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Volumn 3, Issue 2, 2011, Pages 2014-2031

EGFR-targeting as a biological therapy: Understanding Nimotuzumab's clinical effects

Author keywords

Biological therapy; Cancer treatment; EGFR; Nimotuzumab; Targeted therapy

Indexed keywords

BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; IPILIMUMAB; IRINOTECAN; NAVELBINE; NIMOTUZUMAB; PANITUMUMAB; PLACEBO;

EID: 79959759891     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3022014     Document Type: Review
Times cited : (36)

References (72)
  • 1
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer. Semin
    • Mendelsohn, J.; Baselga, J. Epidermal growth factor receptor targeting in cancer. Semin. Oncol. 2006, 33, 369-385.
    • (2006) Oncol , vol.33 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 2
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello, F.; Tortora, G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 2008, 358, 1160-1174.
    • (2008) N. Engl. J. Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 3
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • discussion 3080
    • Weinstein, I.B.; Joe, A. Oncogene addiction. Cancer Res. 2008, 68, 3077-3080; discussion 3080.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 7
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lièvre, A.; Bachet, J.; Boige, V.; Cayre, A.; Le Corre, D.; Buc, E.; Ychou, M.; Bouché, O.; Landi, B.; Louvet, C., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 2008, 26, 374-379.
    • (2008) J. Clin. Oncol , vol.26 , pp. 374-379
    • Lièvre, A.1    Bachet, J.2    Boige, V.3    Cayre, A.4    le Corre, D.5    Buc, E.6    Ychou, M.7    Bouché, O.8    Landi, B.9    Louvet, C.10
  • 9
    • 61449341457 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: An analysis of patients from german centers in the TRUST study
    • Schneider, C.; Heigener, D.; Schott-von-Römer, K.; Gütz, S.; Laack, E.; Digel, W.; Guschall, W.; Franke, A.; Bodenstein, H.; Schmidtgen, C., et al. Epidermal growth factor receptor-related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: an analysis of patients from german centers in the TRUST study. J. Thorac. Oncol. 2008, 3, 1446-1453.
    • (2008) J. Thorac. Oncol , vol.3 , pp. 1446-1453
    • Schneider, C.1    Heigener, D.2    Schott-von-Römer, K.3    Gütz, S.4    Laack, E.5    Digel, W.6    Guschall, W.7    Franke, A.8    Bodenstein, H.9    Schmidtgen, C.10
  • 10
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou, H.; Dahabreh, I.J.; Kanaloupiti, D.; Siannis, F.; Bafaloukos, D.; Kosmidis, P.; Papadimitriou, C.A.; Murray, S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008, 9, 962-972.
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6    Papadimitriou, C.A.7    Murray, S.8
  • 12
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken, J.B.; Trigo, J.; Hitt, R.; Koralewski, P.; Diaz-Rubio, E.; Rolland, F.; Knecht, R.; Amellal, N.; Schueler, A., Baselga, J. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J. Clin. Oncol. 2007, 25, 2171-2177.
    • (2007) J. Clin. Oncol , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3    Koralewski, P.4    Diaz-Rubio, E.5    Rolland, F.6    Knecht, R.7    Amellal, N.8    Schueler, A.9    Baselga, J.10
  • 15
    • 40949091368 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration approval: Panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens
    • Giusti, R.M.; Shastri, K.; Pilaro, A.M.; Fuchs, C.; Cordoba-Rodriguez, R.; Koti, K.; Rothmann, M.; Men, A.Y.; Zhao, H.; Hughes, M., et al. U.S. Food and Drug Administration approval: Panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin. Cancer Res. 2008, 14, 1296-1302.
    • (2008) Clin. Cancer Res , vol.14 , pp. 1296-1302
    • Giusti, R.M.1    Shastri, K.2    Pilaro, A.M.3    Fuchs, C.4    Cordoba-Rodriguez, R.5    Koti, K.6    Rothmann, M.7    Men, A.Y.8    Zhao, H.9    Hughes, M.10
  • 18
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore, M.J.; Goldstein, D.; Hamm, J.; Figer, A.; Hecht, J.R.; Gallinger, S.; Au, H.J.; Murawa, P.; Walde, D.; Wolff, R.A., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007, 25, 1960-1966.
