Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF

Brain, Behavior, and Immunity

Volumn 23, Issue 8, 2009, Pages 1083-1088

  Ding, Jing ^a,b   Yu, Jie Zhong ^c   Li, Qin Ying ^a   Wang, Xin ^b   Lu, Chuan Zhen ^a   Xiao, Bao Guo ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Datong University   (China)

Author keywords

Astrocytes; Fasudil; Granulocyte colony stimulating factor; Oxygen glucose deprivation; Rho kinase inhibitor

Indexed keywords

FASUDIL; GLUCOSE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; LACTATE DEHYDROGENASE; OXYGEN; RHO KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL STIMULATION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; FLUORESCENCE ACTIVATED CELL SORTING; IN VITRO STUDY; ISCHEMIA; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANOXIA; ANTIBODIES, NEUTRALIZING; ASTROCYTES; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOSE; GRANULOCYTE COLONY-STIMULATING FACTOR; HIPPOCAMPUS; MICE; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RHO-ASSOCIATED KINASES;

EID: 73049086233     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.05.002     Document Type: Article

References (29)

1. Bendall S.C., Stewartm M.H., Menendez P., George D., Vijayaragavan K., Werbowetski-Ogilvie T., Ramos-Mejia V., Rouleau A., Yang J., Bosse M., Lajoie G., and Bhatia M. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 448 (2007) 1015-1021
2. Borisoff J.F., Chan C.C., Hiebert G.W., Oschipok L., Robertson G.S., Zamboni R., Steeves J.D., and Tetzlaff W. Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates. Mol. Cell Neurosci. 22 (2003) 405-416
3. Ferrer I., and Planas A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 62 (2003) 329-339
4. Harada M., Qin Y., Takano H., Minamino T., Zou Y., Toko H., Ohtsuka M., Matsuura K., Sano M., Nishi J., Iwanaga K., Akazawa H., Kunieda T., Zhu W., Hasegawa H., Kunisada K., Nagai T., Nakaya H., Yamauchi-Takihara K., and Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat. Med. 11 (2005) 305-311
5. Harper J.M., Krishnan C., Darman J.S., Deshpande D.M., Peck S., Shats I., Backovic S., Rothstein J.D., and Kerr D.A. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc. Natl. Acad. Sci. USA 101 (2004) 7123-7128
6. Honing H., van B.T., van P.S., Dijkstra C.D., van K.R., Collard J.G., and de V.H. RhoA activation promotes transendothelial migration of monocytes via ROCK. J. Leukoc. Biol. 75 (2004) 523-528
7. Hsu J.Y., Stein S.A., and Xu X.M. Temporal and spatial distribution of growth-associated molecules and astroglial cells in the rat corticospinal tract during development. J. Neurosci. Res. 80 (2005) 330-340
8. Ito T., Ohtori S., Hata K., Inoue G., Moriya H., Takahashi K., and Yamashita T. Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Spine 32 (2007) 2070-2075
9. Jordan J.D., Ma D.K., Ming G.L., and Song H. Cellular niches for endogenous neural stem cells in the adult brain. CNS Neurol. Disord. Drug Targets 6 (2007) 336-341
10. Kamai T., Tsujii T., Arai K., Takagi K., Asami H., Ito Y., and Oshima H. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin. Cancer Res. 9 (2003) 2632-2641
11. Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y., and Urabe T. Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J. Cereb. Blood Flow Metab. 26 (2006) 402-413
12. Koyanagi M., Takahashi J., Arakawa Y., Doi D., Fukuda H., Hayashi H., Narumiya S., and Hashimoto N. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J. Neurosci. Res. 86 (2008) 270-280
13. Lepley D., Paik J.H., Hla T., and Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res. 65 (2005) 3788-3795
14. Lingor P., Teusch N., Schwarz K., Mueller R., Mack H., Bahr M., and Mueller B.K. Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J. Neurochem. 103 (2007) 181-189
15. Lu C.Z., and Xiao B.G. G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem. Soc. Trans. 34 (2006) 1327-1333
16. Mueller B.K., Mack H., and Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov. 4 (2005) 387-398
17. Niederost B., Oertle T., Fritsche J., McKinney R.A., and Bandtlow C.E. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J. Neurosci. 22 (2002) 10368-10376
18. Riento K., and Ridley A.J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4 (2003) 446-456
19. Rikitake Y., Kim H.H., Huang Z., Seto M., Yano K., Asano T., Moskowitz M.A., and Liao J.K. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36 (2005) 2251-2257
20. Satoh S., Toshima Y., Hitomi A., Ikegaki I., Seto M., and Asano T. Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. Brain Res. 1193 (2008) 102-108
21. Schäbitz W.R., Kollmar R., and Schwaninger M. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34 (2003) 745-751
22. Schneider A., Kruger C., Steigleder T., Weber D., Pitzer C., Laage R., Aronowski J., Maurer M.H., Gassler N., Mier W., Hasselblatt M., Kollmar R., Schwab S., Sommer C., Bach A., Kuhn H.G., and Schabitz W.R. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115 (2005) 2083-2098
23. Sheikh A.M., Nagai A., Ryu J.K., McLarnon J.G., Kim S.U., and Masuda J. Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia 57 (2009) 898-907
24. Sterpetti P., Marucci L., Candelaresi C., Toksoz D., Alpini G., Ugili L., Baroni G.S., Macarri G., and Benedetti A. Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (2006) G624-G632
25. Sun H.W., Tong S.L., He J., Wang Q., Zou L., Ma S.J., Tan H.Y., Luo J.F., and Wu H.X. RhoA and RhoC-siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. World J. Gastroenterol. 13 (2007) 3517-3522
26. Walker M.R., Patel K.K., and Stappenbeck T.S. The stem cell niche. J. Pathol. 217 (2009) 169-180
27. Watanabe K., Ueno M., Kamiya D., Nishiyama A., Matsumura M., Wataya T., Takahashi J.B., Nishikawa S., Nishikawa S., Muguruma K., and Sasai Y. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25 (2007) 681-686
28. Wataya T., Muguruma K., and Sasai Y. Human pluripotent stem cell and neural differentiation. Brain Nerve 60 (2008) 1165-1172
29. Yanqing Z., Yu-Min L., Jian Q., Bao-Guo X., and Chuan-Zhen L. Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia. Brain Res. 1098 (2006) 161-169