Physiological uncoupling of mitochondrial oxidative phosphorylation. Studies in different yeast species

Journal of Bioenergetics and Biomembranes

Volumn 43, Issue 3, 2011, Pages 323-331

  Guerrero Castillo, Sergio ^a   Araiza Olivera, Daniela ^a   Cabrera Orefice, Alfredo ^a   Espinasa Jaramillo, Juan ^a   Gutiérrez Aguilar, Manuel ^a   Luévano Martínez, Luís A ^a   Zepeda Bastida, Armando ^a   Uribe Carvajal, Salvador ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Branched respiratory chain; Debaryomyces hansenii; Permeability transition; Saccharomyces cerevisiae; Uncoupling; Uncoupling protein; Yarrowia lipolytica

Indexed keywords

OXIDOREDUCTASE; OXYGEN; PROTON; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN;

AEROBIC METABOLISM; ARTICLE; DEBARYOMYCES HANSENII; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; RESPIRATORY CHAIN; SACCHAROMYCES CEREVISIAE; STOICHIOMETRY; YARROWIA LIPOLYTICA; YEAST;

DEBAROMYCES; ION CHANNELS; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES; YARROWIA;

DEBARYOMYCES HANSENII; EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; YARROWIA LIPOLYTICA;

EID: 79959766843     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-011-9356-5     Document Type: Article

References (111)

