling JR, Simon MS, Spirtas R (2003) Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences Study. Fertil Steril 79: 844-851
5. Calderon-Margalit R, Friedlander Y, Yanetz R, Kleinhaus K, Perrin MC, Manor O, Harlap S, Paltiel O (2008) Cancer risks after exposure to treatment for ovulation induction. Am J Epidemiol doi:10.1093/aje/ kwn318
6. Carstairs V, Morris R (1989) Deprivation: explaining differences in mortality between Scotland and England and Wales. Br Med J 299: 886-889
7. Clayton D, Hills M (1993) Statistical Methods in Epidemiology. Oxford University Press: Oxford
8. Committee on Safety of Medicines (1995) Current problems in pharmaco-vigilance. 21: 7
9. Department of the Environment, Transport and the Regions (DETR) (2000) Measuring Multiple Deprivation at the Small Area Level - The Indices of Deprivation 2000. The Stationery Office: London
10. Doyle P, Maconochie N, Beral V, Swerdlow AJ, Tan SL (2002) Cancer incidence following treatment for infertility at a clinic in the UK. Hum Reprod 17: 2209-2213
11. Edmondson HA, Henderson B, Benton B (1976) Liver cell adenomas associated with the use of oral contraceptive. N Engl J Med 294: 470-472
12. Fishel S, Jackson P (1989) Follicular stimulation for high tech pregnancies: are we playing it safe? Br Med J 299: 309-311
13. Ginsburg J, Hardiman P (1991) Ovulation induction with human menopausal gonadotrophins - a changing scene. Gynaecol Endocrinol 5: 57-78
14. Grambsch PM, Therneau TM (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81: 515-526
15. Human Fertilisation Embryology Authority (HFEA) (2008) Facts and Figures 2006 2006. Fertility Problems and Treatment, http://www.hfea. gov.uk/1269.html#1278 (accessed 22 April 2009)
16. International Agency for Research on Cancer (IARC) (1999) IARC Monographs: Hormonal contraception and post-menopausal hormonal therapy Vol. 72, p 293. IARC Press: Lyon
17. International Collaboration of Epidemiological Studies of Cervical Cancer (ICESCC) (2006) Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16563 women with cervical carcinoma and 33 542 women without cervical carcinoma from 25 epidemiological studies. Int J Cancer 119: 1108-1124
18. Jensen A, Sharif H, Frederiksen K, Kjaer SK (2009) Use of fertility drugs and risk of ovarian cancer: Danish Population Based Cohort Study. Br Med J 338: b249 doi: 10.1136/bmj.b249
19. Jensen A, Sharif H, Scare EI, Frederiksen K, Krüger Kjær S (2007) Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study. Cancer Epidemiol Biomarkers Prev 16: 1400-1407
20. Klip H, Burger CW, van Leeuwen FE, the OMEGA Project Group (2002) Risk of hormone-related cancers after ovarian stimulation for in-vitro fertilisation in a cohort of 25 152 women. In Long-term health effects of subfertility treatment Klip H (ed.) 55-80. PrintPartners Ipskamp BV: Enschede, The Netherlands
21. La Vecchia C, Ron E, Franceschi S, Dal Maso L, Mark SD, Chatenoud L, Braga C, Preston-Martin S, McTiernan A, Kolonel L, Mabuchi K, Jin F, Wingren G, Galanti MR, Hallquist A, Lund E, Levi F, Linos D, Negri E (1999) A pooled analysis of case-control studies of thyroid cancer. III. Oral contraceptives, menopausal replacement therapy and other female hormones. Cancer Causes Control 10: 157-166
22. Modan B, Ron E, Lerner-Geva L, Blumstein T, Menczer J, Rabinovici J, Oelsner G, Freedman L, Mashiach S, Lunenfeld B (1998) Cancer incidence in a cohort of infertile women. AmJ Epidemiol 147:1038 -1042
23. Ness RB, Cramer DW, Goodman MT, Kjaer SK, Mallin K, Mosgaard BJ, Purdie DM, Risch HA, Vergona R, Wu AH (2003) Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies. Am J Epidemiol 155: 217-224
24. Office of Population Census and Surveys (OPCS) (1991) Standard Occupational Classification Volume 3. HMSO: London
25. Office of Population Census and Surveys (OPCS) & General Register Office (GRO) for Scotland (1993) Report for Great Britain. Part 2. HMSO: London
26. Orgéas CC, Sanner K, Hall P, Conner P, Holte J, Nilsson SJ, Sundfelt K, Persson I, Seng Chia K, Wedren S, Dickman PW, Czeme K (2009) Breast acncer incidence after hormonal infertility tretament in Sweden: a cohort study. Am J Obstet Gynecol 200, 72. e1-72.e7
27. Ricci E, Parazzini F, Negri E, Marsico S, La Vecchia C (1999) Fertility drugs and the risk of breast cancer. Hum Reprod 14: 1653-1655
28. Ron E, Lunenfeld B, Menczer J, Blumstein T, Katz L, Oelsner G, Serr D (1987) Cancer incidence in a cohort of infertile women. Am J Epidemiol 125: 780-790
29. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (1994) Ovarian tumors in a cohort of infertile women. New Eng J Med 331: 771 - 776
30. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (1995) Risk of cutaneous melanoma in a cohort of infertile women. Melanoma Res 5: 123-127
31. Sasieni P (1995) Tabulation of observed/expected rations and confidence intervals. Stata Technical Bulletin 4: 23:18-23:20
32. Schoenfeld DA (1982) Partial residuals for the proportional hazards regression model. Biometrika; 69: 239-241
33. Shushan A, Paltiel O, Iscovich T, Elchalal U, Peretz T, Schenker JG (1996) Human menopausal gonadotrophin and the risk of epithelial ovarian cancer. Fertil Steril 65: 13-18
34. Swerdlow AJ, Jones ME, British Tamoxifen Second Cancer Study Group (2005) Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study. J Natl Cancer Inst 97: 375-384
35. Venn A, Watson L, Bruinsma F, Giles G, Healy D (1999) Risk of cancer after use of fertility drugs with in-vitro fertilisation. Lancet 354: 1586-1590
36. Venn A, Watson L, Lumley J, Giles G, King C, Healy D (1995) Breast and ovarian cancer incidence after infertility and in vitro fertilisation. Lancet 346: 995-1000
37. Weiss HA, Troisi R, Rossing MA, Brogan D, Coates RJ, Gammon MD, Potischman N, Swanson CA, Brinton LA (1998) Fertility problems and breast cancer risk in young women: a case-control study in the United States. Cancer Causes Control 9: 331-339
38. Whittemore AS, Harris R, Itnyre J, Collaborative Ovarian Cancer Group (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancer in white women. Am J Epidemiol 136: 1184-1203
39. World Health Organisation (1957, 1967, 1977, 1994) Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death, seventh, eight, ninth and tenth revisions. World Health Organisation: Geneva
40. World Health Organisation (1973) Advances in methods of fertility regulation: report of a WHO scientific group. World Health Organ Technical Report Ser. 527 1-42. World Health Organisation: Geneva