    • (2007) J. Clin. Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10
  • 19
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • Fukuoka, M.; Yano, S.; Giaccone, G.; Tamura, T.; Nakagawa, K.; Douillard, J.; Nishiwaki, Y.; Vansteenkiste, J.; Kudoh, S.; Rischin, D., et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J. Clin. Oncol. 2003, 21, 2237-2246.
    • (2003) J. Clin. Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3    Tamura, T.4    Nakagawa, K.5    Douillard, J.6    Nishiwaki, Y.7    Vansteenkiste, J.8    Kudoh, S.9    Rischin, D.10
  • 20
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim, E.S.; Hirsh, V.; Mok, T.; Socinski, M.A.; Gervais, R.; Wu, Y.; Li, L.; Watkins, C.L.; Sellers, M.V.; Lowe, E.S., et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial. Lancet 2008, 372, 1809-1818.
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3    Socinski, M.A.4    Gervais, R.5    Wu, Y.6    Li, L.7    Watkins, C.L.8    Sellers, M.V.9    Lowe, E.S.10
  • 21
    • 79952185499 scopus 로고    scopus 로고
    • Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating epidermal growth factor receptor mutation: Implications for clinical practice and open issues
    • Gridelli, C.; De Marinis, F.; Di Maio, M.; Cortinovis, D.; Cappuzzo, F.; Mok, T. Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating epidermal growth factor receptor mutation: Implications for clinical practice and open issues. Lung Cancer 2011, 72, 3-8.
    • (2011) Lung Cancer , vol.72 , pp. 3-8
    • Gridelli, C.1    de Marinis, F.2    di Maio, M.3    Cortinovis, D.4    Cappuzzo, F.5    Mok, T.6
  • 22
    • 36049011272 scopus 로고    scopus 로고
    • Pharmacodynamic endpoints in primary breast cancer
    • Di Cosimo, S.; Baselga, J. Pharmacodynamic endpoints in primary breast cancer. Ann. Oncol. 2007, 18 (Suppl.9), ix21-ix23.
    • (2007) Ann. Oncol , vol.18 , Issue.SUPPL. 9
    • di Cosimo, S.1    Baselga, J.2
  • 25
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining
    • Peréz-Soler, R.; Saltz, L. Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining? J. Clin. Oncol. 2005, 23, 5235-5246.
    • (2005) J. Clin. Oncol , vol.23 , pp. 5235-5246
    • Peréz-Soler, R.1    Saltz, L.2
  • 26
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture, M.E. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat. Rev. Cancer 2006, 6, 803-812.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 28
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 30
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's Achilles' heel
    • Kroemer, G.; Pouyssegur, J. Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 2008, 13, 472-482.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 32
    • 68949146819 scopus 로고    scopus 로고
    • Nimotuzumab: A novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity
    • Boland, W.K.; Bebb, G. Nimotuzumab: A novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity. Expert Opin. Biol. Ther. 2009, 9, 1199-1206.
    • (2009) Expert Opin. Biol. Ther , vol.9 , pp. 1199-1206
    • Boland, W.K.1    Bebb, G.2
  • 35
    • 77957579026 scopus 로고    scopus 로고
    • Nimotuzumab with chemoradiation confers a survival advantage in treatment-naïve head and neck tumors over expressing EGFR
    • Basavaraj, C.; Sierra, P.; Shivu, J.; Melarkode, R.; Montero, E.; Nair, P. Nimotuzumab with chemoradiation confers a survival advantage in treatment-naïve head and neck tumors over expressing EGFR. Cancer Biol. Ther. 2010, 10, 673-681.
    • (2010) Cancer Biol. Ther , vol.10 , pp. 673-681
    • Basavaraj, C.1    Sierra, P.2    Shivu, J.3    Melarkode, R.4    Montero, E.5    Nair, P.6
  • 37
    • 79957542319 scopus 로고    scopus 로고
    • The emerging role of nimotuzumab in the treatment of non-small cell lung cancer
    • Boland, W.; Bebb, G. The emerging role of nimotuzumab in the treatment of non-small cell lung cancer. Biologics 2010, 4, 289-298.
    • (2010) Biologics , vol.4 , pp. 289-298
    • Boland, W.1    Bebb, G.2
  • 39
    • 74949130000 scopus 로고    scopus 로고
    • Nimotuzumab in pediatric glioma
    • Lam, C.; Bouffet, E.; Bartels, U. Nimotuzumab in pediatric glioma. Future Oncol. 2009, 5, 1349-1361.