1. Albury MS, Affourtit C, Crichton PG, Moore AL (2002) Structure of the plant alternative oxidase. Site-directed mutagenesis provides new information on the active site and membrane topology. J Biol Chem 277:1190-1194 (Pubitemid 34968867)
2. Andersson ME, Nordlund P (1999) A revised model of the active site of alternative oxidase. FEBS Lett 449:17-22 (Pubitemid 29182662)
3. Anraku Y, Ohya Y, Iida H (1991) Cell cycle control by calcium and calmodulin in Saccharomyces cerevisiae. Biochim Biophys Acta 1093:169-177
4. Azzolin L, von Stockum S, Basso E, Petronilli V, Forte MA, Bernardi P (2010) The mitochondrial permeability transition from yeast to mammals. FEBS Lett 584:2504-2509
5. Azzone GF, Zoratti M, Petronilli V, Pietrobon D (1985) The stoichiometry of H+ pumping in cytochrome oxidase and the mechanism of uncoupling. J Inorg Biochem 23:349-356
6. Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD (2007) Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9:550-555 (Pubitemid 46696536)
7. Beauvoit B, Rigoulet M, Bunoust O, Raffard G, Canioni P, Guerin B (1993) Interactions between glucose metabolism and oxidative phosphorylations on respiratory-competent Saccharomyces cerevisiae cells. Eur J Biochem 214:163-172 (Pubitemid 23168531)
8. Berman SB, Watkins SC, Hastings TG (2000) Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: evidence for reduced sensitivity of brain mitochondria. Exp Neurol 164:415-425 (Pubitemid 32008986)
9. Berthold DA, Andersson ME, Nordlund P (2000) New insight into the structure and function of the alternative oxidase. Biochim Biophys Acta 1460:241-254
10. Boles E, Heinisch J, Zimmermann FK (1993) Different signals control the activation of glycolysis in the yeast Saccharomyces cerevisiae. Yeast 9:761-770 (Pubitemid 23228876)
11. Brandt U (2006) Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem 75:69-92
12. Cabrera-Orefice A, Guerrero-Castillo S, Luevano-Martinez LA, Pena A, Uribe-Carvajal S (2010) Mitochondria from the salttolerant yeast Debaryomyces hansenii (halophilic organelles?). J Bioenerg Biomembr 42:11-19
13. Cascante M, Sorribas A, Canela EI (1994) Enzyme-enzyme interactions and metabolite channelling: alternative mechanisms and their evolutionary significance. Biochem J 298(Pt 2):313-320 (Pubitemid 24072471)
14. Cavalheiro RA, Fortes F, Borecky J, Faustinoni VC, Schreiber AZ, Vercesi AE (2004) Respiration, oxidative phosphorylation, and uncoupling protein in Candida albicans. Braz J Med Biol Res 37:1455-1461 (Pubitemid 39369032)
15. Cortes P, Castrejon V, Sampedro JG, Uribe S (2000) Interactions of arsenate, sulfate and phosphate with yeast mitochondria. Biochim Biophys Acta 1456:67-76 (Pubitemid 30015976)
16. Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ (2003) Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278:36027-36031 (Pubitemid 37139922)
17. Cheng S, Clancy CJ, Zhang Z, Hao B, Wang W, Iczkowski KA, Pfaller MA, Nguyen MH (2007) Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue. Cell Microbiol 9:492-501 (Pubitemid 46092174)
18. Czarna M, Jarmuszkiewicz W (2005) Activation of alternative oxidase and uncoupling protein lowers hydrogen peroxide formation in amoeba Acanthamoeba castellanii mitochondria. FEBS Lett 579:3136-3140 (Pubitemid 40797848)
19. de Souza W, Attias M, Rodrigues JC (2009) Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida). Int J Biochem Cell Biol 41:2069-2080
20. den Hollander JA, Ugurbil K, Brown TR, Bednar M, Redfield C, Shulman RG (1986) Studies of anaerobic and aerobic glycolysis in Saccharomyces cerevisiae. Biochemistry 25:203-211 (Pubitemid 16053099)
21. Devin A, Rigoulet M (2007) Mechanisms of mitochondrial response to variations in energy demand in eukaryotic cells. Am J Physiol Cell Physiol 292:C52-C58 (Pubitemid 46115121)
22. Diaz-Ruiz R, Averet N, Araiza D, Pinson B, Uribe-Carvajal S, Devin A, Rigoulet M (2008) Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction? J Biol Chem 283:26948-26955
23. Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW(2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae. FEMS Yeast Res 5:1215-1228 (Pubitemid 41607743)
24. Drose S, Brandt U (2008) The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex. J Biol Chem 283:21649-21654
25. Feniouk BA, Mulkidjanian AY, Junge W (2005) Proton slip in the ATP synthase of Rhodobacter capsulatus: induction, proton conduction, and nucleotide dependence. Biochim Biophys Acta 1706:184-194 (Pubitemid 40037774)
26. Fisher N, Bray PG, Ward SA, Biagini GA (2007) The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol 23:305-310 (Pubitemid 46935569)
27. Fisher N, Warman AJ, Ward SA, Biagini GA (2009) Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays. Meth Enzymol 456:303-320
