RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe

FASEB Journal

Volumn 24, Issue 6, 2010, Pages 1689-1699

  Chen, Wei ^a   Jarzyna, Peter A ^a   Van Tilborg, Geralda A F ^b   Van Nguyen, Anh ^a   Cormode, David P ^a   Klink, Ahmed ^a,c   Griffioen, Arjan W ^d   Randolph, Gwendalyn J ^a   Fisher, Edward A ^e   Mulder, Willem J M ^a   Fayad, Zahi A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Magnetic resonance imaging; Optical imaging

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; FLUORESCENT DYE; GADOLINIUM CHELATE; HIGH DENSITY LIPOPROTEIN; NANOPARTICLE; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING KINETICS; BLOOD VESSEL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONFOCAL MICROSCOPY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MACROPHAGE; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOENZYME TECHNIQUES; INTEGRIN ALPHAVBETA3; LIPOPROTEINS, HDL; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MOLECULAR IMAGING; MOLECULAR PROBES; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; PHAGOCYTOSIS; SARCOMA, EWING'S; SPECTROSCOPY, NEAR-INFRARED; TISSUE DISTRIBUTION; UMBILICAL VEINS;

EID: 77953503310     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-139865     Document Type: Article

References (42)

1. Tabet, F., and Rye, K.-A. (2009) High-density lipoproteins, inflammation and oxidative stress. Clin. Sci. 116, 87-98
2. Florentin, M., Liberopoulos, E. N., Wierzbicki, A., and Mikhailidis, D. P. (2008) Multiple actions of high-density lipoprotein. Curr. Opin. Cardiol. 23, 370-378
3. Williams, K. J., Feig, J. E., and Fisher, E. A. (2007) Cellular and molecular mechanisms for rapid regression of atherosclerosis: from bench top to potentially achievable clinical goal. Curr. Opin. Lipidol. 18, 443-450
4. Lacko, A. G., Nair, M., Prokai, L., and McConathy, W. J. (2007) Prospects and challenges of the development of lipoprotein-based formulaitons for anti-cancer drugs. Exp. Opin. Drug Del. 4, 665-675
5. Shaish, A., Keren, G., Chouraqui, P., Levkovitz, H., and Harats, D. (2001) Imaging of aortic atherosclerotic lesions by 125I-LDL, 125I-oxidized-LDL, 125I-HDL and 125I-BSA. Pathobiology 69, 225-229
6. Frias, J. C., Ma, Y. Q., Williams, K. J., Fayad, Z. A., and Fisher, E. A. (2006) Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging. Nano Lett. 6, 2220-2224
7. Frias, J. C., Williams, K. J., Fisher, E. A., and Fayad, Z. A. (2004) Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J. Am. Chem. Soc. 126, 16316-16317
8. Chen, W., Vucic, E., Leupold, E., Mulder, W. J. M., Cormode, D. P., Briley-Saebo, K. C., Barazza, A., Fisher, E. A., Dathe, M., and Fayad, Z. A. (2008) Incorporation of an apoE-derived lipopeptide in high-density lipoprotein MRI contrast agents for enhanced imaging of macrophages in atherosclerosis. Contrast Media Mol. Imaging 3, 233-242
9. Zheng, G., Chen, J., Li, H., and Glickson, J. D. (2005) Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents. Proc. Natl. Acad. Sci. U. S. A. 102, 17757-17762
10. Chen, J., Corbin, I. R., Li, H., Cao, W. G., Glickson, J. D., and Zheng, G. (2007) Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo. J. Am. Chem. Soc. 129, 5798-5799 (Pubitemid 46748467)
11. Corbin, I. R., Chen, J., Cao, W., Li, H., Lund-Katz, S., and Zheng, G. (2007) Enhanced cancer-targeted delivery using engineered high-density lipoprotein-based nanocarriers. J. Biomed. Nanotechnol. 3, 367-376
12. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
13. Nakayama, A., del Monte, F., Hajjar, R. J., and Frangioni, J. V. (2002) Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol. Imaging 1, 365-377
14. Kim, S., Lim, Y. T., Soltesz, E. G., De Grand, A. M., Lee, J., Nakayama, A., Parker, J. A., Mihaljevic, T., Laurence, R. G., Dor, D. M., Cohn, L. H., Bawendi, M. G., and Frangioni, J. V. (2004) Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotech. 22, 93-97
15. De Grand, A. M., and Frangioni, J. V. (2003) An operational near-infrared fluorescence imaging system for large animal surgery. Technol. Cancer Res. Treat. 2, 553-562 (Pubitemid 38040617)
16. Van Tilborg, G. A., Mulder, W. J. M., van der Schaft, D. W., Reutelingsperger, C. P., Griffioen, A. W., Strijkers, G. J., and Nicolay, K. (2008) Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes. Neoplasia 10, 1459-1469
17. 3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits. FASEB J. 22, 2758-2767
18. Rinninger, F., Deichen, J. T., Jakle, S., Windler, E., and Greten, H. (1994) Selective uptake of high-density lipoprotein-associated cholesteryl esters and high-density lipoprotein particle uptake by human monocyte-macrophages. Atherosclerosis 105, 145-157 (Pubitemid 24086504)