    • (2009) Future Oncol , vol.5 , pp. 1349-1361
    • Lam, C.1    Bouffet, E.2    Bartels, U.3
  • 40
    • 33646434844 scopus 로고    scopus 로고
    • Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: Report from a phase I/II trial
    • Ramos, T.C.; Figueredo, J.; Catala, M.; González, S.; Selva, J.C.; Cruz, T.M.; Toledo, C.; Silva, S.; Pestano, Y.; Ramos, M., et al. Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: Report from a phase I/II trial. Cancer Biol. Ther. 2006, 5, 375-379.
    • (2006) Cancer Biol. Ther , vol.5 , pp. 375-379
    • Ramos, T.C.1    Figueredo, J.2    Catala, M.3    González, S.4    Selva, J.C.5    Cruz, T.M.6    Toledo, C.7    Silva, S.8    Pestano, Y.9    Ramos, M.10
  • 41
    • 27644573890 scopus 로고    scopus 로고
    • Nimotuzumab: Evidence of clinical benefit without rash
    • Allan, D.G.P. Nimotuzumab: evidence of clinical benefit without rash. Oncologist 2005, 10, 760-761.
    • (2005) Oncologist , vol.10 , pp. 760-761
    • Allan, D.G.P.1
  • 43
    • 2442704412 scopus 로고    scopus 로고
    • Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients
    • Crombet, T.; Osorio, M.; Cruz, T.; Roca, C.; del Castillo, R.; Mon, R.; Iznaga-Escobar, N.; Figueredo, R.; Koropatnick, J.; Renginfo, E., et al. Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients. J. Clin. Oncol. 2004, 22, 1646-1654.
    • (2004) J. Clin. Oncol , vol.22 , pp. 1646-1654
    • Crombet, T.1    Osorio, M.2    Cruz, T.3    Roca, C.4    del Castillo, R.5    Mon, R.6    Iznaga-Escobar, N.7    Figueredo, R.8    Koropatnick, J.9    Renginfo, E.10
  • 44
    • 77953664765 scopus 로고    scopus 로고
    • Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin
    • Ramakrishnan, M.S.; Eswaraiah, A.; Crombet, T.; Piedra, P.; Saurez, G.; Iyer, H.; Arvind, A.S. Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin. mAbs 2009, 1, 41-48.
    • (2009) MAbs , vol.1 , pp. 41-48
    • Ramakrishnan, M.S.1    Eswaraiah, A.2    Crombet, T.3    Piedra, P.4    Saurez, G.5    Iyer, H.6    Arvind, A.S.7
  • 45
    • 42949095528 scopus 로고    scopus 로고
    • Multi-center phase II clinical trial of humanized anti-epidermal factor receptor monoclonal antibody h-R3 combined with radiotherapy for locoregionally advanced nasopharyngeal carcinoma
    • Huang, X.; Yi, J.; Gao, L.; Xu, G.; Jin, J.; Yang, W.; Lu, T.; Wu, S.; Wu, R.; Hu, W., et al. Multi-center phase II clinical trial of humanized anti-epidermal factor receptor monoclonal antibody h-R3 combined with radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Zhonghua Zhong Liu Za Zhi 2007, 29, 197-201.
    • (2007) Zhonghua Zhong Liu Za Zhi , vol.29 , pp. 197-201
    • Huang, X.1    Yi, J.2    Gao, L.3    Xu, G.4    Jin, J.5    Yang, W.6    Lu, T.7    Wu, S.8    Wu, R.9    Hu, W.10
  • 46
    • 79953905206 scopus 로고    scopus 로고
    • Results from a pilot study of nimotuzumab with concurrent chemoradiation in patients with locally advanced squamous cell carcinoma of head and neck
    • Abstract 5565
    • Gupta, M.; Madholia, V.; Gupta, N.; Bhowmik, K. Results from a pilot study of nimotuzumab with concurrent chemoradiation in patients with locally advanced squamous cell carcinoma of head and neck. J. Clin. Oncol. 2010, 28, 15s, Abstract 5565.
