Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: Results of a double-blind, placebo-controlled, multicentre trial

Human Reproduction

Volumn 21, Issue 3, 2006, Pages 632-639

  Lambalk, C B ^a   Leader, A ^b   Olivennes, F ^c   Fluker, M R ^d   Andersen, A Nyboe ^e   Ingerslev, J ^f   Khalaf, Y ^g   Avril, C ^h   Belaisch Allart, J ⁱ   Roulier, R ^j   Mannaerts, B ^k  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Civic Parkdale Clinic   (Canada)

^c HÔPITAL ANTOINE BÉCLÈRE   (France)

^d Genesis Fertility Centre   (Canada)

^e University of Copenhagen   (Denmark)

^f AARHUS UNIVERSITY HOSPITAL   (Denmark)

^g GUY S HOSPITAL   (United Kingdom)

^h Clinique Saint Antoine   (France)

ⁱ Centre Hospitalier Intercommunal Jean Rostand   (France)

^j Medical Institute of Reproduction   (France)

^k NV ORGANON   (Netherlands)

more..

Author keywords

Male factor infertility; Mild stimulation; Premature LH rises; Recombinant FSH; Unexplained infertility

Indexed keywords

CHORIONIC GONADOTROPIN; GANIRELIX; LUTEINIZING HORMONE; PLACEBO; PROGESTERONE; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; HORMONE DETERMINATION; HUMAN; INCIDENCE; INDIVIDUALIZATION; INFERTILITY; INTRAUTERINE INSEMINATION; LOW DRUG DOSE; LUTEINIZATION; MAJOR CLINICAL STUDY; MALE INFERTILITY; MULTICENTER STUDY; OUTCOMES RESEARCH; OVARY FOLLICLE; OVULATION INDUCTION; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL;

EID: 33644849768     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei386     Document Type: Article

References (21)

1. Barlow DH (1998) GnRH agonists and in vitro fertilization. J Reprod Med 43,245-251.
2. Berger RL and Boos DD (1994) P values maximized over a confidence set for the nuisance parameter. J Am Statist Assoc 84,1012-1016.
3. Cohlen BJ, Vandekerckhove P, te Velde ER and Habbema JD (2000) Timed intercourse versus intra-uterine insemination with or without ovarian hyperstimulation for subfertility in men. Cochrane Database Syst Rev CD000360.
4. Dodson WC and Haney AF (1991) Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril 55,457-467.
5. Dodson WC, Walmer DK, Hughes CL Jr, Yancy SE and Haney AF (1991) Adjunctive leuprolide therapy does not improve cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination of subfertile women. Obstet Gynecol 78,187-190.
6. European Ganirelix Study Group, Borm G and Mannaerts B (2000) Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: Results of a controlled, randomized, multicentre trial. Hum Reprod 15,1490-1498.
7. Gomez-Palomares JL, Julia B, Acevedo-Martin B, Martinez-Burgos M, Hernandez ER and Ricciarelli E (2005) Timing ovulation for intrauterine insemination with a GnRH antagonist Hum Reprod, 20,368-372.
8. Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF and Schoemaker J (2000) Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: A randomised trial and cost-effectiveness analysis. Lancet 355,13-18.
9. Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, Hill JA, Mastroianni L, Buster JE, Nakajima ST et al (1999) Efficacy of superovulation and intrauterine insemination in the treatment of infertility National Cooperative Reproductive Medicine Network. New Engl J Med 340,177-183.
10. Hannoun A, Abu-Musa A, Kaspar H and Khalil A (1998) Intrauterine insemination IUI: The effect of ovarian stimulation and infertility diagnosis on pregnancy outcome. Clin Exp Obstet Gynecol 25,144-146.
11. Hughes EG (2003) Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility. 'Effective treatment' or 'not a natural choice'? Hum Reprod 18,912-914.
12. Hughes EG, Collins JA and Gunby J (1998) A randomized controlled trial of three low-dose gonadotrophin protocols for unexplained infertility. Hum Reprod 13,1527-1531.
13. Loumaye E (1990) The control of endogenous secretion of LH by gonadotrophin-releasing hormone agonists during ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Hum Reprod 5,357-376.
14. Matorras R, Diaz T, Corcostegui B, Ramon O, Pijoan JI and Rodriguez-Escudero FJ (2002) Ovarian stimulation in intrauterine insemination with donor sperm: A randomized study comparing clomiphene citrate in fixed protocol versus highly purified urinary FSH. Hum Reprod 17,2107-2111.
15. Out HJ and Mannaerts BM (2002) The gonadotrophin-releasing hormone antagonist ganirelix-history and introductory data. Hum Fertil (Camb) 5,G5-10.
16. Pandian Z, Bhattacharya S, Nikolaou D, Vale L and Templeton A (2003) The effectiveness of IVF in unexplained infertility: A systematic Cochrane review. Hum Reprod 18,2001-2007.
17. Ragni G, Alagna F, Brigante C, Riccaboni A, Colombo M, Somigliana E and Crosignani PG (2004) GnRH antagonists and mild ovarian stimulation for intrauterine insemination: A randomized study comparing different gonadotrophin dosages. Hum Reprod 19,54-58.
18. Sengoku K, Tamate K, Takaoka Y, Morishita N and Ishikawa M (1994) A randomized prospective study of gonadotrophin with or without gonadotrophin-releasing hormone agonist for treatment of unexplained infertility. Hum Reprod 9,1043-1047.
19. Sengoku K, Tamate Y, Takaoka Y, Horikawa M, Goishi K, Komori H, Okada R, Tsuchiya K and Ishikawa M (1999) The clinical efficacy of low-dose stepup follicle stimulating hormone administration for treatment of unexplained infertility. Hum Reprod 14,349-353.
20. Shapiro DB and Mitchell-Leef D (2003) GnRH antagonist in in vitro fertilization: Where we are now. Minerva Ginecol 55,373-388.
21. Williams RS, Hillard JB, De Vane G, Yeko T, Kipersztok S, Rhoton-Vlastak A and Sistrom C (2004) A randomised, multicenter study comparing the efficacy of recombinant FSH vs recombinant FSH with Ganirelix during superovulation/IUI therapy. Am J Obstet Gynecol 191,648-653.