19. Hu, G., Lijowski, M., Zhang, H., Partlow, K. C., Caruthers, S. D., Kiefer, G., Gulyas, G., Athey, P., Scott, M. J., Wickline, S. A., and Lanza, G. M. (2007) Imaging of Vx-2 rabbit tumors with alpha nu beta3-integrin-targeted 111 In nanoparticles. Int. J. Cancer 120, 1951-1957
20. Kok, R. J., Schraa, A. J., Bos, E. J., Moorlag, H. E., Asgeirsdottir, S. A., Everts, M., Meijer, D. K. F., and Molema, G. (2002) Preparation and functional evaluation of RGD-modified proteins as alpha v beta 3 integrin directed therapeutics. Bioconjug. Chem. 13, 128-135
21. Koole, R., van Schooneveld, M. M., Hilhorst, J., Castermans, K., Cormode, D. P., Strijkers, G. J., de Mello Donegá, C., Vanmaekelbergh, D., Griffioen, A. W., Nicolay, K., Fayad, Z. A., Meijerink, A., and Mulder, W. J. M. (2008) Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging. Bioconjug. Chem. 19, 2471-2479
22. Mulder, W. J. M., Castermans, K., van Beijnum, J. R., Oude Egbrink, M. G., Chin, P. T., Fayad, Z. A., Lowik, C. W., Kaijzel, E. L., Que, I., Storm, G., Strijkers, G. J., Griffioen, A. W., and Nicolay, K. (2009) Molecular imaging of tumor angiogenesis using alpha v beta 3-integrin targeted multimodal quantum dots. Angiogenesis 12, 17-24
23. Mulder, W. J. M., Koole, R., Brandwijk, R. J., Storm, G., Chin, P. T., Strijkers, G. J., de Mello Donegá, C., Nicolay, K., and Griffioen, A. W. (2006) Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett. 6, 1-6
24. Mulder, W. J. M., Strijkers, G. J., Habets, J. W., Bleeker, E. J., van der Schaft, D. W., Storm, G., Koning, G. A., Griffioen, A. W., and Nicolay, K. (2005) MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle. FASEB J. 19, 2008-2010
25. Brundert, M., Heeren, J., Bahar-Bayansar, M., Ewert, A., Moore, K. J., and Rinninger, F. (2006) Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI. J. Lipid Res. 47, 2408-2421
26. Matveev, S., van der Westhuyzen, D. R., and Smart, E. J. (1999) Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages. J. Lipid Res. 40, 1647-1654 (Pubitemid 29418705)
27. Cormode, D. P., Briley-Saebo, K. C., Mulder, W. J. M., Aguinaldo, J. G. S., Barazza, A., Ma, Y. Q., Fisher, E. A., and Fayad, Z. A. (2008) An apoA-I mimetic peptide HDL-based MRI contrast agent for atherosclerotic plaque composition detection. Small 4, 1437-1444
28. Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., Fisher, E. A., Fayad, Z. A., and Mulder, W. J. M. (2008) Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform. Nano Lett. 8, 3715-3723
29. Strijkers, G. J., Hak, S., Kok, M. B., Springer, C. S., Jr., and Nicolay, K. (2009) Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents. Magn. Reson. Med. 61, 1049-1058
30. Terreno, E., Crich, S. G., Belfiore, S., Biancone, L., Cabella, C., Esposito, G., Manazza, A. D., and Aime, S. (2006) Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Magn. Reson. Med. 55, 491-497
31. Brekke, C., Morgan, S. C., Lowe, A. S., Meade, T. J., Price, J., Williams, S. C. R., and Modo, M. (2007) The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry. NMR Biomed. 20, 77-89
32. Kok, M. B., Hak, S., Mulder, W. J. M., van der Schaft, D. W., Strijkers, G. J., and Nicolay, K. (2009) Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity. Magn. Reson. Med. 61, 1022-1032
33. Modo, M., Hoehn, M., and Bulte, J. W. (2005) Cellular MR imaging. Mol. Imaging 4, 143-164
34. Folkman, J. (1971) Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186
35. Carmeliet, P., and Jain, R. K. (2000) Angiogenesis in cancer and other diseases. Nature 407, 249-257
36. Song, L. P., Li, H., Sunar, U., Chen, J., Corbin, I., Yodh, A. G., and Zheng, G. (2007) Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer imaging and treatment. Int. J. Nanomed. 2, 767-774
37. Stefflova, K., Li, H., Chen, J., and Zheng, G. (2007) Peptide-based pharmacomodulation of a cancer-targeted optical imaging and photodynamic therapy agent. Bioconjug. Chem. 18, 379-388
38. Forrester, J. S., and Shah, P. K. (2006) Emerging strategies for increasing high-density lipoprotein. Am. J. Cardiol. 98, 1542-1549
39. Fuster, V., Moreno, P. R., Fayad, Z. A., Corti, R. C., and Badimon, J. J. (2005) Atherothrombosis and high-risk plaque-Part I: evolving concepts. J. Am. Coll. Cardiol. 46, 937-954
40. Fuster, V., Fayad, Z. A., Moreno, P. R., Poon, M., Corti, R., and Badimon, J. J. (2005) Atherothrombosis and high-risk plaque-Part II: approaches by noninvasive computed tomographic/ magnetic resonance imaging. J. Am. Coll. Cardiol. 46, 1209-1218
41. Conca, P., and Franceschini, G. (2008) Synthetic HDL as a new treatment for atherosclerosis regression: Has the time come? Nutr. Metab. Cardiovasc. Dis. 18, 329-335
42. Kontush, A., and Chapman, M. J. (2006) Antiatherogenic small, dense HDL-guardian angel of the arterial wall? Nat. Clin. Pract. Cardiovasc. Med. 3, 144-153