    • (2010) J. Clin. Oncol , vol.28 , pp. 15
    • Gupta, M.1    Madholia, V.2    Gupta, N.3    Bhowmik, K.4
  • 47
    • 79955425807 scopus 로고    scopus 로고
    • Randomized phase II study of nimotuzumab, an anti-EGFR antibody, plus irinotecan in patients with 5-fluorouracil-based regimen-refractory advanced or recurrent gastric cancer in Korea and Japan: Preliminary results
    • Abstract 87
    • Kim, Y.; Sasaki, Y.; Lee, K.; Rha, S.; Park, S.; Boku, N.; Komatsu, Y.; Kim, T.; KIm, S.; Sakata, Y. Randomized phase II study of nimotuzumab, an anti-EGFR antibody, plus irinotecan in patients with 5-fluorouracil-based regimen-refractory advanced or recurrent gastric cancer in Korea and Japan: Preliminary results. J. Clin. Oncol. 2011, 29, 4s, Abstract 87.
    • (2011) J. Clin. Oncol , vol.29 , pp. 4
    • Kim, Y.1    Sasaki, Y.2    Lee, K.3    Rha, S.4    Park, S.5    Boku, N.6    Komatsu, Y.7    Kim, T.8    Kim, S.9    Sakata, Y.10
  • 48
    • 79954442316 scopus 로고    scopus 로고
    • Phase I clinical trial of the anti-EGFR monoclonal antibody nimotuzumab with concurrent external thoracic radiotherapy in Canadian patients diagnosed with stage IIb, III or IV non-small cell lung cancer unsuitable for radical therapy
    • Bebb, G.; Smith, C.; Rorke, S.; Boland, W.; Nicacio, L.; Sukhoo, R.; Brade, A. Phase I clinical trial of the anti-EGFR monoclonal antibody nimotuzumab with concurrent external thoracic radiotherapy in Canadian patients diagnosed with stage IIb, III or IV non-small cell lung cancer unsuitable for radical therapy. Cancer Chemother. Pharmacol. 2010, 67, 837-45.
    • (2010) Cancer Chemother. Pharmacol , vol.67 , pp. 837-845
    • Bebb, G.1    Smith, C.2    Rorke, S.3    Boland, W.4    Nicacio, L.5    Sukhoo, R.6    Brade, A.7
  • 49
    • 78650189254 scopus 로고    scopus 로고
    • A phase I study of nimotuzumab in combination with radiotherapy in stages IIB-IV non-small cell lung cancer unsuitable for radical therapy: Korean results
    • Choi, H.J.; Sohn, J.H.; Lee, C.G.; Shim, H.S.; Lee, I.; Yang, W.I.; Kwon, J.E.; Kim, S.K.; Park, M.; Lee, J.H., et al. A phase I study of nimotuzumab in combination with radiotherapy in stages IIB-IV non-small cell lung cancer unsuitable for radical therapy: Korean results. Lung Cancer 2011, 71, 55-59.
    • (2011) Lung Cancer , vol.71 , pp. 55-59
    • Choi, H.J.1    Sohn, J.H.2    Lee, C.G.3    Shim, H.S.4    Lee, I.5    Yang, W.I.6    Kwon, J.E.7    Kim, S.K.8    Park, M.9    Lee, J.H.10
  • 51
    • 33744600902 scopus 로고    scopus 로고
    • ClinicalTrials.gov: A service from the U.S, accessed 18 March 2011
    • ClinicalTrials.gov: A service from the U.S. National Institutes of Health. http://clinicaltrials.gov/ (accessed 18 March 2011).
    • National Institutes of Health
  • 53
  • 54
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang, X.D.; Jia, X.C.; Corvalan, J.R.; Wang, P.; Davis, C.G. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001, 38, 17-23.
    • (2001) Crit. Rev. Oncol. Hematol , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5
  • 56
    • 39449125850 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status
    • Akashi, Y.; Okamoto, I.; Iwasa, T.; Yoshida, T.; Suzuki, M.; Hatashita, E.; Yamada, Y.; Satoh, T.; Fukuoka, M.; Ono, K., et al. Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status. Br. J. Cancer 2008, 98, 749-755.
    • (2008) Br. J. Cancer , vol.98 , pp. 749-755
    • Akashi, Y.1    Okamoto, I.2    Iwasa, T.3    Yoshida, T.4    Suzuki, M.5    Hatashita, E.6    Yamada, Y.7    Satoh, T.8    Fukuoka, M.9    Ono, K.10
  • 58
    • 77949886293 scopus 로고    scopus 로고
    • Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
    • Khambata-Ford, S.; Harbison, C.T.; Hart, L.L.; Awad, M.; Xu, L.; Horak, C.E.; Dakhil, S.; Hermann, R.C.; Lynch, T.J.; Weber, M.R. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer. J. Clin. Oncol. 2010, 28, 918-927.
