Glioma specific extracellular missense mutations in the first cysteine rich region of epidermal growth factor receptor (EGFR) initiate ligand independent activation

Cancers

Volumn 3, Issue 2, 2011, Pages 2032-2049

  Ymer, Susie I ^a   Greenall, Sameer A ^a,c   Cvrljevic, Anna ^a   Cao, Diana X ^b   Donoghue, Jacqui F ^a   Chandana Epa, V ^c   Scott, Andrew M ^b   Adams, Timothy E ^c   Johns, Terrance G ^a  

^a MONASH UNIVERSITY   (Australia)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^c CSIRO   (Australia)

Author keywords

Autoactivation; DE2 7EGFR; Dimerization; Disulfide bond; EGFR; Extracellular domain mutation; Free cysteine

Indexed keywords

CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; EXTRACELLULAR DOMAIN; FEMALE; FIBROBLAST; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MISSENSE MUTATION; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; TUMOR XENOGRAFT;

EID: 79959733559     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3022032     Document Type: Article

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