28. Flores-Encarnacion M, Contreras-Zentella M, Soto-Urzua L, Aguilar GR, Baca BE, Escamilla JE (1999) The respiratory system and diazotrophic activity of Acetobacter diazotrophicus PAL5. J Bacteriol 181:6987-6995 (Pubitemid 29536511)
29. Forman HJ, Maiorino M, Ursini F (2010) Signaling functions of reactive oxygen species. Biochemistry 49:835-842
30. Fortes F, Castilho RF, Catisti R, Carnieri EG, Vercesi AE (2001) Ca2+ induces a cyclosporin A-insensitive permeability transition pore in isolated potato tuber mitochondria mediated by reactive oxygen species. J Bioenerg Biomembr 33:43-51 (Pubitemid 32294791)
31. Frank V, Kadenbach B (1996) Regulation of the H+/e- stoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial ATP/ADP ratios. FEBS Lett 382:121-124
32. Friberg H, Connern C, Halestrap AP, Wieloch T (1999) Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerability. J Neurochem 72:2488-2497 (Pubitemid 29242200)
33. Gincel D, Zaid H, Shoshan-Barmatz V (2001) Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function. Biochem J 358:147-155 (Pubitemid 32778108)
34. Gonzalez-Hernandez JC, Cardenas-Monroy CA, Pena A (2004) Sodium and potassium transport in the halophilic yeast Debaryomyces hansenii. Yeast 21:403-412 (Pubitemid 38519105)
35. Gonzalez-Meler MA, Ribas-Carbo M, Giles L, Siedow JN (1999) The effect of growth and measurement temperature on the activity of the alternative respiratory pathway. Plant Physiol 120:765-772 (Pubitemid 29384505)
36. Gosalvez M, Perez-Garcia J, Weinhouse S (1974) Competition for ADP between pyruvate kinase and mitochondrial oxidative phosphorylation as a control mechanism in glycolysis. Eur J Biochem 46:133-140
37. Guerin B, Bunoust O, Rouqueys V, Rigoulet M (1994) ATP-induced unspecific channel in yeast mitochondria. J Biol Chem 269:25406-25410 (Pubitemid 24336225)
38. Guerrero-Castillo S, Vazquez-Acevedo M, Gonzalez-Halphen D, Uribe-Carvajal S (2009) In Yarrowia lipolytica mitochondria, the alternative NADH dehydrogenase interacts specifically with the cytochrome complexes of the classic respiratory pathway. Biochim Biophys Acta 1787:75-85
39. Gustafsson L, Norkrans B (1976) On the mechanism of salt tolerance. Production of glycerol and heat during growth of Debaryomyces hansenii. Arch Microbiol 110:177-183
40. Gutierrez-Aguilar M, Perez-Vazquez V, Bunoust O, Manon S, Rigoulet M, Uribe S (2007) In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Biochim Biophys Acta 1767:1245-1251
41. Gutierrez-Aguilar M, Perez-Martinez X, Chavez E, Uribe-Carvajal S (2010) In Saccharomyces cerevisiae, the phosphate carrier is a component of the mitochondrial unselective channel. Arch Biochem Biophys 494:184-191
42. Hashimoto T, Nakamura Y, Nakamura F, Shirakura T, Adachi J, Goto N, Okamoto K, Hasegawa M (1994) Protein phylogeny gives a robust estimation for early divergences of eukaryotes: phylogenetic place of a mitochondria-lacking protozoan, Giardia lamblia. Mol Biol Evol 11:65-71 (Pubitemid 24034124)
43. Haworth RA, Hunter DR (1979) The Ca2+- induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site. Arch Biochem Biophys 195:460-467
44. Hoefnagel MH, Millar AH, Wiskich JT, Day DA (1995) Cytochrome and alternative respiratory pathways compete for electrons in the presence of pyruvate in soybean mitochondria. Arch Biochem Biophys 318:394-400
45. Hosler JP, Ferguson-Miller S, Mills DA (2006) Energy transduction: proton transfer through the respiratory complexes. Annu Rev Biochem 75:165-187 (Pubitemid 44118030)
46. Jarmuszkiewicz W, Behrendt M, Navet R, Sluse FE (2002) Uncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development. FEBS Lett 532:459-464 (Pubitemid 35441394)
47. Jarmuszkiewicz W, Antos N, Swida A, Czarna M, Sluse FE (2004) The effect of growth at low temperature on the activity and expression of the uncoupling protein in Acanthamoeba castellanii mitochondria. FEBS Lett 569:178-184 (Pubitemid 38844614)
48. Jarmuszkiewicz W, Woyda-Ploszczyca A, Antos-Krzeminska N, Sluse FE (2010) Mitochondrial uncoupling proteins in unicellular eukaryotes. Biochim Biophys Acta 1797:792-799
49. Joseph-Horne T, Hollomon DW, Wood PM (2001) Fungal respiration: a fusion of standard and alternative components. Biochim Biophys Acta 1504:179-195 (Pubitemid 32201892)
50. Jung DW, Bradshaw PC, Pfeiffer DR (1997) Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria. J Biol Chem 272:21104-21112 (Pubitemid 27373969)
51. Kadenbach B (2003) Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Biochim Biophys Acta 1604:77-94
52. Kerscher SJ (2000) Diversity and origin of alternative NADH: ubiquinone oxidoreductases. Biochim Biophys Acta 1459:274-283
53. Kerscher S, Drose S, Zwicker K, Zickermann V, Brandt U (2002) Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I. Biochim Biophys Acta 1555:83-91 (Pubitemid 35246010)
