Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease

Human Reproduction

Volumn 21, Issue 6, 2006, Pages 1432-1435

  Sohrabvand, F ^a   Ansari, Sh ^a   Bagheri, M ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Clomiphene citrate; Letrozole; Metformin; PCOS; Pregnancy rate

Indexed keywords

CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; ESTRADIOL; LETROZOLE; METFORMIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TREATMENT FAILURE; ENDOMETRIUM; FEMALE; FEMALE INFERTILITY; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OVARY FOLLICLE; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; UNSPECIFIED SIDE EFFECT;

EID: 33745609091     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del020     Document Type: Article

References (14)

1. Al-Fozan H, Al-Khadouri M, Tan SL and Tulandi T (2004) A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation. Fertil Steril 82 (6),1561-1563.
2. Bast RC, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF and Frei E III (eds) (2000) Cancer Medicine, 5th edn. Hamilton, BC Decker, pp. 1335-1358.
3. Batukan C and Baysal B (2001) Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome. Arch Gynecol Obstet 265 (3),124-127.
4. Fisher SA, Reid RL, Van Vugt DA and Casper RF (2002) A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women. Fertil Steril 78 (2),280-285.
5. Fleming R, Hopkinson ZE, Wallace AM, Greer IA and Sattar N (2002) Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 87,569-574.
6. Heard MJ, Pierce A, Carson SA and Buster JE (2002) Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril 77 (4),669-673.
7. Mitwally MFM and Casper RF (2001) Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril 75 (2),305-309.
8. Mitwally MFM and Casper RF (2002a) Aromatase inhibition for ovarian stimulation: Future avenues for infertility management. Curr Opin Obstet Gynecol 14 (3),255-263.
9. Mitwally MFM and Casper RF (2002b) Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertil Steril 77 (4),776-780.
10. Mitwally MFM and Casper RF (2005) Single-dose administration of an aromatase inhibitor for ovarian stimulation. Fertil Steril 83 (1),229-231.
11. Mitwally MFM, Biljan MM and Casper RF (2005) Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. Am J Obstet Gynecol 192 (2),381-386.
12. Nestler JE, Jakubowicz DJ, Evans WS and Pasquali R (1998) Effects of metformin on spontaneous and clomiphene - induced ovulation in the polycystic ovary syndrome. N Engl J Med 338 (26),1876-1880.
13. Sammour A, Biljan MM, Tan SL and Tulandi T (2001) Prospective randomized trial comparing the effects of letrozole and clomiphene citrate on follicular development, endometrial thickness, and pregnancy rate in patients undergoing superovulation prior to intrauterine insemination. Fertil Steril 76 (Suppl. 1),S110.
14. Vandermolen DT, Ratts VS, Evans WS, Stovall DW, Kauma SW and Nestler JE (2001) Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 75 (2),310-315.