    • (2010) J. Clin. Oncol , vol.28 , pp. 918-927
    • Khambata-Ford, S.1    Harbison, C.T.2    Hart, L.L.3    Awad, M.4    Xu, L.5    Horak, C.E.6    Dakhil, S.7    Hermann, R.C.8    Lynch, T.J.9    Weber, M.R.10
  • 59
    • 62649134382 scopus 로고    scopus 로고
    • Interaction of antibodies with ErbB receptor extracellular regions
    • Schmitz, K.R.; Ferguson, K.M. Interaction of antibodies with ErbB receptor extracellular regions. Exp. Cell Res. 2009, 315, 659-670.
    • (2009) Exp. Cell Res , vol.315 , pp. 659-670
    • Schmitz, K.R.1    Ferguson, K.M.2
  • 60
    • 0037145332 scopus 로고    scopus 로고
    • Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibody
    • Crombet-Ramos, T.; Rak, J.; Pérez, R.; Viloria-Petit, A. Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibody. Int. J. Cancer 2002, 101, 567-575.
    • (2002) Int. J. Cancer , vol.101 , pp. 567-575
    • Crombet-Ramos, T.1    Rak, J.2    Pérez, R.3    Viloria-Petit, A.4
  • 62
    • 62549129875 scopus 로고    scopus 로고
    • Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
    • Diaz Miqueli, A.; Rolff, J.; Lemm, M.; Fichtner, I.; Perez, R.; Montero, E. Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies. Br. J. Cancer 2009, 100, 950-958.
    • (2009) Br. J. Cancer , vol.100 , pp. 950-958
    • Diaz Miqueli, A.1    Rolff, J.2    Lemm, M.3    Fichtner, I.4    Perez, R.5    Montero, E.6
  • 64
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
    • Viloria-Petit, A.; Crombet, T.; Jothy, S.; Hicklin, D.; Bohlen, P.; Schlaeppi, J.M.; Rak, J.; Kerbel, R.S. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis. Cancer Res. 2001, 61, 5090-5101.
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3    Hicklin, D.4    Bohlen, P.5    Schlaeppi, J.M.6    Rak, J.7    Kerbel, R.S.8
  • 67
    • 67650688162 scopus 로고    scopus 로고
    • The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients
    • Heimberger, A.B.; Sampson, J.H. The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients. Expert Opin. Biol. Ther. 2009, 9, 1087-1098.
    • (2009) Expert Opin Biol. Ther , vol.9 , pp. 1087-1098
    • Heimberger, A.B.1    Sampson, J.H.2
  • 68
    • 50249128651 scopus 로고    scopus 로고
    • Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine
    • Ramírez, B.S.; Alpízar, Y.A.; Fernández, D.R.H.; Hidalgo, G.G.; Capote, A.R.; Rodríguez, R.P.; Fernández, L.E. Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine. Vaccine 2008, 26, 4918-4926.
    • (2008) Vaccine , vol.26 , pp. 4918-4926
    • Ramírez, B.S.1    Alpízar, Y.A.2    Fernández, D.R.H.3    Hidalgo, G.G.4    Capote, A.R.5    Rodríguez, R.P.6    Fernández, L.E.7
  • 69
    • 62349132009 scopus 로고    scopus 로고
    • Monoclonal antibodies for cancer immunotherapy
    • Weiner, L.M.; Dhodapkar, M.V.; Ferrone, S. Monoclonal antibodies for cancer immunotherapy. Lancet 2009, 373, 1033-1040.
    • (2009) Lancet , vol.373 , pp. 1033-1040
    • Weiner, L.M.1    Dhodapkar, M.V.2    Ferrone, S.3
  • 70
    • 65549085367 scopus 로고    scopus 로고
    • Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: Support for a "vaccinal effect" of rituximab
    • Hilchey, S.P.; Hyrien, O.; Mosmann, T.R.; Livingstone, A.M.; Friedberg, J.W.; Young, F.; Fisher, R.I.; Kelleher, R.J.; Bankert, R.B.; Bernstein, S.H. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab. Blood 2009, 113, 3809-3812.
    • (2009) Blood , vol.113 , pp. 3809-3812
    • Hilchey, S.P.1    Hyrien, O.2    Mosmann, T.R.3    Livingstone, A.M.4    Friedberg, J.W.5    Young, F.6    Fisher, R.I.7    Kelleher, R.J.8    Bankert, R.B.9    Bernstein, S.H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.