54. Korshunov SS, Skulachev VP, Starkov AA (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416:15-18 (Pubitemid 27470791)
55. Koshkin V, Wang X, Scherer PE, Chan CB, Wheeler MB (2003) Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J Biol Chem 278:19709-19715 (Pubitemid 36799156)
56. Kovaleva MV, Sukhanova EI, Trendeleva TA, Zyl'kova MV, Ural'skaya LA, Popova KM, Saris NE, Zvyagilskaya RA (2009) Induction of a non-specific permeability transition in mitochondria from Yarrowia lipolytica and Dipodascus (Endomyces) magnusii yeasts. J Bioenerg Biomembr 41:239-249
57. Kowaltowski AJ, Costa AD, Vercesi AE (1998) Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. FEBS Lett 425:213-216 (Pubitemid 28178892)
58. Krauss S, Zhang CY, Lowell BB (2005) The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 6:248-261 (Pubitemid 40314925)
59. Kushnareva Y, Murphy AN, Andreyev A (2002) Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J 368:545-553 (Pubitemid 35454532)
60. Leung AW, Varanyuwatana P, Halestrap AP (2008) The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition. J Biol Chem 283:26312-26323
61. Luevano-Martinez LA, Moyano E, de Lacoba MG, Rial E, Uribe-Carvajal S (2010) Identification of the mitochondrial carrier that provides Yarrowia lipolytica with a fatty acid-induced and nucleotide-sensitive uncoupling protein-like activity. Biochim Biophys Acta 1797:81-88
62. Luvisetto S, Azzone GF (1989) Local protons and uncoupling of aerobic and artificial delta muH-driven ATP synthesis. Biochemistry 28:1109-1116
63. Luvisetto S, Conti E, Buso M, Azzone GF (1991) Flux ratios and pump stoichiometries at sites II and III in liver mitochondria. Effect of slips and leaks. J Biol Chem 266:1034-1042 (Pubitemid 21907222)
64. Magnani T, Soriani FM, Martins Vde P, Policarpo AC, Sorgi CA, Faccioli LH, Curti C, Uyemura SA (2008) Silencing of mitochondrial alternative oxidase gene of Aspergillus fumigatus enhances reactive oxygen species production and killing of the fungus by macrophages. J Bioenerg Biomembr 40:631-636
65. Manon S, Guerin M (1997) The ATP-induced K(+)-transport pathway of yeast mitochondria may function as an uncoupling pathway. Biochim Biophys Acta 1318:317-321 (Pubitemid 27073612)
66. Manon S, Guerin M (1998) Investigation of the yeast mitochondrial unselective channel in intact and permeabilized spheroplasts. Biochem Mol Biol Int 44:565-575 (Pubitemid 28143823)
67. Manon S, Roucou X, Guerin M, Rigoulet M, Guerin B (1998) Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore? J Bioenerg Biomembr 30:419-429
68. Mather MW, Vaidya AB (2008) Mitochondria in malaria and related parasites: ancient, diverse and streamlined. J Bioenerg Biomembr 40:425-433
69. Maxwell DP, Wang Y, McIntosh L (1999) The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci USA 96:8271-8276 (Pubitemid 29328444)
70. Melo AM, Bandeiras TM, Teixeira M (2004) New insights into type II NAD(P)H:quinone oxidoreductases. Microbiol Mol Biol Rev 68:603-616 (Pubitemid 39628528)
71. Millar AH, Wiskich JT, Whelan J, Day DA (1993) Organic acid activation of the alternative oxidase of plant mitochondria. FEBS Lett 329:259-262 (Pubitemid 23252736)
72. Millenaar FF, Benschop JJ, Wagner AM, Lambers H (1998) The role of the alternative oxidase in stabilizing the in vivo reduction state of the ubiquinone pool and the activation state of the alternative oxidase. Plant Physiol 118:599-607 (Pubitemid 128652952)
73. Monzote L, Gille L (2010) Mitochondria as a promising antiparasitic target. Curr Clin Pharmacol 5:55-60
74. Moore AL, Siedow JN (1991) The regulation and nature of the cyanide-resistant alternative oxidase of plant mitochondria. Biochim Biophys Acta 1059:121-140
75. Moreno-Sanchez R, Saavedra E, Rodriguez-Enriquez S, Gallardo-Perez JC, Quezada H, Westerhoff HV (2010) Metabolic control analysis indicates a change of strategy in the treatment of cancer. Mitochondrion 10:626-639
76. Mourier A, Devin A, Rigoulet M (2010) Active proton leak in mitochondria: a new way to regulate substrate oxidation. Biochim Biophys Acta 1797:255-261
77. Nakajima-Shimada J, Sakaguchi S, Tsuji FI, Anraku Y, Iida H (2000) Ca2+ signal is generated only once in the mating pheromone response pathway in Saccharomyces cerevisiae. Cell Struct Funct 25:125-131 (Pubitemid 30453809)
78. Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London, ISBN 0125181213
79. Nicholls DG, Rial E (1999) A history of the first uncoupling protein, UCP1. J Bioenerg Biomembr 31:399-406 (Pubitemid 30053954)
80. Ohya Y, Umemoto N, Tanida I, Ohta A, Iida H, Anraku Y (1991) Calcium-sensitive cls mutants of Saccharomyces cerevisiae showing a Pet- phenotype are ascribable to defects of vacuolar membrane H(+)-ATPase activity. J Biol Chem 266:13971-13977 (Pubitemid 21907449)
81. Ovadi J, Saks V (2004) On the origin of intracellular compartmentation and organized metabolic systems.Mol Cell Biochem 256-257:5-12
