Design, Synthesis, ADME Properties, and Pharmacological Activities of β-Alanyl-D-histidine (D-Carnosine) Prodrugs with Improved Bioavailability

ChemMedChem

Volumn 6, Issue 7, 2011, Pages 1269-1282

  Orioli, Marica ^a   Vistoli, Giulio ^a   Regazzoni, Luca ^a   Pedretti, Alessandro ^a   Lapolla, Annunziata ^b   Rossoni, Giuseppe ^a   Canevotti, Renato ^c   Gamberoni, Luca ^c   Previtali, Massimo ^c   Carini, Marina ^a   Aldini, Giancarlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c Flamma SpA   (Italy)

Author keywords

Carbonyl quenching; Carnosine octyl ester; L and d carnosine; Lipophilic prodrugs; Obese zucker rats

Indexed keywords

3 NITROTYROSINE; ACETIC ACID DERIVATIVE; ACETYL DEXTRO CARNOSINE; ACETYL DEXTRO CARNOSINE ETHYL ESTER; ACETYL DEXTRO CARNOSINE METHYL ESTER; ACETYL DEXTRO CARNOSINE OCTYL ESTER; BENZYLOXY DEXTRO CARNOSINE; BENZYLOXY DEXTRO CARNOSINE METHYL ESTER; BETA ALANYL DEXTRO HISTIDINE; CARBAMIC ACID DERIVATIVE; CARBOXYLESTERASE; CARNOSINE; DEXTRO CARNOSINE ETHYL ESTER; DEXTRO CARNOSINE ISOAMYL ESTER; DEXTRO CARNOSINE ISOPROPYL ESTER; DEXTRO CARNOSINE OCTYL ESTER; DEXTRO CARNOSINE PALMITOYL ESTER; ETHYLOXY DEXTRO CARNOSINE BENZYL ESTER; ETHYLOXY DEXTRO CARNOSINE BUTYL ESTER; ETHYLOXY DEXTRO CARNOSINE ISOPROPYL ESTER; ETHYLOXY DEXTRO CARNOSINE METHYL ESTER; PENTOSIDINE; PROSTAGLANDIN F2 ALPHA; UNCLASSIFIED DRUG; Z DEXTRO CARNOSINE ETHYL ESTER;

ARTICLE; CARBONYLATION; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HYDROLYSIS; DRUG SYNTHESIS; DYSLIPIDEMIA; HUMAN; HYPERTENSION; KIDNEY FUNCTION; LIPID OXIDATION; LIPOPHILICITY; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BIOLOGICAL AVAILABILITY; CARBOXYLESTERASE; CARNOSINE; COMPUTER SIMULATION; DIPEPTIDES; DRUG DESIGN; ESTERS; HUMANS; HYDROLYSIS; PRODRUGS; RATS; RATS, ZUCKER;

EID: 79959733586     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100042     Document Type: Article

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