82. Perez-Vazquez V, Saavedra-Molina A, Uribe S (2003) In Saccharomyces cerevisiae, cations control the fate of the energy derived from oxidative metabolism through the opening and closing of the yeast mitochondrial unselective channel. J Bioenerg Biomembr 35:231-241
83. Perrone GG, Tan SX, Dawes IW (2008) Reactive oxygen species and yeast apoptosis. Biochim Biophys Acta 1783:1354-1368
84. Pietrobon D, Azzone GF, Walz D (1981) Effect of funiculosin and antimycin A on the redox-driven H+- pumps in mitochondria: on the nature of 'leaks'. Eur J Biochem 117:389-394
85. Pietrobon D, Zoratti M, Azzone GF (1983) Molecular slipping in redox and ATPase H+ pumps. Biochim Biophys Acta 723:317-321
86. Pozniakovsky AI, Knorre DA, Markova OV, Hyman AA, Skulachev VP, Severin FF (2005) Role of mitochondria in the pheromoneand amiodarone-induced programmed death of yeast. J Cell Biol 168:257-269 (Pubitemid 40248223)
87. Prieto S, Bouillaud F, Ricquier D, Rial E (1992) Activation by ATP of a proton-conducting pathway in yeast mitochondria. Eur J Biochem 208:487-491
88. Prieto S, Bouillaud F, Rial E (1995) The mechanism for the ATP-induced uncoupling of respiration in mitochondria of the yeast Saccharomyces cerevisiae. Biochem J 307(Pt 3):657-661
89. Rasmusson AG, Soole KL, Elthon TE (2004) Alternative NAD(P)H dehydrogenases of plant mitochondria. Annu Rev Plant Biol 55:23-39 (Pubitemid 38940924)
90. Ricquier D (2005) Respiration uncoupling and metabolism in the control of energy expenditure. Proc Nutr Soc 64:47-52
91. Rottenberg H, Covian R, Trumpower BL (2009) Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles. J Biol Chem 284:19203-19210
92. Schmid R, Gerloff DL (2004) Functional properties of the alternative NADH:ubiquinone oxidoreductase from E. coli through comparative 3-D modelling. FEBS Lett 578:163-168 (Pubitemid 39576119)
93. Schneider A (2001) Unique aspects of mitochondrial biogenesis in trypanosomatids. Int J Parasitol 31:1403-1415
94. Segura C, Blair S (2003) Mitochondria in the Plasmodium genera. Biomedica 23:351-363
95. Siedow JN, Umbach AL (2000) The mitochondrial cyanide-resistant oxidase: structural conservation amid regulatory diversity. Biochim Biophys Acta 1459:432-439 (Pubitemid 30612417)
96. Srere PA (1987) Complexes of sequential metabolic enzymes. Annu Rev Biochem 56:89-124
97. Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF (2004) Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci 24:7779-7788 (Pubitemid 39215681)
98. Takeda M (1981) Glucose-induced inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae. Biochem J 198:281-287
99. Thevelein JM (1994) Signal transduction in yeast. Yeast 10:1753-1790
100. Tovar J, Fischer A, Clark CG (1999) The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica. Mol Microbiol 32:1013-1021 (Pubitemid 29255767)
101. Trumpower BL (1990) Cytochrome bc1 complexes of microorganisms. Microbiol Rev 54:101-129
102. Umbach AL, Siedow JN (2000) The cyanide-resistant alternative oxidases from the fungi Pichia stipitis and Neurospora crassa are monomeric and lack regulatory features of the plant enzyme. Arch Biochem Biophys 378:234-245 (Pubitemid 30397624)
103. van Dam K, Shinohara Y, Unami A, Yoshida K, Terada H (1990) Slipping pumps or proton leaks in oxidative phosphorylation. The local anesthetic bupivacaine causes slip in cytochrome c oxidase of mitochondria. FEBS Lett 277:131-133
104. Velazquez I, Pardo JP (2001) Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Arch Biochem Biophys 389:7-14 (Pubitemid 32911538)
105. Velours J, Rigoulet M, Guerin B (1977) Protection of yeast mitochondrial structure by phosphate and other H+- donating anions. FEBS Lett 81:18-22 (Pubitemid 8172080)
106. Wagner AM, Moore AL (1997) Structure and function of the plant alternative oxidase: its putative role in the oxygen defence mechanism. Biosci Rep 17:319-333 (Pubitemid 27466755)
107. Wallace PG, Pedler SM, Wallace JC, Berry MN (1994) A method for the determination of the cellular phosphorylation potential and glycolytic intermediates in yeast. Anal Biochem 222:404-408 (Pubitemid 24338861)
108. Wilhelm J, Fuksova H, Schwippelova Z, Vytasek R, Pichova A (2006) The effects of reactive oxygen and nitrogen species during yeast replicative ageing. Biofactors 27:185-193 (Pubitemid 44434942)
109. Yamada A, Yamamoto T, Yoshimura Y, Gouda S, Kawashima S, Yamazaki N, Yamashita K, Kataoka M, Nagata T, Terada H et al (2009) Ca2+- induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim Biophys Acta 1787:1486-1491
110. Zitomer RS, Nichols DL (1978) Kinetics of glucose repression of yeast cytochrome c. J Bacteriol 135:39-44 (Pubitemid 8377426)
111. Zundorf G, Kahlert S, Bunik VI, Reiser G (2009) alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience 158:610-616